재발성 삼출성 중이염과 혈청 면역글로불린 농도의 저하

신일호,박동춘,변재용,박문서,차창일,여승근,Shin, Il-Ho,Park, Dong-Choon,Byun, Jae-Yong,Park, Moon-Seo,Cha, Chang-Il,Yeo, Seung-Geun 대한면역학회 2007 Immune Network Vol.7 No.2

Background: Defective or immature antibody responses to pathogens in children may explain the increased susceptibility to acute otitis media. However, there is no study in Korea patients whether a correlation exists between otitis media with effusion and the levels of serum immunoglobulins, IgG subclasses, IgA, IgM and IgE. Methods: 45 children with otitis media with effusion more than 4 episodes in 12 months or 3 episodes in 6 months, 62 children with otitis media with effusion less than 3 episodes in 12 months and 102 children for control group took part in the study at the Department of Otorhinolaryngology of the KyungHee University from May 2004 to Feburary 2007. Serum immunoglobulin levels were determined by nephelometry. And then the relationship between otitis media with effusion and serum immunoglobulin level was evaluated. Results: In otitis media prone group, serum IgG1, IgG2, IgG4, and IgA level was lower than those level of control group, it was significantly decreased (p<0.05). In otitis media group, serum IgA, IgE, and IgG4 level was lower than those level of control. But it was not statistically significant (p>0.05). Conclusion: Lower immunoglobulins in children with otitis media with effusion suggest a generalized decreased antibody responses. Lower levels of serum IgG1, IgG2, IgG4, and IgA may be related with chronicity or intractability of otitis media with effusion.

醫療保險情報시스템을 위한 데이타베이스 硏究

申一浩 成均館大學校 經營大學院 EDPS同門會 1987 EDPS 硏究 Vol.8 No.1

취업 면접지도를 위한 문제은행시스템 구축 방안 탐색

신일호,어윤경 한국진로교육학회 2020 한국진로교육학회 학술대회지 Vol.2020 No.7

IgA and Differentiation-associated Transcription Factors in Chronic Otitis Media with Effusion

신일호,신옥영,차성호,여승근,김영일,이진우 대한이비인후과학회 2009 Clinical and Experimental Otorhinolaryngology Vol.2 No.3

Objectives. Inadequate antibody responses to pathogens may lead to the recurrence of otitis media with effusion (OME). Although B-cell production by antibodies is controlled by transcription factors, the status of these factors has not been assessed in patients with OME. Methods. Expression of immunoglobulin was measured by enzyme-linked immunosorbent assay. Expression of transcription factors Bcl-6, Blimp-1, Pax-5, and XBP-1 was assessed by RT-PCR in the middle-ear fluid of 29 children with >4 OME episodes in 12 months or >3 episodes in 6 months (the OME-prone group) and in 32 children with <3 OME episodes in 12 months (OME group). The relationship between recurrence of OME and expression levels of immunoglobulins and transcription factors in middle-ear fluid was determined. Results. The concentration of IgA in middle-ear fluid was significantly lower in the OME-prone than in the OME group, as was the expression of mRNA encoding the transcription factors Blimp-1 and XBP-1 (P<0.05 each). Expression of mRNA encoding the transcription factors Bcl-6 and Pax-5 was more intense in the OME-prone than in the OME group, but these differences were not significant (P>0.05). Conclusion. Lower concentrations of IgA, Blimp-1 and XBP-1 in middle ear fluid of patients with OME may be related to OME recurrence and chronicity. Objectives. Inadequate antibody responses to pathogens may lead to the recurrence of otitis media with effusion (OME). Although B-cell production by antibodies is controlled by transcription factors, the status of these factors has not been assessed in patients with OME. Methods. Expression of immunoglobulin was measured by enzyme-linked immunosorbent assay. Expression of transcription factors Bcl-6, Blimp-1, Pax-5, and XBP-1 was assessed by RT-PCR in the middle-ear fluid of 29 children with >4 OME episodes in 12 months or >3 episodes in 6 months (the OME-prone group) and in 32 children with <3 OME episodes in 12 months (OME group). The relationship between recurrence of OME and expression levels of immunoglobulins and transcription factors in middle-ear fluid was determined. Results. The concentration of IgA in middle-ear fluid was significantly lower in the OME-prone than in the OME group, as was the expression of mRNA encoding the transcription factors Blimp-1 and XBP-1 (P<0.05 each). Expression of mRNA encoding the transcription factors Bcl-6 and Pax-5 was more intense in the OME-prone than in the OME group, but these differences were not significant (P>0.05). Conclusion. Lower concentrations of IgA, Blimp-1 and XBP-1 in middle ear fluid of patients with OME may be related to OME recurrence and chronicity.

중년여성 휘트니스 클럽 회원의 운동몰입이 스포츠가치관에 미치는 영향

신일호,전병은 대전대학교 기초과학연구소 2016 自然科學 Vol.29 No.-

This study aims to identify What effects the flow experience by the fitness participation has on sports values. And study matters are as follows. First, there will be a significant difference in the sports values under the social and demographic characteristics of fitness club members. Second, the flow experience for exercise of fitness club members will have some effects on sports values. For the study subjects, old woman members in their 40's-50's at the fitness club in Daejun were selected as a population and then extracted by the method of stratified cluster random sampling. Followings are the study results. First, the analysis for the relation between the social and demographic features and sports values is as follows. As to the analysis of variance, the age had no statistically significant difference with the sub-variable of sports values. And the income level had a statistical significance with the personality, physical and sociable values. For the subjective social class, it had a statistical significance with the entertainment, physical, aesthetic, personality and sociable values. The exercise period had a statistical significance with the personality, physical, values, aesthetic and sociable values. And the participation frequency had a statistical significance with the entertainment , personality, physical, economical and aesthetic values. The exercise level had a statistically significant difference with the sub-variables of sports values. Lastly, the analysis for the effects of flow experience on the sports values is as follows. Personality values had a statistical significance with the self-goal modification, time sense modification. Physical values had a statistical significance with the self-goal modification and time sense modification). The economical values had a statistical significance with the clear perception of a goal, self-goal modification and self-control ability. And the entertainment values had a statistical significance with the self-control ability. The aesthetic values had a statistical significance with the self-goal modification, time sense modification and self-control ability. Lastly, the sociable values had a statistical significance with the self-goal modification and time sense modification.

폐쇄성 수면 무호흡 증후군 환자의 구개인두 수술 후 미각의 변화

신일호,김상훈,은영규,신승엽,조중생,김성완 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.12

Background and Objectives Postoperative taste changes after uvulopalatopharyngoplasty (UPPP) is regarded as an unusual and minor complication. This study aims to evaluate the objective changes of taste threshold according to time course and subjective symptoms change. Materials and Method With 45 patients who underwent UPPP and 35 patients who underwent nasal surgery as control group, we have prospectively studied postoperative taste changes using a questionnaire, and an electrogustometer (EGM) with regard to symptoms at 7th, 28th days after the surgery. EGM was measured at 5 areas. Also, we have checked pre-operatively about the serum level of zinc. Results With EGM, the threshold of taste was increased at 7th days after the surgery (p<0.05), but recovered 28th days after the surgery at the posterior part of the tongue in the UPPP group. There were no significant changes in subjective taste dysfunction, smell dysfunction, tongue sensory abnormality, and dysgeusia. Conclusion Taste changes after UPPP was transient and they disappeared within the 1st postoperative month. There were no patients who complained of subjective taste dysfunction, dysgeusia, tongue sensory abnormality after UPPP.

Mitomycin C를 이용한 섬유주절제술에서 결막편에 따른 수술결과 비교

신일호 ( Sin Il Ho ),형성민 ( Hyeong Seong Min ) 대한안과학회 2003 대한안과학회지 Vol.44 No.12

소아 이상두위의 임상 분석

신일호 ( Sin Il Ho ),최미영 ( Choe Mi Yeong ) 대한안과학회 2003 대한안과학회지 Vol.44 No.9

이종 스크린간 협업 서비스를 위한 오픈스크린 서비스 플랫폼 기술

이성희,신일호,이은준,이현우 한국통신학회 2016 정보와 통신 Vol.33 No.5

디지털 사이니지(Digital Signage)는 불특정 다수에게 일대 다형태로 정보를 제공하는 디지털 정보 디스플레이(Digital Information Display)에서 사용자의 상황을 인지하여 개인 맞춤형 콘텐츠를 제공하는 상황인지기반 텔레스크린(TeleScreen)으로 진화했으며, 앞으로의 디지털 사이니지는 옥내외에 위치한 다양한 형태의 사이니지들이 주변 환경과 사용자 상황에 따라 서로 협업하여 서비스를 제공하는 오픈스크린 서비스로 발전할 전망이다. 본 고에서는 오픈스크린(Open-Screen) 서비스의 등장 배경과 개념을 소개하고 하고 본 연구원에서 개발한 오픈스크린 서비스 플랫폼 기술을 소개한다.

갑상선 결절에서 세침흡인검사: Bethesda Classification의 임상적 적용

은영규,류은웅,신일호,권기환 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.7

Background and Objectives To evaluate the usefulness of fine needle aspiration (FNA) for thyroid nodule using the new Bethesda classification. Subjects and Method Patient cytology data were reviewed by retrospective search of thyroid FNA. Cytologic diagnoses were classified as unsatisfactory, benign/negative for malignancy,indeterminate (ID), follicular neoplasm (FN), suspicious for malignancy (SM), and positive for malignancy (PM) according to the proposing of The National Cancer Institute. We analyzed the follow-up FNA diagnoses and the cytologic-histologic correlations. Results Of 1983 patients, 16.8% was classified as unsatisfactory, 73.6% as benign, 1.1% as ID,0.4% as FN, 1.4% as SM, and 6.8% as PM. After the cytologic follow-up, the groups designated as unsatisafactory (80.2%) and ID (50%) mainly showed significant change in diagnosis. Two hundred fifty patients had surgical follow-up. Sensitivity, specificity, and accuracy, positive predictive values and negative predictive values for malignancy of thyroid were 87.6%, 97.2%, 91%,98.3% and 81.2%, respectively. The cytologic-histologic diagnostic discrepancy rate was 13.6%. Conclusion FNA for thyroid nodule using the new Bethesda classification was an accurate and sensitive method for the diagnosis of thyroid nodule, and can provide useful information for the management of thyroid nodule. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:436-40