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심종민,김현진,현지연,최윤라,한정호 대한의학회 2018 Journal of Korean medical science Vol.33 No.15
Background: Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) are usually effective in lung adenocarcinoma patients with anaplastic lymphoma kinase (ALK) rearrangement. However, even after a good response to ALK-TKI therapy, most patients acquire resistance to these agents. Histological transformation is one of several suggested mechanisms of acquired resistance to ALK-TKIs. The clinicopathologic features of four patients with ALK-expressing adenocarcinoma and neuroendocrine features were analyzed. Methods: We selected combined neuroendocrine differentiation in pulmonary adenocarcinoma cases with positive ALK immunostaining. Neuroendocrine differentiation was confirmed by CD56 immunohistochemical stain. Additional ALK fluorescence in situ hybridization (FISH) study and epidermal growth factor receptor (EGFR) mutation tests were also performed. Results: All four cases were positive for ALK immunohistochemistry and no EGFR mutations were detected. Interestingly, the results of ALK FISH assays showed rearrangement in only two cases. Three cases showed combined adenocarcinoma and neuroendocrine component without history of ALK-TKI administration; one of them was treated with crizotinib and experienced partial tumor regression. The remaining case had an adenocarcinoma at initial biopsy and she showed a partial response to crizotinib, and neuroendocrine changes were visible on second biopsy. Then she was treated with ceritinib and achieved a partial response. Conclusion: We suggest that ALK-rearranged adenocarcinoma with combined neuroendocrine component is responsive to ALK-TKIs. Moreover, even after neuroendocrine transformation as a result of resistance to ALK-TKIs, the tumor may have partial response to second generation ALK-TKIs.
High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer
심종민,안혜인,rehman abdul,김현성,이기종,정유민,정민성,백승삼,송영수,장기석 한국유방암학회 2015 Journal of breast cancer Vol.18 No.4
Purpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. Methods: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. Results: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the lowexpression group. However, no correlation was observed between miR-370 and its target protein expression. Conclusion: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.
심종민,고현희,최상준,주진아,김태성,김호중,한정호 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.4
Background: Pulmonary nodular lymphoid hyperplasia (PNLH) is a non-neoplastic pulmonary lymphoid disorder that can be mistaken for malignancy on radiography. Herein, we present nine cases of PNLH, emphasizing clinicoradiological findings and histological features. Methods: We analyzed radiological and clinicopathological features from the electronic medical records of nine patients (eight females and one male) diagnosed with PNLH. IgG and IgG4 immunohistochemical staining was performed in three patients. Results: Two of the nine patients had experienced tuberculosis 40 and 30 years prior, respectively. Interestingly, none were current smokers, although two were ex-smokers. Three patients complaining of persistent cough underwent computed tomography of the chest. PNLH was incidentally discovered in five patients during examination for other reasons. The remaining patient was diagnosed with the disease following treatment for pneumonia. Imaging studies revealed consolidation or a mass-like lesion in eight patients. First impressions included invasive adenocarcinoma and mucosal-associated lymphoid tissue-type lymphoma. Aspergillosis was suspected in the remaining patient based on radiological images. Resection was performed in all patients. Microscopically, the lesions consisted of nodular proliferation of reactive germinal centers accompanied by infiltration of neutrophils and macrophages in various degrees and surrounding fibrosis. Ultimately, all nine patients were diagnosed with PNLH and showed no evidence of recurrence on follow-up. Conclusions: PNLH is an uncommon but distinct entity with a benign nature, and understanding the radiological and clinicopathological characteristics of PNLH is important.
전통문화자원을 활용한 가상현실 콘텐츠 제작 연구 : 하회마을 옥연정사 VR 콘텐츠 사례를 중심으로
심종민,성종현,김해란,김성학,이민석,이가영 글로벌문화콘텐츠학회 2015 글로벌문화콘텐츠학회 학술대회 Vol.2015 No.1
최근 스마트 기기가 대중화되면서 디지털 콘텐츠 제작 및 서비스가 활발히 진행되고 있는 추세이다. 이에 따른 전통문화자원(문화재)를 활용한 가상현실 콘텐츠 제작 역시 활발히 이루어지고 있다. 특히 직접 그 장소(place)에 방문하지 않아도 스마트 기기만 있으면 공간에 구애받지 않고 체험할 수 있는 장점이 있다. 본 연구에서는 하회마을 옥연정사를 시범 지역으로 선정하였다. 류성룡 선생이 집필한 국보 제132호 징비록(懲毖錄)에 대한 역사적 가치가 있는 곳이며, 선생의 가치사상을 재조명할 수 있는 교육적인 부분이 가장 큰 이유였다. HMD(Head Mounted Display)는 머리에 착용하여 가상현실 콘텐츠를 즐길 수 있는 기기이다. 본 콘텐츠는 전통문화자원(역사, 인물, 스토리) 정보를 쉽고 재미있게 접할 수 있을 예정이며, 특히 전통과 디지털이 융합된 콘텐츠 상품제작을 통한 경북 맞춤형 창조경제 혁신 구상에 단계적 실행을 앞당길 것으로 판단된다.
MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma
김예슬,심종민,김현성,방성식,지승윤,박성언,장기석 대한병리학회 2019 Journal of Pathology and Translational Medicine Vol.53 No.6
Background: Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is commonly dysregulated in malignant tumors. The purpose of this study was to analyze the expression of microRNA-374a (miR-374a) in lung adenocarcinoma and correlate its expression with various clinicopathological characteristics. Methods: The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays. The correlation between miR-374a expression and clinicopathological parameters, including clinical outcome, was further analyzed. Results: High miR-374 expression was correlated with advanced pT category (chi-square test, p = .004) and pleural invasion (chi-square test, p = .034). Survival analysis revealed that patients with high miR-374a expression had significantly shorter disease-free survival relative to those with low miR-374a expression (log-rank test, p = .032). Conclusions: miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery.
안혜인,심종민,Rehman Abdul,정민성,백승삼,오영하,박찬금,장기석 대한의학회 2015 Journal of Korean medical science Vol.30 No.4
Fox transcription factors play a critical role in the regulation of a variety of biologicalprocesses. While FoxM1 behaves like the oncogenic transcription factor, FoxO3a is knownas a tumor suppressor by inhibiting FoxM1. This study aimed to investigate theclinicopathological significance of FoxM1 and FoxO3a expression in breast cancer. Expression of FoxM1 and FoxO3a were analyzed by immunohistochemical staining ontissue microarray sections from 236 breast cancer patients, and correlated with variousclinicopathological characteristics. Overexpression of FoxM1 correlated with adverseclinicopathological features, such as larger tumor size, lymph node metastasis, advancedtumor stage, and lymphovascular invasion. The Kaplan-Meier survival curves revealed noprognostic significance of FoxM1 expression. However, in subgroup analyses with patientsof estrogen receptor (ER) positive breast cancers, FoxM1 overexpression associated withpoor disease free and overall survival. No association was found between FoxO3a andFoxM1 expression. Regarding clinicopathological variables, the only association betweenhistologic grade and FoxO3a was observed. In conclusion, FoxM1 overexpression wassignificantly associated with aggressive phenotypes and poor prognosis of ER-positivebreast cancer. These findings suggest the possible role of FoxM1 as a prognostic biomarkerand putative target of anti-cancer therapy.