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심종은 ( Jong Eun Sim ),성순기 ( Soon Ki Sung ),송영진 ( Young Jin Song ),김대철 ( Dae Chul Kim ),한진영 ( Jin Young Han ),최순섭 ( Sun Seob Choi ),김기욱 ( Ki Uk Kim ) 대한뇌종양학회 2006 대한뇌종양학회지 Vol.5 No.2
Objective£ºBrain tumors develop by genetic alterations at gene level. Genetic alteration may be different according to each tumor and subtype. Even though major genetic alterations for the particular tumors are known, there are many minor genetic alterations for the tumors. Authors designed the study in order to see the difference in the genetic profile of meningiomas. Methods£º16 patients of meningioma were operated between Jun 2004 and May 2005. Surgical specimens were prepared for chromosomal study and karyotyping was done by traditional G-banding method. Results£ºChromosome abnormalities have been observed in many cases in meningiomas. In meningiomas, loss of chromosome 22 was the most common, and other abnormalities were translocation between the long arm of chromosome 13 and 22, whole arm translocation between the chromosome 1 and 19, loss of Y chromosome and hyperdiploidy and monosomies for various chromosome. Conclusion£ºChromosomal abnormalities seem to be variable and genetic changes are present in meningioma.