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Vinorelbine의 혈관외 유출로 발생한 항암제 유발 약물반응
장민수 ( Min Soo Jang ),김준희 ( Joon Hee Kim ),양명현 ( Myeong Hyeon Yang ),이강훈 ( Kang Hoon Lee ),한상화 ( Sang Hwa Han ),서기석 ( Kee Suck Suh ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.5
Vinorelbine, a vinca alkaloid anticancer drug, is widely used to treat various cancers. Several dermatological side effects of vinorelbine, such as acral erythema, phlebitis, and severe extravasation reactions, have been reported. Vinorelbine is categorized as non-DNA binding vesicant that undergoes high metabolism and clearance, which limits the degree of tissue injury if extravasation occurs. A 73-year-old male presented with erythematous linear patches on his left wrist and a 51-year-old male presented with erythematous eroded patches and bullae on his right forearm. Histopathologic study showed interface changes with basal vacuolar degeneration and epidermal dysmaturation. Separation of the dermis from the epidermis was observed, as well as interstitial and perivascular inflammatory infiltrates in the dermis. Both patients were being treated with vinorelbine for lung cancer. Before the onset of the skin lesions, accidental intravenous extravasation of vinorelbine had occurred. Herein, we report two cases of chemotherapy induced drug reaction due to extravasation of vinorelbine. (Korean J Dermatol 2016;54(5):372∼376)
Dermoscopy를 보조적으로 이용하여 진단한 폴립모양 Spitz 모반
장민수 ( Min Soo Jang ),이강훈 ( Kang Hoon Lee ),양명현 ( Myeong Hyeon Yang ),김준희 ( Joon Hee Kim ),한상화 ( Sang Hwa Han ),서기석 ( Kee Suck Suh ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.4
Spitz nevus is a benign melanocytic nevus, common in children or young adults, and it has histological features that are confused with those of malignant melanoma. Polypoid Spitz nevus is the benign counterpart of polypoid malignant melanoma. A 22-year-old woman presented with a solitary 1.5×1.5 cm-sized firm polypoid erythematous nodule on the left thigh. On dermoscopy, pink to yellowish lagoons intermingled by white fibrous septa were found but milky red globules or irregular linear vessels were not found. Therefore, melanoma almost could be ruled out cautiously. Histopathology showed symmetrical, well-circumscribed, polypoid architecture with predominant dermal nests of spindle cells. Immunohistochemically, the nevus cells were strongly positive for S-100 protein and negative for HMB-45. Thus, the diagnosis of polypoid Spitz nevus was made. Herein, we report a case of polypoid Spitz nevus that was differentiated from polypoid melanoma by histopathologic and dermoscopic findings. (Korean J Dermatol 2016;54(4):293∼296)