선천비진행야맹증의 분류와 다국소망막전위도 소견

성미선,박태관,온영훈,Mi-Sun Sung,Tae-Kwann Park,Young-Hoon Ohn 대한안과학회 2005 대한안과학회지 Vol.46 No.11

Purpose: To report on the classification of congenital stationary night blindness (CSNB) and multifocal ERG findings. Methods: We studied three patients (case 1-3) with night blindness but normal fundus and one patient (case 4) with decreased vision after trauma with respect to the patients` medical history, familial history, refraction, slit lamp examination, fundus examination, FAG, ERG, and multifocal ERG. Results: The ERG in case 1 showed a decreased rod response, and this patient was diagnosed with Riggs-type CSNB. The typical “negative ERG” was found in all three cases of ERG (except case 1), and these cases were diagnosed with Schubert-Bornschein-type CSNB. Based on Miyake`s classification, case 2 was incomplete, and cases 3 and 4 were complete. The mfERG of the cases with complete Schubert-Bornschein type had delayed implicit times of the first-order kernel and decreased amplitudes of the second-order kernel. The delayed implicit times and the decreased amplitudes of the first- and second-order kernels were found in the cases of Riggs- type and incomplete Schubert-Bornschein-type.

안와에서 발생한 혈관평활근종 1예

성미선,이민정,김남주,정호경,곽상인,Mi Sun Sung,Min Joung Lee,Nam Ju Kim,Ho-Kyung Choung,Sang In Khwarg 대한안과학회 2008 대한안과학회지 Vol.49 No.4

안와가성종양의 임상양상과 스테로이드 반응성에 대한 분석

성미선,오한진,고병이,윤경철,Mi Sun Sung,Han Jin Oh,Byung Yi Ko,Kyung Chul Yoon 대한안과학회 2013 대한안과학회지 Vol.54 No.2

Purpose: To evaluate the clinical features and treatment outcomes of steroid therapy for orbital inflammatory pseudotumor. Methods: Sixty-four patients diagnosed with orbital inflammatory pseudotumor were reviewed retrospectively. Patients with a follow-up period of less than 6 months were excluded from the study. The pseudotumor was classified into myositic, lacrimal, anterior, diffuse, or apical type according to orbital computed tomography findings. All patients were initially treated with systemic corticosteroids and evaluated for response to the treatment. Treatment outcome was considered a “success” if the patient had complete relief of symptoms with no recurrence, and a “failure” if the patient had no or only partial relief of symptoms or showed relapse. Factors affecting the treatment outcome were analyzed. Results: The most frequent lesion subtype was myositis. Periorbital edema was the most common symptom and was evident in 53.1% of the patients. Thirty-eight patients (59.4%) showed treatment success. Age, sex, bilaterality, and mean follow- up length did not correlate with the treatment outcome. A short interval from symptom onset to treatment time and apical subtype were significantly associated with good steroid response (p < 0.05). Conclusions: In orbital inflammatory pseudotumor, myositis was the most common subtype. A short interval from symptom onset to treatment time and apical subtype were associated with good steroid response.

당뇨황반부종에서 망막두께분석기로 측정한 망막두께와 다국소망막전위도의 반응의 연관성

성미선,박태관,이정희,온영훈,Mi Sun Sung,Tae Kwann Park,Jeong Hee Lee,Young Hoon Ohn 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: To assess the correlation between retinal thickness determined with a retinal thickness analyzer (RTA) and the responses of multifocal electroretinogram (mfERG) in patients with diabetic macular edema. Methods: RTA and mfERG were performed in patients with diabetic macular edema (20eyes, 10 patients) and normal subjects (10eyes, 10 patients). The measured retina of RTA and mfERG overlapped based on the anatomical landmarks of the fundus. The center of macula was defined as “Area 1”, and the central 5 degree retina including the center of macula was defined as “Area 2”. The correlations between retinal thickness and the local responses in each area were assessed. Results: The mean retinal thickness of patients with diabetic macular edema was significantly greater than that of normal subject, and the results of mfERG typically represented decreased amplitudes and delayed latencies. In the matching of retinal thickness and local responses in Area 2, amplitudes of N1 & P1 decreased and latency of P1 delayed as the retinal thickness increased. The correlation was prominent in patients with diabetic macular edema. Conclusions: In the matching of RTA and mfERG of patients with diabetic macular edema, retinal thickness and local responses were significantly correlated.

증식당뇨망막병증에서 수정체초음파유화술 및 인공수정체삽입술을 병행한 유리체절제술의 임상분석

성미선,박태관,온영훈,Mi-Sun Sung M,D,Tae-Kwann Park,M,D,Young-Hoon Ohn,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.8

Purpose: To describe the results and complications of combined pars plana vitrectomy and phacoemulsification with intraocular lens implantation in patients with proliferative diabetic retinopathy, and to analysis the factors to be associated with visual outcome. Methods: Retrospective study was performed on 70 eyes of 58 patients who had undergone combined pars plana vitrecotmy and phacoemulsification with intraocular lens implantation because of proliferative diabetic retinopathy. Preoperative, intraoperative, and postoperative complicated factors to be associated with visual outcome were analyzed. Results: The changes of visual acuity were classified into “improved” 57eyes (81%), “stationary” 7eyes (10%), and “decreased” 6eyes (9%). Posterior capsule rupture during operation was occurred in 2 eyes (2.9%). After cataract, macular edema and neovascular glaucoma were developed in order of incidence of postoperative complications. The factors to be associated with visual outcome were diabetic nephropathy, posterior capsule rupture, macular edema, neovascular glaucoma, and retinal detachment. (P<0.05) Conclusions: Combined pars plana vitrectomy and phacoemulsification with intraocular lens implantation may be relatively safe for the patients with proliferative diabetic retinopathy.

삼각맨션 재구축을 통한 사회적 플랫폼 조성에 대한 제안

성미선(Sung, Mi-Sun),구영민(Koo, Young-Min) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.2

가시오가피를 이용한 기능성 건강음료의 제조

성미선(Mi-Sun Sung),정회윤(Hoe-Yune Jung),최준혁(Jun-Hyeok, Choi),이성철(Sung-Cheol Lee),최보화(Bo-Hwa Choi),박성선(Sung Sun Park) 한국생명과학회 2014 생명과학회지 Vol.24 No.9

본 연구에서는 가시오가피 줄기를 이용하여 농축액을 제조한 후 운동수행능력 증진 효과를 확인하고, 관능검사를 통해 가시오가피의 유용한 기능적인 특성을 살린 기호성 있는 건강 음료를 제조한 후 그 품질 특성을 조사하여 가공식품 및 식품소재로서 가시오가피의 활용도를 높이기 위한 기초 연구 자료로 제시하고자 하였다. 본 실험에서 사용한 건가시오가피 줄기의 일반성분 분석 결과 수분함량 6.50±0.12%, 조단백질 5.89±0.16%, 조지방 1.18±0.11%, 조회분 3.03±0.40%로 나타났다. 건가시오가피 줄기 추출물을 이용하여 제조한 가시오가피 농축액의 DPPH 라디칼 소거능은 증류수로 희석한 10% 농축액에서 87.42±1.63%로 나타나 positive control인 butylated hydroxy anisole (BHA) 1%의 DPPH 라디칼 소거활성 88.65±2.42%와 비슷한 수준으로 높은 활성을 보였으며, 최대운동수행능력을 측정한 결과 가시오가피 농축액을 섭취한 생쥐에서 대조군 생쥐에 비해 농도 의존적으로 운동수행 거리와 시간이 증가하는 것으로 확인되었다. 그리고 관능검사를 통해 선호도가 가장 높은 가시오가피 음료를 제조하여 그 특성을 확인한 결과 당도는 14.9 °Brix, pH는 4.51, 색도는 L값(명도) -62.70, a값(적색도) 3.67, b값(황색도) -6.12로 확인되었다. 따라서 본 연구의 결과는 가시오가피 농축액을 이용한 기호도가 증진된 기능성 음료로의 개발이 가능할 것으로 생각된다. This study was carried out to develop a functional healthy drink using 60% ethanol of dried Acanthopanax senticosus stem extract (ASE). The preparation, physical activity, anti-oxidant activity, and sensory properties of ASE were investigated. The moisture, crude protein, crude lipid, and ash contents of dried ASE were 6.50±0.12%, 5.89±0.16, 1.18±0.11, and 3.03±0.40, respectively. The 1,1-Diphenyl-2- picrylhydrazyl (DPPH) radical scavenging activity was 87.42±1.63% at 1/10 folds diluted ASE. In total, 40 male ICR mice were divided into five groups including the control (PBS), positive control (Red ginseng 200 mg/kg/day), and ASE-treated groups at doses of 35, 70, and 140 mg/kg/day for five weeks, respectively. ASE was administrated orally one time per day for five weeks before treadmill exercises, and normal and positive controls were fed PBS and red ginseng extract. In the treadmill test, ASE-treated mice (140 mg/kg/day) could run 1.4 times longer than the control mice. Healthy drinks were prepared with the addition of ASE at levels of 0.97% or 0.49% (A, B, and C type). Among the healthy drinks, the B type (ASE, 0.97%) was revealed to have the highest level of taste and overall acceptability through a sensory evaluation. The brix and pH of the ASE health drink (B type) were 14.9 and 4.51, respectively. These results indicated that the dried stem of Acanthopanax senticosus could be used as a functional material in the health drink industry.

황반부종의 유리체강내 트리암시놀론 주사 후 빛간섭단층촬영에서 나타난 국소 악화

박주연,성미선,이성진,Joo Youn Park,M,D,Mi Sun Sung,M,D,Sung Jin Lee,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: To evaluate the relationship between focal aggravation of the macular edema on retinal thickness change analysis (RTCA) of optical coherence tomography (OCT) and fluorescein angiographic findings in patients after an intravitreal triamcinolone injection (IVTA). Methods: From May 2004 to April 2005, RTCA in a fast macular thickness map (FMTM) of OCT was performed before and 4 weeks after IVTA in patients who had macular edemas caused by diabetic retinopathy and retinal vein occlusion. Patients underwent IVTA, and focal aggravation of the edema was detected. After overlapping the OCT findings onto angiographic pictures, the relationship between the focal aggravation on OCT and the leaking point on angiography was investigated. Result: In the patient group, focal aggravation was found in 5 of 27 eyes (18.5%); in the control group, only 2 of 30 eyes (6.7%) showed focal aggravation. As compared with angiographic pictures, 4 eyes with focal aggravation showed no relation to the leakage on angiography. Conclusions: Focal aggravation of macular edemas after IVTA on RTCA are not related to the leakage on angiography and could be an error from several artifacts. J Korean Ophthalmol Soc 49(5):753-762, 2008

정상안압녹내장에서 시간에 따른 망막신경섬유층 두께변화와 시야변화의 비교분석

이원혁,성미선,신준우,이주화.Won Hyuk Lee. MD. Mi Sun Sung. MD. Jun Woo Shin. MD. Joo Hwa Lee. MD 대한안과학회 2010 대한안과학회지 Vol.51 No.12

Purpose: To evaluate longitudinal changes in retinal nerve fiber layer thickness (RNFL) and visual field in patients with normal tension glaucoma (NTG). Methods: Thirty eyes of 30 NTG patients and 30 eyes of 30 normal control subjects were enrolled in the present study. RNFL thickness was measured using optical coherence tomography (OCT), and visual field tests were performed using a Humphrey visual field analyzer at baseline and 23.3 ± 15.3 months later. Changes in RNFL thickness at each clock-hour segment and visual field sensitivities were analyzed. The rates of change in RNFL thickness were also calculated. Results: Significant differences in RNFL thickness were observed between NTG patients and normal control subjects at the 5, 6, 7 and 12 o’clock positions at baseline (p < 0.001). At follow-up, the RNFL thickness change was not significant for normal control subjects, although it was significant for NTG patients at the 4, 5, 6, 7, 11 and 12 o'clock positions (p < 0.001). Visual field parameters did not change significantly in the normal control subjects or NTG patients. The reduction rates of RNFL thickness were 0.38 μm/month for the NTG patients and 0.11 μm/month for the normal control group, displaying a 3.5-fold faster reduction rate for NTG patients. Conclusions: The NTG group showed greater reductions in RNFL thickness in the upper and lower sectors over time; however, the visual field parameters did not change significantly. The results suggest that progression of glaucoma can be detected in an earlier stage using OCT than can be detected using a visual field test. J Korean Ophthalmol Soc 2010;51(12):1606-1613

안와의 원발성 결막 상피 낭종 1예

이찬희,성미선,김형균,우경인,김윤덕.Chan-Hui Yi. MD. Mi Sun Sung. MD. Hyoung-Gyun Kim. MD. Kyung-In Woo. MD. PhD. Yoon-Duck Kim. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.6

Purpose: To report a case of a primary conjunctival epithelial cyst in the orbit. Case summary: A 60-year-old woman was referred for evaluation of proptosis of the left eye, which had developed about 2 years earlier. Upon initial examination, a movable mass was palpated in the medial aspect of the left orbit. Magnetic resonance imaging of the orbit showed a 2.5 cm-sized, ovoid, cystic mass located between the left eyeball and the medial wall of the orbit. Excisional biopsy of the orbital mass was performed. The orbital mass was a well-circumscribed cystic lesion, adherent to the medial rectus muscle. Histological examination revealed that the cyst was lined with multiple layers of cuboidal epithelium with goblet cells. A diagnosis of primary conjunctival cyst was made. Conclusions: The possibility of primary conjunctival cyst should be considered in the differential diagnosis for an orbital cystic mass. J Korean Ophthalmol Soc 2010;51(6):885-889