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      • KCI등재

        PPAR-$\gamma$ 조절을 통한 여택통기탕(麗澤通氣湯)의 항알레르기와 항염증 효과

        손정민,홍승욱,Son, Jung-Min,Hong, Seung-Ug 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.2

        Objectives : The aim of this study is to investigate the antiallergic effects of YTT on allergic rhinitis by regulation of peroxisome proliferator-activated receptor gamma (PPAR-$\gamma$). Methods : The thirty rats were divided into three groups : normal group, control (allergic rhinitis elicited) group, sample (Yeotaectonggi-tang treated after allergic rhinitis elicitation) group. To induce allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time rats in sample group were oral administration treated by YTT for 7days. The change of the amounts of eosinophil, substance P, MIP-2, PPAR-$\gamma$, IL-4, iNOS were observed in each group. we used the statistical method of ANOVA test(p<0.05). Results : The number of eosinophil in sample group noticeably decreased than control group. And the decrease of substance P and MIP-2 positive reaction were observed in mucosa. YTT inhibited IL-4 and iNOS production, mucus secretion, activation of mast cells and fibrosis remodeling by regulation of PPAR-$\gamma$ activation. Conclusion : According to the above results, it is considered that YTT mitigated mucosa damage on the mice model with allergic rhinitis by regulation of PPAR-$\gamma$.

      • KCI등재

        제천 지역 소재 초등학교 학생들의 아토피 피부염에 대한 설문조사 연구

        손정민,김희택,홍승욱,Son, Son-Jung,Kim, Hee-Taek,Hong, Seung-Ug 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.2

        Objective : The aim of this study was to take a census of elementary school children who have atopic dermatitis(AD) especially the residents of Je-Cheon. Method : We conducted a questionnaire survey of the elementary school children in Je-Cheon who have atopic dermatitis. 96 patients with AD were involved in the survey. The questionnaire was made up of their family history, past history, weaning food, breast-fed or not, dietary treatment and Children's Dermatology Life Quality Index(CDLQI), etc. The student's T-test was used for statistical analysis. Results : Parents and siblings brothers and sisters past history has an effect on patients with AD. With regard to past history of patients, allergic rhinitis was the most common ailment. Formula feeding was common in the group under 6 months of age and the mean age of the start of weaning was 7.25 months. Fruit juice and weaning food of powder type were the first weaning foods in this study. Many parents introduced a grain diet, live diet, bone - soup, egg, milk, cheese and bean curd to their children under 12 months of age. A restricted diet was the most common dietary treatment method in this study. The highest scoring question for CDLQI was itching; the lowest one was related to bullying. Conclusion : We analyzed the patients' family history, past history, weaning food, dietary treatment and Children's Dermatology Life Quality Index(CDLQI), etc. Through this survey, we better understand the actual conditions of elementary school children who had AD in Je-Cheon.

      • KCI등재후보

        아토피 피부염에서 유전자 연구와 사상체질의학적 접근의 상관성에 관한 문헌적 고찰

        손정민,최인화,Son, Jung-Min,Choi, In-Hwa 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.2

        Objectives: The objective of this study is to investigate the correlation between genetic studies on atopic dermatitis. sasang constitution, and sasang constitional study on atopic dermatitis. Methods: We retrieved data on PubMed for the papers of genetic study on atopic dermatitis. And for the papers on genetic study of sasang constitution and sasang constitional study of atopic dermatitis, we referred to papers have reported on domestic medical journal and domestic korean medicine journal. And we investigated correlations among the studies. Results: 1. There are two studies on genetic study on atopic dermatitis. One has been performed to find out genes related to atopic dermatitis by case-control study. The other has been to investigate the correlation between atopic dermatitis and the genes their functions were well-known. 2. Gene study on sasang constitution was performed to observe the distribution of the genes which is related with characteristics of sasang constitution, but there was no significant maldistribution of the genes. 3. There was no correlation between genetic study on atopic dermatitis and genetic study on sasang constitution. Conclusion & Discussion: In the Sasang constitutional study of atopic dermatitis, it seems that further studies on genes related to characteristics of skin, character affecting on behavior, and neurobiological difference among Sasang constitution are required as well as studies on distribution of genes related atopic dermatitis.

      • KCI등재

        태양광 적지분석에 기반한 친환경 주거단지 계획 - 대구광역시를 대상으로 -

        손정민,엄정희,SON, Jeong-Min,EUM, Jeong-Hee 한국지리정보학회 2017 한국지리정보학회지 Vol.20 No.3

        The purpose of this study was to determine a suitable site using GIS for solar energy harvesting for an administrative district in Daegu, which aims at becoming a solar-powered city. From this result, the ecological housing complex was planned on a solar theme in the real site. For this analysis, various indicators and standards were selected based on previous studies and the indicators were divided into the location, exclusion, and class condition. The results showed that the suitable area was $153.95km^2$ and 17.6% for Daegu area, and the highest suitable area appeared to Dalseong-gun. Finally, using suitable site analysis results, we selected the site of Sinseo housing area in Dong-gu and we planned the ecological housing complex for solar energy. This study can be used as base data for the Daegu solar business and its establishment by considering various indicators for analysis of suitable areas in solar energy. Also, the result of the ecological housing complex plan would be helpful in promoting Daegu as a solar-powered city. 본 연구에서는 솔라시티를 지향하고 있는 대구광역시를 대상으로 GIS 프로그램을 이용한 태양광 적지분석을 통해 적지유형을 분류하고, 구군별 적지현황을 알아보고자 하였다. 또한 이 결과를 바탕으로 실제 대상지를 선정하여 솔라에너지를 중심으로 한 친환경 주거단지를 계획하였다. 이를 위해서 기존 사례연구 고찰을 통해 태양광시설 설치 조건 및 기준을 확립하여, 적지 지표를 선정하였고, 선정한 지표를 입지조건, 배제조건, 등급조건으로 구분하였다. 분석 결과 대구광역시 태양광 적지면적은 총 $153.95km^2$로 대구광역시 면적 대비 17.6%를 차지하고 있었으며, 달성군에서 가장 크게 나타났다. 적지 지도를 바탕으로 대구광역시 동구 신서동에 위치한 단독주택단지를 대상지로 선정하여 솔라에너지를 중심으로 한 단지계획을 제시하였다. 본 연구는 대구광역시 태양광 적지분석에 있어 다양한 지표를 고려하고, 분석함으로써 향후 대구광역시 태양광 사업 및 정책에 기초자료로 활용될 수 있을 것이며, 계획한 친환경 주거단지는 솔라시티 대구광역시의 이미지를 명확하게 홍보하는데 기여할 수 있을 것으로 판단된다.

      • KCI등재

        반도체 광증폭기의 상호 이득 변조를 이용한 2.5 Gbps 다채널 가변형 파장변환기

        손정민,이상선,Son, Jung-Min,Lee, Sang-Sun 한국광학회 2005 한국광학회지 Vol.16 No.4

        본 논문에서는 파장 분할 다중화 방식 광통신에의 적용을 목적으로 하는 다채널 가변형 파장 변환기(Wavelnength Convertor)를 구성하여 이의 성능을 분석하였다. 파장 변환기는 반도체 광증폭기(SOA : Semiconductor Optical Amplifier)의 상호 이득 변조(XGM : Cross Gain Modulation) 특성을 이용한 파장 변환 방식이 이용되었다. 2.5 Gbps 광통신 기반 100 CHz의 채널 간격을 갖는 다채널 신호들에 대한 파장 변환 성능을 측정, 분석하였다. 본 파장 변환기의 상호 이득 변조 성능을 측정한 결과, 소광비(Extinction Ratio)와 비트 오류율(BER : Bit Error Rate) 등의 검증에서 2.5 Gbps 기반의 파장 분할 다중화 방식 광통신에 사용하기에 충분한 성능을 보였으며, 이를 통해 최근 개발된 상호 위상 변조 방식(XPM Cross Phase Modulation)의 다채널 파장 변환기와 비교해 상대적으로 간단한 구조를 가지고 제작 및 변조 효율에 우위를 보이는 파장 변환기로서 대체될 수 있음을 밝힌다. A new structure of tunable wavelength converter based on XCM in SOA was tried and analyzed. This converter used single SOA and had very simple structure. In this paper, results were experimentally obtained and demonstrated. Pump signal was generated with NRZ $(PRBS\;2^{31}-1)$ and data rate 2.5 Gbps. WDM multi conveted signals showed more than 8.3 dB extinction ratio. For BER performance, all these converted signals had within 5.0 dB power penalty compared with the pump signal. With these results, we showed that this converter was suitable for 2.5 Gbps WDM multi-channel wavelength converting.

      • KCI등재

        컴퓨터 집적 영상에서의 정교한 요소 영상 추출 및 전처리 방법

        손정민,유훈,Son, Jeong-Min,Yoo, Hoon 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.5

        In this paper, we propose accurate lattice extraction of elemental image array and pre-processing methods in computational integral imaging. Pre-processing methods remove distortions and noises of the image. Such distortions occurred in pickup systems are rotational errors. Distortions will degrade the resolution of reconstructed images. To overcome this problem, we propose our methods for extraction of elemental image array and pre-processing methods. Also, we describe that distortions affect the high quality reconstruction. Optical and computational experiments indicate that reconstructed images applied our methods is better than reconstructed images unapplied our methods. 본 논문에서는 컴퓨터 집적 영상에서의 정교한 요소 영상 추출 및 전처리 기술에 대해 제안한다. 전처리 기술은 영상 복원 과정 전에 영상의 왜곡 및 잡음을 제거하는 기술이다. 픽업 과정에서 발생된 왜곡 및 잡음은 주로 회전 왜곡으로, 복원된 영상의 화질을 저하시킨다. 이 문제점을 극복하기 위해서 요소 영상 추출 및 전처리 방법을 제안하고, 이를 통하여 왜곡 및 잡음이 영상 복원 과정에 미치는 영향에 대해서 설명하였다. 광학 및 컴퓨터 실험을 통하여 교정 전, 후의 복원 영상의 특성을 비교하였다.

      • KCI등재후보

        방풍통성산(防風通聖散)이 아토피 피부염을 유발한 동물모델의 피부 손상에 미치는 영향

        손정민,홍승욱,Son, Jung-Min,Hong, Seung-Ug 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

        Objectives : Atopic dermatitis has a close relationship with damage of skin barrier function. To investigate the effects of Bangpungtongsungsan(BT) extract to the skin damage on mice model after atopic dermatitis elicitation, this study was done through forcing injury to mice's skin. Methods : The BALB/c mice were distributed into three groups: control(CON) group, atopic dermatitis(AD)-elicited group, Bangpungtongsungsan(BT)-treated group. AD-elicited and BT-treated group were caused AD according to the method of Christophers E., Mrowietz and Minehiro. The BT extract was administered for 48 hours to BT-treated group. We observed changes of external dermal formation, eosinophils in vasculature, lipid formation in stratum corneum, distribution of ceramide, distribution of capillary, $I{\kappa}B$ kinase(IKK) and induce nitric oxide synthase(iNOS) mRNA expression. We used the statistical methods of student t-test(p<0.05). Results : After dispensing BT extract into the AD-elicited group, the number of eosinophil as an atopic index in mice noticeably decreased and dermal injury decreased. Also the decrease of hyperplasia, degranulated mast cells, angiogenesis and substance P were shown. The lipid lamellae, lipid protect formation, were repaired and the distribution of ceramide which inhibit protein kinase C(PKC) activation increased, and the PKC caused inhibition of nuclear $factor(NF)-{\kappa}B$ activation. As a result of inhibition of $NF-{\kappa}B$ activation, iNOS production were inhibited and apoptotic cell were increased. Moreover the decrease of IKK and iNOS mRNA expression in BT-treated RAW 264.7 cell were noted. Conclusion : BT mitigated skin damage on mice model after atopic dermatitis elicitation through recovering skin barrier function and inhibiting nuclear $factor(NF)-{\kappa}B$ activation.

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