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안승원,Balachandar Nedumaran,Yuanbin Xie,김돈규,김용득,최흥식 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.1
Bisphenol A bis (2,3-dihydroxypropyl) ether (BADGE.2H₂O) is a component of commercial liquid epoxy resins commonly used in the food-packing industry and in dental sealants. There is evidence that it has significant estrogenic activity. Nur77 plays a crucial role in the regulation of certain genes involved in LH-mediated steroidogenesis in testicular Leydig cells. It was previously demonstrated that Bisphenol A (BPA) stimulates Nur77 gene induction and steroidogenesis. In this study, we investigated the effects of BADGE.2H₂O on Nur77 gene expression and steroidogenesis. Northern blot analysis showed that it increased the expression of Nur77 mRNA and protein, and transient transfection assays demonstrated that it increased the promoter activity and transactivation of Nur77. It also increased the expression of certain steroidogenic genes, such as StAR and 3β-HSD. Finally, over-expression of a dominant negative Nur77 cDNA via adenoviral infection reduced BADGE.2H₂O-mediated progesterone biosynthesis. These results indicate that BADGE.2H₂O disrupts testicular steroidogenesis by increasing Nur77 gene expression.
만성 경부통을 가진 시내버스 운전기사에게 복합 운동프로그램의 효과 : 사례연구
안승원,정영준,Ahn, Seung-won,Jung, Young-june 대한정형도수물리치료학회 2015 대한정형도수물리치료학회지 Vol.21 No.1
Background: Although many of those who drive for a living are exposed to repetitive and awkward posture and whole body vibration which cause them cumulative trauma disorder, therapeutic studies related to the problems from the transport unit are still somewhat inadequate. The purpose of this case report is to identify the effect of combined exercise program on patients suffering chronic neck pain caused by long hour of intra-city bus driving. Method: A total of 4 subjects are selected as patients, all of whom have more than 10 years of experience in intra-city bus transportation services. These people have suffered from neck pain for years. We ran the combined exercise program 3 times a week for 4 weeks and respectively evaluated the results after the 2nd and 4th week. We implemented conventional physiotherapy for 40 minutes, another 40 minutes of combined exercise program, and then educated the patients to enable themselves to do active stretching program as a home program. The combined exercise program contained 3 different stages. 1st stage: active stretching program, 2nd stage combined stabilization exercise and strengthening exercise, 3rd stage: proprioceptive exercise Result: After 4 weeks of intervention, there was enhance in the range of motion. $12^{\circ}$ increase in flexion, $10^{\circ}$ in extension, $6^{\circ}$ in lateral flexion respectively, and $10^{\circ}$ in rotation on average. VAS(visual analgue scale) decreased by 33% on average, NDI(neck diability index) by 28% and fatigability by 23%. Conclusion: There were improved results in the range of motion, NDI, VAS, and in fatigability after applying combined exercise program to intra-city bus drivers exposed to whole body vibration and cumulative trauma disorder.
안승원 한국마린엔지니어링학회 2004 한국마린엔지니어링학회지 Vol.28 No.5
The Primal-Dual Interior-Point (PDIP) method is currently one of the fastest emerging topics in optimization. This method has become an effective solution algorithm for large scale nonlinear optimization problems, such as the electric Optimal Power Flow (OPF) and natural gas and electricity OPF. This study describes major theoretical developments of the PDIP method as well as practical issues related to implementation of the method. A simple quadratic problem with linear equality and inequality constraints
교통사고로 인한 다발성 외상 환자의 국소진동을 동반한 물리치료 중재가 통증 및 관절운동범위, 심리적 상태에 미치는 영향
안승원,정영준,정상모,Ahn, Seung-won,Jung, Young-june,Jung, Sang-mo 대한정형도수물리치료학회 2019 대한정형도수물리치료학회지 Vol.25 No.2
Background: The purpose of this study was to investigate into the effects of physical therapy intervention with local vibration on pain, ROM (range of motion) and psychological status in multiple trauma patients caused by traffic accident. Methods: A patient with multiple trauma were recruited. Before treatment, he was evaluated using numeric pain rating scale (NPRS), Korean-version impact of event scale-revised (IES-R-K), Beck Depression inventory (BDI), passive and active range of motion, and were reevaluated after 4 and 8 weeks of treatment. Results: As a result of comparing the participant before and after the experiment, the score of the IES-R-K and BDI decreased. And the passive and active ROM increased. Conclusion: According to the results above, physical intervention with local vibration by Blackroll Releazer can help improve pain, physical function and psychological status. Also, physical intervention with Blackroll's Releazer technique was able to select interventions depending on the patient's conditional and the desired goal.
UPFC 이상변압기 모델을 사용한 유연송전장치 일차민감도해석
안승원,Thomas W. Gedra 한국마린엔지니어링학회 2004 한국마린엔지니어링학회지 Vol.28 No.5
This paper presents a screening technique for greatly reducing the computation involved in determining the optimal location and types of Flexible AC Transmission System (FACTS) devices in a large power system. The first-order sensitivities of the generation cost for various FACTS devices are derived. This technique requires solving only one optimal power flow (OPF) to obtain sensitivities with respect to FACTS device control variables for every transmission line. To implement a sensitivity-based screening technique, we used a new UPFC model, which consists of an ideal transformer with a complex turns ratio and a variable shunt admittance. A 5-bus system based on the IEEE 14-bus system was used to illustrate the technique.
저항성 운동이 제2형 당뇨모델 고환조직의 항산화효소 및 GLUT8 발현에 미치는 영향
안승원,박세환,윤진환 한국운동생리학회 2017 운동과학 Vol.26 No.4
PURPOSE: This study was performed to examine the effects of resistance exercise training on antioxidant enzymes activity and GLUT 8 expression in testis of OLETF rats. METHODS: At 30 weeks of age the male OLETF rats were divided into three groups: control group (LETO, n=8), diabetes group (OLETF, n=8), and exercise group (OLETF+RE, n=8). The exercise group was conducted to climb a 180 cm vertical (80 degree incline) ladder with weight secured to their tails. For 8 weeks, the rats performed 5 days per week which is gradual ladder climbing exercise. First week, the rats were familiarized with climbing up to the top cage without weight on their tails. After one week of adaptation, training session were commenced with intensity at 30% of each rat’s body weight; angling weight used attached to the tail with a plastic hairclip and string. RESULTS: The results of this study was following; Antioxidant enzymes were significantly differenced by resistance exercise training. In testes of exercise group, SOD/CAT/GPX were significantly higher than those in the diabetes group (p<.05). Also, GLUT8 expression of testes was significantly increased in exercise group compared with diabetes group (p<.05). CONCLUSIONS: Theses results suggest that resistance exercise in early stage of diabetes can improve antioxidant enzymes activity in testes tissue. Also, it positively affects glucose metabolism through increase GLUT 8 expression. Therefore, regular exercise may be an efficient strategy for male reproductive health.