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천식 환자에서 집먼지진드기 감작 유무에 따른 임상적 차이: 순천향 코호트 분석
김정현 ( Jung Hyun Kim ),장안수 ( An Soo Jang ),정신옥 ( Shin Ok Jeong ),지영석 ( Young Seok Ji ),서현정 ( Hyun Jung Seo ),남재형 ( Jae Hyung Nam ),문종주 ( Jong Joo Moon ),백애린 ( Ae Rin Baek ),박종숙 ( Jong Sook Park ),이준혁 ( 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1
Purpose: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. Methods: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. Results: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/ mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. Conclusions: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation. (Allergy Asthma Respir Dis 1(1):50-54, 2013)
국내 허가 및 긴급사용승인된 코로나19 바이러스감염증 치료제의 허가사항 비교 고찰
최민정(Min Joung Choi),서현옥(Hyun Ok Seo),도희정(Hea Jeong Doh),김영림(Younglim Kim),최경숙(Kyoung Suk Choi),박윤주(Younjoo Park),서경원(Kyung Won Seo),정지원(Jeewon Joung),김지연(Ji Yeon Kim),박인숙(In Suk Park),이원재(Wonjae Lee) 대한약학회 2023 약학회지 Vol.67 No.3
In a situation where the development of various treatments is urgently needed to overcome the global outbreak of coronavirus disease 2019 (COVID-19) and the sequential emergence of new variant viruses, Ministry of Food and Drug Safety (MFDS) made tremendous efforts to promptly supply the safe and effective therapeutics manufactured by local and global companies through accelerated marketing authorization or emergency use approvals. To date, seven products (including overlapped) have received marketing authorization or emergency use approvals from MFDS, and their indicated patient group according to the severity, efficacy, and safety information are different by each products. Therefore, this study is to compare the product information and the major clinical outcomes obtained from clinical studies of COVID-19 treatments authorized or approved for emergency use in Korea and to introduce the MFDS’s efforts for establishment of accelerated approval system for COVID-19 treatment and development of relevant guidelines. It is hoped that this study will serve as a reference for the latecomers who is preparing the development of therapeutics for emerging infectious diseases in the future.
프로젝트 접근법에서 혼합연령 집단과 단일연령 집단간의 사회적 행동과 프로젝트 수행능력의 차이
서현옥 한국아동교육학회 1999 아동교육 Vol.8 No.2
The purpose of this study was to examine children's social behaviors and their project -performing capabilities in their kindergarten ages of 4 or 5. 30 four-or five-year-old kindergarteners in a kindergarten, Taegu City, were randomly selected as the subject for this study and assigned to the three experiment groups: 10 four-year-old group, 10 five-year-oid group, and 10 mix-age group, respectively. For the research instruments, 'Play-analysis System', which Jang, Myung-Lim(1996) developed on the basis of the classification designed by Parten(1932), Howes(1980), Johnson(1987) etc. and conversation items from 'Social Behavioral Items List, one of Bronson's Behavioral Observation Lists, were used to assess the children's social-behavior types. The results of this study can be summarized as follows: First, there are statistically significant differences between the experiment groups with regard to such social behaviors as 'onlooking', 'solitary', 'on-my-own' (one of the two 'paralleling' activities, 'mutual recognizant' (one of the two 'paralleling' activities), 'associative', 'pair-cooperative', 'group-cooperative', and 'conversation' activities. Children in the four-year-old group showed more 'solitary' and 'on-my-own' activities than the mixed-age group, and more 'onlooking', 'on-my-own' and 'pair-cooperative' activities than the five-year-old group. Children in the five-year-old group showed more 'on-my-own', 'associative' and 'pair-cooperative' activities than the mixed-age group, and more 'associative' and 'conversation' activities than the four-year-old group. Children in the mixed-age group showed more 'associative' and 'conversation' activities than the four-year-old group, and more 'group cooperative' and 'conversation' activities than the five-year-old group. Second, there are statistically significant differences between the experiment groups with regard to such project-performing capabilities as 'theme-networking', 'project-planning', 'information-extracting', 'idea and information-expressing', and 'project-evaluating' capabilities. The mixed-age group and the five-year-old group showed higher scores in all the project-performing items than the four - year - old group while the mixed-age group showed greater capabilities in 'theme-networking', 'project-planning', and 'information-extracting' items than the five-year-old group.