위암 환자의 혈장 및 종양 조직에서 측정된 그렐린 농도의 임상적 의의

안지영,최민규,홍성권,백용해,노재형,손태성,김성,An, Ji-Yeong,Choi, Min-Gew,Hong, Seong-Kweon,Baik, Yong-Hae,Noh, Jae-Hyung,Sohn, Tae-Sung,Kim, Sung 대한위암학회 2005 대한위암학회지 Vol.5 No.4

목적: 그렐린은 위에서 주로 생산되며 체내 영양상태를 반영하고 에너지 항상성 유지에 관여한다. 위암으로 위 절제수술을 받은 환자의 혈장 및 조직의 그렐린 수치와 임상소견과의 관련성, 혈중 그렐린 수치와 위 암 조직 의 그렐린 수치의 상관성에 대해 알아보고자 한다. 대상 및 방법: 2004년 7월부터 9월까지 위암으로 진단받고 근치적 위전절제술과 위아전절제술을 시행 받은 환자를 대상으로 하였다. 수술 전 3개월 이내에 체중이 5% 이상 감소한 군과 5% 미만으로 감소한 군으로 나누어 임상적 특징, 생화학 검사소견, 체질량지수, 종양의 병기, 조직 유형, 혈액과 조직의 그렐린 펩타이드 농도를 측정하였다. 또한 수술 방법에 따라 수술 전후의 체질량지수, 생화학적 검사 소견, 혈중 그렐린 농도의 변화를 측정하였다. 결과: 체중 감소 정도에 따른 환자들의 임상 양상, 혈중 그렐린 농도, 종양 조직 및 정상조직의 그렐린 수치에는 유의한 차이가 없었고 이들 사이에 상호 연관성 역시 찾을 수 없었다 그러나 두 군 모두에서 종양 조직의 그렐린 수치는 정상 조직의 그렐린 수치에 비해 유의하게(P<0.0001)감소되어 있었고 종양의 분화도에 따라 종양 조직의 그렐린 수치에 유의한 차이가 있었다(P=0.007). 위아전 절제술을 시행 받은 환자들의 수술 후 7일 째 혈장 그렐린 농도는 수술 전 농도의 $36.5{\pm}25.6%$로, 위전절제술을 시행한 경우는 수술 전 농도의 $47.3{\pm}34.3%$로 감소하였다. 절제 범위에 따른 수술 전 후의 혈중 그렐린 농도에는 유의한 차이가 없었다. 결론: 위암의 발생 및 종양의 분화도는 그렐린의 생성에 영향을 미치며 위 조직의 그렐린 수치는 체내 그렐린 생성량을 반영하지 못한다. 위는 그렐린 생성의 주요 장소이며 위 절제 범위에 따라 혈중 그렐린 농도에 유의한 차이가 없는 것으로 보아 위전절술 후 다른 장기에서 그렐린이 대상성으로 더욱 증가하였음을 알 수 있다. 그렐린의 생성에 영향을 미치는 다른 인자들에 대한 추가적인 연구가 필요할 것으로 생각한다. Purpose: Ghrelin, produced primarily in the gastrointestinal tract, including the stomach, has been reported to reflect nutritional status and to control homeostasis by influencing food intake and adiposity. The purpose of this study is to evaluate nutritional status, as well as plasma and gastric tissue ghrelin levels, in patients with gastric cancer who underwent a gastrectomy. Materials and Methods: Eighty patients were analyzed by the degree of weight loss $(weight\;loss{\geq}5%\;or\;<5%)$ and the extent of gastrectomy (subtotal or total gastrectomy). Blood samples were collected from all patients preoperatively and postoperatively especially at seven days. Gastric tissues, including tumor and normal tissues, were obtained from the resected stomach. levels of plasma and tissue ghrelin were measured with a commercial ELISA kit. Results: There were no significant differences in the clinical characteristics and ghrelin levels of plasma, gastric tumor tissue and normal tissue by the degree of weight loss. The ghrelin levels in plasma and tumor tissue showed no correlations with each other while the ghrelin level in tumor tissue was significantly lower than that in normal tissue. The degree of cellular differentiation also had an association with ghrelin production. A gastrectomy proved to decrease significantly plasma ghrelin levels, body mass index, and biochemical markers, regardless of the extent of gastric resection. Conclusion: These results show that gastric cancer affects the production of ghrelin in the gastric mucosa and that ghrelin is mainly produced in stomach even though it could be partially covered by endogenous ghrelin from other organs following a gastrectomy. However, we should further investigate which other factors have an impact on energy consumption, ghrelin secretion, and changes in ghrelin levels after a gastrectomy.

경쟁, 보완관계를 고려한 WiBro 서비스 수요 전망

안지영,이광희,박광만,송영근,An, Ji-Yeong,Lee, Gwang-Hui,Park, Gwang-Man,Song, Yeong-Geun 한국전자통신연구원 2007 전자통신동향분석 Vol.22 No.4

개인용 휴대 인터넷의 개념으로 세계에서 최초로 기술이 개발되고 본격적인 상용화를 개시한 WiBro는 기술개발 초기부터 서비스에 대한 수요예측 작업이 이루어져 왔고, 이는 HSDPA의 경우도 마찬가지이다. 그러나 초기의 수요예측 시점에 가정하였던 여러 가정들이 구체화되고, 정보통신 환경도 변화함에 따라 이제 보다 구체적이고 정확한 수요예측이 이루어질 시점에 도달하였다. 이에 따라 본 고에서는 변화된 여러 환경을 고려하여 WiBro 서비스에 대한 수요예측을 수행하고자 하였다.

일반병동 입원환자의 어려운 기도 예측 여부에 따른 기관 내 삽관의 결과 분석

안지영,최혜란,An, Ji-Young,Choi, Hye Ran 한국중환자간호학회 2014 중환자간호학회지 Vol.7 No.2

Purpose: The purpose of this study was to determine the factors related to airway failure during endotracheal intubation among patients with and without predicted airway difficulty. Methods: Medical records were examined retrospectively. 329 patients who were admitted to the general ward and underwent endotracheal intubation were included. The incidence of airway failure in the two groups was investigated. Results: The group predicted to have airway difficulty consisted of 79 patients (24.0%) and the group without airway difficulty, 250 (76.0%). The number of cases of airway failure was 50 (15.2%). The factors that were associated with airway failure in the group with predicted airway difficulty were the jaw relaxation score, Cormack-Lehane score, and the device of the first endotracheal intubation attempt. The factors that were associated with the airway failure in the group predicted not to have airway difficulty were the induction agent, jaw relaxation score, Cormack-Lehane score, level of training of the personnel with the first endotracheal intubation success, and the device of the first endotracheal intubation attempt. Conclusion: The prediction of airway difficulty during endotracheal intubation was not effective; however, it was meaningful from the perspective of patient safety.

推量 · 推測의 複合辞에 관한 通時的硏究 : 「-かもしれない」를 중심으로

安志英),안지영(An Ji Young 일본어문학회 2015 일본어문학 Vol.70 No.-

古典文学作品および総合雑誌『太陽』から複合辞「-かもしれない」を抽出 した結果、「謡曲」の『国栖』の用例が初出と推測される。先行研究では近世以降の表現とされるが、それより早い南北朝時代から使われていたことが分かる。接続面では採集された初期の用例はすべて用言接続の口頭語であり、当時は用言接続の口頭語中心に使用されたと見られる。以降、19世紀になってから体言接続も現れるようになり、「-かもしれない」が意味 · 用法をより拡大させながら複合辞として定着していったことを示唆する。抽出された用例のうち、「-かもしれない」の意味を表すものの、「-かもしらない」の表現形式として現れているものが見える。これは文語「知る」が他動詞としては四段動詞活用するが、自動詞としては下一段動詞活用する活用体系との意味の類似点によるもので当時の過渡期的表現として使われたものだと推測される。総合雑誌『太陽』において非常に大きな変化を示したのは「-かもしれない」と「-かもしれぬ」の表現であり、1909年を起点とし、「-かもしれぬ」は徐々に用例が減少する反面、「-かもしれない」の使用率は上昇する。そして、引用句と呼応する用例が多数を示している。

複合辞に関する通時的研究

안지영(An, Ji-Young, 安志英) 일본어문학회 2010 일본어문학 Vol.50 No.-

The purpose of this thesis is to analyze the origin of the compound particles tobakari(ni) and n(nu․nai) bakari and bakarini and follow the integration of the compound particles in language over time. The first known appearance of tobakari(ni) in Japanese literature was in the year 951 Yamatomonogatari. Nowadays it means “as if it is so”, but until Meiji era, it meant “Only that”. According to my research, from the Meiji period, the usage of toiwanbakari gradually increased. As result of this influence, the meaning of tobakari (ni) was changed for the similarity. On the other hand, the first known appearance of n(nu․nai)bakari in Japanese literature was in the year 1672 Chikusaibanasi. It is often used with the verb “iu” like “iwanu(iwan)bakari”. And from Meiji period, It's usage increased rapidly Relative Clauses such as n(nu․nai) bakarino . bakarini was derived the Heian period's form of sibakarini . But the first known appearance of tabakarini in Japanese literature was in the 18th century. bakarini was often found in magazine articles and novels. As such, bakarini was used exclusively in written language.

상품의 가치 제고를 위한 헬스케어디자인의 공공성

안지영(An, Jiyoung),박태진(Park, Taejin),이태경(Lee, Taekyung),백진경(Paik, Jinkyung),성윤정(Sung, Yunjung) 인제대학교 디자인연구소 2012 Journal of Integrated Design Research (JIDR) Vol.11 No.2

디자인은 상품을 생산하기 위한 창조적 과정의 실현이자 인공물로서 우리 일상에서 벗어날 수 없는 유, 무형의 존재이며 공적 가치를 포함한다. 본 논문은 인문학적인 관점에서 상품, 디자인 가치, 헬스케어디자인의 공공성을 논하였다. 상품의 인문학적 가치를 제고하기 위해 본 논문은 상품의 경제적 생산관계와 사용가치, 사용가치와 동 일시된 교환가치를 중시했던 마르크스로 거슬러 올라가 분석하였다. 상품가치는 마르크스의 물신숭배(fetishism), 보드리야르의 시뮬라시옹(simulation), 루카치의 물화 (reification)로 표현된다. 본 연구는 헬스케어디자인의 가치와 관련하여 공공성의 인식을 위한 철학적 전제를 마련하는 데에 그 목적이 있다. 공공성의 철학적 전제는 차이의 미감, 공공의 미감, 디자인정치로 표현된다. 첫째, 공공디자인의 주체를 형성하는 차이의 미감은 대상에 대한 규정적 부정(estimmte negation)을 근거로 한다. 자기와 다른 타자, 즉 대상에 대한 인식은 ‘차이’에서 시작된다. 둘째, 주체의 선점이 없는 공백의 공간은 공공의 미감으로 나타난다. 그것은 다양한 배치를 인정할 수 있는 비어 있음의 공간인 동시에 고착되는 소유의 의미를 벗어나 사회적 관계를 형성 할 수 있는 가능태이다. 셋째, 디자인정치는 차이와 공공의 미감이 자리잡을 수 있는 사회적인 관계의 구축이다. Design is realization and an artifact of the creative process to produce goods and also is an intangible as well as tangible presence being indispensable in our everyday life. From the perspective of humanities, this paper aims to discuss product, design values and publicness of healthcare design in the public sphere. The value of humanities of the commodity, economic production values and utility values were represented in this paper. Marxist ideology, which thought highly of exchange values that was identified with utility values, also was considered for the study. In the paper, commodity values were discussed through the relationships between Marx"s fetishism, Jean Baudrillard"s simulation, and reification of Lukas. This study aims to prepare philosophical premises for the recognition of publicness in relation to the values of healthcare design. The philosophical premises of publicnessare expressed with aesthetics of differences, aesthetics of vacancy and design politics. First, the aesthetics of differences constituting the subject of public design are based on definable negation (bestimmte Negation) of the object. The recognition of others who are different from self, namely, of objects begins from "differences.’ Second, vacant space without the preoccupancy of the subject appears as the aesthetics of vacancy. It is possibility of being capable of constantly building social relations getting out of the meaning of fixed possession as well as space of vacancy to admit a number of arrangements. Third, it can be said that design politics is involved with building social relations in which aesthetics of differences and vacancy can be settled.

複合辞-からして의 変遷에 관한 一考察

安志英(An Ji Young) 일본어문학회 2018 일본어문학 Vol.83 No.-

In this paper, we investigate the origin of a compound particle, which is one of modern Japanese grammar, and its transition process. We will focus on the compound particle –karasite and analyze it from the historical point of view. Four examples have been extracted from four case examples of composite words expressing the original meaning by combining the particles “kara” and “site”. The extracted particle -karasite is used in conversation and it can be said that it is an expression commonly used in speech today. In the previous study, an example in 1906 was supposed to be its first attestation of the particle but in this survey it became clear that it was used from around 1787. The word yorisite was used prior to karasite and it was confirmed that yorisite and karasite came to be used together after the Muromachi Period. Eventually, the usage of the word yorisite was lost and is no longer used in modern Japanese language today. In the future, we will advance the comprehensive research of compound words by analyzing the origin and development of such words.

天草本ㆍ国字本『伊曾保物語』에 나타난 原因ㆍ理由表現에 관한 일고찰

안지영(安志英)(An, Ji-Young) 일본어문학회 2011 일본어문학 Vol.55 No.-

本稿は口頭語性の強い『天草本伊曽保物語』と文章語性の強い『国字本伊曾保物語』を対象とし、そこに現れている原因ㆍ理由表現を分析してその特徴を明らかにするものである。『天草本伊曾保物語』における原因ㆍ理由表現には「已然形+ば」「ところで」「ところに」「によって」「ほどに」があり、「已然形+ば」は単純な原因ㆍ理由を表す場合に主に用いられており、「によって」「ほどに」はより因果関係の強い表現として用いられていた。これらの用例数に拠って「によって」「ほどに」の使用時期を予測してみると、「によって」の方が「ほどに」より使用時期が早かったと推測でき、それ以後「ほどに」がより多く用いられていくことが分かる。そして、『国字本伊曾保物語』では見られない「ところで」「ところに」の用例と「已然形+ば」の用例の中、逆接の意味で解釈される用例があるが、このようなものが口頭語的表現といえよう。一方、『国字本伊曾保物語』における原因ㆍ理由表現には「已然形+ば」「ほどに」「によって」「あまり」「ゆえに」がある。「によって」「ほどに」はより因果関係の強い表現として用いられているが、「ほどに」は特に多数見られる。これは「ほどに」が次第に文章語的な性格を持つようになることを示唆していると思われる。

객토와 심토뒤집기 처리가 물푸레나무, 소나무, 잣나무 묘목의 초기 생장과 양분함량에 미치는 영향

안지영 ( Ji Young An ),박병배 ( Byung Bae Park ),변재경 ( Jae Kyung Byun ),조민석 ( Min Seok Cho ),김용석 ( Yong Suk Kim ),한시호 ( Si Ho Han ),김세빈 ( Se Bin Kim ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.1

The production of high quality seedlings is a very important phase in silvicultural systems for successful reforestation or restoration. The purpose of this study was to quantitatively measure both growth performances and nutrient responses of Fraxinus rhynchophylla, Pinus densiflora, and Pinus koraiensis seedlings, which are commercially planted in Korea, according to the different types of soil improvement treatments. We applied soil brought (hereafter ‘brought’), subsoil inversion (hereafter ‘subsoil’), and mixture of brought soil with soil on nursery bed (hereafter ‘mixing’) in a permanent national nursery. Silt and clay contents were the highest at the subsoil treatment and organic material, soil nitrogen and phosphorus concentrations were the lowest at the brought treatment. The growth of F. rhynchophylla was the lowest at the subsoil treatment, but there were no significant differences among treatments. There were significant differences in only root nutrient concentrations of F. rhynchophylla among treatments: nitrogen, phosphorus, and potassium concentrations were the lowest at the subsoil or brought treatment. Mixing treatment increased N contents with deduction of N concentrations (‘dilution’) because of more dry weight increase compared with the amount of N uptake. This study suggested mix of brought soil with soil on a nursery bed in a permanently used nursery can economically be an effective technique to improve soil quality.

서울시 중구 다문화가정 외국 출신 성인의 건강수준, 건강행위, 의료서비스 이용 실태

안지영 ( Ji Young An ),홍혜정 ( Hye Jeong Hong ),이동옥 ( Dongok Lee ),이복남 ( Boknam Lee ),정의식 ( Euisik Jeong ),박정은 ( Jung Eun Park ) 한국보건정보통계학회 2015 보건정보통계학회지 Vol.40 No.3

Objectives: The aim of this study was to explore health status, health behavior, and medical service usage of foreign-born adults from multi-cultural families who actually live in Junggu, Seoul, Korea. This initiative is essential to establish a future medical support service model for multi-cultural families in Korea, which also provides a basis for developing community-based participatory action research. Methods: Samples of this study were 537 multi-cultural households living in Junggu, Seoul, Korea, whose nationality and current residence address were enrolled. Questionnaires were selected from the literature reviewed and modified for this study. Trained interviewers collected data. Data were analyzed using the SAS. Results: Data obtained from 253 adults aged over 19 were analyzed. The identified vulnerable group with priority for managing their health from this study was: Chinese nationality born, length of stay in Korea less than 10 years, the average monthly household income less than 2,000,000 won, and people who were not fluent in Korean language. From the results, the demand related to policy making in this area was identified: community service programs providing classes such as Korean language and Korean cuisine; medical service for menstrual irregularity/amenorrhea, arthritis, oral diseases, and depression; intervention programs for managing/reliving daily stress; the increase number of migrant-friendly healthcare facilities. Conclusions: It was possible to identify the ongoing health status of foreign-born adults of multi-cultural families who have lived in Junggu, Seoul. Migrant-friendly community health center based life cycle and or disease-specific healthcare service could be tailored for them. It also would be the basis for the community based participatory healthcare service model.