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염선경 ( Sun Kyoung Yum ),유민지 ( Min Ji Ryu ),박나윤 ( Na Yoon Park ),김성민 ( Seong Min Kim ),이경욱 ( Kyong Wook Yi ),박현태 ( Hyun Tae Park ),신정호 ( Jung Ho Shin ),허준영 ( Jun Young Hur ),김선행 ( Sun Haeng Kim ),김탁 ( T 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.3
Premenstrual dysphoric disorder (PMDD) is a common condition that temporarily, but repetitively affects patient`s global function. Patients and physicians alike are often uncertain whether prescription medication for PMDD is sufficiently effective. The primary objective of this analysis is signal detection in efficacy of pharmacological treatments in PMDD. Secondary objective is to review which symptoms are likely to respond to which medications. The review included otherwise healthy women with clinician confirmed diagnosis of PMDD who participated in phase 3 clinical trials for the treatment of PMDD. Twelve pair-wise comparisons of drug and placebo for 2,420 patients with PMDD were performed. Oral contraceptives and selective serotonin receptor inhibitor were effective in alleviating symptoms of PMDD compared to placebo. Both Intermittent and continuous administration were more effective than placebo. This meta-analysis provides a signal that pharmacological treatment of PMDD is effective.
한국 여성에서 폐경증상 중 혈관운동증상에 대한 역학 조사
김탁 ( Tak Kim ),박형무 ( Hyoung Moo Park ),윤병구 ( Byung Koo Yoon ),이병익 ( Byoung Ick Lee ),염선경 ( Sun Kyoung Yum ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.3
Objectives: Vasomotor symptoms (VMS) are one of the most annoying symptoms experienced by postmenopausal women. Generally, 75% of women over 50 years of age experience VMS. This study is an epidemiologic survey of menopausal symptoms and VMS in Korean menopausal women. Methods: Survey participants were recruited from Korean provinces based on the Korean population study conducted in 2010 and using multi-level stratification by age and geographic location, and random sampling. Healthy perimenopausal and menopausal Korean women aged between 40 to 60 years and who participated in the interview survey were included in the study. The Korean version of the Menopause Rating Scale (MRS) and the Korean version of Women`s Health Questionnaire (WHQ) was used to investigate the prevalence of menopausal related symptoms and to assess quality of life. Results: Among the 1,500 women, 66% were classified as perimenopause, 28% as menopause, and 7% had undergone hysterectomy. Typically, 41.6% of women in perimenopause reported having experienced VMS in recent six months. About 53.1% of women in early menopause and 36.5% of women in late menopause had experienced VMS in the past six months. Whereas, 30.6% of women with hot flashes, and 27.9% of women with sweating stated that these symptoms were not related to menopause. Conclusion: The prevalence of VMS in Korean women seems to be less than women of Western countries. Overall subjective experience of menopause was perceived as increasingly positive with age. Awareness of menopausal symptoms appeared lower than expected. Perimenopausal and menopausal women in Korea rarely sought medical care. (J Korean Soc Menopause 2012;18:147-154)