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- 저자 : 신금백 (검색결과 67 건)
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신금백 中央醫學社 1989 中央醫學 Vol.54 No.7
The purpose of this study is to evaluate the possibilities of conservation of auto- and homo-transplanted, oral carcinoma experimentally induced by a chemical carcinogen through gross and histopathologic observation. 70 male ; Syrian hamsters were employed in this study, divided into 1 control and 3 experimental groups. .16 animals in control received no treatment. ,34 animals in experimental group 1 had the left pouch mucosa painted 3 times weekly with 0.5% 9,10-dimethyl1,2-benzanthracene (DMBA) in mineral oil. Each 2 animals in control were sacrificed in 4, 6, 8, 10, 12, 14, 16, 20 weeks after experiments, and each 4 animals in experimental group I were sacrificed in 4, 6, 8, 10, 12, 14 weeks after experiments. The pouch mucosae of animals in control and experimental group were removed and routinely processed via hematoxylin-eosin. (H-E) staining for histopathologic observation. Also the left tumorous pouch mucosae of 10 animals among experimental group 1 survived till 16 weeks during experiments were removed and divided into 4 pieces. Among above specimens 1 piece was routinely processed via H-E staining for histopathologic confirmation of carcinoma, and another 1 piece was autotransplanted into pouch mucosa of opposite side in same animal. Also another 1 piece was homotransplanted into pouch mucosa of another 10 Syrian hamsters of experimental group 2, and the other piece was homotransplanted into pouch mucosa of another 10 Syrian hamsters of experimetal group 3 which were injected intramuscularly into femoral muscle 3 times weekly with 5 mg/kg hydrocortisone sodium succinate (HSS) for 16 weeks. After auto- and homo-transplantation the changes of transplanted site were grossly observed, and each 'S animals in each experimental group were injected with HSS for 4 weeks under above conditions. Also the specimens from all transplanted sites in all experimental groups were routinely processed via H-E staining for histopathologic observation. The obtained results were as follows: 1. In general hamster. pouch;, mucosae showed.'.lustopathologic :features of epithelial dysplasia in 10 weeks and carcinoma in 12 weeks under application of 0.5% DMBA in mineral oil 3 times weekly. 2. In general the possibility of conservation of transplanted experimental hamster pouch carcinoma induced by DMBA was lower in homotransplantation than in autotransplantation into hamster pouch mucosa. 3. In general the possibility of conservation of homotransplanted experimental hamster pouch carcinoma induced by DMBA was higher in experimental group 3 ( pre-transplantation-injected with HSS for 16 weeks) than in experimental group 2(: not pre-transplantation-injected with HSS): 4. In general the possibility of conservation of transplanted experimental hamster pouch carcinoma induced by DMBA was not influenced by post-transplantation-injected with HSS for 4 weeks.
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구강병소에 대한 펄스형 Nd: YAG 레이저의 치료효과
신금백 대한안면통증구강내과학회 1997 Journal of Oral Medicine and Pain Vol.22 No.2
In order to set the lasing variables and evaluate, clinically, the therapeutic effects of a pulsed Nd:YAG laser on oral lesion, the author applied the laser energy from a fiberoptic delivered, free running, pulsed Nd:YAG laser (wavelength 1064nm, Pulse duration 120$\mu$sec, fiber diameter 200$\mu$m/320$\mu$m) to 22 cases of oral soft tissue lesions and 6 cases of oral hard tissue lesions. The obtained results were as follows : 1. The effective excision with contact mode and the effective hemostasis of accompanied bleeding with noncontact mode were occurred by lasing on oral soft tissue lesions with fiber diameter of 320$\mu$m under the variables of 2.0~4.0W and 20~50Hz which were controlled into high power/low pulses for excision, low power/high pulses for hemostasis, low power in granulation tissue and high power in fibrous tissue according to therapeutic goals and tissue conditions. 2. About 50% of decreasing effect on hypersensitivity was occurred by lasing with non-contact and contact mode on cervical abrasion which caused dentinal hypersensitivity with fiber diameter of 320$\mu$m under the variables of 0.7 - 1.0W and 10Hz which were applied 2~3 times with 1 week interval. 3. The effective sterilization of infected root canal and lesion of periapical abscess was occurred by lasing with contact and spiral modes on wall of root canal and periapical abscess with fiber diameter of 200$\mu$m of which the tip was placed about 1mm shorter than root canal length under the variables of 1.OW and 10Hz.
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신금백,강기현,채규삼,Shin, Keum-back,Kang, Kee-hyun,Chae, Gyu-sam 대한안면통증구강내과학회 1999 Journal of Oral Medicine and Pain Vol.24 No.2
최근 저자들은 좌측 안검하수, 안면마비, 좌측 협궁부의 부종 및 안모비대칭을 호소하는 49세 한국 여성 환자로부터, 임상적으로 우측 하악지 부위에서의 융기성 경결성 병소를 발견하고, 이에 대한 진단 및 감별진단을 위해 (1) 문진상 직장 선암(直腸 腺癌)에 대한 과거 수술병력 소견, (2) 두부 전산화단층촬영사진상 우측 하악지 전내방에서의 비교적 균질한 괴(塊)의 존재와 이것에 의한 우측 하악지 내측 피질골의 파괴, 또한 경사대(傾斜臺)를 중심으로 뇌실질 조직에 비해 약간 고밀도를 보이는 불규칙한 괴(塊)의 존재와 이것에 의한 접형동(蝶形洞)과 주변 골 및 좌측 상악골의 파괴, 그리고 전신 골스캔상 비강 부위와 좌측 상악골 부위에서의 hot spot의 존재, 그리고 후전방 흉부 일반방사선촬영사진상 전폐야에 걸친 다양한 크기의 수 많은 결절의 산재를 나타낸 영상화 검사 소견, (3) 과거 전신병력 추적 소견상 간 우엽에서의 중심부에 hyperechoic focus를 가진 과녁 모양의 경계가 양호한 괴(塊)의 존재를 나타낸 간부위 초음파 검사 소견을 채득한 후 이들 자료를 종합, 분석, 평가한 결과, 과거 전신병력상의 원발성 직장 선암의 원격 전이에 의해 발생된 것으로 판단되었으며, 또한 영상화 검사에서 관찰된 우측 하악지 내측 피질골의 파괴상 및 좌측 상악골의 파괴상 역시 원발성 직장 선암의 원격 전이에 의해 발생된 것으로 판단되었다. The authors experienced a oral carcinoma involving the medial cortex of the right ramus of mandible and the left side of the maxilla which was metastasized from primary rectal adenocarcinoma based on the comprehensive evaluation of data obtained from (1) the past medical history of primary rectal adenocarcinoma, (2) the computerized tomographic views of the homogeneous mass on the anteromedial region of the right ramus of mandible destructing the medial cortex of the right ramus of mandible, and the irregular mass around the clivus spreading into the sphenoid sinus and destructing the left side of the maxilla ; the bone scanning of hot spots on the nasal region and the left side of maxilla ; the posteroanterior chest radiographic view of multiple nodular radiopacities on the lung, (3) the retrospective review of the sonographic view of a hypoechoic, well-demarcated, target-like mass with central hyperechoic focus on right lobe of liver in a Korean female of 49-year-old who complained the ptosis of left eyelid, the swelling on left zygomatic area, the left facial paralysis, the facial asymmetry and a round-shaped, elevated lesion with a hematoma on the mucosa covering the right ramus of mandible.
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