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신원빈,박지원,최효정,남궁진,김상균,민백기 대한침구의학회 2019 대한침구의학회지 Vol.36 No.3
This study was conducted to investigate whether treatment with Korean medicine might help to improve symptoms of patients diagnosed with Ramsay Hunt Syndrome. A patient diagnosed with Ramsay Hunt Syndrome was hospitalized for 15 days from October 4, 2018 to October 18, 2018 and treated using Korean medicine (Sinbaro3 pharmacopuncture, acupuncture, electroacupuncture, and herbal medicine). Therapeutic effects were evaluated using the Numerical Rating Scale (NRS), House–Brackmann grade, Yanagihara’s score survey, and Digital Infrared Thermographic Imaging (DITI). After treatment, the Numerical Rating Scale score (6 at admission down to 2 points at discharge), House–Brackmann grade (Grade V down to Grade II), Yanagihara’s score (6.0 up to 22.0), and Digital Infrared Thermographic Imaging showed improvement from admission to discharge. Treatment with traditional Korean medicine, may help improve symptoms of Ramsay Hunt Syndrome such as facial nerve paralysis, neuralgia after paraplegia, hearing difficulties, and dizziness.
김연숙,신원빈,Xin Dong,김은경,Weligala Pahalagedara Amila Srilal Nawarathna,김학주,박표잠 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.6
In our previous work, Asterina pectinifera was fermented with Cordyceps militaris mycelia to improve its bioactivities and was reported to have strong antioxidant activities. The aim of the current study was to investigate its anti-inflammatory effect and mechanisms of action. In this study, we observed the inhibitory effect of the extract from fermented A. pectinifera with C. militaris mycelia (FACM) on nitric oxide (NO) production and its molecular mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. FACM could decrease LPS-induced NO production. Western blot analysis showed that FACM could down-regulate LPS-induced expression of inducible NO synthase without affecting cyclooxygenase-2. Moreover, FACM exhibited anti-inflammatory activity in LPSinduced RAW264.7 mouse macrophage cells through proinflammatory mediators including TNF-a and IL-6 via nuclear factor kappa B pathway. FACM inhibited LPSinduced phosphorylation of extracellular-signal-regulated kinase expression. Our results suggest that FACM may be a potential candidate for inflammation therapy by attenuating the generation of cytokines, production of NO, and generation of ROS in RAW264.7 cells.
박지원,윤태경,신원빈,김두리,류원형,전용현,문희영 대한침구의학회 2018 대한침구의학회지 Vol.35 No.3
The purpose of this case study was to use Korean medicine to treat posterior cruciate ligament avulsion fracture. The patient suffered left knee pain resulting from an avulsion fracture and was hospitalized for 59 days and treated with acupuncture and traditional Korean medicine. The effect of the treatment was evaluated using the Numerical Rate Scale, the Western Ontario and McMaster universities Osteoarthritis Index, and the European Quality of Life Five Dimensions. Following treatment of the pain in the left knee, scores for Numerical Rate Scale, Western Ontario and McMaster universities Osteoarthritis Index, and European Quality of Life Five Dimensions were improved. This study suggested that Korean Medicine could be an effective treatment for posterior cruciate ligament avulsion fractures. Further studies are needed to substantiate this conclusion.
다리움직임을 동반한 척추 가동술(SMWLM)과 통합한방치료를 활용하여 호전된 급성 하지 근력저하 4례 : 증례보고
문영주(Young-Joo Moon),신원빈(Won-Bin Shin),류광현(Gwang-Hyun Ryu),이지연(Ji-Yun Lee),전현아(Hyun-A Jeon),임수연(Su-Yeon Lim),김성현(Seong-Hyun Kim),구승혁(Seng-Hyuk, Koo),문현우(Hyun-Woo Moon) 척추신경추나의학회 2020 척추신경추나의학회지 Vol.15 No.2
Objectives The purpose of this study was to investigate the possibility of spinal mobilization with leg movement (SMWLM) using Korean Medicine treatment on acute lower limb muscle weakness through four case studies. Methods SMWLM , with other Korean Medicine treatments, was performed on four patients who underwent treatment at OOOO Korean Medicine Hospital from August 2017 to July 2018. Additionally, results of the Numerical Rate Scale(NRS), EuroQol-FiveDimensions(EQ-5D),Oswestry lowback pain disability questionnaire(ODI), Straight Leg Raise(SLR) test, and Manual Muscle Test(MMT) were evaluated. Results There was a significant increase in NRS, ODI, and EQ-5D scales with im-rovements of SLR angle and MMT figures to a normal range. Conclusions This study suggested that Korean Medicine treatment combined with SMWLM may affect treating acute lower limb muscle weakness. Further clinical studies are needed to establish a definite conclusion.
수근관 증후군의 최근 6년간의 연구 동향 분석: China National Knowledge Ingrastructure (CNKI) 보고 연구를 중심으로
전현아 ( Hyun-a Jeon ),신원빈 ( Won-bin Shin ),임수연 ( Su-yeon Lim ),문영주 ( Young-joo Moon ),이지연 ( Ji-yun Lee ),구승혁 ( Seung-hyeok Ku ),김성현 ( Sung-hyun Kim ),문현우 ( Hyun-woo Moon ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.4
Objective The purpose of this study was to investigate clinical studies between 2015 and 2020 on the traditional Chinese medicine treatment for carpal tunnel syndrome (CTS) using the China National Knowledge Infrastructure (CNKI) database. Methods We searched clinical studies on the Chinese medicine treatment published in traditional Chinese medical journals on CTS through the CNKI search. Fifteen published studies between 2015 and 2020 were chosen and examined for the year of publication, sample size, study design type, diagnosis and evaluation of diverse criteria, treatment period, purpose of the study, and classification based on the treatment technique. Results Out of 73 studies, 15 had practiced various Chinese medical treatments, such as acupuncture, moxibustion, manipulation, herbal medicine application therapy, and external herbal treatment. Conclusions Various studies have investigated the Chinese medicine treatment for CTS in China. To envelope the treatment of CTS in Korean medicine, steady and valuable therapies for high-level clinical research are required. In the future, this study could be helpful in the development of the treatment of CTS with Korean medicine. (J Korean Med Rehabil 2020;30(4):119-132)
민백기,진준수,이도은,신원빈,Jin Hyeon Shin,연인애 대한침구의학회 2020 대한침구의학회지 Vol.37 No.1
The effects of complex Korean medicine treatment including acupotomy, on irritable bowel syndrome (IBS) are reported in this case study. A 54-year-old woman with diarrheal symptoms that alternatively improved and worsened for many years and worsening abdominal pain visited the emergency room and was diagnosed with IBS; she was admitted for approximately 2 weeks at the Acupuncture and Moxibustion Department of National Medical Center (NMC). Numerical rating scale (NRS), irritable bowel syndrome–quality of life (IBS-QOL), and gastrointestinal symptom rating scale (GSRS) scores were evaluated on the day of hospitalization, midway through the hospitalization period, and on the day of discharge. Abdominal pain was measured daily using NRS, and the score decreased from 8 at admission to 0 at discharge. The IBS-QOL percentile score improved from 42 points to 100 points. The total GSRS score also improved, from 30 points to 2 points. These results suggest that complex Korean medicine treatment with acupotomy, is useful for treating internal diseases, such as IBS, as well as musculoskeletal disorders.
경추 유합술 이후 발생한 인접분절 추간판 탈출증 환자에 대한 감압요법을 포함한 한의학적 치료 증례보고
이지연(Ji-Yun Lee),신원빈(Won-Bin Shin),임수연(Su-Yeon Lim),문영주(Young-Joo Moon),전현아(Hyun-A Jeon),남항우(Hang-woo, Nam) 척추신경추나의학회 2019 척추신경추나의학회지 Vol.14 No.2
Objectives : The purpose of this clinical study was to evaluate the effect of spinal decompression with Korean medicine treatment on the herniation of an intervertebral disc (HIVD) in a patient after fusion surgery of a cervical segment. Methods : A single patient was treated with spinal decompression, acupuncture, pharmacoacupuncture, and herbal medication. We measured the Numerical Rating Scale (NRS), Neck Disability Index (NDI), European Quality of Life-5 Dimension (EQ-5D), Cervical Range of Motion (cervical ROM) and the Beck Depression Inventory (BDI) score to evaluate the treatment effects. Results : The patient s post neck pain & pain in both arms improved significantly as suggested by the scores on the NRS, NDI, EQ- 5D, cervical ROM and BDI. Conclusions : Thus, spinal decompression, including Korean medicine treatment, could be taken into consideration for HIVD patients after fusion surgery.
경추부 압통점의 황련해독탕 약침치료를 통한 경추성 어지럼증 환자 호전 치험 3례
임수연 ( Su-yeon Lim ),신원빈 ( Won-bin Shin ),사공종원 ( Jong-won Sakong ),이지연 ( Ji-yun Lee ),전현아 ( Hyun-a Jeon ),문영주 ( Young-joo Moon ),이유라 ( Yu-la Lee ) 대한한방신경정신과학회 2020 동의신경정신과학회지 Vol.31 No.3
Objectives: The purpose of this case report was to evaluate the effectiveness of Hwangryunhaedoktang pharmacupuncture on three patients diagnosed as cervical vertigo. Methods: Three patients were diagnosed as cervical vertigo with cervical sprain, resulting from an alteration of the neck proprioceptive afferents of the upper cervical spine. Hwangryunhaedok-tang pharmacoacupuncture was injected in the patients once daily for 10 days. The symptom change of dizziness was checked daily before and after treatment by the Visual Analogue Scale (VAS) score. The cervical pain and patient satisfaction were checked by the NRS (Numerical Rating Scale), NDI (Neck Disability Index), and the EQ-5D (EuroQol-Five Dimensions). Results: After the treatment, there was significant decrease in the value of the VAS score, measurement of dizziness, as well as the value of the NRS, NDI, a measure of pain. Also, the life quality measured by the EQ-5D improved. Conclusions: The results indicated that the Hwangryunhaedok-tang pharmacupuncture may have an effect on cervical vertigo with cervical pain.
김연숙,김은경,Xin Dong,박진수,신원빈,김수진,고은애,박표잠,임병우 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.5
In this study, we investigated the antioxidant and protective effect of Lindera glauca stem (LGS) extracts against oxidative stress. We compared antioxidant properties of water extract (LGSW) with ethanol extract (LGSE) by determining the contents responsible for antioxidant activities such as polyphenols and flavonoids. Antioxidant properties were also determined by 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP). Lipid peroxidation was estimated using ferric thiocyanate (FTC) and thiobarbituric acid (TBA) method. Both LGSW and LGSE strongly inhibited lipid peroxidation. Especially, LGSE showed a protective effect through increasing cell viability, decreasing intracellular reactive oxygen species (ROS) against tert-butyl hydroperoxide-induced oxidative stress in Chang cells. Furthermore, LGSE increased antioxidant related enzyme activities such as catalase, glutathione S-transferase, glutathione peroxidase, and superoxide dismutase gene expression against oxidative stress in a zebrafish model. Our findings suggest that LGSE could be useful for developing potential therapeutic agents with protective effects against oxidative stress.
기침으로 급성 악화된 요추 추간판 파열 환자의 대용량 약침 및 복합 한방치료 호전사례 1례
류광현,문희영,주아라,추원정,최요섭,문영주,채지원,신원빈 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.6
Objective: The purpose of this study was to report the radiological and symptomatic changes in a patient with acute herniated lumbar disc due to coughing, treated with megadose pharmacopuncture and combined Korean medicine. Methods: MRI examination diagnosed an acute lumbar disc herniation by coughing. We performed a combination treatment of megadose pharmacopuncture and integrated Korean medicine. NRS, ODI, EQ-5D, SLR test, and big toe extension test were checked on admission, after two weeks, on discharge, and after four months to confirm symptom improvements. Results: In the acute stage of lumbar intervertebral disc rupture, megadose pharmacopuncture combined with Korean medicine treatment showed improvement in NRS, ODI, EQ-5D, SLRT, and big toe extension tests. In addition, absorption of the herniated intervertebral discs was observed through an MRI scan on discharge. Conclusions: For patients with herniated lumbar disc acutely deteriorated by coughing, a combination of megadose pharmacopuncture with Korean medicine treatment may be a solution.