갈근 에탄올추출물의 국소뇌허혈 모델에 대한 뇌신경보호 효과

송정빈,최진규,이동헌,Bhakta Prasad Gaire,이창원,부영민,최호영,김호철 대한본초학회 2012 大韓本草學會誌 Vol.27 No.6

Objectives: The purpose of this study was to evaluate the neuroprotective effect of Pueraria lobata extract on focal cerebral ischemia in mice. Methods: Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery using the intraluminal filament model. ICR male mice underwent 90 minutes of middle cerebral artery occlusion (MCAo) followed by 24 hours of reperfusion. Mice were administered Pueraria lobata extract orally at the dose of 300mg/kg just prior to reperfusion. Rotarod test and balance beam test were practiced to assess sensory-motor function 23 hours after MCAo. In rotarod test, the latency to fall on the accelerating rotarod was recorded for 5 min. In balance beam test, the score was graded according to number of slips and latency to cross. The infarct volume was measured 24 hours after MCAo using 2% 2,3,5-triphenyltetrazolium chloride (TTC) staining. Results: Pueraria lobata extract treated group showed significant reduction in infarct volume by 27.3% compared to control group (p<0.05). In rotatod test, it also showed significant extension of latency time compared to control group (67.82±15.08 vs. 5.62±1.06, p<0.001). In contrast to performance in rotarod test, that in balance beam test did not improve with Pueraria lobata extract treatment. Conclusions: We conclude that Pueraria lobata extract has a significant neuroprotective effect and reduces damage of sensory-motor function in MCAo model. These findings suggest that Pueraria lobata could be a potent neuroprotective agent.

자가진단에 따른 여성의 모발 및 두피관리 태도에 대한 연구

송정빈,김진숙 한국인체미용예술학회 2017 한국인체미용예술학회지 Vol.18 No.2

This study attempted to investigate hair and scalp care attitudes through self-diagnosis. The following research problems were examined to suggest a direction for hair and scalp care and for use as basic data for home care suggestions. First, the demographic characteristics of subjects were analyzed. Second, hair and scalp care self-diagnosis was examined. Third, demographic characteristics by hair and scalp care self-diagnosis were investigated. Fourth, differences in care attitude by self-diagnosis were examined. For empirical analysis on the purpose of the study, women living in Seoul were examined from November 1 to 20, 2016. The results found the following: First, hair and scalp care attitudes are comprised of four elements: interpersonal relationships, psychological stability, conspicuous consumption and hygienic management. Second, according to hair and scalp care self-diagnosis, ‘good scalp condition’ was higher than ‘poor scalp condition.’ Third, in terms of hair and scalp care attitudes by age, high scores were found in 20s, 30s and 50s and older in interpersonal relationships. From a hygienic management standpoint, a significant difference was found in those in their 20s and 50s and older. In terms of marital status, ‘married’ revealed outstanding results from the perspective of interpersonal relationships. In terms of occupation, a significant difference was observed in hygienic management. For home care through self-diagnosis, it is necessary to use hair products or to color hair or perm properly. To have a better look, in addition, it is necessary to use related products such as hair treatment packs. Since these products include chemicals, however, they could cause some harm to the scalp. Therefore, it is necessary not to use these products too much and to keep the scalp clean and healthy through their proper use and through scalp massage.

범이론적 모형을 기반으로 한 여성의 두피 및모발관리행위 변화단계 분석 연구

송정빈,김진숙 한국인체미용예술학회 2018 한국인체미용예술학회지 Vol.19 No.4

This study analyzed the stages of change in women’s scalp and hair care behavior based on a transtheoretical model. For this, such changes with influence on hair care to allow individuals to keep engaging in hair care behavior were investigated and the differences and effects examined. The results found the following: First, both density and sensitivity in the characteristics of scalp and hair health according to the two groups differed by point in time. Second, in terms of hair thickness by scalp and hair care, no difference was found between the two groups. Between timing and group, a statistical significance was observed. Third, no statistically significant difference was detected between the groups before and during application of the stages of change. After application, however, statistical significance was found. Fourth, in terms of decision balance in scalp and hair care habits after the application of change stages, no statistically significant difference was found after the application of change stages in the experimental group. In decision balance after the application of change stages in the control group, on the contrary, a significant difference was detected in positive differences. Fifth, in terms of self-efficacy of hair care habits after the application of change stages, no statistically significant difference was observed. Sixth, regarding changes in scalp and hair care behavior after the application of change stages, no significant difference was found in all sub-factors in the experimental group. There was a definite change in scalp care in the experimental group. With the change in scalp and hair environments in the experimental group, the effects of simple scalp massage and scaling were confirmed.

Thermal and Electrical Properties of Thermal-Grease-Insulated REBCO Superconducting Coils With Respect to Winding Tension

송정빈,최윤혁,양동규,김영균,김성겸,최연석,이해근 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.5

This study investigates the thermal and electrical characteristics of a silicon-based grease insulation (GI) GdBCOcoil with respect to the winding tension through charge, sudden discharge, and over-current tests. Charge and suddendischarge test results demonstrate that the charging/discharging delay time increases as the winding tensionincreases; this is because the characteristic resistance of the coil decreases due to the reduced contact resistance. The over-current test results confirm that the thermal/electrical stabilities of the GI coil are considerably enhancedwith an increased winding tension resulting from improved thermal contact and the decrease in the electrical contactresistance between the turn-to-turn layers of the coil. Thus, as the winding tension increases, the charging/dischargingrates decrease whereas the thermal/electrical stabilities improve. Overall, selecting the appropriate windingtension for a GI coil is critical for achieving thermal/electrical stabilities, as well as ameliorating the charging/dischargingdelay phenomenon generally observed in a no-insulation coil.

Neuroprotective effects of herbal mixture HT070 on global cerebral ischemia in rats

송정빈,이동헌,김영식,이현정,이승경,김동국,강신호,신용국,최호영,김호철 대한본초학회 2016 大韓本草學會誌 Vol.31 No.4

Objectives : HT070 is a mixture of herbal extracts from root of Scutellaria baicalensis and stem bark of Eleutherococcus senticosus, which have long been used for stroke therapy in traditional Korean Medicine. The purpose of this study was to investigate the neuroprotective effects of HT070 on global cerebral ischemia and its potential mechanisms. Methods : Transient global cerebral ischemia was produced by 10 min of four-vessel occlusion (4-VO) in male Wistar rats. HT070 was administered orally at a dosage of 200 mg/kg twice at 0 and 90 min after reperfusion. Hippocampal neuronal damage was measured 7 days after reperfusion. To explore the potential mechanisms, we used hydrogen peroxide (H2O2)-induced rat pheochromocytoma (PC12) cells as an in vitro model. PC12 cells were pretreated with HT070 for 1 h and then exposed to 100 μM H2O2 for 6 h in the presence of HT070. Cell viability was measured by MTT assay and the mRNA expression of Bax, Bcl-2, iNOS and COX-2 were measured by quantitative RT-PCR. Results : Oral administration of HT070 at a dose of 200 mg/kg significantly reduced neuronal death in the hippocampal CA1 region by 13.4% as compared to the vehicle-treated group. HT070 increased cell viability, reversed the down-regulated Bcl-2 mRNA level, and suppressed the up-regulated mRNA expressions of Bax, iNOS, and COX-2 in H2O2-treated PC12 cells. Conclusions : HT070 protects against delayed neuronal death after global cerebral ischemia and its neuroprotection properties might be attributed to the inhibition of mitochondrial apoptosis and ROS-generating enzymes.

가시오갈피 줄기의 조직별 유효성분 함량 및 항산화 효능 비교

송정빈,선매향,김영식,이동헌,김호철 한국약용작물학회 2017 한국약용작물학술대회 발표집 Vol.2017 No.09

22.9kV/630A 저향형 초전도 한류기용 전도-냉각 황동 전류인입선 제작 및 특성 실험

송정빈,김주형,권나영,김용우,김호민,심정욱,이방욱,김혜림,현옥배,이해근 한국초전도저온학회 (구 한국초전도저온공학회) 2007 한국초전도저온공학회논문지 Vol.9 No.3

Sprague-Dawley계 흰쥐를 이용한 HT042의 14일 반복 경구투여 독성연구

송정빈 ( Jungbin Song ),이동헌 ( Donghun Lee ),김영식 ( Young-sik Kim ),이승경 ( Seunggyeong Lee ),배진숙 ( Jin-sook Bae ),김호철 ( Hocheol Kim ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.1

Objectives : HT042 is a combination of three herbal extracts from the roots of Astragalus membranaceus , the stems of Eleutherococcus senticosus and the roots of Phlomis umbrosa, which has been demonstrated to increase longitudinal bone growth rate. The aim of this study was to assess the safety of HT042 after repeated oral administration. Methods : A 14-day repeated oral dose toxicity study was conducted using male and female Sprague-Dawley rats. HT042 was administered orally at repeated doses of 500, 1,000 and 2,000 ㎎/㎏/day for 14 days. Clinical signs and mortality were observed daily, whereas body weight and food consumption were recorded weekly throughout the experiment. At the end of the study, blood was taken from the posterior vena cava for hematology and serum biochemistry. All organs of the body surface, subcutis, head, thoracic cavity, and abdominal cavity were observed grossly. Then, the internal organs were removed and weighed. Results : No death occurred and no significant changes in clinical sign, body weight, food consumption and serum biochemistry parameters were observed in male and female rats over the study period. Although there were some alterations in hematologic and necropsy findings, and organ weights, these changes were not considered toxicologically significant. Conclusions : These results suggest that the 14-day repeated administration of HT042 does not produce any significant oral toxicity at doses of up to 2,000 ㎎/㎏/day in male and female rats under the present experimental conditions.

여성들의 자가진단에 따른 모발 및 두피관리 특성에 관한 연구

송정빈(Jeong Bin Song),김진숙(Jin Sook Kim) 한국뷰티산업학회 2017 뷰티산업연구 Vol.11 No.2

본 연구는 모발·두피관리의 자가진단을 통하여 모발·두피에 대한 관리특성은 어떻게 나타나는가에 대한 연구로 모발 및 두피관리 방향을 제시하고 홈케어 조언의 기초 자료로 활용될 것을 기대하며 다음과 같은 연구문제를 수행하였다. 첫째, 조사대상자의 인구통계학적인 특성을 알아본다. 둘째, 모발 및 두피관리 자가진단을 알아본다. 셋째, 모발 및 두피관리의 자가진단구분에 따른 인구통계학적 특성에 대해 알아본다. 넷째, 자가진단에 따른 관리특성에 대해 알아본다. 본 연구의 목적에 따른 실증조사를 위하여 서울지역의 여성을 대상으로 하였다. 연구결과 모발 및 두피관리 자가진단은 두피가 나쁜 상태의 경우보다 건강한 상태의 경우가 더 높았다. 모발 및 두피의 자가진단에 따른 행동관리특성 차이에서는 두피 및 모발관리를 위해 투자하는 시간은 하루에 10분 이내가 가장 많았으며 두피, 모발관리 비용으로 지출되는 금액으로 5만원 미만이 가장 많았다. 모발 및 두피의 자가진단에 따른 제품관리특성 차이에서는 두피. 모발관리 제품을 선택할 때 가장 중요하게 여기는 것은 제품의 효과로 나타났다. 본 연구는 대중화되는 두피모발관리 분야에 대한 관심의 초점이 자가진단에서 비롯됨을 인식하고 자가진단에 따른 관리태도를 분석하여, 앞으로 마련되어야 할 두피모발관리에 대한 기초자료를 제공하는데 의의가 있다. 본 연구의 후속 연구로 남성을 대상으로 하는 연구도 필요한 것을 보이며, 여성을 포함한 남성 또는 남성과 여성의 비교분석에 대한 연구도 이루어지길 바란다. 제언으로는 미용실이나 자가 샴푸시 사용제품에 대한 성분 분석, 사용법 등이 좀더 자세히 폭넓게 이루어져야하며 이에 대한 지식또한 쉽게 접할 수 있기를 바라며 이는 제품회사와 소비자 모두가 관심을 가져야 하는 부분이라고 생각한다. 또한 두피나 모발에 대한 교육프로그램도 좀 더 제공되어야 할 것이다. This study deals with the management characteristics of hair and scalp through self diagnosis of hair and scalp management, and suggested direction of hair and scalp management and expected to be used as basic data of home care advice, The study was expected to show the direction of hair and scalp management and serve as a base for home care advice, research questions as follows were carried out. First, we examine the demographic characteristics of the subjects. Second, the hair and scalp management self-diagnosis is examined. Third, the demographic characteristics of the hair and scalp management according to the self diagnosis classification are examined. Fourth, we examine the management characteristics of self-diagnosis. For the purpose of this study, women in Seoul area were selected for empirical survey. The results of the study showed that the hair and scalp management self-diagnosis was higher in the healthy condition than in the bad condition of the scalp. The difference in the behavioral management characteristics of the hair and scalp according to the self diagnosis is that the time for investing in scalp and hair care is less than 10 minutes per day, and the amount spent on hair and hair care costs was less than 50,000 won. The difference in product management characteristics due to self diagnosis of hair and scalp, the most important thing to consider when choosing a scalp and hair care product is the effectiveness of the product. As a result of analyzing the dietary management characteristics by self diagnosis of hair and scalp, foods that try to eat as often as possible, include bean curd and soybean products, vegetables, meat, fish, dairy products, nuts, eggs, and seafood. Also use hair products, dyeing, and ferm for home care due to self-diagnosis, should use products such as treatment packs to be beautiful in appearance, However, since they are also made of chemical products, they are not the only ingredients that are beneficial to the scalp. Therefore, avoid using a large amount of product, care about proper use and cleanliness including scalp massage.

Comparison of the Active Component Content and Antioxidant Activities of Different Parts of Eleutherococcus senticosus Stem

Jungbin Song(송정빈),Meixiang Sun(선매향),Young Sik Kim(김영식),Donghun Lee(이동헌),Hocheol Kim(김호철) 한국약용작물학회 2017 한국약용작물학회 학술대회논문집 Vol.2017 No.2