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三黃瀉心湯이 ACONITINE 投與 흰쥐의 血壓 및 血淸 酵素活性度에 미치는 影響
沈良洙,文炳淳,金世吉 圓光大學校 韓醫學硏究所 1994 원광한의학 Vol.4 No.1
In order to study the effect of Samhwangsasimtang(三黃瀉心湯) on the blood pressure and serum enzyme(LDH, CPK, GOT and GPT) activities of the rats treated with aconitine, this experiment was conducted. Experimental groups divided into four groups, Normal, Control, Sample I and sample Ⅱ. The control group treated with aconitine by 0.05㎎/㎏ I.P. injection. The sample groups treated with aconitine same as control and administrated 6mg/100g(Sample I) and 60mg/100g(Sample Ⅱ) of Samhwangsasimtang extract. The blood pressure and rectal temperature measured at pre-treat(0), 30, 60, 120 and 180 mins after the aconitine injection and the serum LDH, CPK, GOT and GPT activities evaluated by biochemically. The results were obtained as follows: 1. In changes of the blood pressure the 6mg/100g of Samhwangsasimtang was not effective, and the 60mg/100g of Samhwangsasimtang was significantly effective on the changes of blood pressure induced by aconitine at 30, 60 and 120 mins after administration. 2. In changed of the rectal temperature, the 6mg/100g of Samhwangsasimtang was not effective, and the 60mg/100g of Samhwangsasimtang was significantly effective on the increase of rectal temperature induced by aconitine at 60mins afer administration. 3. In serum LDH activity, and inhibitory effect was shown by the 6mg/100g of Samhwangsasimtang, and significant inhibitory effect was shown by the 60mg/100g of Samhwangsasimtang on the increase of serum LDH activity induced by aconitine. 4. In serum CPK activity, and inhibitory effect was shown by the 6mg/100g and the 60mg/100g of Samhwangsasimtang on the increase of serum CPK activity induced by aconitine. 5. In serum GOT activity, the 6mg/100g of Samhwnagsasimtang was not effective, and an inhibitory effect was shown by the 60mg/100g of Samhwangsasimtang on the increase of serum GOT activity induced by aconitine. 6. In serum GPT activity, the 6mg/100g and the 60mg/100g of Samhwangsasimtang were not effective on the increase of serum GPT activity induced by aconitine.
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지백지황탕(知柏地黃湯) 약침(藥鍼)이 혈압(血壓)에 미치는 영향(影響)
심양수,전문기,김경식,손인철,Shim, Yang-soo,Jeon, Moon-ki,Kim, Kyung-sik,Sohn, In-chul 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4
Objective : This study was performed to investigate the effects of aqua-acupuncture of Jibaikjihwangtang in two-kidney one clip Goldblatt hypertensive rats and spontaneously hypertensive rats. Methods : we injected aqua-acupuncture solution into Shin-Soo ($BL_{23}$) which corresponds to human acupuncture point in two-kidney one clip Goldblatt hypertensive rats and spontaneously hypertensive rats. Systolic blood pressure, renin activity, aldosterone and atrial natriuretic peptide (ANP) plasma levels were tested. Results : Systolic blood pressure decreased significantly after aqua-acupuncture of jibaikjihwangtang. Acupuncture group in two-kidney one clip Goldblatt hyper-tensive rats had deference with control group. In plasma levels of atrial natriuretic peptide, acupuncture group of spontaneously hypertensive rats increased meaningfully but to two-kidney one clip Goldblatt hypertensive rats it was decreased meaningfully. In Serum Aldosterone density, the acupuncture group of spontaneously hypertensive rats had significant alteration than control group, but the acupuncture group of two-kidney one clip Goldblatt hypertensive rats had decreased alteration than control group. Conclusion : According to these results, after Aqua-Acupuncture of Jibaikjihwangtang blood pressure decreased significantly and data suggest that blood pressure reduction activity connected with renin activity reduction in renal hypertensive rat.
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