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Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)
신향미,이기형,송형근,조운동,이건국,이선화,이경미,지길용,윤상순,구지혜,이호창 대한면역학회 2011 Immune Network Vol.11 No.2
Background: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. Methods: We generated seven murine mAbs against human CD45 by injecting cells from different origins, such as human thymocytes, PBMCs, and leukemic cell lines. By using various immunological methods including flow cytometry, immunohistochemistry, and immunoprecipitation, we evaluated the reactivity of those mAbs to CD45 of thymus as well as tonsil lysates. Furthermore, we transiently transfected COS-7 cells with each of gene constructs that express five human CD45 isoforms respectively, and examined the specificities of the mAbs against the transfected isoforms. Results: In case of thymocytes, lymphocytes, and monocytes, all the seven mAbs demonstrated positive reactivities whereas none was reactive to erythrocytes and platelets. The majority of immune cells in formalin-fixed paraffin-embedded thymus and tonsil tissues displayed strong membranous immunoreactivity, and the main antigen was detected near 220 kDa in all cases. Among the mAbs, four mAbs (AP4, DN11, SHL-1, and P6) recognized a region commonly present in all the five isoforms. One mAb, YG27, recognized four isoforms (ABC, AB, BC, and O). Two mAbs, P1 and P14, recognized the isoforms that contain exon A encoded regions (ABC and AB). Conclusion: In this study, we confirmed that AP4, DN11, SHL-1, YG27 and P6, are mAbs reactive with the CD45 antigen whereas P1 and P14 are reactive with the CD45RA antigen.
Plexiform Fibrohistiocytic Tumor of the Neck- A Case Report -
신향미 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.3
Plexiform fibrohistiocytic tumor (PFT) is a rare, low-grade soft tissue tumor that occurrs primarily in children and young adults. The most common location of PFT is the upper extremity, and there are very few reports of PFT in the neck. We report here on a case of PFT presenting as a painless subcutaneous nodule in the neck of a 46-year-old woman. Histologically, this subcutaneous tumor was composed of a plexiform proliferation of histiocyte-like cells and fibroblast- like cells along with a few multinucleated osteoclast-like giant cells. Immunohistochemically, the tumor cells were positive for vimentin, CD68 and smooth muscle actin (SMA).
신향미,성노현 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2
융모막혈관종은 태반에서 발생하는 가장 흔한 양성 종양으로 대개는 크기가 작고 태반체 속에 묻혀 있으며 증상이 없기 때문에 발견되지 않는 경우가 많다. 그러나 드물게 종양이 큰 경우에는 태반의 태아면 또는 모체면쪽으로 돌출하며 양수과다, 조산 등을 나타낼 수 있다 한편 이 종양은 비교적 흔한 종양임에도 불구하고 그 기원세포는 명확히 밝혀지지 않았다. 저자들은 27세 경산부의 태반에서 조산의 원인이 된 장경 8 cm의 융모막혈관종 1예를 경험하고 cytokeratin 18과 CD34에 대한 항체를 이용한 면역조직화학검사로써 융모막혈관종은 융모막반과 고정융모의 혈관에서 기원했을 가능성을 밝혔다. Chorangioma is the most common benign tumor of the placenta. A case of unusually large chorangioma associated with premature delivery is presented. At 26 weeks of gestation, a 27-year-old woman delivered a female infant. The placenta weighed 650 gm and a large, solid mass, measuring 8 cm in diameter, was seen on fetal surface of the placenta protruding into amniotic cavity. Microscopically, the tumor was composed of numerous capillary-sized vessels separated by inconspicuous stroma. Immunohistochemically, tumor cells showed staining for CD34, vimentin, alpha smooth muscle (α-SM) actin and cytokeratin 18. The blood vessels within the chorionic plate and anchoring villi stained for cytokeratin 18, but the vasculature of the terminal villi lacked cytokeratins. In these results, the chorangioma originate most likely from blood vessels of the chorionic plate and anchoring villi.
양수과다증 산모에 Indomethacin 투여후 태아에 발생한 횡경막탈장 1 예
이철규,신향미,전권희,문인근,정은환 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.6
원인불명의 양수과다증 환자 1례를 대상으로 indomethacin을 투여하여 조산방지 및 양수량 감소에 성공적인 결과를 얻었으나 후에 태아의 횡경막 탈장이 발생한 예를 경험하였기에 보고하는 바이다. Indomethacin, a potent prostaglandin synthetase inhibitor, has recently been used in the treatment of polyhydramnios but appears to increase the risk of several important neonatal complications associated with preterm birth. We experienced the first case of diaphragmatic hernia after successful treatment of polyhydramnios with indomethacin and present it with the review of literatures.
안영준,신향미,전권희,문인근,서홍식,송호영,안혜선 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.1
본 저자들은 31세 임산부에서 진행된 부분포상기태가 있으면서 쌍태아 임신을 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. Ultrasonography has become the preferred noninvasive diagnostic imaging modality that enables early confirmation of gestational trophoblastic disease. Twin pregnancy with partial hydatidiform mole and coexisting fetuses was lived at a later gestational age, and had higher preevacuation beta-hCG levels. When disease is not metastatic, chemotherapy is started for a rising or persistantly elevated beta-hCG level. Teh common complications of hydatidiform mole, hemorrhage and infection, decreased in incidence recently due to early diagnosis and evacuation of hydatidiform molar tissue. We recently experienced one case of advanced twin pregnancy with partial hydatidiform mole and coexisting fetuses.
안영준,신향미,전권희,황호원,문인근 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.4
본 저자들은 spiegelberg's criteria를 충족시키는 난소임신 2례를 경험하였기에 문헌적 고찰과 함께 보고하는 바이다. Primary ovarian pregnancy is a rare form of ectopic pregnancy. However, improved diagnosis of acute hemoperitoneum of ovarian origin may reveal a higher incidence than reported earlier. We have experienced two cases of ovarian pregnancy and report with a brief review of literature concerned.
김윤환,오장근,신향미,김영생,Kim, Yoon-Hwan,Oh, Jang-Gun,Shin, Hyang-Mi,Kim, Young-Saeng 대한두경부종양학회 2009 대한두경부 종양학회지 Vol.25 No.2
Dermoid cysts are benign neoplasm that is derived from both ectoderm and mesoderm. They may be found at various sites of the body, but are extremely rare to occur in the lower neck. We present the case of a 22-year old woman with a midline cystic mass anterior to the cervical trachea. The mass was excised under local anesthesia. Histopathologically the diagnosis was confirmed as a dermoid cyst.