HBeAg 보균자, 정상성인 그리고 각종 간질환에서 혈청 Ferritin치에 관한 연구

심승식,정남기 大韓消化器病學會 1991 大韓消化器病學會誌 Vol.23 No.4

목포지역 대기중 화분측정에 대한 연구 , 1992

박찬웅,심승식,정만,박창현,류형선,이영미,천석배,강상구,김지운 대한천식알레르기학회 1993 천식 및 알레르기 Vol.13 No.3

Continuous monitoring of the aualitative and quantitative composition of the airspora is a prerequisite for diagnosis and treatment of respiratory allergic disorders in human beings. As such, survey of airborn pollens has been considered as an essential part of respiratory allergic studies. From July 25th in 1991 to July 24th in 1992, the counts of aeroallergic pollens in Mokpo were monitored to work up a listing of plant species producting airborn pollen. Rotorod sampler was installed on the well-ventilated roof top of an apartment in the center of Mokpo. The results are such as: 1) Twenty six Genera were identified in collected pollen. There were 15 Genera in tree, 2 Genera in grass and 9 Genera in weed. 2) Pollen seasons were divided into tree, grass and weed season but they were overlapped. 3) The tree seaon was from beginning to end of May. The grass season ranged from April to November. The weed season was from middle of August to end of November. 4) The maximum total count was 562 grains/m' 24hr on May 4, 1992. 5) Total number of pollens: Pinus(3502 grains/m, Alnus(1297grains/m), Humulus japonicus(709grains/m), Betula(266grains/m ), Graminaceae(495grains/m). 6) The peak counts of pollens ' Pinus(517 grains/m), Betula(266grains/m), Alnus(237 grains/m), Humulus japonicus(99grains/m 7) Differentiation between the pollen of Cryptomeria and that of Cupressaceae can be established by making investigation into the flowering time. The peak counts of pollens ' Cryptomeria(40grains/m'), Cupressaceae(23 grains/m). 8) The pollen of Artemisia noted three peaks l 73grains/m on September 1, 77 grains/m on September 22, 82grains/m on September 23. It was 15days that were recorded over 20grains/m of the Artemisia pollens during the present investigation. The present paper dealt with the variation patterns in the atmospheric pollen concentration of Mokpo. More information about the distribution of the natural plants as well as the pollen grains is needed. It is also needed to compare the relative incidence of pollen types in different area.

산모와 신생아에서 C형간염바이러스의 수직감염에 관한 연구

정만,심승식,오은아,유영근,장영호,정남기 大韓消化器病學會 1990 大韓消化器病學會誌 Vol.22 No.2

Rotorod Sampler 를 이용한 목포지방 대기 화분 측정

박찬웅,심승식,정만,박창현,류형선,이영미,김지운 대한천식알레르기학회 1992 추계학술대회 초록집 Vol.1992 No.-

췌장 전이가 동반된 십이지장 선암 1예

이영미,류형선,심승식,정 만,박창현,박찬웅,김지운 大韓消化器病學會 1993 大韓消化器病學會誌 Vol.25 No.3

간장 ( 肝臟 ) · 담도 ( 膽道 ) 및 췌장 ( 膵臟 ) : HBeAg 보균자 , 정상성인 그리고 각종 간질환에서 혈청 Ferritin치에 관한 연구

정남기(nam Ki Joung),심승식(Seung Sik Shim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4

N/A In order to compare serum ferritin levels in each groups, the serum ferritin and serum transaminase were measured in 38 normal adults, and 50 patients with HBeAg carriers, 253 patients of various liver diseases (31 patients with acute hepatitis, 80 patients with chronic hepatitis, 119 patients with liver cirrhosis, 23 patients with hepatoma) who were admitted to St. Columban hospital from January 1989 to December 1989. Then we evaluated the relationship of serum ferritin levels in each groups. The following results were obtained. 1) The serum ferritin levels in 38 normal adults were 225 +- 71.06 ng/ml, and 215.50 +- 63.26 ng/ml in HBeAg carriers, but there was no correlatin in two groups. 2) Ferritin levels in each disease groups were higher than normal adults except acute hepatitis and that of liver cirrhosis was significantly elevated (p<0.01). 3) There was no significant correlation in the levels of serum ferritin with the serum ALT activities. 4) Serum ALT was significantly elevated in HBsAg positive patients than HBsAg negative patients in each liver diseases. In conclusion, there was no significant elevation of serum ferritin levels in HBeAg carriers compared with non-carriers.

부신피질자극호르몬과 성장호르몬의 결핍을 보인 1 예

문용,이영미,박창현,김지운,박찬웅,정만,류형선,심승식,천석배,강상구 대한내과학회 1993 대한내과학회지 Vol.45 No.4

Background: Combined ATCH and GH deficiency is a rare disease, Clinical and laboratory features are variable, non-specific and similar to those seen in adrenocortical insufficiency of any cause. Methods: We have exprienced a case of combined ACTH and GH deficiency without combined disease. The patient, 55 years old female, was admitted because of fatigue, nausea and vomiting on admission. Results: Serum sodium was 112 mmol/L, potassium 3. Hmmol/L, serum osmolarity 237m0sm,Kg and urine osmolarity 531 m0sm/Kg. Basal serum cortisol was 0.68 μg/ml, ACTH 12,7pgjml, GH below 0.1 ng/ml, basal urinary 17-hydroxycorticosteroid(17-OHCS) 0.5 μg/dl and blood glucose was 86 mg/dl. Although cortisol did not respond to rapid ACTH stimulation test, it responded to standard ACTH stimulation test. On combinded stimulation test, the cortis1 did not respond and all anterior pituitary hormone showed normal responses except ACTH and GH. In addition, plasma cortisol and ACTH repond to vasopressin test. There was no abnormalities in sellar CT, and hyponatremia was corrected dramatically with prednisolone replacement. Conclusion: Combined ACTII and GI-I deficiency is rare cause of secondary adrenocortical insufficiency, Its clinical manifestation similar to isolated ACTH deficiency in adult. Patients with isolated ACTFI deficiency due to suprapituitary dysfunction may be distinguished from those with intrinsic pituitary disease by stimulation of cortisol and ACTI-I secretion following vasopressin administration. More study needed to identify the definitive cause and hypothalamic-pituitary system.

한국인 산모에서 B형 간염 바이러스의 보유율 변화에 관한 연구

오은아 ( O Eun A ),정숙애 ( Jeong Sug Ae ),정만 ( Jeong Man ),심승식 ( Sim Seung Sig ),양인애 ( Yang In Ae ),최관수 ( Choe Gwan Su ),정남기 ( Jeong Nam Gi ) 대한내과학회 1990 대한내과학회지 Vol.38 No.6

N/A In an attempt to investigate the yearly changes of the HBsAg carrier rate by observing the HBsAg positive rate in full-term pregnant women who are definitely related to the vertical transmission of the hepatitis B virus, as well as to analyze the epidemiologic factors which influence the HBsAg positive rate in pregnant women, we tested HBsAg and checked the histories of about 20 epidemiologic factors in 10,359 prgnant women .who delivered at St. Columban`s Hospital in Mokpo City from April 1, 1985 to June 30, 1989. The results were as follows: 1) Overall HBsAg positivity in all 10,359 pregnant women was 7.9%. 2) The positive rate of HBsAg was unrelated to the frequency or degree of alcohol drinking,smoking, income, nutritional state, hygiene, education, religion, occupation, locality or, injections at home in pregnant women. 3) The positive rates of HBsAg were higher in cases who had acupuncture, venereal disease, who had more than four siblings, and who worked as an institutional worker or hospital staff. The positive rates of HBsAg increased significantly in cases who had blood transfusions(0.025<p<0.05), who had injections at hospitals(p<0.005), who had no hepatitis B vaccination(p<0.005), who had a family history of liver disease(p<0.001) and who were much older(p<0.005). 4) The positive rate of HBsAg was decreased significantly from 9.2% to 7.0% for five years(p<0.001). There were several factors which influence the HBsAg positivity every year. First, the rate of hepatitis B vaccination increased significantly(p<0.001), second, the number of pregnant women who had more than six siblings increased significantly(0.025<p<0.05) and third, the number of pregnant women who had acupuncture decreased significantly(p<0.001). But the number of pregnant women who were over 30 years old increased significantly(p<0.001). 5) The positive rate of HBsAg increased significantly from 7.2% to 13.0% as the age increased(p<0.005). There were several factors which influenced HBsAg positivity by age group. Although the rate of hepatitis B vaccination increased significantly in the older age groups(p<0.001), the positive rate of HBsAg increased more in the older age groups because the numbers of pregnant women who had acupuncture(p<0.001) and a family history of liver disease(p<0.005) increased significantly. The results suggest that the number of HBV carrier pregnant women in Korea decreased progressively every year. Although the rate of hepatitis B vaccination increased significantly, it was not so effective due to the small total number. The number of pregnant women who had acupuncture and a family history of liver disease increased significantly, especially those over 30 years old. So it is important to have a nationwide program of hepatitis B immunization and to educate people on how to interfere with the transmission route in order to eradicate hepatitis B in Korea.

쭈쭈가무시병 218 예의 임상적 고찰

박창현(Chang Hyun Park),박찬웅(Chan Woong Park),심승식(Seung Sig Sim),정만(Mann Jung),이영미(Young Mi Lee),류형선(Hyung Sun Ryeu),김지운(Ji Woon Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

N/A Background: Tsutsugamushi disease is a common febrile illness. For the better understanding it, we need more studies on its clinical and epidemiological characteristics. Methods: We analyzed clinically and epidemiological-ly 218 cases of tsutsugamushi disease which were diagnosed at St. Columban Hospital in 1990 and 1991. Results: Of the 218 cases, the age distribution ranged from teen-agers to the nineties: the 50's, 31.7%: the 60's, 23.4%. and the 40's, 22.5%. Among them. 104 cases were males and 114 cases were females. The ratio of male and female was 1:l.l. The monthly incidence rates were November, 67.4%: October, 24.3%: December, 7.8%: and September, 0.5%. The frequent symptoms and their rates were as follows: fever and chills, 97%: myalgia, 96%: headache, 95%. and fatigue, 83%. Rash, eschar, and lymphadenopathy were observed at the rate of 96%, 85.6%. and 39.4%, respectively. The laboratory findings showed such percentages as elevation of AST, 91.7%: ALT, 68.8%: and alkaline phosphatase, 57.2%. The positive indirect immunofluor-escent antibody test and cross serologic reaction rate of Hantavirus and Tsutsugamushi were observed at the rates of 62.4%, 11.5%, respectively. Increased interstitial markings of the chest X-ray were also observed in 59 cases (27.1%). There were good responses to the treatment of dox-ycycline and chloramphenicol, but no responses to the other antibiotics such as ampicillin and cephapirin. Conclusion: Tsutsugamushi disease is an acute febrile illness which is characterized by fever and chills, head- ache, mylagia, resh, and eachar during autumn and early winter, therefore we make every efforts for the early diagnosis and treatment before serologic examination.

간장및 담도 : 산모와 신생아에서 C형간염바이러스의 수직감염에 관한 연구

정남기(nam Ki Joung),장영호(Yung Ho Chang),유영근(Young Geun Ryoo),정만(Mann Jung),심승식(Seung Shik Shim),오은아(Eun A Ho) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2

N/A In order to confirm the perinatal transmission of hepatitis C virus from pregnant women to newborn infants, anti-HCV was tested in 45 pregnant women and their 46 newborn infants who were negative for HBsAg and IgM anti-HA and who showed elevated ALT in more than 2 follow-up tests. The results were as follows; 1) The mean age of 45 pregnant women was 26.8. There was no significant relationship between epidemiologic factors and elevated ALT in pregnant women. 2) Among 45 HBsAg and IgM anti-HA negative pregnant women, 22 were anti-HBs and anti-HBc positive, 14 were anti-HBc positive only, and 9 were anti-HBs and anti-HBc negative. The degree of abnormal ALT in mothers and infants was unrelated to the hepatitis B viral markers in mothers. There was no significant relationship in the degree of ALT elevation between mothers and infants. 3) Anti-HCV was positive in 7 cases (15.6%) of 45 pregnant women. Anti-HCV was positive in 6 cases (15.2%) of 46 newborn infants. In the 7 anti-HCV positive mothers, anti-HCV was positive for one year or a maximum of four years and ALT was elevated intermittently for more than one year, the same as chronic viral hepatitis. But in the 6 cases of anti-HCV positive infants, anti-HCV disappered within 6 or 12 months in most cases and ALT elevation didnt continue for more than 6 months. 4) Anti-HCV was positive in 4 cases (50%) of 8 newborn infants of anti-HCV positive mothers (p< 0.01). Anti-HCV was positive in 2 (67.7%) of 3 cases whose blood was drawn and stored immediately after birth. The positive rate of anti-HCV was about 15% in 45 pregnant women and their infants who were NANB hepatitis suspects by surrogate tests. Anti-HCV was positive in 50% and ALT was abnormal in all eight infants of chronic HCV carrier mothers. We confirmed the passive transfer of anti-HCV from mother to infant. But we need more evidence to confirm the perinatal transmission of HCV.