이상 우쇄골하동맥과 좌우 총경동맥 공통줄기 기형의 동반 발생: 증례 보고

양고은,이병훈 대한영상의학회 2012 대한영상의학회지 Vol.66 No.4

이상 우쇄골하동맥은 대동맥궁 기형 중에서 가장 흔하게 발생하는 것으로, 빈도는 0.5~1% 정도를 차지한다. 그러나 이상 우쇄골하동맥과 좌우 총경동맥 공통줄기 기형의 동반 발생은 매우 드문 것으로 알려져 있다. 저자들은 특별한 과거 병력이 없는 환자에서, 뇌동맥류 파열이 발생하여 시행했던 CT 혈관조영술과 대동맥궁 조영술을 통하여 진단한 이상 우쇄골하동맥과 좌우 총경동맥 공통줄기 기형의 1예를 경험하여 보고하는 바이다. Aberrant right subclavian artery is the most common anomaly of the aortic arch. The frequency of such irregularity is about 0.5-1% of the population with this condition. Common carotid trunk is another anomaly of the aortic arch. The frequency of coexistence of the two conditions, aberrant right subclavian atery with common carotid trunk, is extremely low. We report such a case of coexistence.

Neutrophil to Lymphocyte Ratio (NLR) as a Predictive Marker for Prognosis in the Patients with Immune Thrombocytopenic Purpura (ITP)

양고은,이미지,유재호,최희원 대한소아혈액종양학회 2016 Clinical Pediatric Hematology-Oncology Vol.23 No.2

Background: Immune thrombocytopenic purpura (ITP) is an autoimmune disorder presenting low platelet count in peripheral blood without any other abnormalities in other blood cell lineage. There were many studies that investigated the mechanism of ITP and the factors related to its chronicity, but much remains controversial. Neutrophil to lymphocyte ratio (NLR) is considered an indicator representing the severity of acute or chronic inflammation. The aim of this study was to assess whether NLR can predict the outcome of ITP and its chronicity. Methods: Patients who were diagnosed as ITP at Dong-A University Hospital between March 2000 and March 2016 were analyzed retrospectively. NLR results and other medical records at diagnosis and after treatment were analyzed and compared between two groups; patients with single episode and chronic ITP group. Results: Of a total of 67 patients, 39 patients (58.21%) were chronic ITP. Patients with single episode showed low NLR at diagnosis than patients with chronic ITP (1.23±1.38 vs. 1.54±1.15, P=0.42), but NLR after recovery were significantly high (1.58±1.71 vs. 1.31±0.76, P=0.21). However, patients with chronic ITP showed a trend of high NLR at the time of relapse. Conclusion: Chronic ITP patients showed higher NLR at the time of diagnosis compared with the patients with single episode. Also, the NLR at the time of relapse showed higher level compared to those at diagnosis. Relationship between NLR and chronic ITP need to be further studied.

비결핵 항산균 폐 질환의 전산화단층촬영 소견: 질환 안정군과 질환진행군의 비교

양고은,한헌,홍지영,옥택근 대한영상의학회 2018 대한영상의학회지 Vol.79 No.2

Purpose: To compare initial CT findings of non-tuberculous mycobacteria (NTM) pulmonary infection between stable and progressed groups and determine whether they could be used to predict disease prognosis and treatment response. Materials and Methods: From July 2006 to October 2013, 71 patients with NTM infection were retrospectively reviewed. Lung lesion pattern of CT finding, specific species, disease duration, and follow-up period were analyzed. These patients were classified into NTM stable (n = 46) and progressed (n = 25) groups. Results: The most common CT findings of NTM infection were small nodules (n = 71, 100%) and bronchiectasis (n = 67, 94%). Large consolidation (> 2 cm, n = 34, 48%) and involvement of more than four lobes (n = 49, 69%) were also commonly observed. According to disease prognosis, large consolidation (n = 18, 72%, p = 0.003), cavitary lesion (n = 17, p = 0.002), and involvement of four or more lobes (n = 21, p = 0.044) on CT were significantly more frequent in disease progressed group than that in the stable group. Conclusion: Among common CT findings of NTM disease, some CT findings such as large consolidation, cavitary lesion, and disease extent are good predictors of response to treatment in NTM pulmonary disease. 목적: 비결핵 항산균 폐 질환 환자에서 초기 CT 소견이 치료 반응 예후·예측에 도움을 줄 수 있는지 알아보기 위해 두 그룹으로 분석, 비교하고자 하였다. 대상과 방법: 2006년 7월부터 2013년 10월까지 비결핵 항산균 폐 질환으로 진단된 114명의 의학적 기록을 후향적으로분석하였다. 이 중 전산화단층촬영을 치료 전후에 시행한 71명(평균 나이 68세, 남성 29명과 여성 42명)이 본 연구에 포함되었다. 각 환자에 대하여 나이, 성별, 비결핵 항산균 균주, 질병 이환 기간, 추적 관찰 기간을 분석하였다. 질환의 경과에따라 안정군(n = 46)과 진행군(n = 25)으로 나누었고 진행군은 추적관찰 1년 후에도 객담도말검사 양성, 영상의학 검사에서 악화 소견을 보이는 경우로 정의하였으며, 안정군은 객담도말 검사 음성 또는 영상의학적 소견 호전으로 정의하였다. 결과: 가장 흔하게 나타나는 CT 소견은 작은 결절이었고(n = 71, 100%), 기관지 확장(n = 67, 94%), 2 cm 이상의 큰 기강 경과(n = 34, 48%), 폐엽 4개 이상의 침범(n = 49, 69%) 또한 흔하게 보이는 소견이었다. CT 소견 중 예후 관련하여서는, 큰 기강 경화(n = 18, 72%, p = 0.003)와 공동성 병변(n = 17, 59%, p = 0.002)이 안정 그룹보다 진행그룹에서유의하게 높은 비율로 관찰되었다. 4개 폐엽 이상의 넓은 부위의 침범 소견 또한 유의하게 높은 빈도로 관찰되었다(n = 21, p = 0.044). 기관지 확장은 비결핵 항산균 질환의 예후와 유의한 연관성은 보이지 않는 것으로 나타났다(p = 0.29). 결론: 비결핵 항산균 폐 질환 환자에서 발견되는 초기 고해상도 CT 소견 중, 큰 기강 경화와 공동성 병변, 4폐엽 이상의넓은 부위의 침범은 비결핵 항산균이 1년 후에도 객담도말검사가 양성이거나 영상의학 검사에서 악화 소견을 보이는 환자에서 유의하게 높은 빈도로 보이는 소견으로, 비결핵 항산균 치료에 있어 불량한 예후를 예측할 수 있는 인자라고 할 수있다.

Suppressive Effects of Red Ginseng Preparations on SW480 Colon Cancer Xenografts in Mice

양고은,박동선,이진수,송병섭,전태환,강신정,전정희,신선희,정헌상,이화정,김윤배 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.6

Anti-tumor efficacies of a red ginseng preparation (RGP) and a cytolase-treated red ginseng preparation (Cytolase-RGP) in an in vitro cytotoxicity assay and in nude mice xenografted with human colon adenocarcinoma (SW480) cells were investigated. The immune-enhancing effect of the preparations was also assessed using a carbonclearance test. The concentrations of protopanaxadiols (including Rb1) and protopanaxatriols (including Rg3)were much higher (1.42-3.43-fold) in Cytolase-RGP than in RGP. RGP and Cytolase-RGP were cytotoxic in vitro to SW480 in a dose-dependent manner, exhibiting IC_50 values of 255 and 1,090 μg/mL, respectively. In vivo, the 4-week application of 300 mg/kg RGP or Cytolase-RGP suppressed tumor growth in tumor-bearing mice, decreasing the tumor weight and volume by 15.6-19.3 and 24.4-27.1%, respectively. In the carbon-clearance assay, a 7-day treatment of RGP or Cytolase-RGP at a dose of 300 mg/kg enhanced the phagocytic index of blood macrophages by 307 and 402%of control value, respectively. The results suggest that Cytolase-RGP is superior to RGP in SW480 tumorsuppressive efficacy, and that the increased antitumor activity of Cytolase-RGP might be due to the improved immunomodulatory activity, rather than due to any increase in the cytotoxic activity.

다중흐름모형을 적용한 정책과정 연구 : 소말리아 피랍행위에 대한 정부의 대응변화를 중심으로

이동규,양고은 위기관리 이론과 실천 2013 Crisisonomy Vol.9 No.9

수차례 소말리아 해적에 의한 피랍 사건이 발생하였으나, 군사작전을 통해 구출된 사례는 한 사례에 불과하다. 그렇다면, 정부는 왜 소말리아 해적행위에 대하여 군사작전을 감행했는지, 왜 이러한 정책변동이 발생하였는지 주목할 필요가 있다. 본 연구에서는 불확실한 상황에서 어떻게 정책이 결정되는지를 설명하는 다중흐름모형을 적용하여, 정부 대응이 변화하게 된 맥락을 밝히고자 한다. 그리고 일상적이지 않고 모호한 상황에서의 정부의 정책대응변동과정을 분석한다. 연구목적을 위해 2006년 동원호 사건 이후 2011년 삼호주얼리호 사건까지의 기간을 중심으로 소말리아 해적의 피랍행위에 대한 정부의 대응변화과정을 탐색적 사례 연구를 통해 분석한다. 분석 결과, 몇 가지 연구 함의를 발견할 수 있었다. 첫째, 비일상적이고 국민의 생명과 재산에 관련되는 긴급한 사안에도 다중흐름모형의 적용 가능성을 확인할 수 있었다. 둘째, 문제흐름과 정치흐름, 그리고 정책흐름 간의 상호 작용을 발견할 수 있었다.

The effect of first nocturnal ejaculation timing on risk and sexual behaviors of Korean male adolescents

이미지,양고은,Hee Won Chueh,박재홍,유재호 대한소아내분비학회 2018 Annals of Pediatirc Endocrinology & Metabolism Vol.23 No.1

Early Neonatal Respiratory Morbidities in Term Neonates

김현아,양고은,김묘징 대한신생아학회 2015 Neonatal medicine Vol.22 No.1

Purpose: This study aimed to investigate the respiratory morbidities in term neonates,as well as their relationship with mode of delivery and gestational age. Methods: Medical records of term infants with respiratory symptoms, who were admitted to the neonatal intensive care unit (NICU) of Dong-A University Hospital from Jan 2008 to Dec 2013, were retrospectively reviewed. Term neonates with respiratorydiseases, such as transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), neonatal pneumonia, meconium aspiration syndrome (MAS), pneumothorax, and persistent pulmonary hypertension of the newborn (PPHN), were included. The respiratory morbidities were investigated according to the gestational age (<39 weeks vs. ≥39 weeks) and/or mode of delivery (with labor vs. without labor). Results: A total of 260 term neonates were enrolled in the study. The average gestationalage was 38+6±1.3 weeks, while the birth weight was 3,233.7±462.0 g. The most common respiratory disease encountered in term neonates was TTN (n=98, 37.7%), followed by MAS (n=76, 29.2%), spontaneous pneumothorax (n=27, 10.4%), PPHN (n=24, 9.2%), neonatal pneumonia (n=19, 7.3%), and RDS (n=16, 6.2%). Incidence of TTN and RDS was higher in neonates aged <39 weeks than in those aged ≥39 weeks. Higher incidence of spontaneous pneumothorax and RDS was observed in neonates delivered before the onset of labor. The incidences of TTN, spontaneous pneumothorax,and RDS were higher in the elective cesarean section group before 39 weeks of gestation. Conclusion: Respiratory morbidities in term neonates are affected by the gestational age (<39 weeks vs. ≥39 weeks) and/or mode of delivery (with labor vs. without labor).

The effect of first nocturnal ejaculation timing on risk and sexual behaviors of Korean male adolescents

이미지,양고은,최희원,박재홍,유재호 대한소아내분비학회 2017 Annals of Pediatirc Endocrinology & Metabolism Vol.22 No.1

Purpose: This study evaluated the effect of first nocturnal ejaculation timing on risk and sexual behaviors of Korean male adolescents. Methods: We analyzed data from the 10th edition of the Korea Youth Risk Behavior Web-based survey that was conducted with male high school adolescents in grades 10–12. The survey included 17,907 adolescents, and 10,326 responded their experience of first nocturnal ejaculation. Of these, 595 had their first nocturnal ejaculation in ≤grade 4 (“early puberty”) and 9,731 had their first nocturnal ejaculation in ≥grade 5 (“normal puberty”). We analyzed differences between these 2 groups in risk and sexual behaviors. Results: Early first nocturnal ejaculation showed a positive association with sexual intercourse (odds ratio [OR], 3.27; 95% confidence interval [CI], 2.56–4.17), sexual debut at elementary school age (OR, 7.45; 95% CI, 5.00–11.10), and having had a sexually transmitted disease (OR, 6.60; 95% CI, 3.94–11.08). After a multiple logistic regression to adjust for socio-demographic variables, early first nocturnal ejaculation was still positively associated with sexual intercourse (OR, 2.73; 95% CI, 2.03–3.69), sexual debut at elementary school age (OR, 5.96; 95% CI, 3.47–10.22), and having had a sexually transmitted disease (OR, 5.17; 95% CI, 2.52–10.20). Early first nocturnal ejaculation was positively associated with alcohol consumption, smoking, and substance use. However, this was not statistically significant after adjusting for several socio-demographic variables. Conclusion: There is a positive association between early nocturnal ejaculation and sexual behaviors in male adolescents. Proactive education about sexual behaviors is required for adolescents who reach sexual maturity early

호텔의 규모와 정규직 비율을 고려한 서비스업의 효율성 분석 연구: 호텔업을 중심으로

김도훈,설지은,양고은,김영준,김창희 한국경영학회 2022 한국경영학회 통합학술발표논문집 Vol.2022 No.8

정규직 비율과 규모를 고려한 효율성 연구: 국내 호텔업을 중심으로

김도훈,설지은,양고은,김창희 한국서비스경영학회 2023 서비스경영학회지 Vol.24 No.1

This study analyzed the efficiency of the hotel industry using bootstrap DEA, and classified it into a quartile according to the ratio of regular workers and the weight of the scale. As a result of conducting a test on the average difference in the efficiency of each quadrant using a one-way ANOVA, this study identified that hotels with a large scale and a high ratio of regular workers were the most efficient. According to the weight of the hotel classification, although the difference in efficiency distribution between each quadrant is not clear, the null hypothesis of quadrant 1 and quadrant 2, the null hypothesis of quadrant 1 and quadrant 3, and the null hypothesis of quadrant 1 and quadrant 4 were rejected. Analyzing quadrant 1 with distribution differences, this findings provide evidence for hotel industry that it is crucial to secure a high ratio of regular workers and a large scale. 본 연구에서는 호텔업의 효율성을 부트스트랩 DEA를 통하여 분석한 뒤, 정규직 비율과 규모의 가중치에 따라 4분위수로 분류하였다. 일원배치분산분석을 통해 각 Quadrant의 효율성의 평균 차이에 대한 검정을 실시한 결과 호텔의 규모가 크고, 정규직 비율이 높은 호텔이 가장 효율적인 것으로 나타났다. 호텔 분류의 가중치에 따르면, 각 Quadrant 사이의 효율성 분포 차이가 명확하지는 않지만, Quadrant 1과 Quadrant 2의 귀무가설, Quadrant 1과 Quadrant 3의 귀무가설, 그리고 Quadrant 1과 Quadrant 4의 귀무가설이 기각됐다. 분포 차이를 보인 Quadrant 1을 분석하면 호텔업에서 높은 정규직 비율과 많은 객실 수를 가지는 것이 효율성을 향상시킬 수 있다는 점을 밝혀내었다.