전국 한방의료기관 한의사 대상 한의 변증활용 현황 조사

여민경,박기현,장은수,이영섭,Yeo, Minkyung,Park, Kihyun,Jang, Eunsu,Lee, Youngseop 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : The aim of this study was to survey the present utilization of pattern identification(PI) in the clinical field among Korean Medicine Doctors. Method : This survey was conducted from Oct. 1 to Oct. 31, 2014 by face-to-face interview using structured questionnaire. The subjects were 400 korean medicine doctors who worked in hospitals or clinics. The questionnaire consisted of two sections - a demographics section(i.e., sex, age, clinical experience, place of work, residence and so on) and the main research section(i.e., the PI utilization rate, the utilization of PI systems, the utilization of PI in the clinical domain and in the treatment domain, the correlation between utilization PI and so on). Results : This study revealed that subjects used the PI to 66.7% of their patients on average. The utilization rate of PI in patients was significantly higher for female physicians than for male physicians, for physicians worked in clinics than for physicians who worked in hospitals and for physicians with more than 10 years clinical experience than for physicians with less than 10 years clinical experience. In the utilization of PI systems, Visceral PI was most as 92.0%. There were significant difference on the PI utilization rate according to utilization of Meridian and Collateral PI, Triple Energizer PI, Defense, Qi, Nutrient and Blood PI, Six-Meridian PI and Six Excesses PI. As a result of analysing the PI utilization rate by clinical domain and in the treatment domain, the Treatment and the Drug Treatment showed the highest values. Among utilized PI systems, the correlation coefficients between Defense, Qi, Nutrient and Blood PI and Triple Energizer PI showed the highest value, but the correlation coefficients between Sasang Constitutional Medicine with the each PI showed substantially lower value. Conclusion : The results of this study demonstrate that usage of PI was higher than usage of U code(in KCD) usage in clinical field. we suggested that additional studies on using PI and developing more appropriate standardized tool should be conducted to widen scope of PI's utilization.

수용액에 용출된 에폭시수지 화합물의 TiO₂광분해효과와 생물독성에 미치는 영향

여민경,조은정 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3

Epoxy resins are mostly used as a molding material for drinking water tank Bisphenol A is used as a constituent material for epoxy resins and is widely suspected to act as an endocrine disruptor In this study, we investigated embryo hatching in zebrafish reared to water undergone leaching process of expoxy resin and found a decreased survival rate Bisphenol A eluted from epoxy resin to drinking water tank was completely degraded by T₁O₂, photocatalysis We detected 7 8 ng/ml of bisphenol A in epoxy resin tank and observed that the concentration was undetectable after 48h photocatalysis over T₁O₂ There was no toxicity in hatching rates in zebrafish and morphugenesis after photocatalysis The effect of T₁O₂, photocatalysis reactions on the catalase activities to the fly stage of zebrafish was also examined At 1 week post hatching, catalase activities were higher both in the group of epoxy resin with 48 h T₁O₂ photocatalysis and to the T₁O₂ photocatalysis for 48 hours were higher than control group However catalase activities of the treatment group of epoxy resin by T₁O₂ photocatalysis for 48 hours were similar to control to 5 weeks post hatching tries In conclusion, the toxicity of T₁O₂ photocatalysis was not observed to this zebrafish.

Effects of CuxTiOy nanometer particles on biological toxicity during zebrafish embryogenesis

여민경,강미숙 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.3

This study investigated the toxicity of Cu (1, 10, 15, and 25 mol%) loaded TiO2 and pure TiO2 nanometersized photocatalysts during the development of zebrafish embryogenesis. The hatch rate decreased in the CuxTiOy nanoparticles exposed groups (10, 20 ppt) compared to pure TiO2 nano-particles (10, 20 ppt) exposed or control groups. These CuxTiOy and TiO2 nanoparticles led to developing mutated embryos with abnormal notochord formation, no tail, damaged eyes and abnormal heart development. Exposure to CuxTiOy and pure TiO2 nanoparticles led to glutathione increase, catalase activity increase, GST increase and GSR increase than control. Penetration of the CuxTiOy and pure TiO2 nanoparticles to the embryo was also tested. It was observed that CuxTiOy and pure TiO2 nanoparticles penetrated into cells. Moreover CuxTiOy penetrated into the skin, nerve and yolk sac epithelium cells on the zebrafish larvae as aggregated particles, which may induce the direct interaction between nanoparticles and cell to cause adverse biological responses. As a result, the Cu-loaded TiO2 nanoparticles had the toxicity of zebrafish embryo and larvae in the water environment.

Zebrafish발생기에서 TiO2(P-25) 나노 입자의 생물 독성

여민경,조윤희 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.3

수용액에 용출된 에폭시수지 화합물의 TiO₂광분해효과와 생물독성에 미치는 영향

여민경,조은정 환경독성보건학회 2004 한국독성학회 심포지움 및 학술발표회 Vol.- No.-

Removal of microplastics using biomaterials

여민경 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.0

전국 한방의료기관 한의사 대상 만성질환의 변증활용 현황 조사

여민경,박기현,이영섭 대한예방한의학회 2017 대한예방한의학회지 Vol.21 No.2

Objectives : The aim of this study was to survey the present utilization of pattern identification(PI) by chronic disease and using PI system in the clinical field among Korean medicine doctors. Methods : This survey was conducted from Oct. 1 to Oct. 31, 2014 by face-to-face interview using structured questionnaire. The subjects were 400 Korean medicine doctors who worked in hospitals or clinics. The questionnaire consisted of whether use clinical experience by chronic disease and the utilization of PI, the utilization of PI systems, the PI utilization rate, and the correlation between utilization PI and so on. General elements consisted of sex, age, clinical experience, place of work, district and so on. Results and Conclusions : This study revealed that clinical experience by chronic disease used 24.0-90.8%. The most chronic diseases were chronic fatigue and chronic pain, and least disease was cancer. Experience of the utilization of PI among Korean medicine doctors who have clinical experience was 87.8-97.1%. Also, the most utilized disease was chronic gastritis & gastric ulcer, and least disease was dyslipidemia. In this case, the most common cases were using the one PI between the utilization of PI systems, and the utilization ratio of Visceral PI was the highest. Phi coefficient between the PI systems in chronic diseases divided into positive correlation and negative correlation. The correlation of dementia between Triple energizer PI and Six excesses PI was the highest at positive correlation, and the frequency of occurrence between Defense, Qi, Nutrient and Blood PI was the highest at positive correlation. The correlation of osteoarthropathy between Meridian and Collateral PI and Sasang Constitutional Medicine was the highest at negative correlation. Also the frequency of occurrence between Qi, Blood, Fluid and Humor PI and Sasang Constitutional Medicine was the highest at negative correlation. We hope that additional studies on systematic PI research of chronic disease which needed to be in korean oriental medicine and meet the needs of clinical consumer continue based on this study.

Clinical Significance of an HPV DNA Chip Test with Emphasis on HPV-16 and/or HPV-18 Detection in Korean Gynecological Patients

여민경,이아원,허수영,박종섭 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.4

Background: Human papillomavirus (HPV) is a major risk factor for cervical cancer. Methods: We evaluated the clinical significance of the HPV DNA chip genotyping assay (MyHPV chip, Mygene Co.) compared with the Hybrid Capture 2 (HC2) chemiluminescent nucleic acid hybridization kit (Digene Corp.) in 867 patients. Results: The concordance rate between the MyHPV chip and HC2 was 79.4% (kappa coefficient, κ = 0.55). The sensitivity and specificity of both HPV tests were very similar (approximately 85% and 50%, respectively). The addition of HPV result (either MyHPV chip or HC2) to cytology improved the sensitivity (95%, each) but reduced the specificity (approximately 30%, each) compared with the HPV test or cytology alone. Based on the MyHPV chip results, the odds ratio (OR) for ≥ high-grade squamous intraepithelial lesions (HSILs) was 9.9 in the HPV-16/18 (+) group and 3.7 in the non-16/18 high-risk (HR)-HPV (+) group. Based on the HC2 results, the OR for ≥ HSILs was 5.9 in the HR-HPV (+) group. When considering only patients with cytological diagnoses of “negative for intraepithelial lesion or malignancy” and “atypical squamous cell or atypical glandular cell,” based on the MyHPV chip results, the ORs for ≥ HSILs were 6.8 and 11.7, respectively, in the HPV-16/18 (+) group. Conclusions: The sensitivity and specificity of the MyHPV chip test are similar to the HC2. Detecting HPV-16/18 with an HPV DNA chip test, which is commonly used in many Asian countries, is useful in assessing the risk of high-grade cervical lesions.

1P-666 Biological toxicity effects of biodegradation using hydra protein on Nano Graphene oxide and Nano-silver during zebrafish embryogenesis

여민경,이진아,김순석 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.0

인삼 사포닌이 운동 흰쥐의 골격근 크레아틴 키나제 동위효소의 활성에 미치는 영향

여민경,남상열 한국통합생물학회 1991 동물학회지 Vol.34 No.3

본 연구는 인삼 사포닌(Ponax ginseng C.A. Meyer)이 수영운동을 부하시킨 웅성 횐쥐(Sprague-Dawley 계, 360 $\pm$ 40 9)의 대퇴근 크레아틴 키나제(Creative Kinase, CK: E.C. 2.7.3.2) 동위효소 활성에 미치는 영향을 연구하였다. 운동군은 3시간 동안 수영운동시켰으며 ,인삼군은 인삼 사포닌을 체중 Kg 당 120 mg 복강투여하였다. 인삼 사포닌을 투여한 운동군은 수영운동 1시간 전에 인삼 사포닌을 투여한 후 3시간 동안 수영시켰다. 인삼군의 MB-CK의 활성은 대조군보다 유의하게 증가하였다(P<0.01). 또한 인삼 비투여 운동군과 인삼 투여 운동군에서의 MM-CK활성은 대조군보다 각각 현저하게 증가하였고(P < 0.01와 P < 0.05), 특히 인삼 투여 운동군에서 BB-CK활성이 대조군보다 유의하게 증가하였다(P < 0.01). 인삼 사포닌은 일반적으로 CK-동위효소의 활성을 증가시키고, 운동은 MM-CK의 활성을 현저하게 증가시켰으며, 인삼 투여 운동군에서 BB-CK의 활성이 인삼 비투여 운동군보다 현저하게 증가하였다. 따라서 인삼 사포닌과 운동이 CK동위효소 활성에 상승의 효과를 나타내는 것으로 생각된다.