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      • 청간탕가미방과 레보도파와의 상승 및 부작용억제 효과 연구

        송택진 경희대학교 대학원 2017 국내박사

        RANK : 248639

        Background and Purposes : This study was undertaken to evaluate the synergistic effect of the combination treatment of L-dopa and Cheunggantang-gamibang on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse models of Parkinson’s disease And also investigate the side effect reduction of the combination treatment of L-dopa and Cheunggantang-gamibang. Materials and methods : Male C57BL/6 mice were devided into 8 groups(n=8 in each group). MPTP in saline was injected at 30mg/kg/day once a day for 5 days to make Parkinson’s disease. After housing for 1 week, for various dose-treated groups, L-dopa of 5mg/kg, 10mg/kg and 20 mg/kg were administered intraperitoneally everyday for 8 days . Additionally, Cheunggantang-gamibang group Mice were fed an experimental diet supplement with Cheunggantang-gamibang everyday for 8 days. Behavior test including the cylinder test, the pole test, and the rotarod test was performed. And dyskinesia score was also evaluated. Immunohistochemical analyses were used to assess the expression levels of tyrosine hydroxylase (TH), FosB, Enkephalin, substance P in the brain And the concentration glutamate content of motor cortex. Results : The combination treatment shows improvement on motor function compared to L-dopa treatment. It can make reduce effective dose of L-dopa to improve behavioral deficit. The combination treatment group resulted significant reduction in the impaired motor activity. It helps L-dopa induced dyskinesia restored effectively. In immunohistochemical analyses, The combination treatment appeared decrease of FosB in ST and great increase of TH in SN. With the combination treatment, level of Enk in GPe was greatly reduced and level of SP in SNr was increased. The combination treatment increased glutamate contents effectively. Conclusion: The combination treatment Cheunggantang-gamibang with L-dopa shows synergistic effect and the side effect reduction. The present study suggests that Cheunggantang-gamibang may be promising as a complement drug for the treatment of PD patients.

      • 공중보건한의사를 대상으로 한 한의약공공보건사업의 개선방향

        송택진 원광대학교 한의학전문대학원 2012 국내석사

        RANK : 248639

        한의약공공보건사업을 실제 수행하고 있는 공중보건한의사들이 한의약공공보건 사업 수행과정에서 문제점으로 인식하고 있는 부분과 개선방향을 설문조사하고 이를 토대로 한의약공공보건사업 지원조직의 개선방향을 연구하였다. 1. 한의약공공보건사업의 활성화 여부에 대해서는 한의약공공보건사업이 잘 이루어지고 있는 지 살펴본 결과 54.2%가 잘 이루어지지 않고 있다고 응답하였으며, 특히 연차가 높을수록, 허브보건소가 아닌 경우 활발히 이루어지지 않는 것으로 조사되었다. 2. 한의약공공보건사업이 잘 이루어지지 않는 이유에 대하여 살펴본 결과 표준화된 매뉴얼과 기술지원 부족을 가장 큰 이유로 꼽았으며, 사업진행을 위한 교육 및 훈련부족, 사업담당 공무원의 협조부족, 잦은 인력교체로 인한 사업의 연계성 유지 미비의 순으로 나타났다. 3. 한의약공공보건사업 활성화를 위해서는 예산확보 및 시설, 장비의 확충을 가장 많이 응답하였으며, 보건인력 양성 과정 내 한의약 공공보건사업 교육과정 개설 및 전문인력 양성, 지속적이고 체계적인 전문인력의 상주 순으로 조사되었다. 4. 한방공공보건평가단의 건강증진재단과 통합에 대하서는 4.07(5점 만점)로 통합이 필요하다고 응답하였다. 통합이 필요한 이유에 대해서는 한의약공공보건사업이 국가 공공보건시스템 안으로 포함되기 위한 필수적 절차이기 때문이라는 응답이 가장 많았으며, 통합이 필요없는 이유에 대해서는 통합될 경우 한의약의 독자적 특징을 인정받기 어렵다는 응답이 가장 많았다. 이상의 결과를 살펴보면 한의약공공보건사업의 활성화를 위해서는 예산확보 및 시설․ 장비의 확충, 보건인력 양성 과정 내 한의약 공공보건사업 교육과정 개설 및 전문인력 양성, 지속적이고 체계적인 전문인력 상주 등 정책적인 육성이 필요하며, 한의약공공보건사업의 효율적인 지원을 위해서는 현재의 한방공공보건평가단을 해소하고 건강증진재단으로의 통합 등 발전적 방안을 모색할 필요가 있다 생각된다. 주제어 : 한의약공공보건사업, 공중보건한의사, 한방공공보건평가단 This study was to conduct a questionnaire survey of Public Health Oriental Medical Doctors (PHOMDs) who had participate in the Traditional Korean Medicine Healthcare Program (TKMHP) about their perceived problems and solutions, and to make suggestions to improve the organizations supporting the TKMHP on the basis of the results of the said survey. 1. Regarding the question about whether the TKMHP had been activated well, 54.2% of the respondents answered that it had poorly operated, especially at older and non-Hub Health Centers. 2. Concerning the reasons why the TKMHP had poorly operated, the lack of standardized manuals and technical supports ranked first, followed by insufficient education and training for program implementation and operations, inadequate cooperation and assistance of officials in charge of the program, and too frequent personnel changes leading to interrupted program operations. 3. For the question about considerations required to activate the TKMHP, the answer of increasing the budget, facilities and equipments was chosen by the most respondents, followed by introducing a TKMHP training course in the educational courses for healthcare professionals and developing professionals, and sustainable and systematic residence of professionals. 4. Regarding incorporation of the National Traditional Korean Medicine Research & Development Center (NTKMDC) in the Korea Health Promotion Foundation (KHPF), the respondents answered that such the incorporation would be necessary as much as 4.07 points (5 points of a perfect score). As the reasons why such the incorporation would be required, the answer of because it would be essential to incorporate TKMHP into the national public health system was predominant, whereas as the reasons why such the incorporation would be unnecessary, the answer of because it would be difficult to accept the unique characteristics of traditional Korean medicine was predominant. Based upon the results mentioned above, it is considered that activation of the TKMHP will require politic supports such as increasing the budget, facilities and equipments, introducing a TKMHP training course in the educational courses for healthcare professionals and developing professionals, and sustainable and systematic residence of professionals, and it will be necessary for more efficient supports for the TKMHP to seek substantially evolutive strategies, e.g., incorporation of the current NTKMDC into the KHPF keywords : Traditional Korean Medicine Healthcare Program, Public Health Oriental Medical Doctors, National Traditional Korean Medicine Research & Development Center

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