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류명환,이성철,신호동,신민교,송호준 대한본초학회 2004 大韓本草學會誌 Vol.19 No.3
Objectives : This study is carried out to specify Anti-tumor effects of liver cancer from HA(Herba Ajugae multiflorae). Methods : NCTC1469 mouse normal liver cell line was cultured in various concentrations of Nitrofurantion(NFT) for 72 hours. By adopting the MTS assays for cell viability, the activities of TNF-α and LDH, DNA synthesis and PKC, and the protein synthesis, it is shown that NFT induces liver cancer. Results : The Anti-tumor effects of the extract from HA are as follows. 1 NFT decreased cell viability in separate concentration after cultured NCTC cells were treated with 1~50μM for 72 hours. 2 NFT increased cell numbers and PKC activity when NCTC cells were incubated with 10μM NFT for 72 hours. 3 NFT decreased DNA and Protein synthesis . On the other hand, increased LDH, PKC and TNF -α activity when NCTC liver cells were grown in various concentrations of NFT for 72 hours. 4 HA, on the effect of NFT-induced carcinogenecity, increased cell viability of NCTC, Protein and DNA synthesis, but decreased activity of LDH and PKC, also TNF-α. Conclusions : From the above results, it could be concluded that NFT had cytotoxic and carcinogenic effect on cultured NCTC cell line derived from mouse normal liver. Therefore, HA had beneficial protection of NFT-induced carcinogenecity.
이현,최원규,신호동,황병욱,이상진,이상호 대한영상의학회 2008 대한영상의학회지 Vol.58 No.1
Surgical correction of a cervicothoracic deformity is difficult with a potential risk of vascular injury. Comprehensive preoperative vascular evaluation is important for safe and successful surgery. The use of multi-detector computed tomography angiography (MDCTA) allows a combined display of vascular and osseous structures of the musculoskeletal system. However, no clinical reports have described the use of MDCTA for surgical planning of anterior cervicothoracic surgery in patients with vascular malformation. The case of a 7-year-old girl with congenital cervicothoracic kyphoscoliosis who underwent preoperative MDCTA evaluation and successful correction is presented in this report.
Ovalbumin으로 유발시킨 喘息에 대한 黃芩의 물 추출물의 효과
황대룡,이성철,신호동,신민교,김재홍,정종길,송호준 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4
Objectives : To evaluate effect of allergy by Radix Scutellariae Water Extract(RS), the biochemical changes associated with allergy were measured in Broncho Alveola Lavage Fluid(BALF), serum, splenocyte and lung of mice. Methods : After induction of allergic inflammation asthma by treatment of Ovalbumine(OVA), RS were taken orally for five successive days on mice, respectively. Results : In the total cell of BALF , the RS(1000mg/kg) treated group was significantly reduced compared to control level, and the reduction of eosinophil showed significantly at concentration of RS(300, 1000 mg/kg). Substantial decrease IgE antibody formation was significantly observed by administration with RS(300, 1000㎎/㎏), whereas IgG1, IgG2a antibody formation was not affected in serum from RS treated mice. The content of IL-4 exhibited physiological role in lung, splenocyte was not significantly reduced compared to control group after treatment of RS, but IL-5 was significantly reduced at concentration of RS (300, 1000㎎/㎏). Conclusions : From the above result, it could be concluded that Radix Scutellariae Water Extract showed beneficial effect on the allergic asthma.