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제대혈 유래 인간 비만세포에서의 세포증식 및 히스타민 분비에 대한 Interleukin 9의 영향
안강모 ( Kang Mo Ahn ),이광신 ( Kwang Shin Lee ),신미용 ( Mi Yong Shin ),박화영 ( Hwa Young Park ),안연화 ( Yeon Hwa Ahn ),손대열 ( Dae Yeul Son ),이상일 ( Sang Il Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2002 소아알레르기 및 호흡기학회지 Vol.12 No.4
목적: Interleukin 9(IL-9)는 Th2 싸이토카인의 일종으로서 알레르기 염증반응의 병태생리에 관여하는 것으로 알려져 있다. 본 연구에서는 IL-9이 주요 알레르기 염증세포의 하나인 인간 비만세포에 어떠한 영향을 주는지를 알아보기 위하여 시행되었다. 방법:본 연구에서는 인간 제대혈에서 CD34 (+) 세포를 분리한 후 stem cell factor(SCF), IL-3, IL-6를 투여함으로써 비만세포를 선택적으로 배양하였다. 8주간 배양이 끝 Purpose:Interleukin-9(IL-9), one of Th2-type cytokines, might be important in the pathophysiology of allergic diseases. We investigated the effect of IL-9 on human mast cells by assessing cell proliferation and histamine release. Methods: Human umbilical
안강모 ( Kang Mo Ahn ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.3
Food allergy is an adverse food reaction as a result of immune mechanisms and is a key component in food safety issue. The prevalence of food allergy is known to be up to 6% of children and 3∼4% of adults. A nationwide cross-sectional questionnaire survey of Korean children in 1995 and 2000 revealed that there was a tendency of the prevalence of food allergy to increase. The most common allergen was egg, followed by milk, fish, and seafoods, such as crab, lobster and shellfish. However, this does not seem to reflect the true prevalence because diagnosis of food allergy was based on questionnaires but not food challenge tests but. Various symptoms are manifested in patients with food allergy depending on whether IgE- or non-IgE-mediated mechanisms are involved. The gold standard for diagnosing food allergy is double-blind placebo-controlled food challenge test (DBPCFC), which is both time- and effort-consuming. In clinical practice, a convincing history and positive specific IgE are very important for the diagnosis of IgE-mediated food allergy, and quantification of food-specific IgE is considered a useful test in some foods, such as egg, milk, peanut and fish in the pediatric population. The patients and their caregivers need to be educated about the way to avoid exposure to food allergens. However, recent progress in understanding of the immunopathogenesis of food allergy will lead to novel therapeutic approaches in the future. (Korean J Asthma Allergy Clin Immunol 2011;31:163-169)
생후 6개월 이하의 중등증 및 중증 아토피피부염 환자에서 위험요인 분석
안소현 ( So Hyun Ahn ),서원희 ( Won Hee Seo ),김수정 ( Su Jung Kim ),황수정 ( Su Jung Hwang ),박화영 ( Hwa Young Park ),한영신 ( Young Shin Han ),정상진 ( Sang Jin Chung ),이희철 ( Hee Chul Lee ),안강모 ( Kang Mo Ahn ),이상일 ( Sa 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2005 소아알레르기 및 호흡기학회지 Vol.15 No.3
채소와 과일, 생선 섭취 강조 영양중재교육이 아토피 피부염 영유아의 중증도 변화에 미치는 효과
이희진(Hee Jin Lee),안강모(Kang Mo Ahn),한영신(Young Shin Han),정상진(Sang Jin Chung) 대한지역사회영양학회 2013 대한지역사회영양학회지 Vol.18 No.5
Atopic dermatitis (AD) is believed to be associated with the intake of antioxidant nutrients and fatty acids due to its immunological dysfunction. The purpose of this study was to examine the effects of nutrition education promoting vegetable, fruit, and fish intake on the severity of AD in children. Children with AD aged 6 months to 5 years were randomly assigned into education and control groups, and followed for 1 year. Seventy-six children completed the study (38 for control, 38 for education). The education group received education promoting the intakes of antioxidantrich foods (vegetables, fruits) and n-3 fatty acid foods (fish). A 24-hour food recall was collected for the diet information. After education, all vegetables (p < 0.001), fruits (p < 0.01), and fish (p < 0.05) intakes per 1000 kcal increased significantly in the education group, whereas only vegetable intake increased in the control group (p < 0.001). The SCORAD index, the severity of atopic dermatitis, decreased significantly in the education group (p < 0.05). Increased consumption of dietary vitamin E was significantly associated with reduction in the SCORAD index, after adjusting for age and gender (p < 0.05). A nutritional education program to increase vegetable, fruit, and fish intake may be effective in reducing the severity of AD, and vitamin E intake may be associated with the decreased severity of AD. More controlled studies on the relationship between these intakes and severity of AD, with intensive diet and/or supplement intervention programs, are needed to obtain conclusive results. (Korean J Community Nutr 18(5) : 515~524, 2013)