變方牛黃淸心元 현탁액(SUV-3)에 對한 臨床試驗 報告

安日會,文炳淳,金世吉,新民敎 최신의학사 1989 最新醫學 Vol.32 No.12

中風前兆症에 關한 東西醫學的 考察

安日會,楊慶錫 圓光大學校 韓醫學硏究所 1996 원광한의학 Vol.6 No.1

Stroke-one of the most frequent causes to death with heart disease and malignant tumor-was disease which was accompany with disorders of speech, motor, emotion, consciousness, etc.. It was due to sudden cerebrovascular circulatory disdrder. It remained serious sequela to stroke patients, so their normal social livings were impossible. Therefore, the study about prevention and therapy of strike was sincerely requested. If TIA was recognized previously and treated adequately, stroke was prevented or its progress was obstructed. After bibliographic study about TIA with classical and mordern medicine books was studied, the results were obtained as follows. 1. Causes of TIA based on analysis of successive precrptions were pung, heat, phlegm, haw, insufficient of the Qi(vital energy), insufficient of the blood, insuffient of the Yin. It's causes based on modern medicine book were microembulus, cerebrovascular failure caused to decressing of blood pressure. 2. Motor disorder, sensory disorder, dysarthria, remember disorder, visual difficulty, etc. were discripted as symptoms of TIA in both mordern medicine books and classical medicine books. But, spasm of muscle, facial palsy, tinnitus, oppressed feeling in chest, sputum etc, other symtoms of TIA were discripted only classical medicine books. 3. Oriental medical therapy of TIA was emphasized to care about diet, living, sexual desire, emotion. Eu-pung-tang and Cheonma-hwan were most frequent in prescriptions, and intensions of these prescriptions were analized to enriching the liver and kidney, dispersing exepathic wind and pathogenic heat, enriching the Qi(vital energy) and blood, phlegm-eliminating and heat-clearing) 4. Western medical theraphy of TIA was classified two type. First, preservatory treatment were rest, regulation of blood pressure, anti-thrombotheraphy; antiaglulinant(heparin, warfarin, dicumarol), inhibitory agent of platelet agglegation(aspirine, dipyridamole, urokinase). Secondary, surgury was endarterectomy, extracerebral-intraccerebral bypass surgury, etc.

사궁산(莎芎散)이 실험동물(實驗動物)의 지혈(止血), 뇌압(腦壓), 혈압(血壓) 및 심혈관계(心血管系)에 미치는 영향(影響)

안일회,박영순,김세길,An, Il-Hoe,Park, Young-Soon,Kim, Seh-Gil 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.1

According to the original documents, Sagungsan is considered as an effective drug for controlling the hypertensive epistaxis induced by tension of autonomic nerve and it's hyperfunction. The present experiment was designed to understand the effect of Sagungsan extract on the hemostatic action, intracranial pressure, blood pressure and cardiovascular system in experimental animals. And thus the bleeding time, prothrombin time, capillary dilation, blood pressure, Intracranial pressure, and enzymatic analysis of the ATPase activities were studied. The result obtained here were as followings: 1. Sagungsan water extract reduced the bleeding time in mouse, and prolonged the prothrombin time in rabbits. 2. The drug extract increased the tail volume by capillary dilation in rats. 3. The drug extract inhibited the increase of intracranial pressure and arterial blood pressure in rabbits. 4. At the early time, the increase of arterial blood pressure by the drug extract significantly inhibited by pretreated atropin and regitine in rabbits. 5. The drug extract relaxed the smooth muscle by stimulating the Mg2+-Ca2+-ATPase activities of gastric sarcoplasmic reticulum isolated from rabbit stomach. 6. The drug extract stimulated the heart contraction by inhibiting the $Mg^{2+}-Ca^{2+}-ATPase$ activities of cardiac sarcoplasmic reticulum isolated from rabbit heart. The inhibitory mechanism was reversible and noncompatitive. 7. The drug extract increased the hepatic blood volume by stimulating the hepatic total ATPase activities and hepatic metabolism. 8. The drug extract acted as a tranquilizer by inhibiting the neural Na+-K+-ATPase activity. According to the results, Sagungsan water extract dilated the capillaries, stimulated the heart beat, and thus increased the blood flow with decreasing the intracranial pressure and blood pressure. These effects stanches the epistaxis collectively.

原方牛黃淸心元 현탁액(SU-3) 에 對한 臨床試驗 報告

安日會,文炳淳,金世吉,辛民敎 최신의학사 1990 最新醫學 Vol.33 No.2

杞菊地黃湯 煎湯液이 家兎의 血壓陸下에 미치는 影響

安日會,金世吉 圓光大學校 漢醫科大學 1989 圓光漢醫大論文集 Vol.- No.6

Gi Kook Jee Hwang Tang has been applie in the oriental medicine, and so it has exerted good therapeutic effect on the hypertension, but the effectiveness and the mechanism of Gi Kook Jee Hwang Tang on the blood pressure are not clarified. This experiment was carried out in order to revaluate the hypotensive action of the water extract of Gi Kook Jee Hwang Tang pharmacologically and to clarify the mechanism of this action in rabbits. The change of the blood pressure was observed after the administration of the water extract of Gi Kook Jee Hwang Tang(GKJHT) into an ear vein of rabbits. The following results were obtained: 1. Blood pressure manifested gradual response by the fall of 6.3, 12.5, 20.0 percent in proportion to the administration of 0.1, 0.3, 1.0ml/㎏ of GKJHT, respectively. 2. Administration of GKJHT to the rabbits pretreated with Atropine did nit show any significant differened in the blood pressure, compared with that of the control grop. 3. Administration of GKJHT to the rabbits pretreated with propranolol did not show any significant differened in the blood pressure, compared with that of the control grop. 4. Administration of GKJHT to the rabbits pretreated with Regitine showed significant differened in the blood pressure, compared with that of the control grop. 5. Administration of GKJHT to the rabbits pretreated with Cyproheptadine did not show any significant difference in the blood pressure, compared with that of the control grop. From the above results, it is suggested that GKJHT has the action on adrenergic α-receptor, and so decrease periperal resistance of blood vessel, the above result that GKJHT can be used in good therapeutic effect on the hypertension.

변방우황청심원(變方牛黃淸心元) 환제(丸劑) 및 현탁액(懸濁液)에 대(對)한 임상적(臨床的) 고찰(考察)

안일회,김세길,Ahn, Il-Hoe,Kim, Se-Gil 대한한방내과학회 1991 大韓韓方內科學會誌 Vol.12 No.1

We performed the effect of Woohwangchungsim-won suspension (group A), pills(group B) in patients with circulatory system disease. Total 63 patients were classified into group A and group B. The results obtained were as follows ; 1. The highest effect was showed that group A was blood pressure, group B was anxiety, the lowest effect was showed that group A was insomnia, group B was blood pressure. 2. Generally, pills was somewhat higher than suspension, but suspension was somewhat higher in more than good effect. 3. In depressed blood pressure, group A, group B were 82.6%, 63.6% in fair effect and more respectively. 4. There was no side effect in overall cases.

原方牛黃淸心元 현탁액(SU-3)에 대한 임상시험 보고

安日會,文炳淳,金世吉,辛民敎 대한본초학회 1989 大韓本草學會誌 Vol.4 No.1

杞菊地黃湯 煎湯液이 家兎의 血壓降下에 미치는 影響

安日會(Ill Hoyi, An),金世吉(Sea Gil Kim) 대한한의학회 1989 대한한의학회지 Vol.10 No.1

疎風湯이 腦血栓症 初期 患者에 미치는 影嚮

鄭長均,安日會 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1

We understand the meaning of The SoPoongTang's using and compared with western medical treatment of cerebral thrombosis, so except that The SoPoongTang is effective of preventing early cerebral thrombosis' degeneration. therefore, we had prescribed the estract of The SoPoongTang in 47 early cerebral thrombosis patients for a week from April, 1994 to December, 1994 and the result was as follows; 1. We observed recovering rates after a week; Headache 40%, Dizziness 87.5%, Insomnia 505, Neck stiffness 83.3%, Redface 755, Palpitation 100%; Avearge recovering rates 68.8%. 2. We observed the states of consciousness after a week; There were increasing from 41 patients to 43 patients in Gr-4 and decreasing from 5 patients to 3 patients in Fr-3. 3. We observed the states of swallowing after a week; There were increasing from 37 patients to 44 patients in having G.D. decreasing from 7 patients to 3 patients in having S.D and from 6 patients to 0 patients in having L.D. 4. We observed the states of motor weakness after a week. Upper Limb - There were degeneration in 12 patients(25.5%), changelessness in 25 patients(53%), and improvement in 10 patients(21%) Lower Limb - There were degeneration in 5 patients(10.6%), changelessness in 31 patients (66%), and improvement in 11 patients(23.4%) As a result, The SoPoongTang has effect in preventing of the most serious neurological symptoms-hemiplegia, bysphsia, metal disorder in early cerebral thrombosis. Additionally I recommend that we should compare and reserch three cases; independent priescription group(which are) used Urokinase, Heparine, etc. at the begining of Cerebral thrombosis in western medicine; a tretment group which are given combination of Western and Oriental medicine silmultaneously; and this study.

急性 附子 草烏 中毒에서 甘豆湯과 苦蔘의 應用

李承武,安日會,李彦政,金炯均,金東雄 대한한의학회 1993 대한한의학회지 Vol.14 No.2