안중증근무력증의 안과적 임상 양상

서용훈,양원진,오신엽 대한안과학회 2023 대한안과학회지 Vol.64 No.10

목적: 안중증근무력증 환자의 안과적 임상 양상을 알아보고자 하였다. 대상과 방법: 2011년 1월부터 2022년 8월까지 본원 안과 및 신경과에 내원하여 안중증근무력증으로 진단받은 환자 중 6개월 이상추적 관찰이 가능하였던 58명을 대상으로 안과적 임상 양상 및 경과를 후향적으로 분석하였다. 결과: 총 58명의 환자에서 발병 시 평균 연령은 55.52 ± 15.60세로 남성 29명, 여성 29명이었다. 항아세틸콜린수용체항체검사에서양성 31명으로 양성률은 53.45%였고, 반복신경자극검사는 양성 19명, 음성 38명으로 33.33%에서 이상을 보였다. 항체 양성군에서전신근무력증으로 더 많이 진행하였으며(p=0.011), 더 많은 흉부 이상 소견을 보였다(p<0.001). 복시와 안검하수가 동반된 복합군에서수평, 수직복시가 모두 있는 경우가 많았으며(p<0.001), 사시의 양상이 복시 증상 단일군에서는 내사시, 복합군에서는 외사시가 가장많아 차이가 있었다(p=0.029). 또한 증상 복합군에서 항체 농도가 높게 측정되었으며(p=0.034), 반복신경자극검사에서 이상 소견을보이는 경우가 많았고(p=0.022) 더 많은 흉부 이상 소견을 보였다(p=0.022). 결론: 안중증근무력증 환자에서 항아세틸콜린수용체항체 양성군에서 전신 중증근무력증으로 진행한 경우가 많았고, 복시와 안검하수가 동반된 복합군에서 항아세틸콜린수용체항체 농도가 높았으며, 수평사시와 수직사시가 함께 동반되는 경우가 많았다. Purpose: We investigated the ophthalmic manifestations observed in patients diagnosed with ocular myasthenia gravis. Methods: In total, 58 patients diagnosed with ocular myasthenia gravis visited the ophthalmology and neurology departments between January 2011 and August 2022. Patients were followed for > 6 months; their ophthalmic manifestations were analyzed retrospectively. Results: The study included 29 males and 29 females with a mean age of 55.52 ± 15.60 years. Among the patients, 31 tested positive for anti-acetylcholine receptor antibodies, resulting in a positive rate of 53.45%. Abnormalities in repeated nerve stimulation tests were observed in 33.33% of the patients. The antibody-positive group exhibited a higher frequency of progression to generalized myasthenia gravis (p = 0.011) and a higher incidence of chest abnormalities (p < 0.001) compared to the antibody- negative group. Horizontal and vertical diplopia were commonly observed in a complex group of patients with diplopia and blepharoptosis (p < 0.001); there was a difference in the pattern of strabismus between the diplopia single group with esotropia and the complex group with exotropia (p = 0.029). In addition, the combination group demonstrated a higher antibody titer (p = 0.034), a higher frequency of abnormalities in repeated nerve stimulation tests (p = 0.022), and a higher incidence of chest abnormalities (p = 0.022). Conclusions: The anti-acetylcholine receptor antibody-positive group had a higher incidence of progression to generalized myasthenia gravis; moreover, the complex group of patients with diplopia and ptosis exhibited elevated levels of anti-acetylcholine receptor antibodies and frequently accompanied both horizontal and vertical strabismus.

안면골 골절의 발생 인자에 대한 통계학적 분석

서용훈,김영준,Suh, Yong Hoon,Kim, Young Joon 대한두개안면성형외과학회 2012 Archives of Craniofacial Surgery Vol.13 No.1

Purpose: Statistical analysis of facial bone fractures has been performed in various papers. However, reports on risk factors for facial bone fractures are rare. In order to prevent facial bone fractures, it is important to determine the risk factors for their occurrence. This study seeks to perform a statistical analysis on and identify the risk factors associated with facial bone fractures. Methods: A retrospective study was performed to assess facial bone fractures in patients presenting from October 2009 to January 2011 through a chart review. The data collected included age, gender, etiology, and alcohol consumption. Data was analyzed using multinomial logistic regression analysis. The significance level was set at p<0.05 and SAS ver. 9.2 was used. Results: A total of 489 patients were analyzed. The patients' age ranged from 2 to 85 years (mean age, $31.8{\pm}15.4$ years). The ratio of men to women was 5.0:1. The predominant group was age below 19 years old (30.9%). The main causes of facial bone fractures were assaults (37.8%), falls (27.2%), and sport accidents (19.5%). On multinomial logistic regression analysis, age, especially in the teen group was associated with assaults (p<0.05) resulting in facial bone fractures. Alcohol consumption was significantly associated with assaults and falls (p<0.05) leading to facial bone fractures. Conclusion: Facial bone fracture is a challenging problem, because of its high incidence and financial cost. The findings of this study indicate that more effective policies aimed at reducing alcohol intake and teenage violence are needed.

크론병 환자에서 다발성 안와근염에 동반된 톨로사-헌트증후군

서용훈,이주황,오신엽 대한안과학회 2022 대한안과학회지 Vol.63 No.5

목적: 우측 안구통과 양안 수평복시가 발생한 크론병 환자에서 안와 자기공명영상검사를 통해 다발성 안와근염에 톨로사-헌트증후군이 동반된 1예를 보고하고자 한다. 증례요약: 46세 여자 환자가 내원 2개월 전 우측 안구통 및 편두통이 발생하였고, 내원 3일 전부터는 급성 수평복시가 발생하여 내원하였다. 환자는 4년 전 크론병을 진단받고 면역억제제를 복용 중이었다. 안구운동검사상 우안 -3.0의 외전 제한 소견과 크림스키검사상 우안 내사시 소견이 관찰되었다. 안와 자기공명영상검사에서 양안 다발성의 외안근 조영증강과 외안근 비대 소견이 관찰되었고, 우측 해면정맥굴에 조영증강이 관찰되었다. 이에 양측 다발성 안와근염 및 우측 톨로사-헌트증후군으로 진단하고, 3일간 고용량 스테로이드를 투여하였으며 이후 경구 약제로 감량하여 치료하였다. 치료 1주째에 우측 안구통이 소실되었고, 치료 3개월 후 우안 외전제한 및 내사시가 완전 소실되었다. 결론: 안와근염과 톨로사-헌트증후군은 특발성의 비특이적 육아종성 질환으로, 두 질환이 동반하여 나타나는 경우는 흔하지 않기에본 증례를 보고하는 바이다.

GWR 기반 대시매트릭 매핑 기법을 이용한 건물 단위 현재 인구 추정

서용훈,이건학 한국지도학회 2023 한국지도학회지 Vol.23 No.1

COVID-19 is a respiratory disease that is likely to be transmitted through respiratory droplets and aerosols. The indoor space of the building is very vulnerable to the broad spread of COVID-19, and urban environment that many people are densely populated at high-rise buildings due to the intensive land-use may be more vulnerable to these diseases. Moreover, since the population distribution in the urban area changes over time dynamically, understanding of the spatio-temporal change of urban population is a key for the epidemiological investigation of COVID-19. However, it is difficult to examine the de facto population resided in a specific building at a specific time period. Therefore, this study attempts to suggest an alternative way of estimating the horizontal and vertical distribution of urban population at a particular time period. More specifically, we estimate the de facto population at a building scale using a dasymetric mapping method based on geographically weighted regression (GWR) model. In general, a dasymetric mapping enables us to estimate more detailed population at a finer scale using ancillary data. In this study, building usage and total floor area are utilized as ancillary data and heterogeneous distribution of population is incorporated by the GWR model. As a result of analysis, we can suggest the detailed population estimation at the building scale finer than statistical enumeration units over the entire area of Seoul. It is expected that the estimated de facto population at the building scale would be utilized for important fundamental information for the epidemiological surveillance of pandemic diseases like COVID-19 and the establishment of the effective prevention plan of epidemics. 코로나19는 비말을 통해 전염되는 호흡기 질환으로 건물의 실내 공간은 코로나19의 대규모 감염에 매우 취약한 곳이다. 집약된 토지 이용으로 인해 수많은 사람들이 고층의 건물에 밀집해 있는 도시 환경은 이러한 질병에 더 취약할 수 있다. 뿐만 아니라 도시의 인구 분포는 시간에 따라 역동적인 변화를 보이기 때문에 코로나19와 같은 전염병에 대한 역학 조사의 성공은 도시 인구의 시공간적 변화를 얼마나 잘 이해하는지에 달려있다. 하지만 특정 시간대에 특정 건물에 분포하고 있는 현재 인구 밀도를 파악하는 것은 무척 어려운 일이다. 따라서 본 연구는 특정 시간대의 도시 인구의 수평적, 수직적 분포를 보다 정확하게 추정하기 위한 대안을 제시하고자 한다. 보다 구체적으로 지리가중회귀(GWR) 모델에 기반한 대시메트릭 매핑 기법을 이용하여 건물 단위의 현재 인구를 추정하였다. 일반적으로 대시메트릭 매핑 기법은 보조 자료를 사용하여 기존의 공간 스케일을 넘어 보다 상세한 수준의 인구 분포를 추정할 수 있도록 해준다. 본 연구에서는 건물의 용도와 연면적을 보조 정보로 활용하였으며, GWR 모델을 이용하여 지역적으로 이질적인 인구 분포 특성을 반영하였다. 연구 결과, 서울시 전체에 걸쳐 집계구보다 상세한 건물 단위 수준의 인구 분포를 추정할 수 있었다. 건물 단위의 현재 인구 추정은 코로나19와 같은 팬데믹 전염병의 역학 조사나 효과적인 방역 대책 수립을 위한 중요한 기초 자료로 활용될 수 있을 것으로 기대한다.

안면부 골절에 사용된 흡수성 보형물의 지연성 이물반응: 증례보고

서용훈,김영준 대한성형외과학회 2011 Archives of Plastic Surgery Vol.38 No.6

Purpose: Absorbable implants are frequently used to fix facial bone fractures, because they are radiolucent and compatible with magnetic resonance imaging (MRI). Despite their increasing usage, however, there have been few reports about their long-term side-effects. In this paper, a case in which absorbable implants led to a foreign body reaction 17 months after their insertion is presented. Methods: A previously healthy 19-year-old male fell from a flight of stairs and visited the authors’ hospital with right periorbital pain. Zygomaticomaxillary fracture involving right orbital floor was detected via a facial bone computed tomography (CT). Internal fixation with absorbable implants was followed by open reduction. 17 months after the surgery,the patient complained of localized periorbital swelling. Removal of the granulomatous lesion including the absorbable implants along with their biopsy and culture was performed. Results: The granulomatous lesion around the implants was firm and extended into the maxillary sinus. The histologic finding showed a microabscess with a foreign body reaction. Methicillin-sensitive Staphylococcus aureus growth was confirmed in the culture. No definite abnormal symptoms ensued after the complete removal. Conclusion: A microabscess-forming granulomatous lesion around the absorbable implant can cause delayed symptomatic foreign body reaction despite its rare occurrence. Complete removal of the lesion including implants is expected to have a successful outcome if it is encountered.

국지 온도를 고려한 서울특별시 공공 무더위 쉼터 접근성 분석: 고령층을 중심으로

서용훈(Yong-Hun Suh),배성윤(Seong-Yun Bae),정송희(Song-Hee Jeong) 대한지리학회 2022 대한지리학회 학술대회논문집 Vol.2022 No.6

L1210 세포증식에 대한 Glycyrrhizin의 억제작용 기전

殷載淳,徐龍勳,權鎭,柳東和,吳贊鎬,蘇俊魯,全焄,黃甲洙 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The purpose of this research was to investigate the mechanism of inhibitory action of Glycyrrhizin(GZ) on the proliferation of mouse leukemia cell-line, L1210 cells. The cytotoxic activity was tested using a colorimetric tertrazolium assay(MTT assay), the apoptosis was tested using flow cytometry. Nitric oxide(NO) production form mouse peritoneal macrophage was tested using a Griess method and the phagocytosis of human polymorphonuclear cells was tested using a lucigenin chemiluminescence. GZ ingibited the proliferation of L1210, BALB/c 3T3 cells and mouse thymocytes at 50 ug/ml/ GZ did not affect nitric oxide production from mouse peritoneal macrophages in vitro, but ingibited nitric oxide production from lipopolysaccharide and y-interferon treated macrophages. Macrophages of GZ-administered mice accelerated NO production. The proliferation of L1210 cells apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. The apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. GZ increased the phagocytosis of human polymorphonuclear cells. These results suggest that GZ inhibit the proliferation of L1210 cells not only as a direct cytotoxic agent o tumor cells, but also by the enhancement of NO production and phagocytic activity.

반복적인 유리체출혈로 발현한 추정 잠복결핵 관련 중간포도막염

이주황,서용훈,이은철 대한안과학회 2022 대한안과학회지 Vol.63 No.3

Purpose: We report a case of recurrent vitreous hemorrhage in a patient with presumed latent tuberculosis-related intermediate uveitis, and we review the literature. Case summary: A 58-year-old male visited our clinic complaining of ocular pain, conjunctival hyperemia, decreased vision, and uncontrolled intraocular pressure (IOP) in the left eye. The best-corrected visual acuity (BCVA) was 0.4 and the IOP of the left eye was 34 mmHg. Slit lamp examination revealed conjunctival hyperemia, corneal edema, and inflammatory cells in the anterior chamber and anterior vitreous; fundus examination revealed mild vitreous opacity attributable to vitritis. The high IOP and the intraocular inflammation were treated with antiglaucoma agents and corticosteroids under the impression of chronic anterior uveitis and uveitic glaucoma. Of the tests performed to identify the cause of the uveitis-related vitreous hemorrhage, the interferon- gamma release assay was positive. A presumptive diagnosis of latent tuberculosis-related uveitis was made after pulmonary tuberculosis was excluded by our respiratory internal medicine department. Isoniazid was administered for 9 months. The vitreous hemorrhage recurred 1 month after antituberculosis therapy commenced but, at 2 months, all of the hemorrhage was absorbed and the BCVA improved to 1.0 without further recurrence. Conclusions: Intraocular tuberculosis can present with various clinical manifestations. If tuberculosis-related uveitis is presumed, tests for latent and manifest tuberculosis should be scheduled to allow of early diagnosis and immediate antituberculosis therapy.

다중 프로브 구형 근거리장 안테나 측정시스템

장건호,박세호,서용훈,임영철,금홍식 한국전자파학회 2020 전자파기술 Vol.31 No.4

태권도 수련이 남자 청소년의 신체구성, 체력 및 골밀도에 미치는 영향

송종국 ( Jong Kook Song ),서용훈 ( Yong Hun Seo ),김현배 ( Hyun Bae Kim ),박수연 ( Soo Yeon Park ) 한국운동영양학회 2005 Physical Activity and Nutrition (Phys Act Nutr) Vol.9 No.2