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성원재,박성호,정윤철,한석길,김현영,김희태,김주한,김영서 대한신경과학회 2016 대한신경과학회지 Vol.34 No.3
Wernicke’s encephalopathy is an acute neurological deterioration due to a reversible brain lesion caused by thiamine deficiency. Most of the affected patients are thiamine-depleted alcoholics, and the condition usually involves the medial thalami, mammillary bodies, and periaqueductal area. However, there are rare reports of lesions in the cerebellum and cerebral cortex, especially in patients with nonalcoholic Wernicke’s encephalopathy. We report a case of nonalcoholic Wernicke’s encephalopathy involving atypical diffuse cortical regions, and review previously reported cases.
김희진,노민영,성원재,Mony de Leon,Elizabeth Pirraglia 대한고령친화산업학회 2022 대한고령친화산업학회지 Vol.14 No.2
Objective: Two core pathologies of Alzheimer's disease (AD), abnormal amyloid-beta protein deposition and increased hyper-phosphorylation of tau protein, vary according to the stage of disease. We investigated whether tau hyper-phosphorylation at serine 396 in the extra-neuronal stage of neurofibrillary tangles as an early biomarker. Methods: We studied 24 individuals with AD, 16 cognitive healthy normal controls (HC), and 19 individuals with mild cognitive impairment (MCI). We analysed cerebrospinal fluid concentrations of β-amyloid 1-40 (Aβ40), β-amyloid 1-42 (Aβ42) using sandwich ELISAs and Innotest for total tau (T-tau), phosphorylated tau 231, and phosphorylated tau 396 (P-tau 231, P-tau 396). Cerebrospinal fluid biomarkers of AD were evaluated for an association with clinical parameters and other related biological data. Results: Levels of P-tau 396 were lowest in HC compared to those in the AD and MCI groups (each p<0.001, and p=0.009). When Z-scores of total tau, P-tau 231, and P-tau 396 were compared among groups, the AD patients showed higher Z-scores of total tau and P-tau 231 than the other two groups. Differences in Z-score of P-tau 396 were observed between HC and the AD (p < 0.001) and MCI groups. The levels of Aβ42, Aβ40, T- tau, and P-tau 231 were correlated with clinical data and medial temporal atrophy in the AD and MCI groups. Conclusion: The levels of P-tau 396 in the cerebrospinal fluid showed significant differences between HC and the other two groups. Levels of P-tau 396 could be useful as a biomarker to predict disrupted neuronal integrity before the disease.
Hemorrhagic Listerial Encephalitis in a Patient with Systemic Lupus Erythematosus: A Case Report
이현규,이지영,이영준,김영서,김현영,성원재,박동우 대한영상의학회 2017 대한영상의학회지 Vol.76 No.5
A 31-year-old female with systemic lupus erythematosus (SLE) presented with fever, headache, seizures and mental status changes. Brain MRI showed T2 hyperintense lesions in the cerebellum and frontal white matter and a lesion in the cerebellum exhibited hemorrhagic changes and peripheral ring enhancement. The MRI features of listerial encephalitis are difficult to differentiate from those of neuropsychiatric SLE and various other diseases. Here, we report a case of hemorrhagic listerial encephalitis in a patient with SLE.