http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Autophagy Regulates Formation of Primary Cilia in Mefl oquine-Treated Cells
신지현,배동준,김은성,김한별,박소정,주윤경,조두신,조동규,김상엽,조동형 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4
Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specifi c regulators of autophagy, we screened chemical libraries and identifi ed mefl oquine, an anti-malaria medicine, as a potent regulator of primary cilia in human retinal pigmented epithelial (RPE) cells. Not only ciliated cells but also primary cilium length was increased in mefl oquine-treated RPE cells. Treatment with mefl oquine strongly induced the elongation of primary cilia by blocking disassembly of primary cilium. In addition, we found that autophagy was increased in mefl oquine-treated cells by enhancing autophagic fl ux. Both chemical and genetic inhibition of autophagy suppressed ciliogenesis in mefl oquine-treated RPE cells. Taken together, these results suggest that autophagy induced by mefl oquine positively regulates the elongation of primary cilia in RPE cells.
소규모 복합 상업건물의 공간 콜래보레이션 현황과 효과 - 겔러리, 아트샵, 카페가 콜래보레이션 된 헤이리 예술마을을 중심으로 -
신지현,신경주 한국문화공간건축학회 2015 한국문화공간건축학회논문집 Vol.- No.50
In order to satisfy various needs of users, space collaboration is popular in commercial space design. Recently, commercial space is popular for its provision of comfortable and unique space. This study reviewed the present status and effect of complex commercial buildings which collaborate gallery, art shop, and cafe with area of more than 300 square meters and less than 500 square meters and are located in Heyri Artist Valley in Paju, Korea. As a result, among the 6 buildings reviewed, more than 83 % were collaboration of a gallery and a cafe with overlapping area of 25-52 squire meters which saved 7-15 % of gross floor area. However, in these cases, negative effects were shown at either gallery or cafe. Planning lighting, furniture, the line of flow, and entrance considering the purpose of each space can help maximizing the synergistic effect so further study is needed for such an extent.
지열시스템 순환펌프 변유량 제어를 활용한 운영 방안개발
신지현,최동희,조영흠 한국건축친환경설비학회 2018 한국건축친환경설비학회 논문집 Vol.12 No.5
The purpose of this study is to develop an operating method of geothermal heat pump system to prevent waste of energy due to inefficient operation. As the interest in energy saving is increasing, the development and use of renewable energy systems is increasing. In korea, While the geothermal system with excellent performance is installed, the other heat source system is used as the main heat source, or the system operates in the partial load state, resulting in waster of energy by controlling the fixed flow rate of the geothermal circulation water. Therefore, the purpose of this study is to develop an operating method of several geothermal heat pump system through the variable water flow rate control method of circulation pump. The proposed operating method is tested through simulation
신지현,이성옥 한국미용학회 2001 한국미용학회지 Vol.7 No.1
The purpose of the study on the beauty of Vie face in Ox murals of Koguro. In this study, we investigated face of the men and women through photographs revealed in the murals of Koguro. Therefore, on attempt was made to make a brief Summary of the entire countenance and face in the Ere of Koguro. As is known, the face of die women and men in the murals of Koguro are used White shin, long and simple shaped brows, small mouse.
신지현,김수환,김병국,조진희,김성원,이범준,김예원 대한비과학회 2012 Journal of rhinology Vol.19 No.1
Background and Objectives: Allergic rhinitis is closely related to asthma. The skin prick test is an essential diagnostic tool for allergic disease. We evaluated differences in skin sensitization patterns between groups of patients with allergic rhinitis or asthma, or allergic rhinitis with asthma, in Korea. Materials and Methods : From 2000 to 2009, patients with positive results from skin prick testing were divided into three groups: allergic rhinitis (AR), allergic asthma (AS), and allergic rhinitis with allergic asthma (AR+AS). We analyzed demographic data, rhinitis and asthma symptoms, and sensitization patterns. Results : The most common aeroallergen was the house dust mite. The age distributions of the three disease groups differed significantly. Sensitization number, sensitization index, and atopy index were all significantly higher among the AR+AS group than among the AR or AS groups. Conclusion: Patients with allergic rhinitis with high numbers of skin sensitizations or intensive positivities should be considered to have concomitant asthma or to be at high risk for asthma development.
2001 년 유행 컬러 트랜드 고찰 : 패션 트랜드 중심으로 on the basic of the Fashion
신지현,이성옥 한국미용학회 2000 한국미용학회지 Vol.6 No.2
Color is probably the most important element of design. It influences emotions. It help us to express ourselves as individuals. It influences our impressions of others, as well. Color is also one of the most important features drawing someone to a clothing item for clser examination in a store or catalogue. Throughout our lives, we are surrounded by color. It play an important part in the interior and exterior of out homes and businesses, in our clothing choices, and in the selection of just about everything we use or posses. Some fashion autthorities categorize us by our personal coloring and the seasons of the year. Generally we think of color as that which we see in opaque objects of surfaces. We are seldom concerned with where this color eminates or what laws of physics come into play to make us perceive color pigment as it is. Therefore, it is important to understand that the origin or source of color is light. Although it is a very complicated theory, it is important knowledge for anybody.
Isolation and Characterization of Chicken NPAS3
신지현,정혜윤,이경은,김재상 한국뇌신경과학회 2010 Experimental Neurobiology Vol.19 No.2
Here we describe characterization of chicken neuronal Per-Arnt-Sim domain 3 (NPAS3) gene during embryogenesis including examinations of expression pattern and function of the gene. RTPCR assay showed that the primary tissue of expression for this gene is the central nervous system (CNS) while RNA in situ hybridization assay confirmed that NPAS3 was expressed in the ventricular zone of developing neural tube as early as Hamburger-Hamilton (HH) stage 20. Ectopic over-expression of the gene in ovo in the developing chicken neural tube by electroporation had little effect on stem cell population, overall neurogenesis, and motor neuron differentiation. We discuss the implications of our observation.
신지현 한국미용학회 2000 한국미용학회지 Vol.6 No.2
A dearth of rain forced the prehistoric ancestors of the Egyptians to desert the plains on either side of the Upper Nile. The Old Kingdom covering ten dynasties was followed by the Middle Kingdom consisting of Dynasties XI-XVII. The giganties pyramids were a product of the Fourth Dynasty. The Middle Kingdom was the classic period of Egyptian history in which listerature and poetry, sculpture and architecture flourished. There were Semitic invasions and the effects were reflected in art and dress after the fall of Dynasty XII. The New Kingdom and the Late Period, embracing Dynasties XVIII-XXX, had a brilliant beginning but not so glorious an end. Art the height of prosperity during the time of Rameses II many great temples were built; but in 525 B.C. 1. (Ancient Kingdom, Dynasties I-X) Make up: oils and unguents; stibium for eye; green or black eye shadow; kohl; veins of chest sometimes outlined in blue; lips painted with carmine, fingertips and toes colores with henna. Hair: Black wig: wig of real hair worn by well to do, of wool by lowest class. 2. (Middle Kingdom, Dynasties XI-XVII) Make-up: body oils of $quot;various kinds, including castor oil; eye and brow made longer with kohl; eyeshadow of blue or green made of malachite; henna used to color fingertips and toes; superfluous hair plucked; special care given to teeth; bone or ivory false teeth held in place with gold wires; false beard attached by a gold chin strap sometimes worn by queen. Hair: short bob similar to type worn by man; sometimes rather long with curled ends, worm behind ears. 3. (New Kingdom, Dynasties XVIII XXX) Hair: artificial wig; long wavy hair; sometimes longer wig ending in corkscrew curls; after 1150 B.C. wig sometimes dyed blue or red; wig with hair parted in middle and rippled to shoulder; one type showing the ears and with neat rolls hanging down below collarbone, resembling the claft.
신지현,김수환,김성원,박찬순,조진희,양명재,강준명 대한비과학회 2009 Journal of rhinology Vol.16 No.1
Background and Objectives:There are increasing evidence suggesting that the endoscopic approach can be used successfully for the treatment of benign sinonasal tumors. In the present study, we reviewed a 12-year experience of our institution for endoscopic management of benign sinonasal tumors. Materials and Methods:We retrospectively reviewed the medical records and radiologic findings of 185 patients who underwent endonasal endoscopic resection of benign sinonasal tumors at the Catholic Medical Center between 1996 and 2007. Result:Inverted papilloma (119 cases, 64.3%) was most common, followed by hemangioma (14 cases), pyogenic granuloma (11 cases), angiofibroma (9 cases), and osteoma (7 cases). The most common symptom was nasal obstruction (70.8%). Sixteen cases (8.6%) recurred after endoscopic resection (12 cases of inverted papilloma, 2 cases of ossifying fibroma, and 2 cases of fibrous dysplasia). No major complications were reported. Conclusion:Endoscopic approach allows for successful surgical outcomes and good cosmetic effects among patients with benign sinonasal tumors. We suggest that, in selected cases, benign tumors involving the sinonasal tract can be safely and radically removed using the endoscopic technique. Background and Objectives:There are increasing evidence suggesting that the endoscopic approach can be used successfully for the treatment of benign sinonasal tumors. In the present study, we reviewed a 12-year experience of our institution for endoscopic management of benign sinonasal tumors. Materials and Methods:We retrospectively reviewed the medical records and radiologic findings of 185 patients who underwent endonasal endoscopic resection of benign sinonasal tumors at the Catholic Medical Center between 1996 and 2007. Result:Inverted papilloma (119 cases, 64.3%) was most common, followed by hemangioma (14 cases), pyogenic granuloma (11 cases), angiofibroma (9 cases), and osteoma (7 cases). The most common symptom was nasal obstruction (70.8%). Sixteen cases (8.6%) recurred after endoscopic resection (12 cases of inverted papilloma, 2 cases of ossifying fibroma, and 2 cases of fibrous dysplasia). No major complications were reported. Conclusion:Endoscopic approach allows for successful surgical outcomes and good cosmetic effects among patients with benign sinonasal tumors. We suggest that, in selected cases, benign tumors involving the sinonasal tract can be safely and radically removed using the endoscopic technique.