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엄상용,김용대,김헌,홍장수 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.2
Apolipoprotein A1 (ApoA1) is the major protein component of high density lipoprotein (HDL) cholesterol in blood, and ApoA1 genetic polymorphisms modulate the blood lipid profiles. This study was conducted in order to investigate the association between three genetic polymorphisms (rs670, rs5069, and rs5070) of ApoA1 and blood lipid profiles in postmenopausal Korean women. A total of 130 postmenopausal women who visited a hospital in order to undergo screening tests were subjects of this study. Genetic polymporphisms and blood lipid profiles were determined using a direct sequencing and spectrophotometric assay, respectively. A significant linkage disequilibrium was observed between all tested single nucleotide polymorphisms. ApoA1 rs5070 genetic polymorphism showed a marginally significant association with HDL cholesterol levels (p=0.066). After adjusting for age, body mass index, smoking, alcohol drinking, medication, hypertension, and diabetes mellitus, we found that the ApoA1 rs5070 genetic polymorphism is a significant determinant of HDL cholesterol levels (β=4.421, p=0.037). According to the results of this study, ApoA1 rs5070 genetic polymorphism may be an important genetic marker associated with HDL cholesterol in postmenopausal Korean women.
엄상용,김헌 대한의학회 2013 Journal of Korean medical science Vol.28 No.3
The objective of this study was to develop new spirometric reference equations for the Korean population using the raw data of the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV, 2007–2009). A total of 4,753 healthy lifelong nonsmokers without respiratory diseases and symptoms were selected as the reference population. Spirometric reference equations were derived through multiple regression analysis. The newly developed reference equations for spirometry parameters were as follows: FEV1 (L) = -0.00025410 × (Age [years])2 + 0.00012644 × (Height [cm])2 −0.00262 × Weight (kg) + 0.61493 (Men); FEV1 (L) = -0.00017538 × Age2 +0.00009598 × Height2 − 0.00231 × Weight + 0.46877 (Women); FVC (L) =-0.00000219 × Age3 + 0.0000006995642 × Height3 + 1.19135 (Men); FVC (L) = 0.0167 × Age − 0.00030284 × Age2 + 0.0000005850287 × Height3 + 0.77609(Women); FEV1/FVC (%) = -0.00289 × Age2 − 0.16158 × Height3 + 114.13736 (Men);FEV1/FVC (%) = -0.21382 × Age − 0.00000143 × Height3 + 97.62514 (Women). The newly developed spirometric reference equation in this study can be used as criteria for the interpretation of spirometry results and the diagnosis of respiratory diseases in Korean adults.
엄상용,김진용,Yong Hoon Yoon,Sinwon Lee,김영학,송재관 대한심장학회 2014 Korean Circulation Journal Vol.44 No.1
Paravalvular leaks (PVLs) often occur after surgical valve replacement. Surgical reoperation has been the gold standard of therapy forPVLs, but it carries a higher operative risk and an increased incidence of re-leaks compared to the initial surgery. In high surgical risk pa-tients with appropriate geometries, transcatheter closure of PVLs could be an alternative to redo-surgery. Here, we report a case of success-ful staged transcatheter closures of a fistula tract between the aorta and right atrium, and mitral PVLs after mitral valve replacement andtricuspid annuloplasty.
엄상용 한국코칭능력개발원 2003 코칭능력개발지 Vol.5 No.1
본 연구는 치매환자를 대상으로 운동치료를 통하여 혼자 이동할 수 있고 일상생활을 영위할 근력을 강화시키며 낙상과 근육 경직을 예방하여 독립적인 생활을 할 수 있도록 도움을 주고, 나아가 치매요양원이나 가정에서 실제적으로 활용할 수 있는 기초 자료를 제공하는데 목적이 있다. 운동치료의 주요 목적은 근력과 근지구력 및 균형능력의 증진과 기능부전을 예방하여 삶의 질을 높이는데 있다. 운동치료의 일반원칙을 살펴보면, 환자의 특성상 단순한 동작을 되풀이해야 하고 격려와 보상이 있어야 하며 그룹운동이 권장되고 오전이나 오후에 운동을 해야 한다 운동 강도보다 시간과 빈도가 중요하고 시간과 빈도보다는 순응도가 더 중요하다. 치매환자의 운동검사에는 심폐지구력 (6분 걷기), 근지구력 (앉았다 일어서기), 근력 (악력), 유연성 (좌전 굴), 평형성 (눈뜨고 외발서기), 민첩성 (누웠다 일어서기) 검사가 있으며 분기별로 측정하여 평가하고 검사가 불가능한 경우 검사를 생략하고 가장 낮은 단계의 운동부터 시작한다. 치매환자의 운동량은 주당 2-3회 빈도, 최대심박수의 60-80% 즉 , VO₂max 42-70% 강도, 일회 20-60 분이 효과적이다. 치매환자를 대상으로 한 운동치료는 환자에게 할 수 있다는 자신감과 성취감을 줄뿐만 아니라 불안 과 우울증을 완화시켜 치매의 진행속도를 지연시키는데 매우 효과적일 것으로 기대된다.
엄상용 한국이벤트컨벤션학회 2005 이벤트 컨벤션 연구 Vol.1 No.2
This study aims to find key factors that increase the important factor and the user satisfaction of the event information web-sites. The results of the collected data reveal that information quality, system quality, perceived usefulness, playfulness and community affect on the important factors of the event information web sites. However, community do not affect on the important factor of the event information web sites. This result shows that "community" which is an affecting factor in a commerce web site, are not interesting to user who access event information web sites. Moreover, they consider the quality of information more than community. Based on this research, we can see that the most important factor for the user satisfaction of the event information web site is the information quality. .