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양대혁,박영환,전흥재 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
In this study, we designed poly(lactic-co-glycolic acid) (PLGA) meshes immobilized with thrombin which can enhance the hemostatic effect. After argon plasma treatment of PLGA, various concentration of thrombin (1, 2 and 4 IU/cm2) was conjugated to the substrate through ketimine reaction (THR-PLGA), and their efficacies on hemostasis were evaluated in vitro and in vivo. The in vitro and in vivo tests exhibited that THR-PLGA meshes exhibited higher thrombin and FXIIIa activities than pristine PLGA. In particular, THR4-PLGA showed a rapid hemostatic effect. Our findings suggested that THR4-PLGA mesh may have a potential as hemostatic agent for treatment of organ laceration. **This work was supported by the Ministry of Trade, Industry & Energy (MOTIE, Korea) (10047811, 20003560 and 20004627) and by the National Research Foundation of Korea (NRF) (2017R1D1A1B03033195) of Korea.
히드라진 가교 PAN 입자의 가수분해 및 흡습발열 특성
양대혁,박흥수,김영호,Yang, Dae-Hyuk,Park, Heung-Su,Kim, Young-Ho 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.1
Polyacrylonitrile (PAN) particles synthesized by dispersion/emulsion polymerization of acrylonitrile monomer were cross-linked with hydrazine in order to prevent its dissolution in water when they were subjected to hydrolysis. Hydrazine-crosslinked PAN (cPAN) particles were hydrolyzed with NaOH solution in order to impart them with high hydrophilicity. The effects of the cross-linking degree, i.e., the hydrazine concentration during the cross-linking of PAN, NaOH concentration on the hydrolysis behavior of cPAN particles and their particle shapes were analyzed. Results revealed that cross-linking of PAN with 5% hydrazine solution at $110^{\circ}C$ for 3 hours and hydrolysis of cPAN with 5% NaOH solution at $80^{\circ}C$ for 3 hours is suitable for the preparation of highly hydrophilic and water-insoluble PAN particles. Then, hydrophilicity and the heat release property of the hydrolyzed, cross-linked PAN (h-cPAN) particles were examined. The h-cPAN particles exhibited a temperature rise of up to $11^{\circ}C$ by water absorption and a moisture regain of up to 23% at $20^{\circ}C$ and 65% RH, depending on the hydrazine cross-linking and NaOH hydrolysis conditions. Cotton fabrics were treated with h-cPAN dispersion solutions of different concentrations by a normal pad-dry process. The temperature changes of the treated fabrics by water absorption were measured. The h-cPAN treated fabrics showed higher temperature rise by moisture absorption compared to untreated one. It indicates that the particles can be used as a potential moisture-absorbing heat release finishing agent for textiles.
양대혁,권일근,박하나,배민수,이정복,허동녕,이원준,박영민,조영환,김덕수 한국고분자학회 2012 Macromolecular Research Vol.20 No.6
The purpose of this study was to evaluate the effects of a GENESIS-BCPTM scaffold composed of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) on bone formation. The rela tive ratio of components forming GENESIS-BCPTM was investigated by confirming the molar ratio of Ca/P through energy dispersive spectrometer (EDS) analysis. The results being that the scaffold is comprised of 60% HAp and 40% β-TCP. Moreover,scanning electron microscopy (SEM) images showed a unique surface morphology similar to a soccer ball. X-ray diffraction (XRD) analysis showed that the porosity, crystallinity, and Ca/P ratio were 65.5%, 84.9%, and 1.61%,respectively. In vitro tests including cytotoxicity and cell proliferation showed a good biocompatibility of GENESIS-BCPTM. In vivo tests, including mouse skull test, and hematoxylin and eosin stains of GENESIS-BCPTM implanted in rabbit and human subjects showed that the bone graft is effective to accelerate new bone formation. It was concluded that GENESIS-BCPTM can be used as an effective alloplast bone graft.
양대혁,권일근,배민수,Lingjuan Qiao,허동녕,이정복,이원준,박재홍,이덕원,황유식 한국고분자학회 2012 Macromolecular Research Vol.20 No.7
The goal of this study was to evaluate the potential of beta-tricalcium phosphate (β-TCP) particles coated with difference concentrations (1 and 10 mM) of simvastatin acid (SVA) on bone formation in vitro. Changes in the surface morphologies and chemical compositions of SVA1-β-TCP and SVA10-β-TCP suggested that SVA was coated on their surface. These particles were further investigated by scanning electron microscopy (SEM) observations and X-ray photoelectron spectroscopy (XPS) measurements. By measuring ultraviolet/visible (UV/Vis) spectroscopy,we found that simvastatin acid (SVA) released in a sustained manner over the period of 28 days even though the initial burst happened within 1 day. These results verify that SVA1-β-TCP and SVA10-β-TCP can be useful as a biocompatible bone graft substitutes. Biocompatibility was evaluated by cytotoxicity tests, live/dead assay,and proliferation of preosteoblast cell-line (MC3T3-E1) cells culture. The results of assays for ALP activity, calcium deposition, and mRNA expressions of alkaline phosphatase (ALP) and osteopontin suggest that the amount of SVA plays an important role in accelerating bone formation in vitro.
양대혁,김현주,김재광,전흥재,박경순 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-
A redox-sensitive beta-cyclodextrin nanoparticle (b-CD NP) system was prepared for the controlledrelease of curcumin (CUR), and its therapeutic efficacy on liver cancer was compared with that of CUR invitro. 1-Dodecanethiol (DDT) was conjugated to per-6-thiol-b-CD by disulfide bond formation though anoxidation reaction (b-CD-ss-DDT). Rhodamine B (RhoB) was included into the b-CD-ss-DDT cavity byinclusion complex formation (b-CD-ss-DDT-ic-RhoB). CUR was encapsulated into b-CD-ss-DDT-ic-RhoBaggregates by self-assembly through dialysis method. The composition, morphology, size distributionand zeta potential of b-CD-ss-DDT-ic-RhoB NPs were characterized by proton nuclear magneticresonance (1H NMR), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy(TEM) and dynamic light scattering (DLS), respectively. It was found that CUR was released from b-CDss-DDT-ic-RhoB/CUR NPs due to the dissociation of b-CD-ss-DDT through a reduction reaction. b-CD-ss-DDT-ic-RhoB/CUR NPs had a higher cellular uptake ratio and a greater anticancer effect on mousehepatoma Hepa 1-6 cells than CUR, mainly attributed to the improved water-solubility of CUR afterencapsulating it in the NPs. Our findings suggest that b-CD-ss-DDT-ic-RhoB NPs can be used asnanocarriers for delivering CUR into cancer cells, thereby serving as a clinical therapeutic agent for livercancer treatment.