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양진호,Andrea McDowell,서호찬,김성원,민택기,지영구,최영우,박해심,편복양,김윤근 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.5
Purpose: Associations between a wide variety of diseases and the microbiome have been extensively verified. Recently, there has been a rising interest in the role the microbiome plays in atopic dermatitis (AD). Furthermore, metagenomic analysis of microbe-derived extracellular vesicles (EVs) has revealed the importance and relevance of microbial EVs in human health. Methods: We compared the diversity and proportion of microbial EVs in the sera of 24 AD patients and 49 healthy controls, and developed a diagnostic model. After separating microbial EVs from serum, we specifically targeted the V3–V4 hypervariable regions of the 16S rDNA gene for amplification and subsequent sequencing. Results: Alpha and beta diversity between controls and AD patients both differed, but only the difference in beta diversity was significant. Proteobacteria, Firmicutes, and Bacteroidetes were the dominant phyla in healthy controls and AD patients, accounting for over 85% of the total serum bacterial EVs. Also, Proteobacteria, Firmicutes, Actinobacteria, Verrucomicrobia, and Cyanobacteria relative abundances were significantly different between the AD and control groups. At the genus level, the proportions of Escherichia-Shigella, Acinetobacter, Pseudomonas, and Enterococcus were drastically altered between the AD and control groups. AD diagnostic models developed using biomarkers selected on the basis of linear discriminant analysis effect size from the class to genus levels all yielded area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy of value 1.00. Conclusions: In summary, microbial EVs demonstrated the potential in their use as novel biomarkers for AD diagnosis. Therefore, future work should investigate larger case and control groups with cross-sectional or longitudinal clinical data to explore the utility and validity of serum microbiota EV-based AD diagnosis.
Ku 대역 위성통신용 5 W GaN MMIC 전력증폭기
김성형,진일비,양영구 한국전자파학회 2023 한국전자파학회논문지 Vol.34 No.11
본 논문에서는 150-nm GaN-HEMT 공정을 사용하여 Ku 대역 3-stage MMIC 전력증폭기를 설계하였다. 출력단에서 high pass 구조를 사용하여 회로의 크기를 줄이고 구동 증폭단에서 높은 부하 임피던스를 선택함으로써 높은 효율을 얻었다. 0.5 ms 주기의 10 % duty cycle 펄스 CW 신호를 사용하여 전력증폭기를 측정한 결과 13∼16 GHz 대역에서 포화전력37∼38 dBm, 34∼41 %의 power added efficiency(PAE)와 26∼30 dB의 전력이득 측정결과를 보인다. 제작된 전력증폭기의크기는 3.6×1.1 mm2이며 위성통신용 모듈의 송신부에 사용하기 적합하다. In this study, a 3-stage power amplifier monolithic microwave integrated circuits (MMIC) in the Ku-band frequency range is designed using a 150-nanometer GaN-HEMT process. High efficiency is achieved by employing a high-pass structure at the output stage to reduce the circuit size and selecting a high output impedance at the driver amplification stage. When measuring the power amplifier using a 0.5 ms period and 10 % duty cycle pulse continuous wave (CW) signal, the results indicate a saturated power of 37∼38 dBm in the 13∼16 GHz range with a power added efficiency (PAE) of 34∼41 % and a power gain of 26∼30 dB. The power amplifier is sized 3.6×1.1 mm², demonstrating suitability for use in the transmission section of satellite communication modules.
A VLSI Design for Digital Pre-distortion with Pipelined CORDIC Processors
박종강,문준영,김경훈,양영구,김종태 대한전자공학회 2014 Journal of semiconductor technology and science Vol.14 No.6
In a wireless communications system, a pre-distorter is often used to compensate for the nonlinear distortions that result from operating a power amplifier near the saturation region, thereby improving system performance and increasing the spectral efficiency for the communication channels. This paper presents a new VLSI design for the polynomial digital pre-distorter (DPD). The proposed DPD uses a Coordinate Rotation Digital Computing (CORDIC) processor and a PD process with a fully-pipelined architecture. Due to its simple and regular structure, it can be a competitive design when compared to existing polynomial-type and approximated DPDs. Implementing a fifth-order distorter with the proposed design requires only 43,000 logic gates in a 0.35 μm CMOS standard cell library.
김유선,최준표,김민혜,박한기,양세정,김윤섭,김태범,조유숙,오연목,지영구,이상도,김윤근 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.3
Purpose: Recent experimental evidence shows that extracellular vesicles (EVs) in indoor dust induce neurtrophilic pulmonary inflammation, which is a characteristic pathology in patients with severe asthma and chronic obstructive pulmonary disease (COPD). In addition, COPD is known to be an important risk factor for lung cancer, irrespective of cigarette smoking. Here, we evaluated whether sensitization to indoor dust EVs is a risk for the development of asthma, COPD, or lung cancer. Methods: Serum IgG antibodies against dust EVs were measured in 90 healthy control subjects, 294 asthmatics, 242 COPD patients, and 325 lung cancer patients. Serum anti-dust EV IgG titers were considered high if they exceeded a 95 percentile value of the control subjects. Age-, gender-, and cigarette smoke-adjusted multiple logistic regression analyses were performed to determine odds ratios (ORs) for asthma, COPD, and lung cancer patients vs the control subjects. Results: In total, 4.4%, 13.6%, 29.3%, and 54.9% of the control, asthma, COPD, and lung cancer groups, respectively, had high serum anti-dust EV IgG titers. Adjusted multiple logistic regression revealed that sensitization to dust EVs (high serum anti-dust EV IgG titer) was an independent risk factor for asthma (adjusted OR, 3.3; 95% confidence interval [CI], 1.1-10.0), COPD (adjusted OR, 8.0; 95% CI, 2.0-32.5) and lung cancer (adjusted OR, 38.7; 95% CI, 10.4-144.3). Conclusions: IgG sensitization to indoor dust EVs appears to be a major risk for the development of asthma, COPD, and lung cancer.
김혜윤(Hye yun Kim),양영구(Youngoo Yang),이재호(Jae-ho Lee),박성수(Sungsoo Park) 한국철도학회 2014 한국철도학회 학술발표대회논문집 Vol.2014 No.10
본 논문에서는 고속열차 위치정보의 정밀도를 개선하기 위하여 한국철도기술연구원에서 수행중인 “400km/h급 고정밀 철도 위치검지 기술개발”국가 R&D과제를 통해 개발중인 철도교통 트랜스폰더 시스템의 환경시험 요구사항을 연구하였다. 철도교통 트랜스폰더 시스템은 차량 하부에 설치 되는 리더, 지상에 설치되는 태그 및 이동장비인 프로그래머로 구성되며, 각 하부 시스템 별로 설치 위치가 상이하므로, 이를 고려하여 온도, 방진 및 방수, 진동, 충격 등 환경시험 요구사항을 도출할 필요가 있다. 본 논문에서는 IEC, EN, KS 및 유로발리스 규격 등을 참고하여 철도교통 트랜스폰더 시스템의 환경시험 요구사항을 도출하였다. Korea Railroad Research Institute has been conducting a national R&D project of “Technology development on the position detection for the 400km/h class railroad with high precision” in order to improve precision in location information for high-speed trains. In this paper, environmental testing requirements for the railway transponder system is presented. The railway transponder system is composed of an RFID reader beneath the train, RFID tags along the track, and a portable programmer. Since installation location of each component is different, it is necessary to derive requirements for environmental tests, such as temperature, dust and moisture, mechanical stress, etc. Environmental requirements of the railway transponder system are presented, considering IEC, EN, KS, and Eurobalise standard.