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5-Fluorouracil이 腸粘膜에 미치는 病理組織學的 變化에 對한 實驗 硏究
宋達孝 충남대학교 대학원 1975 論文集 Vol.4 No.-
The histopathological changes in the intestinal mucosa after 5-Fluorouracil, 200㎎/㎏ body weight, intraperitoneal injection were investigated, and the results obtained were as follows. 1. The retrogressive changes in the glandular and surface epithelium were most prominent at 3rd and 4th day after the drug administration. 2. The decrease of the goblet cells in the intestinal mucosa was in peak after 3rd and 4th experimental day, and the cells were completely disappeared from the mucosa. 3 The atrophic changes of the villi of the small intestine were more marked in the 3-4 day after drug administration. 4. The mitotic figures in the intestinal cryptal cells were significantly increased in numbers after 3 days in the colon and 6 days in the small intestine, respectively. 5. The dysplastic changes in the intestinal mucosa were appeared from 3rd to 7th experimental day and thereafter disappeared.
Recent advances of aromatic C-F bond borylation and its application to positron emission tomography
송달님,이상희,이병철,김상은,이은성 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2
Carbon-fluorine (C-F) bonds have been found ubiquitously in pharmaceuticals, radiopharmaceuticals, agrochemicals, and material science due to their unique properties such as thermal and oxidative stability and lipophilicity to improve bioavailability. For the past five years, there have been significant advances in F-18 fluorination of aromatic complex molecules combined with the development of late-stage fluorination reactions. More recently, direct incorporation of F-18 to fluorinated aromatic molecules via borylation of C-F bonds has been developed by Niwa and Hosoya. In this minireview, we will discuss the progress of C-F bond borylation of fluorinated arenes utilizing transition metal catalysts and the impact on the development of F-18 radiotracers for positron emission tomography (PET). J Radiopharm Mol Probes 1(2):80-87, 2015
송달원(Dal Won Song),손수길(Su Gil Sohn),최종원(Jong Won Choi),신승진(Seung Jin Shin),김태종(Tae Jong Kim),남성일(Sung Il Nam),안병훈(Byung Hoon Ahn) 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.1
Background and Objectives: Fine needle aspiration (FNA) cytology is a simple, safe and relatively accurate procedure of diagnosing thyroid nodules. Although the frozen section biopsy is well known as more reliable method than FNA and has high specificity, whether it is necessary it leaves room for adverse criticism. Authors have compared preoperative FNA cytology and frozen section biopsy with permanent histologic findings and evaluated the significance of FNA cytology and frozen section biopsy. Materials and Methods: The medical records of 110 patiens who underwent FNA cytology and frozen section during thyroidectomy from September. 1997 to December. 2001 at the Department of Otolaryngology, School of Medicine, Keimyung University were analyzed retrospectively. Results: Sensitivity, specificity, accuracy of FNA was 75%, 91.4%, and 85.5% respcetively. Sensitivity, specificity and accuracy rate of frozen section biopsy were 92.5%, 100% and 97.3% respectively. Conclusion: FNA is simple, with rare complication and its diagnostic accuracy is comparatively so high that it is being used as primary test to diagnosis thyroid nodules. But frozen section is more accurate and may be helpful to suspicious FNA findings or if it beyond capacity of FNA. Therefore despite of the fact that the intra-operative frozen is more expensive and time consuming, it is very helpful to the treatment of thyroid nodules by using jointly with FNA.