텍스트마이닝과 주경로 분석을 이용한 미발견 공공 지식 추론 - 췌장암 유전자-단백질 유발사슬의 경우 -

안혜림,송민,허고은,Ahn, Hyerim,Song, Min,Heo, Go Eun 한국비블리아학회 2015 한국비블리아학회지 Vol.26 No.1

This study aims to infer the gene-protein 'brings_about' chains of pancreatic cancer which were referred to in the pancreatic cancer related researches by constructing the gene-protein interaction network of pancreatic cancer. The chains can help us uncover publicly unknown knowledge that would develop as empirical studies for investigating the cause of pancreatic cancer. In this study, we applied a novel approach that grafts text mining and the main path analysis into Swanson's ABC model for expanding intermediate concepts to multi-levels and extracting the most significant path. We carried out text mining analysis on the full texts of the pancreatic cancer research papers published during the last ten-year period and extracted the gene-protein entities and relations. The 'brings_about' network was established with bio relations represented by bio verbs. We also applied main path analysis to the network. We found the main direct 'brings_about' path of pancreatic cancer which includes 14 nodes and 13 arcs. 9 arcs were confirmed as the actual relations emerged on the related researches while the other 4 arcs were arisen in the network transformation process for main path analysis. We believe that our approach to combining text mining analysis with main path analysis can be a useful tool for inferring undiscovered knowledge in the situation where either a starting or an ending point is unknown. 본 연구에서는 췌장암의 유전자-단백질 상호작용 네트워크를 구성하고, 관련 연구에서 주요하게 언급되는 유전자-단백질의 유발관계 사슬을 파악함으로써, 췌장암의 원인을 규명하는 실증적인 연구로 이어질 수 있는 미발견 공공 지식을 제공하려 하였다. 이를 위하여 텍스트마이닝과 주경로 분석을 Swanson의 ABC 모델에 적용해 중간 개념인 B를 방향성을 가진 다단계 모델로 확장하고 가장 의미 있는 경로를 도출하였다. 본 연구의 주제가 된 췌장암의 사례처럼 시작점과 끝점조차 한정할 수 없는 미발견 공공 지식 추론에서 주경로 분석은 유용한 도구가 될 수 있을 것이다.

항이뇨호르몬분비이상증후군 환자에서 Tolvaptan과 3% 염화나트륨의 저나트륨혈증 개선 효과 평가

안혜림,황보신이,최선 한국병원약사회 2020 병원약사회지 Vol.37 No.1

Background : The syndrome of inappropriate secretion of anti-diuretic Hormone (SIADH) is a disease, characterized by water retention and hyponatremia. According to the American Journal of Medicine treatment guideline, the administration of hypertonic saline (3% sodium chloride, 3% NaCl) is recommended for patients, who don’t respond to water restriction. Vasopressin V2 receptor antagonists such as tolvaptan can be administered to patients whose blood sodium concentration is not normalized by 3% NaCl or who have moderate to severe hyponatremia. However, the study that directly compared the effects of the two drugs was insufficient to evaluate the effect of vasopressin receptor antagonist and 3% NaCl. The purpose of this study was to compare and evaluate the effect of the tolvaptan tablet and 3% NaCl injection. Methods: From June 2015 through August 2016, all patients diagnosed as SIADH, with hyponatremia ([Na+]<135 mEq/L), were administered tolvaptan (T-group) or 3% NaCl (N-group). We analyzed electronic medical records retrospectively. Results : The mean daily dose of each drug was 14.5 mg of tolvaptan, 428.2 ml of 3% NaCl, and the serum sodium levels significant increased after administration in the T-group (n=26) and the N-group (n=79) (p<0.0001, respectively). In particular, an average increase of 11.6 mEq/L in the T-group and 6.5 mEq/L in the N-group was achieved during the first 24 hours (p<0.0001), and 12.6 mEq/L in the T-group and 9.5 mEq/L in the N group for 48 hours (p<0.0001), showing significant increases in the T-group. There was no significant difference in the proportion of patients with normalized serum sodium level following treatment (96.2% for the T-group, 81.0% for the N-group, p=0.111), and the mean number of days to normalization was significantly shorter for the T-group 1.4 days and 3.7 days for the N-group (p<0.0001). Side effects were nausea and vomiting in 3.9% (one patient) of the T-group, sensory abnormality and weakness in 2.5% (two patients) of the N-group. Average price per patient during treatment was 62,368 won in the T-group, and 11,682 won in the N-group (p<0.0001). Conclusion : Both drugs showed improvement in hyponatremia in SIADH patients, and tolvaptan made more rapid increase in sodium level in the blood compared to 3% NaCl. However, since the change in serum sodium due to tolvaptan is close to the recommended upper limit (within 12 mEq/L per 24 hours), there is risk of potential side effects. Thus, careful monitoring of sodium levels and dose adjustments are needed and also, it is necessary to select a medicine in consideration of the cost.

Non-Dipper Status and Left Ventricular Hypertrophy as Predictors of Incident Chronic Kidney Disease

안혜림,박성하,유태현,강신욱,유정화,이용규,유민아,류동열,김승정,강덕희,최규복 대한의학회 2011 Journal of Korean medical science Vol.26 No.9

We have hypothesized that non-dipper status and left ventricular hypertrophy (LVH) are associated with the development of chronic kidney disease (CKD) in non-diabetic hypertensive patients. This study included 102 patients with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2. Ambulatory blood pressure monitoring and echocardiography were performed at the beginning of the study, and the serum creatinine levels were followed. During the average follow-up period of 51 months, CKD developed in 11 patients. There was a significant difference in the incidence of CKD between dippers and non-dippers (5.0% vs 19.0%, P < 0.05). Compared to patients without CKD, patients with incident CKD had a higher urine albumin/creatinine ratio (52.3 ± 58.6 mg/g vs 17.8 ±29.3 mg/g, P < 0.01), non-dipper status (72.7% vs 37.4%, P < 0.05), the presence of LVH (27.3% vs 5.5%, P < 0.05), and a lower serum HDL-cholesterol level (41.7 ± 8.3 mg/dL vs 50.4 ± 12.4 mg/dL, P < 0.05). Based on multivariate Cox regression analysis, non-dipper status and the presence of LVH were independent predictors of incident CKD. These findings suggest that non-dipper status and LVH may be the therapeutic targets for preventing the development of CKD in non-diabetic hypertensive patients.

다시 현장으로 돌아간 한 유아교사의 사건화된 경험: 들뢰즈의 존재론에 기초한 후기 질적 연구

안혜림,강승지,이연선 한국유아교육학회 2019 유아교육연구 Vol.39 No.5

The purpose of this study is to look at the experience of an early childhood teacher who returned to the early childhood educational field based on the Deleuze's ontology. The post-qualitative research moves beyond traditional methods and frameworks and so that it is an appropriate research method for this study to view teachers’ experience and growth as an ontological transformation by paying attention to ‘what happened’ between retirement and reemployment. The study found that an early childhood teacher, who had a strong experience in graduate school after retirement, had intense experiences that doubted what they had taken for granted. In other words, they wanted to hear children’s voice, were able to reflect on themselves, and listened to their inner voice by encountering incidental experiences. These results show that the life of a teacher is a continuous movement. The retirement and re-employment periods of teachers also need to be viewed as ‘becoming’ and look into their real life. It is expected to see early childhood teachers’ experience and life as a new movement of ‘becoming,’ and to view early childhood education field as a potential place for being created through eventualized experience. 본 연구는 다시 현장으로 돌아간 한 유아교사의 사건화된 경험을 들뢰즈의 존재론에 기초한 후기 질적 연구를 통해 읽어내고자 하였다. 후기 질적 연구는 기존 방식과 틀을 벗어나 자료를 생성되는 것으로 보고 퇴직과 재취업 사이의 교사의 경험과 성장을 존재론적 변형으로 바라보고자 하는 본 연구에 적합한 연구방법이다. 연구결과에 따르면, 퇴직 후 대학원에서 유아교사는 당연하다고 믿어왔던 것을 의심하게 되는 강렬한 경험들을 우연히 마주하면서 아이들의 진짜 이야기가 듣고 싶어졌으며, 이러한 ‘배움’은 아이들의 살아있음을 보고 싶어지게 했고, 교사 주체로 살고 싶어지게 했으며, 아이와 함께하는 민주의 장을 꿈꾸게 했고, 자기에게 온 ‘배움’이 자기를 통해/인해/함께 아이들에게 전해지길 원하게 하였다. ‘배움’은 아이들과의 새로운 마주침을 꿈꾸는 교사로의 변형을 가져왔고, 한 유아교사를 다시 현장으로 돌아가도록 이끌었다. 이러한 유아교사의 경험과 삶은 단회적 변화가 아닌 끊임없이 자기를 생산하는 ‘유아교사-되기’의 연속적 운동으로 볼 수 있으며, 삶을 욕망하고 생성하는 자로서 유아교사를 볼 수 있게 한다. 이처럼 교사의 퇴직과 재취업 기간 또한 ‘되기’로서 바라보고 삶의 실재를 들여다볼 필요가 있으며, 유아교사를 ‘되기’를 욕망하는 주체로, 유아교사의 경험과 삶을 새로운 ‘되기’의 운동으로, 유아교사와 아이들이 함께하는 유아교육현장을 사건화된 경험을 통해 ‘되기’가 생성되는 잠재성의 장으로 바라볼 수 있기를 기대한다.

포스터 발표 전시 순서 : 신장 ; 혈액투석 치료를 받는 말기신부전 환자에서 혈관 석회화의 예측 인자로서 osteoprotegerin (OPG) 및 fetuin-A의 유용성 (초)

안혜림,이용규,신유근,김좌경,문성진,이정은,하성규,박형천 대한내과학회 2009 대한내과학회지 Vol.77 No.4S

혈액투석 치료를 받는 말기신부전 환자에서 혈관 석회화의 예측 인자로서 osteoprotegerin (OPG) 및 fetuin-A의 유용성

안혜림,이용규,신유근,김좌경,문성진,이정은,하성규,박형천 대한내과학회 2009 대한내과학회 추계학술대회 Vol.2009 No.-

약인성 질환 관련 정보제공 사례

안혜림 한국병원약사회 2009 병원약사회지 Vol.26 No.3

Dexmedetomidine을 투여한 내과중환자실 환자의 심혈관계 부작용 발생률과 위험인자 분석

안혜림,김지원,안서현,박애령,황보신이 한국병원약사회 2020 병원약사회지 Vol.37 No.3

Background : Dexmedetomidine is a selective α2 agonist with sedative, analgesic, and sympatholytic properties. Dexmedetomidine has cardiovascular risks such as hypotension and bradycardia. For this reason, the U.S. Food and Drug Administration (FDA) recommends the short-term use of dexmedetomidine less than 24 hours. Therefore, this study was aimed at analyzing the current status and risk factors of the cardiovascular side effects of dexmedetomidine. Methods : A retrospective chart review of all adult critically ill patients in the medical intensive care units who received dexmedetomidine from January 2016 to May 2017 was performed. The incidence, risk factors and prognosis of the cardiovascular adverse effects were analyzed. Results : The total number of patients was 135, and the mean hours of dexmedetomidine administration was 165 hours. A total of 102 patients (75.6%) developed cardiovascular side effects. Among them, hypotension occurred in 99 patients (73.3%), of which 53 patients (53.5%) developed hypotension within 24 hours. Bradycardia occurred in eight patients (5.9%), of which two patients (25.0%) developed bradycardia within 24 hours. Multivariate analysis of the risk factors for hypotension showed an association between hypotension and low baseline mean arterial pressure (MAP)(p=0.028), patients with acute respiratory distress syndrome (ARDS)(p=0.030) and those given norepinephrine (p=0.017). The incidence of hypotension was lower in patients with underlying hypertension (p=0.030). Univariate analysis of the risk factors for bradycardia showed that the incidence of bradycardia was higher in patients with lower baseline heart rates (p=0.033), higher body weight (p=0.008), and those undergoing hemodialysis (p=0.009). Also, there were no significant differences in the days of mechanical ventilation, the number of hospital days, and the mortality rate in patients with hypotension or bradycardia. Conclusion : Dexmedetomidine was associated with a higher incidence of cardiovascular side effects. Specifically, patients who were diagnosed with lower MAP, ARDS, or in combination with norepinephrine use were more likely to develop hypotension. Therefore, it is necessary to closely monitor cardiovascular adverse effects in patients with these risk factors.

The Distinct Impact Dimensions of the Prestige Indices in Author Citation Networks

안혜림,박지홍,Ahn, Hyerim,Park, Ji-Hong Korean Society for Information Management 2016 정보관리학회지 Vol.33 No.2

본 연구는 명망성 지표(closeness prestige, input domain, proximity prestige)를 인용 네트워크 내에서 특정 노드의 영향력 측정을 위한 유용한 척도로 제안하는 것을 목적으로 한다. 명망성 지표의 영향력 측정기준에 대해 알려진 바가 없으므로 본 연구는 이 세 개의 명망성 지표와 다른 영향력 지표를 비교하고자 한다. 무방향 네트워크의 중심성 지표와 유사하게 명망성 지표는 유방향 네트워크에서 특정 중심 노드들을 차별화 시켜준다. 저자 인용 네트워크에서 수행된 상관분석과 주성분분석을 통하여 본 연구는 기존 영향력 지표와 차별된 명망성 지표만의 측정기준을 발굴하였다. 세 개의 무방향 네트워크 중심성 지표와 더불어 단순인용수, h-index, PageRank를 본 연구에서 제시한 명망성 지표와 비교하였다. 이러한 명망성 지표는 기존 영향력 지표와는 차별화된 영향력을 측정하고 있다는 결과를 도출하였으며 명망성 지표는 간접적인 영향력을 기존의 다른 영향력 지표는 직접적인 영향력을 반영한다. This study aims at proposing three prestige indices-closeness prestige, input domain, and proximity prestige- as useful measures for the impact of a particular node in citation networks. It compares these prestige indices with other impact indices as it is still unknown what dimensions of impact these indices actually measure. The prestige indices enable us to distinguish the most prominent actors in a directed network, similar to the centrality indices in undirected networks. Correlation analysis and principal component analysis were conducted on the author citation network to identify the differentiated implications of the three prestige indices from the existing impact indices. We selected simple citation counting, h-index, PageRank, and the three kinds of centrality indices which assume undirected networks as the existing impact measures for comparison with the three prestige indices. The results indicate that these prestige indices demonstrate distinct impact dimension from the other impact indices. The prestige indices reflect indirect impact while the others direct impact.

내 생애 최초의 직접민주주의 경험, ‘블록체인심사’ : ‘좋아요!’ 투표로 따뜻하고 복된 공동체를 만들다

안혜림 한국지역정보개발원(구 자치정보화조합) 2018 지역정보화 Vol.111 No.-