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박주현,고영진,김종현,이종인,신지남,임성훈,임선 대한재활의학회 2004 Annals of Rehabilitation Medicine Vol.28 No.2
Objective: The purpose of this study was to investigate the effect of ischemic stroke on bone metabolism. Method: Female Sprague-Dawley rats (12 weeks old, n=48) were randomly divided into 4 separate groups; sham operation group (group A), stroke group (group B), ovariectomy group (group C), and stroke-ovariectomy group (group D). Two weeks after performing ovariectomy, cerebral ischemia was induced. The bone mineral density (BMD) and osteocalcin and carboxy-terminal telopeptide (CTX) were measured on three periods: the day before ischemia and 1 and 3 weeks post-stroke. All data were statistically analyzed. Results: One week after cerebral ischemia, lumbar spine BMD of group B and D although statistically insignificant showed a lower BMD score in comparison to group A and C, respectively. Three weeks after ischemia, compared to group C, the BMD score of lumbar spine in group D was reduced significantly (p<0.05). At one week post-stroke, compared with group A and C, the value of osteocalcin in group B and D were reduced significantly, respectively (p<0.05). One and three weeks after ischemia, the CTX value in all groups showed no statistical difference. Conclusion: The authors concluded that ischemic stroke affected bone metabolism by decreasing osteoblastic activity in the early phase of stroke rat.
임형우 ( Hyung Woo Lim ),신지남 ( Ji Nam Shin ),강현욱 ( Hyun Wook Kang ),유지원 ( Ji Won Yoo ),김진석 ( Jin Seok Kim ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1
Overlap syndrome is a combination of major features of more than one rheumatic disease present in the same patient such as rheumatoid arthritis (RA), systemic lupus erythematosus, systemic sclerosis, and polymyositis. Polymyositis and RA are independent rheumatic diseases that may have a variety of overlapping clinical, radiological, and pathological manifestations according to different accepted criteria. Overlap syndrome with RA and polymyositis is rarely reported worldwide. We reported a rare case of overlap syndrome RA and polymyositis with relevant literatures.