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세라마이드 함유 서방성 시스/코어 복합사의 제조와 세라마이드 방출 특성
양광웅,노용환,김의화,전한용,김찬,Yang, Gwang Wung,Rho, Yong Hwan,Kim, Eui Hwa,Jeon, Han Yong,Kim, Chan 한국섬유공학회 2018 한국섬유공학회지 Vol.55 No.4
Ceramide-containing sheath/core composite fibers were prepared by a melt-spinning process, for improving skincare clothing and mitigating atopic dermatitis. We built a database for selecting the base polymer containing the ceramide, encapsulating it, and optimizing the parameters of the unit manufacture of a master-batch chip, to apply the subsequent process. We also evaluated how single-filament, spinning-composite-filament, and draw-textured-yarn manufacturing conditions affect the physical properties of the yarn. Furthermore, the effects of an eccentric sheath/core- and sheath/core-type structure on the sustained release of the ceramide were investigated. As a result, the possibility of the production of ceramide-containing sustained-release polypropylene yarns was verified by HPLC analysis.
Polyester/Micro-modal 원단의 수분전이 거동 특성과 피부 보습 효과
양광웅,홍성연,전한용,Yang, Gwang Wung,Hong, Sung Yeon,Jeon, Han Yong 한국섬유공학회 2013 한국섬유공학회지 Vol.50 No.2
Polyester/polypropylene (PP) and polyester/micro-modal (PMM) fabrics with double structures were prepared by subtracting loops on the skin side and face side, respectively. The moisture management properties of the PP and PMM fabrics were characterized using a moisture management tester (MMT), after which the properties were compared with those of cotton. Results showed that PP has better moisture management properties and faster distribution properties as compared with those of cotton. PP can easily transfer sweat from the skin side to the surface side to keep the skin side dry. By contrast, the moisture content remains high on the skin side of PMM as compared with cotton. The moisture content and transepidermal water loss (TEWL) during the short-term test periods were analyzed using PMM, after which the results were compared with those of cotton. After applying lotion in the PMM fabric, its TEWL significantly improved (P<0.05). Base on the results of the MMT and TEWL tests, PP could be used in summer to remove irritants and sweat. PMM can be used in winter to improve skin barrier functions.
세라마이드 함유 3차원 섬유 구조체의 아토피 피부염에 대한 임상평가
양광웅,노용환,이승훈,장선호,김찬 한국섬유공학회 2019 한국섬유공학회지 Vol.56 No.2
In this study, we prepared a 3D fiber structure containing pseudo-ceramide and conducted four weeks of clinical tests on 45 subjects having skin dryness and itching. The clinical test was conducted on functional clothing groups before and after the application of the atobarrier cream. Statistically significant results were obtained from the SCORAD Index, skin hydration, VAS, TWEL, and effectiveness surveys. The clinical test results confirmed that wearing functional clothing alone can help alleviate symptoms of atopic skin diseases such as itching and skin dryness. Moreover, the results verified that the simultaneous use of the atobarrier cream increases the effect of complex interactions. The study showed that the use of the materials and structure of fabric can alleviate dermatopathy such as atopy.
아토피성 피부질환 완화용 세라마이드 함유 3차원 섬유 구조체 디자인 및 평가
양광웅,노용환,김의화,이승훈,김찬,Yang, Gwang Wung,Rho, Yong Hwan,Kim, Eui Hwa,Lee, Seung Hoon,Kim, Chan 한국섬유공학회 2018 한국섬유공학회지 Vol.55 No.6
The ceramide-contained 3D textile structure was designed for itch relief in atopic dermatitis. We confirmed the ability of the prepared 3D fabric to control humidity in the human skin surface, according to composition and density of moisture controlling textile structure, to mitigate atopic dermatitis. With respect to itch relief functionality, the ceramide-contained 3D fabric is chemically treated using insoluble polyphenols, and the protein enzyme is inactivated by an aggregation experiment between polyphenols and bovine serum albumin, which is considered as a standard protein. From the evaluation of the anti-oxidation factor of cotton- and nylon-treated tannin and gallotannin, we concluded that the ceramide-contained 3D fabric is suitable to apply as skin care clothing.
아토피 피부염 모델인 NC/Nga 실험쥐에 세라마이드 함유 3차원 섬유 구조체가 미치는 효과
양광웅,노용환,김의화,김찬,이승훈 한국섬유공학회 2019 한국섬유공학회지 Vol.56 No.1
In this study, we worked on a fiber structure containing ceramide and evaluated its impacts on the wet and dry-type atopic caused by the atopic dermatitis (AD) ointment and TNCB in the NC/Nga Mice. We also measured and evaluated the ability to control the enzyme activity in the DNA and RNA levels using the enzyme-linked immunosorbent assay analysis, sensory evaluation, TWEL (transepidermal water loss) and moisture content measurements. We conducted a statistical analysis to assess the improvements in AD and the mitigation between the control groups using a histopathological analysis and the Western blotting evaluation. The amount of TWEL in the TNCB group, which is a wet-type atopicinduced group, was significantly higher than that in the dry-type AD-induced group. A serological analysis revealed a significant reduction of the Immunoglobulin E level in all the wearing groups (M-1, M2, C-1, C-2) compared to the negative control on the 35th day of the experiment. It was confirmed that the ceramide-contained 3-D fiber structure recovers and improves the skin barrier function among the Nc/Nga mice. The NC/Nga mice in-vivo results of the ceramide-containing 3-D fiber matrix are applicable in the design of customized skin care garments effective in relieving and improving the dry and wet-type AD.