http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
서지선,최주리,임예현,한평림 한국뇌신경과학회 2015 Experimental Neurobiology Vol.24 No.4
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within 2~3 years of symptom onset. The pathophysiology mechanism underlying ALS is not yet clearly understood. Moreover the available medication for treating ALS, riluzole, only modestly improves neurological symptoms and increases survival by a few months. Therefore, improved therapeutic strategies are urgently needed. In the present study, we investigated whether rosmarinic acid has a therapeutic potential to alleviate neurological deterioration in the G93A-SOD1 transgenic mouse model of ALS. Treatment of G93A-SOD1 transgenic mice with rosmarinic acid from 7 weeks of age at the dose of 400 mg/kg/day significantly extended survival, and relieved motor function deficits. Specifically, disease onset and symptom progression were delayed by more than one month. These symptomatic improvements were correlated with decreased oxidative stress and reduced neuronal loss in the ventral horns of G93A-SOD1 mice. These results support that rosmarinic acid is a potentially useful supplement for relieving ALS symptoms.
서지선,박현아,강재헌,김경우,조영규,허양임,박여린 대한임상건강증진학회 2014 Korean Journal of Health Promotion Vol.14 No.3
Background: Obesity not only does increase the incidence of breast cancer, but also affects the course of treatment,recurrence and mortality. This study aims to evaluate on the obesity status of Korean breast cancer survivorsand their obesity-related lifestyles. Methods: The study included 125 Korean female breast cancer survivors aged over 19 year old enrolled in the2009-11 Korean National Health and Nutrition Examination Survey. Women who answered ‘yes’ to the question‘have you ever been diagnosed breast cancer by a physician?’ was defined as a breast cancer survivors. Height, weight, and waist circumference were measured and Body mass index (BMI) was calculated. Body fatpercent was assessed by dual X-ray absorptiometry (DXA). Standardized surveys by trained interviewers wereused to investigate survivors’ obesity-related lifestyles such as physical activities, sleeping hours and nutrientsintake. Results: 48.4% of Korean breast cancer survivors were obese. 44.7% had abdominal obesity and 89.2% hadbody fat percent over 30. Their physical activity level was generally low; only 22.5% maintained health-enhancinglevel of physical activities. Fat intake (14.4 [0.8] %) was as low and carbohydrate intake (74.2 [1.2] %) washigh. However, daily dietary fiber intake was low (10.5 [1.1] g). Factors that were found to be significantly relatedwith obesity in Korean breast cancer survivors were low education level (P=0.042), smoking (P<0.001),having chronic diseases (P=0.002) and short sleeping hours (P<0.001). Conclusions: It is mandatory for physician to evaluate obesity status of breast cancer survivors as soon as theirdiagnosis and give proper intervention to maintain healthy weight and healthy obesity related lifestyle. 연구배경: 비만은 유방암의 발생뿐만 아니라 치료과정과 재발 및 사망에 영향을 미친다. 본 연구에서는 한국인유방암 생존자의 비만도를 확인하고, 비만관련 생활 습관을 평가하고자 하였다. 방법: 2007-2011년 국민건강영양조사 에 참여한 19세 이상 한국인 여성 유방암 생존자 125명을 대상으로 하였다. 훈련 받은 면접원의 인터뷰로 의사진단 유방암 병력을 확인하여 병력이 있는 경우, 유방암 생존자로 정의하였다. 비만도는 키와 체중을 측정하여 체질량지수를 계산하고, 허리둘레를 측정하였으며, dual X-ray absorptiometry (DXA)를 사용한 체질방률로 평가하였다. 비만관련 생활 습관으로 신체활동도, 수면 및 영양소 섭취를 표준화된 설문지로조사하였다. 결과: 한국인 유방암 생존자의 48.4%가 비만이었다. 복부비만이 있는 경우가 44.7 (6.4)%였으며, 체지방률이30%를 넘는 경우가 89.2%였다. 신체활동도도 낮아 건강증진형 신체활동도를 유지하고 있는 유방암 생존자는 22.5(5.1)%에 불과하였다. 지방 섭취는 14.0 (0.8)%로 낮았지만, 탄수화물 섭취가72.3 (1.2)로 높았고 일일 섬유소 섭취가 10.5 (1.1) g으로 낮았다. 한국인 유방암 생존자에서 비만도와 관련 있는 요인으로는 낮은 교육수준(P=0.042), 흡연(P<0.001), 만성질환유병(P=0.002), 짧은 수면 시간(P<0.001)이었다. 결론: 한국인 유방암 생존자의 비만도는 높았으며, 비만관련 생활 습관도 바람직한 수준에 미치지 못하였다. 유방암 진단 직후부터 비만과 비만관련 생활 습관에 대한 평가와 중재가 필요하다.
서지선,김재만 木浦大學校 基礎科學硏究所 2003 基礎科學硏究誌 Vol.21 No.-
In the shrimp industry, female shrimps are preferred to males because the female grow faster and 1.5 to 2 times larger than male. The female, however, is not distinguished from male in appearance before it grow up to adult stage. This discourages the cultivators for the final yield drops by the biased male selection. In order to meet this problem, we tried to develop genetic diagnosis technique. Poly A mRNA was isolated from male testes to synthesize testis cDNA. The sum total 172㎍ of whole RNA was obtained from frozen teses in liquid nitrogen. By using biotin-labeled oligo (dT)_(20) and streptavidin-coated magnetic particles, 25㎕ of poly A^(+) RNA (573.8㎍/㎖) was yielded. Vector-primer was made to have Not I oligo (dT)_(25) primer at one end and it was hybridized to poly A^(+) RNA to construct cDNA by using reverse transcriptase. Synthesis of cDNA was confirmed by E. coli transformation and Southern hybridization.