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실시간 지하공동구 화재 온도 예측을 위한 Residual CNN-LSTM 모델 연구
안요셉,윤효근 한국정보과학회 2024 정보과학회논문지 Vol.51 No.2
Underground utility tunnels (UUTs) play major roles in sustaining the life of citizens and industries with regard to carrying electricity, telecommunication, water supply pipes. Fire is one of the most commonly common disasters in underground facilities, which can be prevented through proper management. This paper proposes a hybrid deep learning model named Residual CNN-LSTM to predict fire temperatures. Scenarios of underground facility fire outbreaks were created and fire temperature data was collected using FDS software. In the experiment, we analyzed the appropriate depth of residual learning of the proposed model and compared the performance to other predictive models. The results showed that RMSE, MAE and MAPE of Residual CNN-LSTM are each 0.061529, 0.053851, 6.007076 respectively, making Residual CNN-LSTM far superior to other models in terms of its predictive performance.
부모의 음주문제가 대학생 자녀의 대인관계에 미치는 영향에서 부모화의 매개효과
안요셉 알코올과 건강행동학회 2023 알코올과 건강행동연구 Vol.24 No.2
Objectives: This research aims to understand the mediating role of parentification in the association between parental drinking problems and interpersonal relationships among college students. Methods: Utilizing a cross-sectional design, data were collected both through online and offline means. The study encompassed responses from 281 university students aged 18 to 29. The mediation effect of parentification on the relationship between parental drinking problems and the interpersonal relations of students was examined using bootstrapping analysis in jamovi 2.23.21 solid version for macOS. Results: Notable correlations emerged among the primary variables. Parental drinking problems exhibited a negative correlation with students' interpersonal relations and a positive correlation with parentification. Crucially, parentification mediated the effects of both fathers' and mothers' drinking problems on two specific aspects of interpersonal relations: caring for others and managing conflicts. However, no significant differences were discerned based on parental gender. Conclusion: This study reveals the significant impact of father' and mother' drinking problems on the interpersonal relations of college-aged children through parentification. The findings underscore the profound influence of both fathers' and mothers' drinking problems on the interpersonal dynamics of college-aged children, mediated by parentification, irrespective of the gender of the parent. The implications of this study emphasize the need for intervention strategies and policies that account for familial dynamics, and social contexts, aiming to mitigate interpersonal challenges faced by college students from families grappling with alcohol-related issues.
이동성,리빈,이윤정,천현자,류일환,지연주,채권우,권요셉,손지우,강현규,이성희,안인파,이호섭 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.4
Taraxaci Herba has long been used in herbal medicine for their choleretic, anti-heumatic and diuretic properties. In the present study, we investigated the effects of origin plants of Taraxaci Herba, Taraxacum coreanum Nakai, as an anti-inflammatory agent in lipopolysaccharide(LPS)-induced microglial activation in BV2 cells. NNMBS273, the EtOH extracts of roots T. coreanum was examined for anti-neuronal inflammatory activity as new drug development. The roots of T. coreanum, showed the potent anti-neuroinflammatory effects on LPS-induced inflammation in microglial BV2 cells. The anti-inflammatory effects of NNMBS273, the EtOH extracts of roots T. coreanum was demonstrated by the suppression of pro-inflammatory mediators, including pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-α and interleukin-1β). These results suggest that the roots T. coreanum may be a promising candidate for the treatment of neurodegenerative diseases related to neuroinflammation.
소형 전자 기기의 열설계를 위한 복합층 방열시트의 등가 열물성 측정법
이요셉(J.S. Lee),박경의(K.U. Park),김동현(D.H. Kim),임영태(Y.T. Im),김인중(I.J. Kim),안원기(W.K. Ahn),김민수(M.S. Kim),홍석호(S.H. Hong) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
Portable electronic devices generate heat more and more because of high power and thinner design specifications. The excessive heat makes the devices operate not properly and makes customers feel uncomfortable. To dissipate such excessive heat, various multi-layer heat spreading sheets (HSS) are attached to the various components of electronic devices. This study is conducted for the optimized thermal design of portable devices in the aspect of an analytical simulation modeling of HSS. First of all, test module which is similar to the product was employed and the test was done following the Graphite sheet. This result is used as input data for the computer simulation to calculate the equivalent thermal properties. Then the analytical result is compared and verified with theoretical thermal properties. Finally, thermal properties which can be applied to the concept design stage have been proposed.
국제 물거래 대비 가상수 거래량 산정 : 국내 물발자국 적용값 도출
박성제,이민현,박계영,안요셉 한국수자원학회 2020 한국수자원학회논문집 Vol.53 No.S-1
수자원 수급계획은 보통 물수지분석에서 파악된 수자원의 양에 따라 수립한다. 그러나 그것은 상품의 이동과 같은 국제교역을 고려하지 않은 폐쇄적인 수급계획이다. 물수지분석에 가상수 개념을 도입하면 상품의 수출량과 수입량을 고려한 수자원 수급계획을 수립할 수 있다. 기존에 활용하는 직접적인 물 사용(지역 내에서 가용한 각종 수자원)과 가상수를 고려한 간접적인 물 사용(지역 외에서 수입한 상품생산에 소요된 타 지역의 수자원)을 종합적으로 고려하기 때문이다. 그러나 한국에서는 아직 가상수의 개념이 국가 수자원계획 수립에 본격적으로 반영되고 않고 있다. 국내외에서 발표된 가상수 산정연구 논문에서는 가상수 산정과정이 생략되거나 일부만 제시된 사례가 많다. 따라서 가상수의 산정과정 및 거래량의 적절성을 파악하여 실무에 활용하는데 큰 어려움이 존재하고 있다. 본 연구는 한국에서 수출입하는 가상수량 산정을 위한 물발자국 적용값을 구체적으로 제시하고자 한다. 농축산물의 국제 이동량, 물발자국 적용값, 가상수 거래량을 파악하는 과정을 기술하고, 이를 기존연구와 비교하고자 한다. 따라서 본 연구에서 제시한 산정과정과 산정기준은 물발자국 및 가상수 연구를 수행하는 연구자들에게 유용한 기초자료를 제공할 것이다. The amount of water resources identified by water balance analysis are usually used to formulate water resources plans. However, this does not consider the trade in goods between countries. It is possible to use virtual water to come up with a supply and demand plan by looking at the export and import of products. This is because it looks comprehensively at the direct water use (water resources within the region) and indirect water use (water resources of other regions from imported products). Yet South Korea does not actively use the concept of virtual water in the national water resources plan. There is difficulty with calculating and identifying the appropriate virtual water amount as many of the research papers present only few of the cases or omit the calculation process. This paper introduces detailed water footprint values for calculating the virtual water trade for South Korea. The international movement, water footprint, and virtual water trade of agricultural and livestock products are presented and compared to existing research. The water footprint and virtual water research in this paper can be utilized as baseline data for future researchers.
이동성,리빈,이윤정,천현자,류일환,지연주,채권우,권요셉,손지우,강현규,이성희,안인파,이호섭 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.4
<P> Taraxaci Herba has long been used in herbal medicine for their choleretic, anti-heumatic and diuretic properties. In the present study, we investigated the effects of origin plants of Taraxaci Herba, Taraxacum coreanum Nakai, as an anti-inflammatory agent in lipopolysaccharide(LPS)-induced microglial activation in BV2 cells. NNMBS273, the EtOH extracts of roots T. coreanum was examined for anti-neuronal inflammatory activity as new drug development. The roots of T. coreanum, showed the potent anti-neuroinflammatory effects on LPS-induced inflammation in microglial BV2 cells. The anti-inflammatory effects of NNMBS273, the EtOH extracts of roots T. coreanum was demonstrated by the suppression of pro-inflammatory mediators, including pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-α and interleukin-1β). These results suggest that the roots T. coreanum may be a promising candidate for the treatment of neurodegenerative diseases related to neuroinflammation.</P>
이동성,리빈,이윤정,천현자,류일환,지연주,채권우,권요셉,손지우,강현규,이성희,안인파,이호섭 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.4
Taraxaci Herba has long been used in herbal medicine for their choleretic, anti-heumatic and diuretic properties. In the present study, we investigated the effects of origin plants of Taraxaci Herba, Taraxacum coreanum Nakai, as an anti-inflammatory agent in lipopolysaccharide(LPS)-induced microglial activation in BV2 cells. NNMBS273, the EtOH extracts of roots T. coreanum was examined for anti-neuronal inflammatory activity as new drug development. The roots of T. coreanum, showed the potent anti-neuroinflammatory effects on LPS-induced inflammation in microglial BV2 cells. The anti-inflammatory effects of NNMBS273, the EtOH extracts of roots T. coreanum was demonstrated by the suppression of pro-inflammatory mediators, including pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-α and interleukin-1β). These results suggest that the roots T. coreanum may be a promising candidate for the treatment of neurodegenerative diseases related to neuroinflammation.
고경남,임호준,김혜리,강형진,박경덕,신희영,안요셉,이지원,유건희,성기웅,구홍회,임영탁,박준은,박병규,박현진,서종진 대한의학회 2017 Journal of Korean medical science Vol.32 No.4
This multicenter, prospective trial was conducted to develop an effective and safe reinduction regimen for marrow-relapsed pediatric acute lymphoblastic leukemia (ALL) by modifying the dose of idarubicin. Between 2006 and 2009, the trial accrued 44 patients, 1 to 21 years old with first marrow-relapsed ALL. The reinduction regimen comprised prednisolone, vincristine, L-asparaginase, and idarubicin (10 mg/m2/week). The idarubicin dose was adjusted according to the degree of myelosuppression. The second complete remission (CR2) rate was 72.7%, obtained by 54.2% of patients with early relapse < 24 months after initial diagnosis and 95.0% of those with late relapse (P = 0.002). Five patients entered remission with extended treatment, resulting in a final CR2 rate of 84.1%. The CR2 rate was not significantly different according to the idarubicin dose. The induction death rate was 2.3% (1/44). The 5-year event-free and overall survival rates were 22.2% ± 6.4% and 27.3% ± 6.7% for all patients, 4.2% ± 4.1% and 8.3% ± 5.6% for early relapsers, and 43.8% ± 11.4% and 50.0% ± 11.2% for late relapsers, respectively. Early relapse and slow response to reinduction chemotherapy were predictors of poor outcomes. In conclusion, a modified dose of idarubicin was effectively incorporated into the reinduction regimen for late marrow-relapsed ALL with a low toxic death rate. However, the CR2 rate for early relapsers was suboptimal, and the second remission was not durable in most patients.
백광열,김기환,박정현,Jae Im Lee,김옥희,홍하은,서해연,최호중,안요셉,이태윤,김세준 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
The limitations of stem cells have led researchers to investigate the secretome, which is the secretory materials in stem cells, since the principal mechanism of action of stem cells is mediated by the secretome. In this study, we determined the antifibrotic potential of the secretome released from miR-150-transfected adipose-derived stromal cells (ASCs). The secretome released from ASCs that were transfected with antifibrotic miR-150 was obtained (referred to as the miR150 secretome). To validate the antifibrotic effects of the miR-150 secretome, we generated in vitro and in vivo models of liver fibrosis by treating human hepatic stellate cells (LX2 cells) with thioacetamide (TAA) and subcutaneous injection of TAA into mice, respectively. In the in vitro model, more significant reductions in the expression of fibrosisrelated markers, such as TGFβ, Col1A1, and α-SMA, were observed by using the miR-150 secretome than the control secretome, specifically in TAA-treated LX2 cells. In the in vivo model, infusion of the miR-150 secretome into mice with liver fibrosis abrogated the increase in serum levels of systemic inflammatory cytokines, such as IL-6 and TNF-α, and induced increased expression of antifibrotic, proliferation, and antioxidant activity markers in the liver. Our in vitro and in vivo experiments indicate that the miR-150 secretome is superior to the naive secretome in terms of ameliorating liver fibrosis, minimizing systemic inflammatory responses, and promoting antioxidant enzyme expression. Therefore, we conclude that miR-150 transfection into ASCs has the potential to induce the release of secretory materials with enhanced antifibrotic, proliferative, and antioxidant properties.