http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 신흥기 (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Glutamate가 가토의 적출 심방수축 및 동방결절세포의 활동전압에 미치는 효과
한성욱,신흥기,김기순,김진혁 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1
To examine effects of glutamate on the cardiac function, changes in atrial contractility and action potential of rabbit sinus node cell were determined folllowing superfusion of isolated cardiac cells with Tyrode solution containing different amounts of glutamate. At low concentrations(0.05-0.08%) glutamate significantly decreased action potential amplitude (APA) of pacemaker cells whereas at the high concentration with glutamate changes in overshoot (OS) potential paralleled that of APA. When the nodal cells were superfused with glutamate solution no changes in rate of spontaneous firing (RSF) from pacemaker was observed whereas action potential duration (APD??: time to 60% repolarization) was significantly shortened. Glutamate increased the maximum rate of upstroke potential (dV/dt). On the other hand glutamate invariably increased atrial contractility in a dose-dependent manner. In the atrial strips treated with verapamil (10μM) or Mn??(0.5-2mM), the decreased atrial contractility was not altered by glutamate. The results suggest that glutamate can act directly on the cardiac cells of rabbit heart, resulting in a positive inotropism of the atrium and an alteration in transmembrane potentials of pacemaker cells.
-
Glycine에 의한 가토심방근 및 동방결절세포의 활동전압의 변동
최경훈,김진혁,고상돈,신흥기,김기순,Choe, Kyung-Hoon,Kim, Jin-Hyuk,Koh, Sang-Don,Shin, Hong-Kee,Kim, Kee-Soon 대한생리학회 1988 대한생리학회지 Vol.22 No.2
The effect of glycine, structurally the most simple amino acid was investigated on the electrophysiological characteristics of the isolated superfused atrial muscle and sinus node cells of the rabbit heart. Superfusion of the sinus node cell with glycine solution (3, 5 and 8 mM) produced concentration-dependent increments of OS (overshoot potential) and MDP (maximum diastolic potential). Generally action potential amplitude increased as a result of greater increment of OS than that of MDP. The changes in action potential of the sinus node cell peaked in $7{\sim}10{\;}minutes$ after onset of superfusioin. On the contrary to the response to intravenously administered glycine, the rate of spontaneous firing of sinus node cell was invariably increased following superfusion with glycine. Action potential duration manifested as $APD_{60}$ (time to 60% repolarization) was significantly shortened by glycine. And the electrophysiological effects of glycine on the atrial muscle cell were similar to that on the sinus node cells. The results of present study suggest that glycine can exert direct effects on the atrial muscle and sinus node cells of the rabbit heart.
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
