흰쥐 말초 혈액 림프구의 분자량 44 kD 단백의 인산화

안영수(Young Soo Ahn),주일로(I-Lo Jou),오도연(Do Yeun Oh),임승욱(Seung Wook Lim),박경선(Kyung Sun Park) 대한약리학회 1991 대한약리학잡지 Vol.27 No.2

흰쥐 말초혈액에서 얻은 T 림프구를 아드레날린성 β-수용체 효현제 및 concanavalin A(Con-A)로 자극해 다음과 같은 결과를 얻었다. 자극이 없는 상태에서의 주 인산화 단백은 분자량 44kD, 등전점 6.8의 단백이었으며 효현제로 자극시키면 분자량 44kD, 등전점 6.3의 단백이 새로이 인산화되어 나타났다. 이 분자량 44kD, 등전점 6.3의 단백은 forskolin에 의해 역시 인산화되며 A-kinase 억제제인 H-8을 전처치하면 인산화의 억제가 나타났다. 또한 Con-A로 자극시키면 44 kD/pI 6.3 단백의 인산화가 증가되었으며 이 인산화의 증가는 CaM kinase 억제제인 W-7 전처치에 의해 억제되었다. H-7은 분자량 44 kD, 등전점 6.8 단백의 인산화를 감소 시켰다. 이상의 결과로 분자량 44 kD 등전점 6.3의 단백은 A-kinase와 CaM kinase 모두에 의해 인산화 되는 기질단백으로서 tryptic peptide map상에서 44 kD/pI 6.8 단백과 44 kD/pI 6.3 단백은 서로 다른 단백임을 알 수 있었다. Using T-lymphocytes obtained from rat peripheral blood, we found that the 44kD/pI6.8 protein was the major phosphoprotein of T-lymphocytes under basal condition, and that the 44kD/pI6.3 protein was a new phosphoprotein appeared in T-lymphocytes stimulated with β-agonist. The phosphorylation of the 44kD/pI6.3 protein was also induced by forskolin but inhibited by H-8 pretreatment. To clarify the character of the 44kD/pI6.3 protein, we used Con-A and kinase inhibitors, H-7 and W-7. Con-A stimulation induced phosphorylation of 44kD/pI 6.3 protein but that was inhibited by W-7 pretreatment. The phosphorytation of 44kD/pI6.3 protein was not induced by the PKC activator, PMA. Instead, the phosphorylation of 44kD/pI6.8 protein was reduced by H-7, a PKC inhibitor. From the above results,it can be concluded that the 44kD/pI6.3 protein can be a common substrate for A-kinase and CaM kinase. The two dimensional tryptic peptide mapping revealed that the 44kD/pI6.8 and 44kD/pI6.3 proteins are different.

급성 간질성 폐렴

안영수 ( Young Soo Ahn ),라동집 ( Dong Jib Rha ),이상무 ( Sang Moo Lee ),김현태 ( Hyeon Tae Kim ),어수택 ( Soo Taek Uh ),김용훈 ( Yong Hoon Kim ),박춘식 ( Choon Ski Park ),박재성 ( Jae Soung Park ),최득린 ( Deuk Lin Choi ),진소영 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.6

High-k HfO2와 HfO2/Al2O3/HfO2 적층막의 구조 안정성 및 전하 트랩핑 특성 연구

안영수 ( Young Soo Ahn ),허민영 ( Min Young Huh ),강해윤 ( Hae Yoon Kang ),손현철 ( Hyun Chul Sohn ) 대한금속·재료학회 2010 대한금속·재료학회지 Vol.48 No.3

In this work, high-k dielectric stacks of HfO2 and HfO2/Al2O3/HfO2 (HAH) were deposited on SiO2/ Si substrates by atomic layer deposition as charge trapping layers in charge trapping devices. The structural stability and the charge trapping characteristics of such stacks were investigated using Metal-Alumina- Hafnia-Oxide-Silicon (MAHOS) structure. The surface roughness of HfO2 was stable up to 11 nm with the insertion of 0.2 nm thick Al2O3. The effect of the thickness of the HAH stack and the thickness of intermediate Al2O3 on charge trapping characteristics were investigated for MAHOS structure under various gate bias pulse with duration of 100 ms. The threshold voltage shift after programming and erase showed that the memory window was increased with increasing bias on gate. However, the programming window was independent of the thickness of HAH charge trapping layers. When the thickness of Al2O3 insertion increased from 0.2 nm to 1 nm, the erase window was decreased without change in the programming window.

Haloperidol 이 심혈관계에 미치는 영향

안영수(Young-Soo Ahn) 대한약리학회 1975 대한약리학잡지 Vol.11 No.2

Haloperidol, a butyrophenone, was synthetized by Janssen and introduced for the treatment of psychosis. Although structurally different from the phenothiazines, the butyrophenones share many of their pharmacological properties, such as inhibition of conditioned avoidance response, blocking effect of amphetamine reaction, producing catalepsy, antishock effect and protection against the lethal effects of catecholalmines. Chlorpromazine can lower the arterial blood pressure through its adrenergic blocking activity, its direct effect in relaxing vascular smooth muscle, its direct effect in depressing the myocardium and its action in a complex manner on the central nervous system. In the case of haloperidol, however, was not clarified the mechanism of lowering the blood pressure. The present paper describes the effects of haloperidol on cardiovascular system to investigate the mechanisms of its actions on the arterial blood pressure. The results are followings; 1. In anesthetized cats, intravenous administration of haloperidol and chlorpromazine in the dose of 0.1mg/kg produced a slight decrease in the blood pressure, which followed by complete recovery within 30 ~ 60 minutes. In the dose of 3mg/kg, however, both produced an abrupt and marked decrease of the blood pressure, which followed by delayed recovery. 2. Haloperidol in the dose ranges of 0.1mg to 3.0mg/kg tended to produce the heart rate slowing in the cats, while chlorpromazine has no effect on the rate. 3. Following administration of haloperidol or chlorpromazine, epinephrine reversal in the arterial blood pressure was observed in the cat, however the responses of norepinephrine and acetylcholine were little affected. 4. In the isolated rabbit atrium the contractility was depressed by haloperidol in the doses over 0.5mg per 100ml, but the rate was not affected. In contrast, the epinephrine-induced contractility was not depressed after haloperidol treatment. However, the increased rate of atrium by epinephrine was partially blocked after haloperidol. 5. In the isolated rabbit aortic strip, epinephrine-induced contraction was blocked by haloperidol. With the above results, it may be concluded that the hypotensive effect of haloperidol was largely due to α-adrenergic blocking properties and the direct effect in depressing the myocardium as well as its action on central nervous system.

T. S. 엘리엇과 낭만주의

안영수(Ahn Young-soo) 한국T.S.엘리엇학회 1995 T.S. 엘리엇 연구 Vol.2 No.-

고양이에서 체표냉각에 따른 심혈관계 변동에 관한 연구

안영수(Young Soo Ahn),고창만(Chang Mann Ko),이우주(Woo Choo Lee) 대한약리학회 1983 대한약리학잡지 Vol.19 No.1

Hypothermia is an essential preparatory procedure for cardiac surgery, which lows the metabolic rate and myocardial oxygen demand. However, hypothermia itself is a stress enough to change the tonus of sympathoadrenal system, especially the cardiovascular responses to the catecholamines. It is reported that the positive chronotropic and inotropic response of catecholamines is exaggerated during hypothermia because of decreased norepinephrine uptake at the junctional cleft or decreased catecholamine metabolism. On the other hand, there are evidences of diminished catecholamines responses in low temperature ana further, interconversion of adrenergic receptors is also suggested. Present investigation was planned to observe the cardiovascular changes and its responses to catecholamines during surface hypothermia in cat. Healthy mongrel cats, weighing 2 ~ 3 kg, anesthetized with secobarbital(30 mg/kg), were permitted to hypothermia by external cooling technic. Esophageal temperature, ECG (lead II), heart rate, left ventricular pressure with dP/dt, carotid artery pressure and left ventricular contractile force were monitored with Polygragh (Model 7, Grass), and the respiration was maintained with artificial respirator (V 5 KG, Narco). Followings are summarized results. 1) Surface cooling caused progressive decrease of body temperature and reached l8.8 ± 0.8˚C and 16.9 ± 0.6˚C in 120 and 150 min respectively, after immersion into ice water, and ventricular fibrillation was developed at 20.4 ± 0.65˚C. 2) Heart rate, blood pressure and myocardial contractility were decreased after initial increase as the body temperature falls. 3) Systolic and diastolicdd P/dt of left ventricular pressure were decreased and that the decrement of diastolic dP/dt was more marked. 4) On ECG, ST depression, Twave inversion and prolongation of PR interval were prominent in hypothermia, and moreover, the prolongation of PR interval was marked just prior to the development of ventricular fibrillation. 5) The cardiovascular responses to catecholamines, especially to isoproterenol, were suppressed under hypothermia.

PS 강봉으로 이체화된 강합성 라멘교의 개발을 위한 실험연구

안영수 ( Young Soo Ahn ),정지승 ( Jaee Seung Chung ) 한국안전학회(구 한국산업안전학회) 2012 한국안전학회지 Vol.27 No.4

In recent years, various research and developments to introduce composite bridges of new concept have been performed. The types of integral bridge and portal rigid frame bridge are having advantages in bridge maintenance and structural efficiency by eliminating expansion joints and bridge supports. However, the detail of typical girder-abutment connection has problems such as complexity of construction and increase of the construction cost. A new type of bridge, called prestress integral composite girder (PIC girder) bridge, is proposed in this study, which decreases the cost of construction and improves the efficiency of construction by simplifying the detail of construction for girder-abutment connection. PIC girder bridge has the connection detail in which the steel girder and the abutment are integrated by using the PS bar installed in the connection, In this study, finite element analysis and mock-up load test are conducted to evaluate the propriety of design, the effective of fabrication and structural safety for PIC girder bridge, The adequacy of the PIC giredr bridge is verified by the results of static/dynamic load test and finite element analyses.

고주파용 대용량 단위 유전체 제조공정과 ZrO₂ 첨가에 따른 전기적 특성 연구

안영수,김준수,박주석,김홍수,한문희,노광수,Ahn, Young-Soo,Kim, Joon-Soo,Park, Joo-Seok,Kim, Hong-Soo,Han, Moon-Hee,No, Kwang-Soo 한국세라믹학회 2002 한국세라믹학회지 Vol.39 No.9

$ZrO_2$ 첨가량 변화에 따른 전기적 특성과 고주파 대용량 세라믹 캐패시터 제조공정 조건을 규명하기 위하여 고주파 대용량 세라믹 캐패시터의 제조 및 전기적 특성에 관하여 연구하였다. 단위 캐패시터는 테이프 캐스팅법으로 제조되었으며, 유전체 및 바인더의 최적조성은 57.5∼60.0: 42.5∼40.0 wt%이다. 슬러리의 점도는 4000∼5000 cps이며, 이 슬러리를 사용하여 제조한 그린 테이프는 뛰어난 캐스팅 상태를 유지하고 있다. 80$^{\circ}C$에서 200 kg/$cm^2$의 성형압으로 성형함으로서 최적의 적층 상태를 얻을 수 있었다. 단위 캐패시터의 전기적 특성, 특히 절연파괴 특성을 증진시키기 위하여 $ZrO_2$를 첨가하였다. $ZrO_2$ 첨가량이 1 wt%에서부터 5 wt%까지 첨가한 경우에는 단위 캐패시터의 유전상수 및 유전손실에 큰 영향을 미치지 못하였다. 또한 유전상수도 10 kHz에서 500 kHz 사이의 주파수 범위에서 큰 변호가 없었다. 내전압은 3 wt%를 첨가한 경우 $CaZrO_3$에 형성 및 입자크기 감소로 인하여 증진됨을 확인할 수 있었다. Fabrication and electrical characterization of R. F. High-power unit capacitors were investigated to study on condition of fabrication processing for R. F. High-power unit capacitor and electrical characteristics according to addition of $ZrO_2$. The unit capacitors were fabricated using tape casting. The optimum mixture ratio of dielectrics and mixing binder for the slurry fabrication was 57.5∼60.0: 42.5∼40.0 wt%. The slurry viscosity was 4000∼5000 cps and casting state of green tape fabricated using these slurry was excellent. Optimum stacking was made by 200 kg/$cm^2$ pressure with 80$^{\circ}C$ heating. $ZrO_2$ was added to improve the electrical characteristics of unit capacitor, especially breakdown characteristics. The dielectric constant and loss factor of the unit condenser having different $ZrO_2$ amounts was not changed in the addition range of 1 to 5 wt%. Also, dielectric constant was not changed in the frequency range of 10 to 500 kHz. It was found that characteristics of resistance voltage was improved through the formation of $CaZrO_3$ and the reduction of particle size as about 3wt% $ZrO_2$ was added.

Studies on the Reduction of SO₂ Injury to Hibiscus syriacus L. by Use of Growth Regulant, CCC

Ahn Young-Soo(安永秀),Yeam Do- Yi(廉道義) 한국원예학회 1977 Horticulture, Environment, and Biotechnology Vol.18 No.2

PS 강봉으로 일체화된 강합성 라멘교의 거더-교대 접합부에 대한 피로 성능 평가

안영수(Young-Soo Ahn),오민호(Min-Ho Oh),정지승(Jee-Seung Chung),이상윤(Sang-Yoon Lee) 한국콘크리트학회 2012 콘크리트학회논문집 Vol.24 No.3