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김성수 ( Sung Su Kim ),이성철 ( Sung Cheol Lee ),신호동 ( Ho Dong Shin ),신민교 ( Min Kyo Shin ),김재홍 ( Jae Hong Kim ),송호준 ( Ho Joon Song ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A Objectives : Asthma is characterized by acute and chronic airway inflammation, and the severity of the airway hyperreactivity correlates with the degree of inflammation. The goal of this study was to investigate the effects of the Radix Platicodi(RP) used to treat allergic asthma, on a well-characterized mouse model of allergic asthma. Methods : Mice sensitized intraperitoneally and challenged intratracheally with conalbumin were treated with RP 24hr after the first intratracheal challenge. The effects of RP on allergic airway hyperreactivity, inflammation, antigenspecific antibody production, cytokine profiles were evaluated. Results RP treatment virtually eliminated airway hyperreactivity and markedly reduced the total number of cells and the percent eosinophils in bronchoalveolar lavage fluids compared with the control group. RP treatment decreased antigen- specific IgE, IgG2a, IL-4, IL.-5, and IL-13 levels, but IFN-γ synthesis increased as compared with control group. Conclusions : From the above results, RP exhibits anti-airway hyperresponsiveness, anti-airway inflammation, and immunoregulatory effects on Thl/Th2 response, which may be useful for treatment of allergic asthma.