기술연관분석을 이용한 연구개발 의사결정 정보 도출

오경준(Kyung-Joon Oh) 한국기술혁신학회 2000 기술혁신학회지 Vol.3 No.3

산전진단된 선천성 낭종성선종양폐기형의 임신결과

오경준 ( Kyung Joon Oh ),양혜진 ( Hye Jin Yang ),이경아 ( Kyung A Lee ),이승미 ( Seung Mi Lee ),이준호 ( Jun Ho Lee ),박찬욱 ( Chan Wook Park ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),신희철 ( Hee Chul Syn ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.4

목적: 산전진단된 선천성 낭종성선종양폐기형의 진단 정확도와 임신결과 및 예후에 영향을 미치는 인자를 확인하고자 하였다. 연구 방법: 1999년 1월부터 2008년 6월까지 서울대학교병원에서 산전초음파를 통해 선천성 낭종성선종양폐기형으로 진단된 32예를 대상으로 산모 및 신생아의 의무기록을 후향적으로 조사하였다. 결과: 산전초음파검사를 통해 선천성 낭종성선종양폐기형으로 진단된 32예 중 24예에서 추적관찰이 이루어 졌다. 출생 후 조직검사나 영상의학검사를 Objective: To determine the accuracy of antenatal diagnosis, pregnancy outcome and the predictors for adverse outcome in antenatally diagnosed congenital cystic adenomatoid malformation (CCAM). Methods: A retrospective review was performed on a total of 32

모체태아의학

오경준 ( Kyung Joon Oh ),( Roberto Romero ),( Jee Yoon Park ),( Joonho Lee ),( Agustin Conde-agudelo ),( Joon-seok Hong ),( Bo Hyun Yoon ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Background: Cervical insufficiency is a risk factor for spontaneous midtrimester abortion or early preterm birth. Intra-amniotic infection has been reported in 8-52% of such patients and intraamniotic inflammation in 81%. Some professional organizations have recommended perioperative antibiotic treatment when emergency cervical cerclage is performed. The use of prophylactic antibiotics is predicated largely on the basis that they reduce the rate of complications during the course of vaginal surgery. However, it is possible that antibiotic administration can also eradicate intra-amniotic infection/inflammation and improve pregnancy outcome. Objective: To describe the outcome of antibiotic treatment in patients with cervical insufficiency and intra-amniotic infection/inflammation. Study Design: The study population consisted of 22 women who met the following criteria: (1) singleton pregnancy; (2) painless cervical dilatation of >1 cm between 16.0 and 27.9 weeks of gestation; (3) intact membranes and absence of uterine contractions; (4) transabdominal amniocentesis performed for the evaluation of the microbiologic and inflammatory status of the amniotic cavity; (5) presence of intra-amniotic infection/inflammation; and (6) antibiotic treatment (regimen consisted of ceftriaxone, clarithromycin, and metronidazole). Amniotic fluid was cultured for aerobic and anaerobic bacteria and genital mycoplasmas, and polymerase chain reaction for Ureaplasma spp. was performed. Intraamniotic infection was defined as a positive amniotic fluid culture for microorganisms or a positive polymerase chain reaction for Ureaplasma spp., and intra-amniotic inflammation was suspected when there was an elevated amniotic fluid white blood cell count (≥19 cells/mm3) or a positive rapid test for metalloproteinase-8 (sensitivity 10 ng/mL). For the purpose of this study, the “gold standard” for diagnosis of intra-amniotic inflammation was an elevated interleukin-6 concentration (>2.6 ng/mL) using an enzyme-linked immunosorbent assay. The results of amniotic fluid interleukin-6 were not available to managing clinicians. Follow-up amniocentesis was routinely offered to monitor the microbiologic and inflammatory status of the amniotic cavity and fetal lung maturity. Treatment success was defined as resolution of intra-amniotic infection/inflammation or delivery ≥34 weeks of gestation. Results: Of 22 patients with cervical insufficiency and intra-amniotic infection/inflammation, 3 (14%) had microorganisms in the amniotic fluid. Of the 22 patients, 6 (27%) delivered within 1 week of amniocentesis and the remaining 16 (73%) delivered more than 1 week after the diagnostic procedure. Among these, 12 had a repeat amniocentesis to assess the microbial and inflammatory status of the amniotic cavity; in 75% (9/12), there was objective evidence of resolution of intra-amniotic inflammation or intra-amniotic infection demonstrated by analysis of amniotic fluid at the time of the repeat amniocentesis. Of the 4 patients who did not have a follow-up amniocentesis, all delivered ≥34 weeks, 2 of them at term; thus, treatment success occurred in 59% (13/22) of cases. Conclusion: In patients with cervical insufficiency and intraamniotic infection/inflammation, administration of antibiotics (ceftriaxone, clarithromycin, and metronidazole) was followed by resolution of the intra-amniotic inflammatory process or intra-amniotic infection in 75% of patients and was associated with treatment success in about 60% of cases.

천연가스산업 연구개발 투자 평가 연구

박승민(Seung-Min Park),오경준(Kyung Joon Oh) 한국가스학회 2000 한국가스학회지 Vol.4 No.4

네트워크 효과를 고려한 천연가스산업의 기술적 효율성 분석

이정동(Jeong-Dong Lee),오경준(Kyung-Joon Oh) 한국기술혁신학회 2000 기술혁신학회지 Vol.3 No.3

에어로졸 자기조립에 의한 실리카 나노분말의 표면개질

길대섭,장희동,장한권,조국,김선경,오경준,최진훈,Kil, Dae-Sup,Jang, Hee-Dong,Chang, Han-Kwon,Cho, Kuk,Kim, Sun-Kyung,Oh, Kyoung-Joon,Choi, Jin-Hoon 한국재료학회 2010 한국재료학회지 Vol.20 No.2

Surface modification of silica nanoparticles was investigated using an aerosol self assembly. Stearic acid was used as surface treating agent. A two-fluid jet nozzle was employed to generate an aerosol of the colloidal suspension, which contained 20 nm of silica nanoparticles, surface modifier, and ethyl alcohol. Powder properties such as morphology, specific surface area and pore size distribution were analyzed by SEM, BET and BJH methods, respectively. Surface properties of the silica power were analyzed by FT-IR. The OH bond of the $SiO_2$ surface was converted to a C-H bond. It was revealed that the hydrophilic surface changed to a hydrophobic one due to the aerosol self assembly. Morphology of the surface treated powder was nanostructured with lots of pores having an average diameter of around $2\;{\mu}m$. Depending on the stearic acid concentration (0.25 to 1.0 wt%), the pore size distribution of the particles and the degree of hydrophobicity ranged from 1.5 nm to 180 nm and 29.6% to 50.2%, respectively.

양수세포와 태아조직에서 세포유전학검사 결과의 불일치

박정우 ( Jeong Woo Park ),강혜심 ( Hye Sim Kang ),오경준 ( Kyung Joon Oh ),박찬욱 ( Chan Wook Park ),안현숙 ( Hyun Sook Ahn ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12

We present two fetuses who were prenatally diagnosed by amniocentesis as having chromosomal mosaicism but who had a normal karyotype in the fetal blood by cordocentesis. One of the both fetuses had Turner and the other had trisomy 20 mosaicism. The prognosis for Turner mosaicism and trisomy 20 mosaicism diagnosed prenatally has yet to be established. The pregnancy with 45,X/46,XX mosaicism was terminated at 23+3 weeks` gestation. Autopsy findings showed no features of Turner`s syndrome. Postnatal cytogenetic analysis revealed 45,X[4]/46,XX[52] mosaicism in skin and 46,XX in the lung tissue. The other fetus had amniocytes with trisomy 20 mosaicism and fetal cord blood cells with a normal karyotype. The baby was delivered at 38+2 weeks` gestation. At birth and 3 months after birth, no apparent abnormal findings were found. These cases with chromosomal discrepancy among various fetal tissues are rare. Two cases were discussed with the review of literature.

조기진통 임신부에서 임상적 감염의 비침습적 예측

이성윤 ( Sung Youn Lee ),박교훈 ( Kyo Hoon Park ),오경준 ( Kyung Joon Oh ),정은하 ( Eun Ha Jeong ),김시내 ( Shi Nae Kim ),정희정 ( Hee Jung Jung ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.11

목적: 본 연구의 목적은 양막파수 없이 조기진통으로 입원한 임신부에서 비침습적 임상지표를 이용하여 입원 후 발생한 임신부 또는 신생아의 임상적 감염의 가능성을 예측할 수 있는 모형을 만들고자 하였다. 연구 방법: 양막파수 없는 조기진통(임신 20.0~35.0주) 임신부 165명에서 경질초음파로 자궁경부길이를 측정하였고 임신부 혈액에서 백혈구 수를 측정하였다. 임상적 감염은 임신부에서 분만 시 임상적 융모양막염이 발생하거나 혹은 신생아에서 선천성 패혈증이 발생한 경우로 정의하였다. 통계분석은 receiver operating characteristic (ROC) 곡선과 논리회귀분석을 사용하였다. 결과: 임상적 감염의 빈도는 5% (8/165)였다. 임상적 감염이 존재한 군은 존재하지 않는 군보다 입원 시 임신주수가 유의하게 낮았고, 자궁경부길이도 유의하게 짧았으나 백혈구 수는 유의하게 높았다. 논리회귀분석을 시행하여 최종 모형이 만들어 졌으며 이때 혈액 백혈구 수, 자궁경부길이, 임신주수가 가장 중요한 예측인자로 선택되었다. 이 모형은 Hosmer와 Lemeshow검정에서 적절한 통계적합도를 보여주었으며(P=0.202), ROC 곡선에서 area under curve값은 0.822로 측정되어 유용한 예측력을 보여주었다. 결론: 양막파수 없이 조기진통으로 입원한 임신부에서 자궁경부길이, 혈액 백혈구 수, 임신주수의 임상지표를 기반으로 한 모형을 이용하면 비침습적으로 임신부 또는 신생아의 임상적 감염을 예측할 수 있다. Objective: To develop a model based on non-invasive variables to predict the probability of subsequent maternal and/or neonatal clinical infection in women admitted to hospital for preterm labor with intact membranes. Methods: Transvaginal ultrasound for measurement of cervical length was performed and maternal blood was collected for the determination of white blood cell (WBC) count at admission in 165 consecutive women with preterm labor (between 20.0 and 35.0 weeks). Clinical infection was defined as the presence of clinical chorioamnionitis at delivery or early onset neonatal sepsis. Receiver operating characteristic (ROC) curves and logistic regression analysis were used for statistical analyses. Results: The prevalence of clinical infection was 5% (8/165). Women who developed clinical infection had a significantly lower median gestational age at admission, a lower shorter median cervical length, and a higher median WBC count as compared to those who did not develop clinical infection. Logistic regression analysis was performed and a final model was chosen, which included maternal blood WBC, cervical length, and gestational age as the best predictors of clinical infection. A risk score was calculated containing these 3 variables for each patient. The model was shown to have an adequate goodness of fit (P=0.202), and the area under the ROC curve was 0.822, indicating reasonably good discrimination. Conclusion: In women admitted to hospital for preterm labor with intact membranes, the risk for the subsequent maternal and/or neonatal clinical infection can be predicted non-invasively with a risk score based on cervical length at admission, maternal blood WBC, and gestational age.

만삭 전 조기양막파수 임신부에서 양수 내 백혈구 수와 태반 염증성 병변의 관련성에 관한 연구

정은하 ( Eun Ha Jeong ),박교훈 ( Kyo Hoon Park ),오경준 ( Kyung Joon Oh ),이성윤 ( Sung Youn Lee ),김시내 ( Shi Nae Kim ),정희정 ( Hee Jung Jung ),이정연 ( Jeong Yeun Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.2

목적: 만삭 전 조기양막파수 임신부에서 양수 내 백혈구 수와 태반 염증성 병변의 존재 및 정도와의 관련성을 확인하고자 한다. 연구방법: 만삭 전 조기양막파수로 입원한 단태임신 임신부 중 양수 내 백혈구 수 측정 및 양수 배양검사를 위해 경복부 양수천자가 시행되고, 양수 천자 후 72시간 내에 조기분만(임신 24.0-35.6주 사이)되었으며, 태반의 조직학적 검사가 시행된 90명의 임신부를 대상으로 하였다. 결과: 조직학적 융모양막염의 빈도는 32%였으며 양성 양수 배양인 경우는 21%였다. 태반 염증성 병변이 존재하는 경우는 존재하지 않는 경우에 비하여 양수 내 백혈구 수가 유의하게 많았다. 양수 내 백혈구 수는 교란변수의 영향을 보정한 후에도 태반 염증성 병변의 존재와 유의한 관련성을 나타내었다. 또한 양수 내 백혈구 수는 각각의 태반 부위별 염증 정도가 심할수록 유의하게 증가하였다. 태반 염증성 병변 존재를 가장 잘 예측할 수 있는 양수 백혈구 수의 절단치는 25개/mm3였고 이때 민감도 62%, 특이도 77%를 나타내었다. 결론: 만삭 전 조기양막파수 임신부에서 양수 내 백혈구 수는 태반의 염증성 병변의 존재 및 정도와 유의한 관련성을 가지고 있으며 산전에 이의 존재 유무를 예측할 수 있는 독립적 인자이다. Objective: To examine the relationship between amniotic fluid (AF) white blood cell (WBC) count and the presence and severity of inflammatory lesions of the placenta in women with preterm premature rupture of membranes (PPROM). Methods: This retrospective cohort study included 90 consecutive women with PPROM (24.0-35.6 weeks) who met the following criteria: singleton gestation; transabdominal amniocentesis performed to obtain AF for culture and WBC count; delivery within 72 hours of amniocentesis; placental histologic examination after preterm delivery. Results: The prevalence of histologic chorioamnionitis was 32% (29/90) and that of positive amniotic fluid culture was 21% (19/90). Patients with histologic chorioamnionitis had a significantly higher AF WBC count than those without this lesion. Logistic regression analysis demonstrated that AF WBC count had a significant relationship with histologic chorioamnionitis after controlling for gestational age and AF culture. The median AF WBC count increased significantly according to the higher severity of inflammation in each type of placental histologic section. According to receiver operating characteristic curve analysis, the best cut-off value of AF WBC count for predicting histological chorioamnionitis was 25 cells/mm3, with a sensitivity of 62% and a specificity of 77%. Conclusion: Both the presence and greater severity of inflammatory lesions of the placenta are associated with an elevated AF WBC count. AF WBC count is an important and independent predictor for inflammatory lesions of the placenta in women with PPROM.

임신 중기의 리스테리아 감염으로 인한 자궁내태아사망

신재준 ( Jae Jun Shin ),최지영 ( Ji Young Choe ),김선민 ( Sun Min Kim ),이승미 ( Seung Mi Lee ),오경준 ( Kyung Joon Oh ),박찬욱 ( Chan Wook Park ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),박성혜 ( Sung Hye Park ),신희철 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.3

Listeriosis is an infectious disease caused by Listeria monocytogenes, a gram positive, facultatively anaerobic bacterium. Listeriosis occurs primarily in newborn infants, elderly patients, immunocompromised patients and pregnant women. One third of the patients are pregnant women, and complications of this disease include miscarriage, stillbirth and preterm labor. We experienced a case of listeriosis in a singleton pregnancy at 23rd week of gestation that presented with fever, chill, lower abdominal pain, backache, and eventually resulted in fetal death in utero. Autopsy results of the stillborn baby, as well as blood and amniotic fluid culture of the mother confirmed Listeria monocytogenes infection. Proper antibiotics therapy thereafter led to clear recovery of the infected mother. We report this case with a brief review of literature.