Transcranial Doppler를 利用한 腦硬塞 患者의 血流速度와 血管 反應性에 대한 臨床的 考察

안탁원,김병탁,Ann, Taek-won,Kim, Byeong-tak 대한한방안이비인후피부과학회 1998 한방안이비인후피부과학회지 Vol.11 No.1

Background : The vasoreactivity of cerebral artery is currently the subject of increasing interest. Transcranial Doppler Sonography(TCD) is an accurate method of monitoring the blood flow velocities of the cerebral artery. We wished to assess the vasoreactivity between age-matched normal and cerebral infarction group. Method : We performed TCD findings in 40 normals and 20 cb-inf. subjects who arrived at hospital during 48 hours after attack. The former were devided into twenties normal group and fifties normal group. Result : 1. Fibrinogen levels showed significant changes between age-matched normal and cb-inf. group. 2. $V^{MEAN}$ of the both side Carotid Siphon during rest state increased significantly in cb-inf. group as compared with the age-matched normal group. 3. $V^{MEAN}and\;V^{MAX}$ of the both side carotid siphon during breath-hold state increased significantly in cb-inf. group as compared with the age-matched normal group. 4. Vasoreactivity of cerebral artery increased significantly in cb-inf. group as compared with the age-matched normal group. 5. $V^{MEAN}and\;V^{MAX}$ of the both side Radial artery during heat-stimuration state increased significantly in cb-inf. group as compared with the age-matched normal group. 6. Vasoreactivity of Radial artery increased significantly in cb-inf. group as compared with the age-matched normal group.

腦血管性 痴?에 對한 東西醫學的 考察

안탁원,홍 석,김희철 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

In the literatual study on the cerebral vascular dementia, the results were as follows: 1. Cerebral vascular dementia is so called apoplectic dementia(중풍치태), because it almost occurs after apoplexy, the attack rate has gradually increased by increase of life, so it exert a harmful influence to geriatric diseases. 2. The etiological factors are summarized on deficiency in the heart, kidney, liver, pathogenic wind(風) pathogenic fire(火) phlegm(痰) and stagnated blood(瘀血) in the oriental medicine, and multiple cerebral infarction, cerebral anemia, decrease of cerebral vascular flow are etiological factors in the occidental medicine. 3. The region of infarction and attack of cerebral vascular dementia have a close connection, and generally the cerebral vascular dementia easily occur in injury of white matter of brain. 4. Symptoms of cerebral vascular dementia are dysphasia, walking disorder, hemiplegia, sensory paralysis, disturbance of memory, judgement, calculation, emotion incontinence, speech impediment, silence or talkative, lower thinking ability and depersonalization, and symptoms are aggravated by stage. 5. Therapeutic herb medicine are Palpungsan(八風散), Baepungsan(排風散), Jinsaanshinhwan(辰砂安神丸), Sabacksan(四白散), Kanghwalyupungsan(姜活愈風散), Woowhangchengshimwhan(牛黃淸心丸), and they are used to dispelling pathogenic wind, soothe the nerves(安神), dispel pathogenic heat from lung, nourish the blood.

四象體質別 腦血流 變化에 대한 臨床的 考察

安鐸源 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.11 No.1

1.Purpose We inquire into difference of blood flow velocity according Sasang Constitution. 2.Method We selected observation group that they are 251 patients among of the patients who are had a medical early examination of stroke. We classified observation group by Sasang Constitution and compared each of measured blood flow velocity by TCC. 3.Result 1) We found out that Taeumin is highest in fat rate, height and blood pressure. 2. Blood flow mean velocity of MCA is not found out significant differene by Sasang Constitution. But, Taeumin is found out highest in left and right. 3) Taeumin is found out that blood flow velocity of Siphon sinus ICA is highest.

Transcranial Doppler를 이용(利用)한 급성기뇌경색(急性期腦硬塞)이 추골기저동맥계(椎骨基底動脈係) 혈관(血管)의 혈류속도(血流速度)에 미치는 영향(影響)

안탁원,김윤식,Ahn, Teck-Won,Kim, Yoon-Sik 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5

Objectives : To determine the effects on blood flow of vertebrobasal vascular system in cerebral infarction, Methods : We altered 33 normal patients and 12 patients who were diagnosed cerebral infarction on Rt. middle cerebral artery(MCA) region and 8 patients who were diagnosed cerebral infarction on Lt, MCA region, and measured the mean velocity, systolic to diastolic rate(SD rate), asymmetrical index(A/I) by TCD. Results : The mean velocity of posterior cerebral artery(PCA), vertebral artery was increased in same direction as infarcted site and the mean velocity of basal artery was more increased than control, and the SD rate of PCA, vertebral artery, basal artery was larger than control. The A/l of PCA, vertebral artery was revealed that mean velocity of vertebrobasal vascular system is increase the same direction as infarcted area. Conclusion : TCD examination within 7 days(acute stage) after stroke can help to predict the infarcted direction.

김치에 대한 사상체질의학적(四象體質醫學的) 고찰(考察)(I)

안탁원,Ann Taek-Won 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.1

Purposes This study is for the constitutional health in daily life by adding the Sasang Constitutional points to the kimchi's nutritional ones. It lays the foundation of the development of both new medical kimchis and production of various kinds of kimchis according to different constitution. Methods We have examined the Keemy(氣味) and effect(效能) of kimchi represented in the Korean medicine [Dongyibogam(東醫寶鑑), Hyangyaggibseongbang(鄕藥集成方), Choongyakdaesajeon(中葯大辭典)] and Leejema's literature [DongyiSoosebowon(東醫壽世保元), Dongmooyugo(東武遺稿), Chobon kwon(草本卷)]. Results 1) There are 18 kinds of materials in kimchi, 9 main materials and 9 additional ones. 2) There are mustard, red pepper, garlic, leek, ginger, salt, green onion, and dropwort as good materials of kimchi for Soeumin, which are mostly Shinon(辛溫) or Yeoll(熱). 3) There are eggplant, oyster, chinese cabbage, shrimp, cucumber, and sesame as good materials of kimchi for Soyangin, which are mostly Gam(甘) or Ham(寒) or Ryang(凉), Han(寒). 4) There are bracken, perilla, radish, and taro as good materials of kimchi for Taeumin. which are mostly ShinGam(辛甘) or OnPyeong(溫平), Ryang(凉) Han(寒).

뇌혈관성(뇌혈관성) 치매(痴?)에 대(對)한 동서의학적(東西醫學的) 고찰(考察)

안탁원,홍석,김희철,Ann, Tak-Weon,Hong, Seog,Kim, Hee-Chul 한국한의학연구원 1996 한국 한의학연구소 논문집 Vol.2 No.1

In the literatual study on the cerebral vascular dementia, the results were as follows : 1. Cerebral vascular dementia is so called apoplectic dementia, because it almost occurs after apoplexy, the attack rate has gradually increased by increase of life, so it exert a harmful influence to geriatric diseases. 2. The etiological factors are summarized on deficiency in the heart, kidney, liver(心, 腎, 肝虛), pathogenic wind(豊) pathogenic fire(火) phlegm(痰) and stagnated blood(瘀血) in the oriental medicine, and multiple cerebral infarction, cerebral anemia, decrease of cerebral vascular flow are etiological factors in the occidental medicine. 3. The region of infarction and attack of cerebral vascular dementia have a close connection, and generally the cerebral vascular dementia easily occur in injury of white matter of brain. 4. Symptoms of cerebral vascular dementia are dysphasia, walking disorder, hemiplegia, sensory paralysis, disturbance of memory, judgement, calculation, emotion incontinence, speech impediment, silence or talkative, lower thinking ability and depersonalization, and symptoms are aggravated by stage. 5. Therapeutic herb medicines are Palpungsan(八風散), Baepungsan(排風散), Jinsaanshinhwan(辰砂安神丸), Sabacksan(四白散), Kanghwalyupungsan(姜活愈風散), Woohwangchungshimhwan(牛黃淸心丸), and they are used to dispelling pathogenic wind(祛風), soothe the nerves(安神), dispel pathogenic heat from lung, nourish the blood(淸肺養血).

腦硬塞에 對한 He-Ne laser 靜脈血管內 照射의 效果

朴陽春,安鐸源,金東熙,金炳卓 대전대학교 한의학연구소 2000 한의학연구소 논문집 Vol.9 No.1

Background: Intravascular Laser Irrardiation of Blood(ILIB) is used in disorder of cerebral and peripheral blood circulation, dysfunction of brain, atherosclerosis etc., but there are little study about ILIB in oriental medicine. We wished to assess the efficacy of ILIB for the treatment of cerebral infarction. Method: The study group comprised 40 patients who arrived at hospital during 48 hours after attack. All patient were divided into two group. The control group was treated with Uhuangcheongsimhuan(牛黃淸心丸), Seonghyangjeonggisan(星香正氣散), acupuncture therapy only, while the ILIB group was treated with above therapy plus 5 days of irradiation of He-Ne Laser(1.8∼2.5mW, 50min. per day). In rat model of middle cerebral artery(MCA) occlusion, the control group was not treated, while the ILIB group was treated with irradiation of He-Ne Laser(1.8∼2.5mW, 24sec.). Result:1. Symptom improve scores did not showed significant difference between control and ILIB group. 2.Vasoreactivity of carotid siphon did showed significant difference between control and ILIB group. 3.Vasoreactivity of radial artery did not showed significant difference between control and ILIB group. 4.PT, a-PTT did not showed significant changes between before and after treatment in both group. Fibrinogen significantly increased after treatment in ILIB group(p<0.05)), but it was in normal degree. 5.ILIB showed a significant decrease of brain ischemic area and edema in rat model of middle cerebral artery(MCA) occlusion. Conclusion : These findings suggest that additional treatment of ILIB is not more useful than traditional therapy only in acute cerebral infarction. But ILIB showed potential effect in rat model of MCA occlusion. So further investigation will be necessary.

四象體質 判別 檢査紙 問項의 妥當性과 信賴性 및 應答者 個體分析에 관한 硏究

李華燮,安鐸源 대전대학교 한의학연구소 2004 한의학연구소 논문집 Vol.12 No.2

1. The values of Cronbach's alpha for the Taeyang, Taeum, Soyang and Swum questionnaire were 0.7955, 0.7776, 0.8545, and 0.8601 respectively. These results indicate a highly satisfactory level of internal consistency for the questionnaire. 2. If the deletion of an item increases Cronbach's alpha then what that means is that the deletion of that item improves reliability. Therefore, any items that result in substantially greater values of alpha than the overall alpha may need to be deleted from the questionnaire to improve its reliability. 3. Factor analysis was performed on the 81 questionnaires. Based on the scree plot and the number and decrement of eigen values greater than one, three to four factor solution was most significant. 4. The hierarchical cluster analysis was performed on the 81 Sasang constitution questionnaire. These results suggested that two or four clusters identified with homogeneous groups 5. The hierarchical cluster analysis was performed on the 1046 responders. These results suggested that two, three, or four clusters might identified with homogeneous groups. Furthermore, there were statistically significant difference among the each group by ANOVA(P<0.0001).

東醫壽世保元의 文獻的 資料에 根據한 中風 治療에 대한 考察

李華燮,安鐸源 대전대학교 한의학연구소 2002 혜화의학회지 Vol.11 No.1

The purpose of this study was to find the way of treatment and prevention the stroke by Sangsang constitutional medical therapy. I came to get some conclusions after considering literatures of 《Dongyi Suse Bowon》and the conclusions as follows. 1. In 《Dongyi Suse Bowon》the stroke of Soumin is caused by 'Interior cold disease'. When 'Interior Yin' can not descend, the disease arise. In this case Lee Je-ma used 'Sohabhyang-won(蘇合香元)' , 'Chulaek-su(鐵液水)' . 2. The stroke of Soyangin is caused by 'Interior heat disease'. When the hot Qi of stomach and spleen is blocked, the disease arise. In this case Lee Je-ma used 'Dokhwal-jihwang-tang(獨活地黃湯)' , 'Jihwang-baekho-tang(地黃白虎湯)'. 3. The stroke of Taeumin is caused by 'Dry and heat disease'. When the heat of liver and the dryness of lung is excessive, the disease arise. In this case Lee Je-ma treated with 'Woohwang-chungsim-hwan(牛黃淸心丸)'. 'Wonji-sukchangpo-tang(遠志石菖浦湯)' , and 'Kwache-san(瓜帝散)' etc. Above results indicate that not only taking medicine but also filling up the Healthy energy(保命之王) is important to treat stroke.

뇌경색(腦硬塞)에 대(對)한 He-Ne laser 정맥혈관내(靜脈血管內) 조사(照射)의 효과(效果)

박양춘,안탁원,김동희,김병탁,Park, Yang Chun,Ann, Taek Won,Kim, Dong Hee,Kim, Byeong Tak 대전대학교 한의학연구소 2000 혜화의학회지 Vol.9 No.1

연구배경(硏究背景): He-Ne laser 정맥혈관내(靜脈血管內) 조사(照射) (Intravascular Laser Irradiation of Blood : ILIB)가 말초(末梢) 및 뇌혈관순환장애(腦血管循環障碍), 뇌기능장애(腦機能障碍), 동맥경화(動脈硬化) 등의 예방(豫防)과 치료(治療) 목적(目的)으로 사용(使用)되고 있으나 이에 대한 한의학(韓醫學)에서의 연구(硏究)는 찾아보기 힘들다. 이에 저자(著者)는 발병(發病) 48시간(時間) 이내(以內)에 내원(來院)하여 뇌전산화단층촬영(腦電算化斷層撮影)으로 진단(診斷)된 초기(初期) 뇌경색(腦梗塞) 환자(患者)에서 ILIB의 효과(效果)를 평가(評價)하고자 본(本) 연구(硏究)를 시행(施行)하였다. 아울러 흰쥐의 국소(局所) 뇌허혈(腦虛血)에 미치는 영향(影響)을 측정(測定)하였다. 방법(方法) : 대상(對象) 환자(患者) 40명(名)을 UC-SHJGS(우황청심환(牛黃淸心丸)-성향정기산(星香正氣散))만을 투여(投與)한 대조군(對照群)과 UC-SHJGS 투여(投與)와 ILIB를 병용(倂用)한 치료군(治療群)으로 나누어 시행(施行)하였다. 대상환자(對象患者)는 모두 변증(辨證)과 무관(無關)하게 UC, SHJGS만을 투여(投與)하고 침치료(鍼治療)는 중풍칠처혈(中風七處穴)로 한정(限定)하였으며 5일간(日間)의 치료기간(治療期間) 동안 치료군(治療群)에서는 출력(出力) 1.8-2.5mW의 He-Ne laser를 1일(日) 1회(回) 50분(分) 동안 조사(照射)하였다. 동물실험(動物實驗)은 흰쥐를 대상(對象)으로 중대뇌동맥(中大腦動脈)을 결찰(結紮)하여 국소(局所) 뇌허혈(腦虛血)을 유발(誘發)하고 대조군(對照群)과 ILIB를 실시(實施)한 실험군(實驗群)으로 나누어 그 허혈면적(虛血面積)과 부종율(浮腫率)을 측정(測定)하였다. 결과(結果) : 1. 증상호전지수(症狀好轉指數)는 대조군(對照群)과 치료군(治療群) 사이에 유의(有意)한 차이(差異)가 없었다. 2. 치료전후(治療前後) 측정(測定)한 내경동맥(內頸動脈) siphon부(部)의 혈관반응성(血管反應性)은 대조군(對照群)과 치료군(治療群)에서 모두 유의성(有意性)있는 변화(變化)가 없었다. 3. 치료전후(治療前後) 측정(測定)한 요골동맥(橈骨動脈)의 혈관반응성(血管反應性)은 대조군(對照群)과 치료군(治療群)에서 모두 유의성(有意性) 있는 변화(變化)가 없었다. 4. 치료전후(治療前後) 측정(測定)한 PT, a-PTT은 대조군(對照群)과 치료군(治療群)에서 모두 유의성(有意性)있는 변화(變化)가 없었고, fibrinogen은 치료군(治療群)에서 치료전(治療前)보다 유의성(有意性) 있게 증가(增加)하였으나 평균값이 정상(正常) 범위(範圍)에서 벗어나지 않았다. 5. 국소(局所) 뇌허혈(腦虛血) 동물(動物) 실험(實驗)에서는 실험군(實驗群)에서 신경학적(神經學的) 결손(缺損), 허혈(虛血) 면적율(面積率), 부종율(浮腫率)이 유의성(有意性)있게 감소(減少)하였다 결론(結論) : 이상(以上)의 연구(硏究) 결과(結果) 뇌경한(腦硬寒)의 초기(初期) 치료(治療)에서 기존(旣存)의 한의학(韓醫學) 치료(治療)에 ILIB를 추가(追加)하는 것이 치료(治療) 효과(效果)를 증가(增加)시킨다는 증거(證據)는 없었으며 동물(動物) 실험(實驗)에서는 뇌경색(腦梗塞)의 치료(治療)에 응용(應用)할 수 있는 가능성(可能性)을 보여주고 있으나 그 효과(效果)와 적응증(適應症)을 구체적(具體的)으로 증명(證明)하기 위한 체계적(體系的)이고 다양(多樣)한 임상실험(臨床實驗)이 지적(持績)되어야할 것으로 생각된다. Background : Intravascular Laser Irrardiation of Blood(ILIB) is used in disorder of cerebral and peripheral blood circulation, dysfunction of brain, atherosclerosis etc., but there are little study about ILIB in oriental medicine. We wished to assess the efficacy of ILIB for the treatment of cerebral infarction. Method : The study group comprised 40 patients who arrived at hospital during 48 hours after attack. All patient were divided into two group. The control group was treated with Uhuangcheongsimhuan(牛黃淸心丸), Seonghyangjeonggisan(星香正氣散), acupuncture therapy only, while the ILIB group was treated with above therapy plus 5 days of irradiation of He-Ne Laser(1.8~2.5mW, 50min. per day). In rat model of middle cerebral artery(MCA) occlusion, the control group was not treated, while the ILIB group was treated with irradiation of He-Ne Laser(1.8~2.5mW, 24sec.). Result : 1. Symptom improve scores did not showed significant difference between control and ILIB group. 2. Vasoreactivity of carotid siphon did not showed significant difference between control and ILIB group. 3. Vasoreactivity of radial artery did not showed significant difference between control and ILIB group. 4. PT a-PTT did not showed significant changes between before and after treatment in both group. Fibrinogen significantly increased after treatment in ILIB group(p<0.05)), but it was in normal degree. 5. ILIB showed a significant decrease of brain ischemic area and edema in rat model of middle cerebral artery(MCA) occlusion. Conclusion : These findings suggest that additional treatment of ILIB is not more useful than traditional therapy only in acute cerebral infarction. But ILIB showed potential effect in rat model of MCA occlusion. So further investigation will be necessary.