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Helicobacter pylori 연구동향 및 전망: Helicobacter pylori에 의한 위질환 발생의 분자생물 기전
여말희 ( Mar Ie Yeo ),함기백 ( Ki Baik Hahm ) 대한소화기학회 2005 대한소화기학회지 Vol.46 No.3
Helicobacter pylori (H. pylori) causes chronic gastritis in human stomach, a minority of which progress to peptic ulcer disease, atrophic gastritis, or gastric malignancies. Clinical outcomes of H. pylori infection has been shown to depend on the variability of H. pylori virulence factors, host susceptibility, environmental factors and their interactions. This review provides an update on the molecular pathogenesis of H. pylori infection, focused on H. pylori virulence factors, H. pylori-gastric epithelium interactions, and modulation of host cell signaling. Understanding of H. pylori molecular pathogenic mechanism will facilitate the development of novel treatment strategies for eradication of the bacterium and prevention of H. pylori-induced gastropathy. (Korean J Gastroenterol 2005;46: 181-188)
여말희 ( Marie Yeo ),조성원 ( Sung Won Cho ),함기백 ( Ki Baik Hahm ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.5
In the post-genomic era, the focus of research is now moving to functional genomics employing the information on predicted gene products provided by genome sequencing. Proteomics, the global analysis of structures, functions, and interactions of whole cel