생활 스트레스에 대한 심박변이와 혈청 코티졸과의 관계

신숙희,Shin, Sook Hee 대한핵의학기술학회 2014 핵의학 기술 Vol.18 No.2

일상생활에서 경험하는 다양한 사건들은 모두 스트레스인자로 작용하여 이에 대한 대처가 부적절하면 인체의 항상성이 파괴되어 정신 및 신체질환의 발생에 영향을 주며 인체의 면역반응에 부정적인 영향을 주어 질병에 대한 대처능력을 떨어뜨려 다양한 만성질환에 대한 감수성을 높일 수 있다. 스트레스에서 내분비학적 및 생화학적 반응을 이용하는 근거는 신체 대부분의 시스템이 스트레스 중 변화하고 이런 변화를 나타내는 생물학적 지표가 스트레스와 관련된다는 근거에 의해 신체적 반응에 대한 생화학적 반응으로서 스트레스 호르몬인 코티졸 측정과 생리적인 스트레스반응으로서 여러 가지의 생리신호 중에 혈압(blood pressure)과 심박변이도(heart rate variability, HRV)를 측정하여 스트레스 반응 수준을 측정하여 상관관계를 분석하였다. 전체 94명의 피실험 대상자의 혈청 코티졸의 농도는 평균 11.22 ng/mL 이었고 최저 3.6ng/mL에서 최고 23.3 ng/mL의 분포를 나타냈다. 남녀 집단을 나누어 분석하면 남자가 13.71 ng/mL 으로 여자 10.47 ng/mL 보다 유의하게 높았다(p<0.05). 생리신호 중 혈압을 남녀 집단으로 구분하여 분석한 결과 수축기혈압 평균이 남자가 133 mmHg으로 여자 117 mmHg보다 통계적으로 유의하게 높았다(p<0.05).확장기 혈압의 평균은 남자가 81mmHg로 여자의 76.4 mmHg 보다 높았으나 유의하지 않았다. 심박변이도 중 교감신경 활동을 보여주는 LF/HF ratio 비도 남자가 3.09 로 여자 1.77 보다 유의하게 높게 나타났다(p<0.05). Purpose The physiological and biochemical responses of healthy men and women to life stress were measured in order to investigate the correlation between these two responses under the normal situation. Materials and Methods The population of the research is some randomly chosen health college students located in Daejeon City during the period from August to September 2014, and the sample of 94 students. Heart rate variability (HRV), blood pressure (BP) were selected as physiological stress indices and serum cortisol level was used as a biochemical stress biomaker. The data which is collected used SPSS19.0 programs and frequency and percentage and T-test, correlation. Results Male showed the significant higher value of serum cortisol level (p<0.05), BP (p<0.05), and LF/HF ratio of HRV (p<0.05) than female. The difference of BP between correlated significantly with serum cortisol level (p<0.05). The LF/HF ratio of HRV also correlated significantly with serum cortisol level (p<0.05) Conclusion We suggest that LF/HF ratio of HRV and BP may be good indices for the assessment of life stress.

일부 지역 임상병리과 학생의 코로나19에 대한 지식, 태도 및 위험 인식과 감염예방 행위에 관한 연구

신숙희(Shin, Sook Hee),박선구(Park, Sun Gu) 한국보건기초의학회 2021 한국보건기초의학회지 Vol.14 No.2

This study aims to investigate the knowledge, attitude toward and perceived risk of COVID-19 in clinical laboratory science students. This study also attempts to identify the factors influencing the performance of infection prevention behavior. From October 1st to October 30th, 2021, a face-to-face survey was conducted on the students in the Department of Clinical Laboratory Science. A total of 150 students participated in this study. There was a higher percentage of female students (86.7%) than male students (13.3%). For data analysis, independent t-test, one-way ANOVA analysis, Pearson’s correlation analysis, and multiple regression analysis were used. The percentage of correct answers in relation to knowledge about COVID-19 was 88.5%. In response to the questions about attitude towards COVID-19, the result was 73.8 points (mean). As for the questions about risk perception the result was 35 points (mean). When it came to the question about prevention behavior the result was 80.7%. It was confirmed that the preventative behavior for COVID-19 did not significantly correlate with knowledge of COVID-19 (r=0.040, p=0.629) and had a significant net correlation with attitude toward and perceived risk of COVID-19 (r=0.291, p<0.001). A stepwise multiple regression analysis was conducted by adding attitude toward and perceived risk of COVID-19 to the correlation analysis, where factors such as current year of study, living status, and college life satisfaction were first encountered. It was concluded that living status (β=0.25, p=0.003), current year of study (β=0.17 and p=0.037), and attitude toward and perceived risk of COVID-19 (β=0.19, p=0.019) were significant. The results of this study can be used as data for future clinical laboratory science students as well as the prevention of COVID-19 infection. These results can also be used for education on new infectious diseases and the development of COVID-19 infection prevention programs.

우리나라 성인에서 혈청 지질성분비가 허혈성 심장질환 발생에 미치는 위험도 평가

신숙희(Shin, Sook-Hee),이태용(Lee, Tae-Yong) 한국산학기술학회 2012 한국산학기술학회논문지 Vol.13 No.5

본 연구에서는 우리나라 30세 이상 성인들의 허혈성심장질환(ischemic heart disease, IHD) 발생률을 계산하 고, 지질지표(콜레스테롤, 중성지방, 고밀도지단백콜레스테롤, 저밀도지단백콜레스테롤)가 허혈성심장질환 발생에 미치 는 위험도를 파악하고자 19개 대학 및 종합병원의 건강검진센터에서 검진을 받은 417,642명을 대상으로 1993년 9월 부터 2009년 6월까지 평균 8.5년동안 허혈성심장질환의 발생을 추적관찰하였다. 자료수집은 검진자들에 대한 설문조 사지를 이용하였고, 허혈성심장질환의 발생여부는 국민건강보험공단의 데이터베이스에서 확인하였다. 발생률은 발생밀 도로 계산하였고, 혈청지질 지표에 따른 허혈성심장질환의 발생 위험도는 콕스의 비례위험 회귀모형을 이용하여 연 령, BMI, 생활양식을 보정한 상태에서 성별에 따른 위험요인별 위험비와 95% 신뢰구간을 계산하였다. 연구결과 TC/HDL 비의 증가에 따라 IHD의 발생 위험비는 남자에서 1.21배에서 1.84배까지, 여자는 1.26배에서 1.86배까지 증 가하였으며, TG/HDL 비의 증가에 따른 IHD의 발생 위험비는 남자에서 1.17배에서 1.49배까지, 여자는 1.42배에서 1.97배까지, LDL/HDL 비에 따라 IHD의 발생 위험비는 남자에서 1.26배에서 1.82배까지, 여자는 1.26배에서 1.68배까 지 증가하였다. 결론적으로 혈청지질지표는 심혈관질환의 중요한 위험요인으로 총콜레스테롤, 저밀도지단백콜레스테롤, 중성지방은 혈 중 농도가 높을수록, 고밀도지단백콜레스테롤은 낮을수록 IHD의 위험이 높아지는 것으로 나타났고, TC/HDL 비, TG/HDL 비, LDL/HDL 비에서 단독의 지질지표보다 위험도가 더 높게 나타나는 경향이 있었다. 따라서 추후 허혈성 심장질환의 예방 및 관리에는 혈청지질지표의 비도 감안하여야 한다. This study conducted to investigate incidence rate and association of serum lipid profiles with incidence of ischemic heart disease. Study subjects consisted of 417,642 adults aged 30 years and over, who underwent physical examination and responded to questionnaire from health examination center of 19 university general hospitals. Hazard ratio of risk factor for ischemic heart disease (IHD) were calculated by Cox's proportional hazard regression model adjusted for ages, BMI and lifestyle (drinking, smoking and exercising). For TC/HDL ratio, hazard ratio of IHD in male increased from 1.21 times to 1.84 times increase with TC/HDL ratio, and that in female also increased from 1.26 times to 1.86 times. For TG/HDL ratio, hazard ratio of IHD in male increased from 1.17 times to 1.49 times increase with TG/HDL ratio, and that in female also increased from 1.42 times to 1.97 times. For LDL/HDL ratio, hazard ratio of IHD in male increased from 1.26 times to 1.82 times increase with LDL/HDL ratio, and that in female also increased from 1.26 times to 1.68 times. In conclusion serum lipid indexes are the significant risk factors for cardiovascular diseases. The higher the concentration of TC, LDL and TG is, the lower the concentration of HDL is, hazard ratio for IHD increased. Ratio of TC/HDL, TG/HDL and LDL/HDL were also verified to be significant risk factors for IHD.

갈조류 에탄올 추출물의 항산화 활성

신숙희 ( Sook Hee Shin ),강상모 ( Sang Mo Kang ) 한국미용학회 2021 한국미용학회지 Vol.27 No.4

This study attempted to investigate the functionality of Dactylosiphon bullosus, Sporochnus radiciformis, and Zonaria diesingiana extracts among algae as cosmetic ingredients. For this, antioxidant experiments were performed. D. bullosus, S. radiciformis and Z. diesingiana extracts were prepared with a 70% ethanol concentration to measure antioxidant activities. In terms of DPPH radical scavenging activity, Z. diesingiana was the highest with 94.20±0.28%. In ABTS radical scavenging activity, Z. diesingiana was the highest with 96.26±0.98%. In terms of the total phenolic contents and NO radical scavenging activity, Z. diesingiana was the highest with 47.19±2.07 mg gallic acid/g and 92.87±1.79%, respectively. The above results show that Z. diesingiana extract has the greatest antioxidant activity, confirming its potential as a cosmetic ingredient.

밀도 개념 학습에서 자기 조절 전략과 인지 갈등 및 개념 변화의 관계

강석진,신숙희,노태희,Kang, Suk-Jin,Shin, Sook-Hee,Noh, Tae-Hee 대한화학회 2002 대한화학회지 Vol.46 No.1

In this study, students' responses to anomalous data in studying ‘density' were analyzed, and the relationships among trait/state self-regulation strategies, the degree of cognitive conflict, and conceptual change were examined. A trait self-regulation strategy test, a preconception test, and a test of response to anomalous data were administered to 352 eighth graders. Among them, 146 students whose preconceptions were consistent with the presented initial theory were selected. After they had read a scientific explanation, a state self-regulation test and a researcher-made conception test were administerd. There were no significant correlations among the subcategory scores of trait/state self-regulation strategies and the degree of cognitive conflict. The scores of the conception test were significantly correlated with those of trait planning, trait effort, state planning, state self-monitoring, and state effort. State effort was only a significant predictor on students' conceptual change. 본 연구는 밀도 개념 학습에서 학생들의 변칙 사례에 대한 반응을 분석하고, 특성 및 상태 자기 조절 전략과 인지 갈등 및 개념 변화의 관계를 조사하였다. 중학교 2학년 학생 352명을 대상으로 특성 자기 조절 전략 검사, 선개념 검사, 변칙 사례에 대한 반응 검사를 실시하여, 제시한 초기 이론과 일치하는 선개념을 가진 146명을 선택하였다. 학생들이 과학적 원리를 학습한 후 상태 자기 조절 전략 검사와 개념 검사를 실시하였다. 특성 및 상태 자기 조절 전략의 하위 범주 점수들과 인지 갈등 정도는 유의미한 상관이 없었다. 개념 검사 점수는 특성 계획, 특성 노력, 상태 계획, 상태 자기 점검, 상태 노력 점수와 유의미한 상관이 있었다. 상태 노력만이 개념 변화에 대한 유의미한 예언 변인이었다.

유방암 수술환자가 Tamoxifen복용기간 중 발생하는 FSH와 E2의 수치 변화

권원현,문기춘,김혜숙,이인원,신숙희,Kwon, Won-Hyun,Moon, Ki-Choon,Kim, Hye-Sook,Lee, In-Won,Shin, Suk-Hee 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.2

Purpose: As many patients often showed the value of menopause although they were women of childbearing age, this study looked into their previous history. According to the findings, they were patients with a mastectomy due to breast cancer and were taking breast cancer treatment Tamoxifen (the women hormone inhibitor) after chemotherapy. This study is conducted to examine changes in FSH and E2 concentration of patients breast cancer patients of childbearing age according to Tamoxifen used to prevent recurrence of breast cancer and proliferation of mammary parenchyma. Materials and Methods: This study aims to investigate similarity in patients treated with surgery who were in their childbearing age and in values of FSH and E2 by dividing test results of FSH and E2 requested at the department of nuclear medicine among patients who visited this hospital from Jan. 2009 to Mar. 2010 into women of childbearing age (n=50), menopausal women (n=50), and patients with breast cancer surgery who take Tamoxifen (n=50) and then comparing the test results. Results: The FSH and E2 test results of 50 patients were compared and analyzed as average${\pm}$standard deviation, and the results showed that the figure of women of childbearingage (n=50) was FSH : $7.14{\pm}6.19$, E2 : $138.76{\pm}85.40$, that of menopausal women (n=50) was FSH : $52.12{\pm}24.43$, E2 : $15.06{\pm}4.43$, and that of patients with breast cancer surgery who were in their childbearing age (n=50) was FSH : $44.21{\pm}21.07$, E2 : $13.53{\pm}4.26$. When these different results of FSH and E2 were compared, the value of patients with breast cancer surgery who were in their childbearing age with Tamoxifen was somewhat similar to that of menopausal women. Conclusion: The test results of FSH and E2 have reportedly found the test values of patients with breast cancer surgery could be similar to that of menopausal women eventhough they were in their childbearing age due to the women hormone inhibitor Tamoxifen. Therefore, if a tester conducts this experiment after understanding the clinical meaning, the reliability of the tester reporting test results would be increased.

변칙 사례에 대한 초등학생들의 반응 연구

강석진(Suk Jin Kang),신숙희(Sook Hee Shin),노태희(Tae Hee Noh) 한국과학교육학회 2002 한국과학교육학회지 Vol.22 No.2

The types and the characteristics of students` responses to anomalous data in studying `boiling point` were investigated, and the degree of cognitive conflict and conceptual change were compared by students` cognitive variables. Tests regarding field dependence-independence and logical thinking ability, a preconception test, and a test of responses to anomalous data were administered to 137 sixth graders. Among them, 90 students whose preconceptions were consistent with the presented initial theory were selected. After learning the scientific concept, students` conceptual change was examined. Six types of responses identified were as follows: Rejection, reinterpretation, exclusion, uncertainty, belief decrease, and theory change. The main responses were rejection (33%) and theory change (39%). The results of Mann-Whitney U test indicated students who were field independent and had higher logical thinking abilities felt more cognitive conflict and exhibited more conceptual change.

겨우살이 Lectin의 간기능 영향

장철수 ( Choul Soo Chang ),신숙희 ( Sook Hee Shin ) 대한임상검사과학회 2002 대한임상검사과학회지(KJCLS) Vol.34 No.2

In the present study, the author investigated changes in liver function caused by Viscum album lectin. πle lectin was purified by 0.15 M NaCl extraction, amnonium sulfate precipitation, sepharose 4B affmity chromatography and gel filtration using sephadex 0-150 with plant material from Viscum album collected in Mt. Duk Yui. After 72 h of CC14 iniection (in olive oil, 1:1, 2 mg/kg) there was a significant increase in serum AST and AL T levels relative to the control group. However, treatment. of either Viscum album extracts and purified lectin offered no protection against CC14-induced hepatotoxicity. Histological observation basically supported the resu1t obtained from serum enzyme assay. The livers of rats challenged with CC14 produced a marked increase in cytoplasmic vacuoles and inflammatory cells in number, while the number of necrotic cells and swollen hepatocytes did not change significnatly. Rats administered olive oil alone did not have a change in the normal hepatic architecture. Histological observation of a liver section in rats treated 72 h with either Viscum album extract or purified lectin CC14-induced liver damage showed numbers of cytoplasmic vaculoe and necrotic cells. The numbers of inflammatory cells were, however, increased markedly. πle nurmal hepatic architectural pattem was lost in a Hematoxylin-eosin stain. These results suggest the conc1usion that Viscum album lectin has a physiological effect of hepatotoxicity activator.

Fasting Urine을 사용한 Microalbumin의 참고치에 관한 연구

김지영 ( Ji Young Kim ),진광호 ( Kwang Ho Jin ),배애영 ( Ae Young Bae ),김예나 ( Ye Na Kim ),서상원 ( Sang Won Seo ),이나리 ( Na Ree Lee ),전하영 ( Ha Young Jeon ),신숙희 ( Sook Hee Shin ) 대한임상검사과학회 2006 대한임상검사과학회지(KJCLS) Vol.38 No.3

Microalbuminuria is most frequently caused by kidney damage from diabetes. Moreover, many other conditions can lead to kidney damage, such as high blood pressure, heart failure, cirrhosis, or systemic lupus erythematosus (SLE). The measurement of the microalbumin in urine may be useful for the early diagnosis or as a predictor of nephropathy in diabetes. The most common method for getting a quantitative measurement of urinary protein relies on a 24-hour urine collection. The result of this method is accurate. But 24hr urine collection is difficult to obtain and variations in volume are frequent. Also the patients complain about urine collection. We tried to measure reference values for microalbumin using fasting urine and compare them with the albumin/creatinine ratio using 24hr urine. The concentrations of microalbumin in fasting urine and 24hr urine were 7.1±3.8 mg/L, 5.7±2.9 mg/L (r=0.61, p=0.27), respectively. The albumin/creatinine ratios using fasting urine and 24hr urine were 8.7±4.2 g/mg, 8.7±4.0 g/mg (r=0.76, p=0.88), respectively. This study indicated that the measurement of microalbumin in fasting urine was an easy and simple method for early diagnosis or to predict nephropathy in diabetes. Thus, setting up the reference value using fasting urine may be useful in the screening test for the diabetic nephropathy patients instead of using the 24hr albumin excretion rate (AER).

『 일명 그레이스 』에 나타난 여성의 역사인식

김순식,신숙희 明知大學校 人文科學硏究所 2005 인문과학연구논총 Vol.27 No.-

The heroine, Grace Marks, in Alias Grace by Margaret Atwood is represented as a woman historiographer. Her name is very ironic compared to the title of the book. It is compounded with the two nouns, grace and marks. Although its literal meaning is glory and traces, it is twisted metaphorically. Grace suffers to death and experiences the crisis of memory lapse and erasing. At the beginning of the novel, she is presented as an “unnameable” being based on her race, gender and class and further as an “unspeakable” being because she is a murderess. As a subaltern she doesn’t have her own traces and voices in the official discourses. Her story is fabricated in a wrong way by the male “authorities” and historians. In spite of her confined environment, Grace can threaten and disrupt the patriarchal discourses by storytelling with her clever use of free-association and dreams. The androcentric texts have many unfilled gaps and holes so that Grace fills them with her own story and historical self-consciousness, And she turns her role to be the deliberate quilt narrator. In the process of rethinking of History, Grace dialogically struggles for the textual space and reconstructs both her hidden/lost stories and the other women’s lives.