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한국인 여성에서 인터루킨-1 수용체 안타고니스트 유전자 다형성과 비만 및체질과의 관련성 연구
문성원 ( Seong Won Moon ),박종하 ( Jong Ha Park ),염승룡 ( Seung Ryong Yeom ),이수경 ( Soo Kyung Lee ),신병철 ( Byung Cheul Shin ),권영달 ( Young Dal Kwon ),송용선 ( Yung Sun Song ),최현주 ( Hyun Joo Choi ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.4
목적: Interleukin-1 receptor antagonist(IL-1ra)의 혈장 농도는 비만에서 증가되며 강한 유전적 통제를 받는다. 이에 비만과 IL-1ra 유전자 다형성 및 사상체질과의 관계를 연구하고자 하였다. 방법: 67명의 정상군, 133명의 과체중군, 61명의 비만군 대상자에서 IL-1ra 유전자의 intron 2에서의 penta-allelic 86-bp tandem repeat 빈도를 조사하였으며, IL-1ra의 유전자형은 PCR을 통해 분석하였다. 체지방량과 체지방률은 체성분분석기를 이용하였으며, 사상체질 분석은 QSCC II 프로그램을 이용하였다. 결과: 정상체중군에 비하여 과체중과 비만군에서 A1A2 carrier의 빈도가 높았으며, 대립유전자 2형 보유자의 빈도가 정상체중군에 비하여 과체중과 비만군에서 2배정도 높게 나타났으나 통계학적인 유의성은 없었다. 태음인의 빈도는 정상체중군에 비하여 과체중과 비만군에서 높게 나타났으며, 특히 IL-1ra A2- carrier인 과체중과 비만군에서의 태음인의 빈도가 높게 나타났다.결론: IL-1ra 유전자 다형성은 BMI에 대하여 중요한 영향을 주는 인자는 아닌 것으로 보이나, 본 연구는 비만과 비만 후보유전자로서의 IL-1ra 유전자의 다형성 및 사상체질과의 관계를 규명하려고 하였다는 데에서 그 의의가 있다.
절식요법(節食療法)을 시행한 환자들의 특성에 대한 임상적 고찰
문성원 ( Seong Won Moon ),김정환 ( Jeong Hwan Kim ),윤경환 ( Kyoung Hwan Yun ),김미영 ( Mi Young Kim ),임양의 ( Yang Eui Lim ),송용선 ( Yung Sun Song ) 한방비만학회 2003 한방비만학회지 Vol.3 No.1
Objectives: The aim of this study is to investigate the properties of the patients treated by fasting therapy. Methods: We measured PIBW, BMI, BFR and WHR of the patients and investigated the purpose of fasting therapy, the cause of weight increase, the times of weight increase, the duration of fasting therapy and the number of times of fasting therapy. Result: 1. The major age group was females in twenites. 2. The PIBW, BMI, BFR and WHR were highest in fifties. 3. In the purpose of fasting therapy, "for beauty" was the most. 4. In the cause of weight increase, diet disorder was the most. 5. The number of times of fasting therapy was the most in thirties. Conclusions: Above study shows that evaluation of obesity is important and more researches into fasting therapy were reguired.
체중감량(體重減量)을 목적(目的)으로 절식료법(節食療法)을 시행(施行)한 환자(患者)의 체성분변화(體成分變化)에 관한 림상적(臨床的) 고찰(考察)
문성원 ( Seong Won Moon ),박성철 ( Sung Cheul Park ),진신영 ( Sin Young Jin ),이수경 ( Soo Kyung Lee ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2002 한방재활의학과학회지 Vol.12 No.1
Objectives : The aim of this study is to investigate by evaluating body composition whether patients treated by fasting therapy maintain and improve their body compositions or not. Methods : We examined the body compositions of 20 patients three times(before fasting, on the 2nd refeeding day, over 3 months later) by In Body 2.0. Results : 1. From "before fasting" to "on the 2nd refeeding day", mean muscle mass was significantly decreased by 4.46±1.80kg(p<0.05), while from "on the 2nd refeeding day" to "over 3 months later", it was significantly increased by 3.16±1.35kg(p<0.05). 2. From "before fasting" to "on the 2nd refeeding day", mean body fat mass was significantly decreased by 3.59±2.79kg(p<0.05), and from "on the 2nd refeeding day" to "over 3 months later", it was also significantly decreased by 2.63±3.37kg(p<0.05). 3. From "before fasting" to "on the 2nd refeeding day", mean body fat rate was decreased by 0.54±2.17% but not significantly(p>0.05), and from "on the 2nd refeeding day" to "over 3 months later", it was significantly decreased by 4.06±2.88%(p<0.05). 4. From "before fasting" to "on the 2nd refeeding day", mean abdominal fat rate was significantly decreased by 0.02±0.02%(p<0.05), and from "on the 2nd refeeding day" to "over 3 months later", it was also significantly decreased by 0.03±0.03%(p<0.05). Conclusions : Body fat rate and abdominal fat rate were significantly reduced after fasting therapy by oriental medicine.
동서 협진 비만클리닉을 이용한 비만환자 37례에 관한 임상 관찰
김미영 ( Mi Young Kim ),문성원 ( Seong Won Moon ),이정한 ( Jeong Han Lee ),박진상 ( Jin Sang Park ),김혜정 ( Hye Jeong Kim ),신병철 ( Byung Cheul Shin ),송용선 ( Yung Sun Song ) 한방비만학회 2003 한방비만학회지 Vol.3 No.1
Objectives: The purpose of this study is to evaluate the effect of treatment in obesity clinic in east-west collaboration center, furthermore to search for how to join and improve east medicine and west medicine more closely. Methods: 37 patients were classified into four groups by Body Mass Index(BMI); normal, overweight, 1st obesity and 2nd obesity groups. Weight, BMI, body fat rate and abdominal fat rate were compared in each group by paired t-test. Results & Conclusions: In distribution of sex, male were 10(27%), female were 27(73%). Mean age was 34±13 and the patients in twenties were the most. Among four groups, the number of 2nd obesity groups was the most. Most patients had a preferance for western medication and ear acupunture therapy. In general we could find the correlation between the effect of obesity treatment and the degree of obesity. The more the obesity degree was, the more weight loss was.
박성진(Sung Jin Park),송성원(Seong Won Song),성동호(Dong Ho Seong),박동식(Dong Sik Park),김승섭(Seung Seop Kim),고징유(Gou Jinyu),안주희(Ju Hee Ahn),윤원병(Won Byung Yoon),이현용(Hyeon Yong Lee) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.8
발효더덕의 기능성식품 및 화장품 소재로서의 이용 가능성을 조사하기 위해 발효더덕의 열수 추출물의 총 페놀 함량, 총 플라보노이드 함량, 전자공여능, SOD 유사활성, 아질산염 소거능, 환원력을 측정하였다. 발효더덕 추출물의 총 페놀 함량은 2.79 ㎎/100 g, 총 플라보노이드 함량은 6.19㎎/100 g으로 생더덕보다는 총 플라보노이드 및 총 페놀화합물이 많이 함유한 것으로 나타났다. 전자공여능은 발효더덕 추출물에서 32.9~74.9%, 생더덕에서 8.0~17.9%의 범위로 발효더덕 추출물에서 비교적 높은 활성을 나타내었다. SOD 유사활성을 측정한 결과 생더덕 추출물은 0.6~16.5%, 발효더덕 추출물은 3.5~21.6%의 범위로 분석되었으며, 농도에 따른 유의적 증가 현상을 나타내었다. 아질산염 소거능은 모든 pH 조건(pH 1.2, 3.0, 4.2, 6.0) 하에서 발효더덕 추출물이 높은 아질산염 소거능을 나타내었으며, pH가 증가할수록 감소하였다. 환원력의 경우에는 발효더덕 추출물이 1,000㎍/mL에서 0.65의 값으로 가장 높은 활성을 보였다. 이상의 결과로부터 발효더덕 추출물은 항산화능이 있음을 확인할 수 있었으며, 발효더덕의 이러한 우수한 결과의 확인을 위하여 발효에 의한 성분 변화에 대하여 더욱 연구가 필요할 것으로 사료된다. To investigate the applicability of hot water extract from Codonoposis lanceolata (CL) and fermented Codonoposis lanceolata (FCL) as functional food and cosmeceutical material, its total phenolic contents, total flavonoids, electron donating ability (EDA), SOD-like activity, nitrate-scavenging ability (NSA), reducing power were examined. Total phenolic contents of CL and FCL were 0.54 ㎎/100 g and 2.79 ㎎/100 g, respectively, and total flavonoids contents were estimated as 2.26 mg/100 g for CL and 6.16 mg/100 g FCL. The EDA of CL and FCL were 8.0~17.9% and 32.9~74.9%. The SOD-like activities of CL and FCL were 0.6~16.5% and 3.5~21.6%, respectively, and the activity was dependent on the sample concentration. The NSA was pH dependent, and was the highest at pH 1.2 and the lowest at pH 6.0. The NSA of FCL was higher than that of CL. The FCL extract showed the highest reducing power (0.65) at the concentration of 1,000 ㎍/mL. Based on the above results, we deemed that the FCL might have potential antioxdant activities.
진신영 ( Shin Young Jin ),이수경 ( Soo Kyung Lee ),박성철 ( Sung Chul Park ),문성원 ( Seong Won Moon ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2002 한방재활의학과학회지 Vol.12 No.1
Objectives : There were few reports on the treatment of "YookWi" by oriental medicine. The study on the effect of the treatment conducted on the "Yookwi" patient will suggest the treatment plan for the more effective treatment. Methods : The acupuncture was accomplished by "Geum-Eum(金陰)" type method. The herbal medicine was given and the mat exercise was done one time a day. Results : After treatment, a remarkable improvement was not made for muscular strength. But the body weight and the circumferences of arm and thigh were little increased. Conclusions : The more study of the effective treatment on "Yookwi" is needed.