증례 : 하악과두 (下顎顆頭) 및 경부골절의 제선골 절단술에 의한 처치증례

신효근(Hyo Keun Shin) 전북대학교 의과학연구소 1982 全北醫大論文集 Vol.6 No.1

下齒槽神經 切除後 再生에 關한 組織學的 硏究

Hyo Keun Shin(辛曉根) 대한구강악안면외과학회 1979 대한구강악안면외과학회지 Vol.5 No.1

The author obserbed the regeneration of the inferior alveolar nerve sectioning of the rabbits histologically. Sixteen rabbits were used in this experiment. The weight of the animals varied from 1.5~2.0kg. As a method, under general anesthesia by means of intravenous injection 1% Pentotal Sodium 25mg/kg. Right mandible were dissected partially on the inferior mandibular border at the anterior border of masseter muscle with the round bur. And inferior alveolar nerves were sectioned to 5mm by surgical scissor. The rabbits were killed at periods of one, three, five, seven weeks. The right jaws were removed, fixed in 10% formalin, Paraffin embedded and stained with Hematoxylin and Eosin, Masson s trichrome, Gomori s for reticulin fiber. The results were as follows. 1. One week-Initiation of new bone formation along the surface of mandibular canal was mainly in the area of injury to the inferior alveolar nerve. There was evidence of myelin degeneration (Wallerian degeneration) phagocytic cells were present in the areas of degeneration in both proximal and the distal segment of the severed nerve. 2. Three weeks-Osteophytic bone and osteoid tissue formation on the surface of mandibular canal. At the distal portion of the proximal segment, there was a decrease in the amount of myelin degeneration but an increase in the activity of Schwann cell. The nerve buds emanating in a wavy pattern from the proximal segment. 3. Seven weeks-The endosteum nad returned to a normal physiologic state. The myelin degeneration at the distal portion at the nerve appeared in less quantity than at the proximal portion.

口蓋裂患者에 있어서 Hotz Plate 使用症例와 그 手術 및 顎骨發育에 關하여

Hyo Keun Shin(辛曉根) 대한구강악안면외과학회 1986 대한구강악안면외과학회지 Vol.12 No.2

Lip repair in connection with pre and postoperative orthopedic care results in good arch alignment and good occlusion in early mixed dentition. The orthopedic appliance (Hotz plate) used is a plate of compound soft and hard aciylic resin. We used Hotz plate in 6 cases of cleft palate patients (1 month - 6 month of age). As the results, facilitating feed and normalizing tongue posture and swallowing were observed.

악골 결손부의 Hydroxylapatite 및 PCBM ( Particulated Cancellous bone and marrow ) 의 혼합사용시 치유과정에 관한 실험적 연구

신효근(Hyo Keun Shin),윤철희(Cheul Hee Yun) 대한악안면성형재건외과학회 1987 Maxillofacial Plastic Reconstructive Surgery Vol.9 No.1

N/A By recent studies, HAP implant showed biocompatibility with host tissue, in that no toxic or foreign body reaction was found. HAP was known to have osteophilic property but not osteogenetic ability. This study examined the healing process on histologic basis following implantation with HAP-PCBM mixture on the inferior border of rabbit mandible. The results were as follows: 1. Mild inflammatory response was observed at 1st week, but foreign body reaction and inflammatory response were not observed after 2nd week. 2. Osteoclastic, phagocytic activity was observed prominently on the grafted bone at 1st, 2nd week. Immature bone appeared at adjacent to the resorbing grafted bone. 3. New bone was boned with HAP particles directly without intervening tissue after 4th week. 4. At 8th, 12th week, mature bone was observed to have infiltrated between the HAF particles and osteoclastic activities were not noted. 5. Bony bridge between underlying cortical bone and HAP particles was observed after 4th week.

The Report on the Medical Voluntary Activities for Cleft Lip and Palate in Vietnam by the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons

함태훈,신효근,김종렬,류동목,유선열,김경원,박영욱,정영수,Hahm, Tae-Hoon,Shin, Hyo-Keun,Kim, Jong-Ryul,Ryu, Dong-Mok,Ryu, Sun-Youl,Kim, Kyoung-Won,Park, Young-Wook,Jung, Young-Soo Korean Cleft Lip and Plate Association 2010 대한구순구개열학회지 Vol.13 No.1

대한악안면성형재건외과학회는 2004년도부터 매년 인도적 차원에서 의료 환경이 낙후된 Vietnam의 cleft lip and palate 환자들을 치료하기 위해 무료로 해외 진료 봉사 활동을 해왔다. 초창기 해외 진료 봉사 활동 당시 베트남 의료 기술 발달이 미비하여 준비해야 할 것들이 많았으나 이 후 베트남의 경제 발전과 함께 의료 시설 및 의료 기술이 발달함에 따라 준비 품목 등이 간단명료해지고 현지 지원 및 수술 준비도 원활히 진행되었다. 이러한 무료 의료 봉사 활동을 계기로 개발도상국의 낙후된 의료 시설 및 의료 기술 발전, 의료 혜택을 받지 못한 구순 구개열 환자의 정상적 안모 및 기능 회복, 조건 없는 의료 봉사 활동을 통한 민간외교 효과 및 양국간의 우호 증진 등의 성과가 있었다. 대한악안면성형재건외과학회에서는 2009년도 역시 베트남 National Institute of Odonto-stomatology 에서 11월17일부터 26일까지 cleft lip and palate 무료수술진료단(단장 신효근)을 보내 수술봉사 활동을 펼치고 돌아 왔다. 일반적인 구순구개열 뿐만 아니라 양측성 안면열(Bilateral Facial Cleft), 사경(Torticollis) 등의 희귀 기형을 포함하여 수술을 진행하였으며 총 31례의 수술을 성공적으로 마쳤으며 지난 6년 동안의 성과와 함께 이에 대한 보고를 하고자 한다.

구개열(口蓋裂) 환자(患者)에 있어서 구개(口蓋) 성형술후(成形術後) 비인강(鼻咽腔) 폐쇄(閉鎖)에 관(關)한 임상적(臨床的) 연구(硏究)

고광희,신효근,Koh, Kwang-Hee,Shin, Hyo-Keun 대한악안면성형재건외과학회 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.1

In order to find the causes of velopharyngeal incompetency after primary palatorrhaphy in cleft patients, we analyzed the form and function of the velopharyngeal space of fifteen operated cleft palate patients and five normal subjects. The velopharyngeal function was evaluated by lateral cephalometric radiography, velopharyngography and hypernasality cul-de-sac test. The obtained results were as follows. 1. The rate of velopharyngeal incompetency was twenty percent, three of the fifteen operated patients. Two of them were complete cleft palate and the other was incomplete one. 2. The length of soft palate and levator eminence were longer in normal group than those of good speech group and complete cleft palate group during phonation of /i/ (P<0.05). The lengthening rate of soft palate was smaller in good and poor speech group than that of normal group(P<0.05), and, reduced in order, normal group, complete cleft palate group and incomplete palate group(P<0.05). 3. The nasopharyngeal distance had no significant difference between all groups at rest, but, smaller in normal group than that of both cleft palate group(P<0.05), good speech group and poor speech group(P<0.05) during phonation of /i/ The difference in nasopharyngeal distance between rest and /i/ phonation was greater in normal group than that of both cleft palate group, good speech group and poor speech group. 4. The moving distance of sop palate reduced in order, normal group, incomplete cleft palate group, complete cleft palate group(P<0.05). 5. The distance between lateral pharyngeal wall had no significant difference between all groups in rest, but, smaller than that of complete cleft palate group in normal group(P<0.01) and increased in order normal group, good speech group, poor speech group(P<0.01) during phonation of /a/. The mobility of lateral wall was reduced in order, normal group, good speech group poor speech group(P<0. 01). 6. There was low corelationship between the mobility of lateral pharyngeal wall and soft palate. Therfore, it suggest that the movements of lateral pharyngeal wall and soft palate occurs independently.

순열, 구개열 환자 부모의 두부 방사선 사진의 통계적 연구

이종환,신효근,Lee, Jong-Han,Shin, Hyo-Keun 대한악안면성형재건외과학회 1991 Maxillofacial Plastic Reconstructive Surgery Vol.13 No.3

The parents of twenty-five patients with cleft lip(with or without cleft palate), CL(P) and the parents of fifteen non-cleft patients were studied. Area measurements of cranium of brain case from lateral and frontal roentgenograms. The most important finding of this investigation was that the CL/CP parents had a significantly smaller brain case than did the control subjects. A smaller brain case may well be one morphological characteristic predisposing toward the cleft anomaly. The results obtained were as follows, 1) Total area measurements for brain case of parents of CWCP patients were significantly smaller than those in the control group, on the frontal view. 2) A significantly smaller parietal and occipital region on the frontal view vas noted in the parents of CL/CP patients. 3) A significantly smaller parietal region on the lateral view was noted in the mothers of CL/CP patients. 4) A significantly smaller mastoid area on the lateral view was noted in the parents of CL/CP patients.

패혈증에서 Heat Shock Protein 70의 과도발현이 Inducible Nitric Oxide Synthase의 발현에 미치는 효과

이용근 ( Yong Keun Lee ),신효근 ( Hyo Keun Shin ),권운용 ( Woon Yong Kwon ),서길준 ( Gil Joon Suh ),윤여규 ( Yeo Kyu Youn ) 대한외상학회 2008 大韓外傷學會誌 Vol.21 No.1

Purpose: The aim of this study was to evaluate the effect of overexpression of heat shock protein 70 (HSP70) on the expression of inducible nitric oxide synthase and on the concentration of nitric oxide and to determine the mechanism for the relationship between HSP70 and inducible nitric oxide synthase (iNOS) in sepsis. Methods: Experiments were performed on male Sprague-Dawley rats, and sepsis was induced by using cecal ligation and puncture (CLP). Glutamine (GLN) or saline was administered 1 h after initiation of sepsis. We acquired serum and lung tissues from the rats 12 h or 24 h after initiation of sepsis. We analyzed the concentration of nitric oxide, the expression of HSP70 in the lung, and the gene expression of iNOS in the lung. Results: In CLP+GLN, glutamine given after initiation of sepsis enhanced the expression of HSP70 in the lung at 12 h (CLP+GLN vs. CLP:: 47.19 ± 10.04 vs. 33.22 ± 8.28, p = 0.025) and 24 h (CLP+GLN vs. CLP: 47.06 ± 10.60 vs. 31.90 ± 4.83, p = 0.004). In CLP+GLN, glutamine attenuated the expression of iNOS mRNA in the lung at 12 h (CLP+GLN vs. CLP: 4167.17 ± 951.59 vs. 5513.73 ± 1051.60, p = 0.025) and 24 h (CLP+GLN vs. CLP: 9,437.65 ± 2,521.07 vs. 18,740.27 ± 8,241.20, p = 0.016) and reduced the concentration of nitric oxide in serum at 12 h (CLP+GLN vs. CLP: 0.86 ± 0.48 vs. 3.82 ± 2.53 umol/L, p = 0.016) and 24 h (CLP+GLN vs. CLP: 0.39 ± 0.25 vs. 1.85 ± 1.70 umol/L, p = 0.025). Conclusion: The overexpression of HSP70 induced by the administration of glutamine in sepsis attenuated the gene expression of iNOS and reduced the concentration of nitric oxide.

코콜이 환자의 sleep splint 착용 전후의 음향학적 및 공기역학적 연구

정세진,김현기,신효근,Jung, Se-Jin,Kim, Hyun-Gi,Shin, Hyo-Keun 대한치과의사협회 2011 대한치과의사협회지 Vol.49 No.4

Snoring and obstructive sleep apnea (OSA) are common sleep disordered breathing conditions. Habitual snoring is caused by a vibration of soft tissue of upper airway while breath in sleeping, and obstructive sleep apnea is caused by the repeated obstructions of airflow for a sleeping, specially airflow of pharynx. Researchers have shown that snoring is the most important symptom connected with the obstructive sleep apnea syndrome The treatment is directed toward improving the air flow by various surgical and nonsurgical methods. The current surgical procedures used are uvulopalatopharyngoplasty(UPPP), orthognathic surgery, nasal cavity surgery. Among the nonsurgical methods there are nasal continuous positive air pressure(CPAP), pharmacologic therapy. weight loss in obese patient, oral appliance(sleep splint). Sleep splint brings the mandible forward in order to increase upper airway volume and prevents total upper airway collapse during sleep. However, the precise mechanism of action is not yet completely understood, especially aerodynamic factor. The aim of this study evaluated the effect of conservative treatment of snoring and OSAS by sleep splint through measured aerodynamic change by an aerophone II. We measured a airflow, sound pressure level, duration, mean power from overall airflow by aerophone II mask. The results indicated that on a positive correlation between a decrease in maximum airflow rate and a decrease in maximum sound pressure level, on a negative correlation between a decrease in maximum airflow rate and a increase in duration.

AN EXPERIMENTAL STUDY OF $GUIDOR^{(R)}$ BARRIER MEMBRANE ABOUT BONE PROMOTION AROUND DENTAL IMPLANTS PLACED INTO EXTRACTION SOCKET IN DOGS

양명철,진우정,신효근,김오환,Yang, Myeong-Cheol,Jin, Woo-Jeong,Shin, Hyo-Keun,Kim, Oh-Hwan Korean Association of Maxillofacial Plastic and Re 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

이 연구의 목적은 성견의 발치와에 식립된 implants에 새로운 골 형성을 유도할 목적으로 사용한 흡수성막의 골유도재생술을 평가하고자 하였다. 성견의 제 3소구치를 발거하고 cylindrial HA-coated implants를 식립하였다. 실험군에는 흡수성막인 $GUIDOR^{(R)}$ 를 덮어 보호를 하고, 대조군은 막으로 보호하지 않았다. 성견은 1, 2, 4개월에 차례로 희생하였으며, 치유과정 및 골형성 정도의 평가를 위해 임상적, 방사선학적, 그리고 조직학적 관찰을 통한 다음과 같은 결론을 얻었다. 1. 치유리간 동안에 실험군의 흡수성막의 안정성과 조직의 만족할 만한 치유능력을 볼 수 있었다. 2. 술후 4개월 정도에서 막이 완전한 흡수를 볼 수 있었다. 3. 미숙골이 정상적인 충판의 성숙골로 바뀌는데 약 4개월의 시간이 필요하였다. 4. 대조군에 비하여 실험군에서 더 많은 골형성을 관찰할 수 있었다. 5. 흡수성막이 implant 매식에 유용하게 이용될 수 있으리라 평가한다. The aim of this study was to evaluate bone promotion of bioreabsorbable guided tissue regeneration for generating new bone adjacent to osseointegrated implants in dogs. Third premolars were extracted in dgo mandibles. Cylindrical HA-coated implants were placed into extracted sockets in dogs. And test sites were protected by $GUIDOR^{(R)}$ matrix barrier. But control sites were not protected by membrances. The sites were examined clinically, radiologically, and histologically after 1, 2, and 4 months to assess bone regeneration. The results obtained were as foolows : 1. There were the good healing and the stability of $GUIDOR^{(R)}$ matrix barrier in experimental site during the healing period. 2. Complete resorption of $GUIDOR^{(R)}$ matrix barrier was clinically observed about 4 months postoperatively. 3. The woven bone changed to mature bone with a normal cortical plate and mature, resting periosteum after 4 months. 4. In experimental site, there was a significantly greater bone promtion than observed in control site. 5. $GUIDOR^{(R)}$ matrix barrier was useful for the preparation of immediate dental implants.