옥천 서산성의 현황과 정밀지표조사 성과

서문영 충북대학교 중원문화연구소 2023 중원문화연구 Vol.31 No.-

옥천 서산성은 ‘관산성 전투(554)’와 연관되는 ‘관산성’의 비정지로유력하게 추정되고 있으며, 옥천 분지의 관문으로서 고대 옥천 지역핵심 방어 산성으로 평가되는 매우 중요한 유적에 해당한다. 이 글에서는 옥천 서산성의 위치와 환경을 알아보고, 사료와 지리지 등을 검토하여 옥천 서산성 일대가 관산성으로 비정되는 정황을간략하게 살펴보았다. 이후 정밀지표조사의 내용에 대해 언급하는 것으로 옥천 서산성 정밀지표조사를 통해 밝혀진 고고학적 성과를 소개하고자 하였다. 정밀지표조사를 통하여 파악된 서산성의 둘레는 약 1,025m이고 성내 면적은 31,727㎡이다. 성벽은 모두 4개의 구간으로 구분하여 조사를 진행하였으며, 20∼40m 간격으로 단면측점을 설정하여 육안으로 확인되는 성벽의 단면형태를 파악하였다. 성내 시설로는 문지 3곳을 추정하였으며, 그 외에도 건물지 6곳, 치성 1곳, 집수시설 1곳을 추정하였다. 성내시설은 가시권 분석, 경사방향분석 등을 통하여 산성의 일반현황을 면밀하게 검토하였다. 특히가시권 분석을 통해 서산성의 감제권이 옥천분지를 향하고 있으며, 주변 500m 내에 위치하고 있는 삼양리 토성, 삼거리 토성과 상호보완적인 관계임을 확인할 수 있었다. 옥천 서산성에서 수습된 유물은 삼국시대의 토기편과 기와편을 비롯하여 조선시대의 백자편과 기와편까지 다양한 시기에 걸쳐 확인되었다. 이는 『세종실록지리지』·『신증동국여지승람』의 기록과 대조해 보았을 때, 삼국시대부터 조선시대까지 성곽이 운영되었음을 미루어 짐작할 수 있게 해주는 물질자료이다. 성내 평탄지와 규모를 고려하면고대에는 치소성으로 운영되었을 가능성도 이번 조사를 통해 짐작할수 있었다.

Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017

서문영,문신제,김신혜,박미정 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.2

Background: Phthalates and bisphenol A (BPA) are synthetic chemicals widely used in daily life. This study investigated urinaryphthalate and BPA levels in Korean children and their associations with obesity. Methods: A total of 2,351 children aged 3 to 17 years who participated in the Korean National Environmental Health Survey 2015to 2017 were included. Urinary dilution was corrected using covariate-adjusted standardization (CAS). We examined the geometricmean (GM) concentrations of urinary phthalate metabolites, including di (2-ethylhexyl) phthalate (DEHP) metabolites (mono [2-ethyl-5-hydroxyhexyl] phthalate, mono [2-ethyl-5-oxohexyl] phthalate, and mono [2-ethyl-5-carboxypentyl] phthalate [MECPP]), mono-benzyl-phthalate (MBzP), mono (carboxyoctyl) phthalate (MCOP), mono (carboxy-isononyl) phthalate (MCNP), mono (3-carboxypropyl) phthalate, and mono-n-butyl-phthalate (MnBP), and BPA. We also analyzed the odds ratio (OR) for obesity accordingto the quartiles of each analyte. Results: The urinary GM levels of DEHP metabolites and MnBP were notably higher among Korean children than among American, Canadian, and German children. The CAS-applied GM concentrations of most analytes, except for MBzP, MCOP, and MCNP,were higher in children aged 3 to 5 years than in those aged 6 to 17 years. The OR for obesity in the highest quartile of MECPP wassignificantly higher than in the lowest quartile after adjusting for covariates. However, the other phthalate metabolites and BPA werenot significantly associated with obesity. Conclusion: The concentrations of urinary DEHP metabolites and MnBP were higher in Korean children than in children in Westerncountries. Urinary MECPP exposure, but not other phthalates or BPA, showed a positive association with obesity in Korean children. Further studies are required to elucidate the causal relationships

Trend of Menarcheal Age among Korean Girls

서문영,김신혜,Anders Juul,박미정 대한의학회 2020 Journal of Korean medical science Vol.35 No.49

Background: Menarcheal age has been decreasing worldwide. However, few recent studies have observed trends in menarcheal age in larger populations, and the cutoff age for early menarche remains unclear. Therefore, we aimed to analyze recent trends of menarcheal age and to determine the cutoff age of early menarche based on nationally representative data. Methods: We conducted a cross-sectional study of 351,006 Korean girls aged 12–18 years who were born in 1988–2003 based on the data of the 2006–2015 Korea Youth Risk Behavior Survey. We identified the distribution of age at menarche using the complex sample Cox regression model. Trends in the prevalence of early menarche were determined using the complex sample linear model. Results: Ninety-five percent of all the participants reported they had experienced menarche. The mean menarcheal age was 13.0 years (95% confidence intervals [CIs], 12.92–13.04) for girls born in 1988 and decreased to 12.6 years (95% CI, 12.54–12.61) for girls born in 2003. The cutoff age (the 3rd percentile value) for early menarche was 10.5 years during the study period. The prevalence of early menarche significantly increased from 1.8% in 2006 to 3.2% in 2015 (P-for-trend < 0.001). Downward trends of menarcheal age were noted across all body mass index groups, and this trend was most prominent in the obese group. Conclusion: We reported an ongoing downward trend in menarcheal age in Korean girls born in 1988–2003, decreasing by 0.4 years over the 15 years.

청주 송절동 유적의 철기유물 변화

서문영(Seo, Moon-young) 충북대학교 중원문화연구소 2019 중원문화연구 Vol.27 No.-

Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018

채지운,서문영,김신혜,박미정 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.6

Background: There is a lack of recent research on the changes in risk factors for metabolic syndrome (MetS) in the Asian pediatric population. We aimed to determine the 12-year trends in the prevalence of MetS and relevant lifestyle factors such as smoking, exercise, and calorie intake among Korean adolescents.Methods: We investigated trends in MetS and lifestyle factors among 6,308 adolescents aged 12 to 18 years from the Korea National Health and Nutrition Examination Survey, 2007 to 2018.Results: The prevalence of MetS was stable from 2007 to 2018 (1.7% to 2.2%). There were significant increases in the prevalence of central obesity (from 8.1% to 11.2%, P=0.012) and hyperglycemia (from 5.3% to 10.4%, P<0.001) and decreases in hypo-high-density lipoprotein (HDL)-cholesterolemia (from 22.4% to 14.8%, P<0.001). Total calorie intake and calorie intake from fat significantly increased (P<0.001), whereas calorie intake from carbohydrates significantly decreased (P<0.001) during the study period. The proportions of tobacco smokers and regular walkers significantly decreased from 2007 to 2018. After controlling for all covariates, total calorie intake was positively correlated with waist circumference (P<0.05). HDL-cholesterol was negatively associated with carbohydrate consumption (P<0.01) and positively associated with fat consumption (P<0.001). Regular walking and regular strength training were associated with lower waist circumference (P<0.05). Smoking was associated with lower fasting glucose levels (P<0.01).Conclusion: Although the prevalence rate of MetS is stable among Korean adolescents, the prevalence of central obesity and hyperglycemia has increased greatly in the recent decade. Public education on proper dietary intake and lifestyle modification is required.

Possible Role of Amyloid B-(1-40)-BSA Conjugates in Transdifferentiation of Lens Epithelial Cells

이광원,서문영,김동환,박선영,주천기 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.2

We investigated whether amyloid β (Aβ) aggregates have transforming growth factor β- like cytokine activity and cause transdifferention of lens epithelial cells, leading to certain types of cataract. In order to mimic Aβaggregates, Aβ-(1-40) was crosslinked to bovine serum albumin (BSA) with disuccinimidyl suberate according to a previously described procedure. When human lens epithelial B-3 (HLE B-3) cells were treated with the Aβ-(1-40)-BSA conjugates, we observed the translocation of Smad-3, as well as the induced mRNA levels of fibronectin (FN), collagen type I (Col I), smooth muscle actin (SMA) and matrix metalloproteinase-2 (MMP-2). In addition, we investigated the morphology of rat whole lens cultured for 5 days in the presence of Aβ-(1-40)-BSA, and the immunohistochemical localizations of Aβ-(1-40)/amyloid precursor protein (APP) in human clinical tissues beneath the anterior capsules. In rat whole lens cultures, treatment with Aβ-(1-40)-BSA produced a transformed morphology that had multiple layers of lens epithelial cells. To compare the anterior capsules in anterior subcapsular cataracts with those in nuclear cataracts, immunohistochemical studies of Aβ/APP in human clinical tissues revealed that the predominant immunostaining of Aβ occurs in the anterior epithelial plaques, which likely produces the abnormal extracellular matrix. Thus, these findings suggest that Aβaggregates in vivo are possibly involved in the regulatory process by which lens epithelial cells may transdifferentiate into fibroblast-like cells, as well as help understand the mechanisms which lead to certain types of cataractogenesis.

Caffeic Acid Induces Glutathione Synthesis through JNK/AP-1- mediated γ-Glutamylcysteine Ligase Catalytic Subunit Induction in HepG2 and Primary Hepatocytes

양성용,강정한,서문영,이광원 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.5

Previously our research found that caffeic acid (CA) has antioxidant activity in vitro and in vivo. However, the antioxidant mechanism of CA has not been clearly demonstrated. We investigated the protective mechanism of CA on oxidative stress in HepG2 cells and primary hepatocytes. We focused on the effects of CA on glutathione (GSH) synthesis and its mechanisms. Reporter gene assay, transient transfection, quantitative reverse transcription-polymerase chain reaction and western blot were performed to confirm the mechanisms of antioxidant capacity. CA increased GSH level and γ- glutamylcysteine ligase (γ-GCL) activity. γ-Glutamylcysteine ligase catalytic subunit (GCLC) mRNA and protein levels were significantly increased following treatment with CA, whereas no changes were observed in the γ-GCL modifier subunit levels in HepG2 and rat hepatocytes. CA phosphorylated JNK, and activated the AP-1 transcription factor. These results show that the intracellular GSH levels and GCLC increased through the JNK/AP-1 pathways by CA treatment.

중,고등학생의 인터넷 중독과 관련 변인 연구

전영자 ( Young Ja Jeon ),서문영 ( Moon Young Seo ) 대한가정학회 2006 Human Ecology Research(HER) Vol.44 No.3

생강나무(Lindera obtusiloba Blume) 잎 70% 에탄올 추출물의 단회와 14일 반복투여 독성시험의 안전성 평가

홍충의(Chung-Oui Hong),서문영(Young Seomun),구윤창(Yun-Chang Koo),남미현(Mi-Hyun Nam),이현아(Hyun Ah Lee),김지훈(Ji-Hoon Kim),왕증(Wang-Zeng),양성용(Sung Yong Yang),이성희(Sung-Hee Lee),노수환(Su Hwan No),이광원(Kwang-Won Lee) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.10

생강나무는 한국, 일본, 중국 등지에서 자생하며 열, 복통, 타박상, 출혈 등에 민간요법으로 사용되어온 식물이다. 이 논문의 목적은 오래전부터 민간요법으로 사용되어온 생강나무 잎의 안전성을 평가하고자 생강나무 잎 70% 에탄올 추출물을 암수 각 군당 5마리씩 5000(단회투여 독성시험), 0, 500, 1000, 2000(14일 반복투여 독성시험) ㎎/㎏의 용량으로 단회경구투여와 14일 반복경구투여를 실시하여 15일간의 사망률, 일반증상, 체중변화, 조직병리, 혈액학적 및 혈액 생화학적 검사를 실시하였다. 시험기간 중 사망동물은 암수 모든 시험군에서 관찰되지 않았으며, 일반증상, 체중변화, 조직병리, 혈액학적 및 혈액생화학적 검사에서 투여와 관련된 변화는 관찰되지 않았다. 이상의 결과로 보아 생강나무의 단회투여 독성은 5000 ㎎/㎏ 용량을 상회하며, 14일 반복투여의 최고용량인 2000 ㎎/㎏ 용량에서도 아무런 독성이 나타나지 않는 것으로 보아 최대무독성량은 이 농도를 상회하는 것으로 판단된다. 이로써 생강나무는 안전한 소재로서 식재료 또는 건강기능식품의 원료로서도 사용이 가능하다고 볼 수 있다. Lindera obtusiloba Blume (LO), which is widely distributed in Korea, Japan and China, has traditionally been used as a popular folk medicine for the treatment of fever, abdominal pain, bruise and extravation. The purpose of this study was to examine the toxicities of the single and 14-day repeated doses in Sprague-Dawley rats orally administrated with LO at doses of 0, 500, 1000, 2000 (14-day repeated toxicity test) and 5000 (single toxicity test) mg (dry weight)/㎏ of body weight/day. The results showed that there was no difference in body weight change, food intake, water consumption, or organ weight among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally administered LO and the control group, there was no statistical significance in hematological test or serum biochemical values. There were no evidences of histopathological alteration as well as abnormal gross finding mediated by single and 14 days treatments with LO. These results suggest that no observed adverse effect level (NOAEL) of the oral application of LO was considered to be more than 2000 mg/kg in rats under the conditions employed in this study.

외과계 병동 환자 경장영양 주입에 따른 관리실태

김윤정,권아영,김소윤,김수정,문미르,박경희,백영미,백소희,변은정,서문영,오숙영,이미란,이은지,임현빈,조임숙,천호정,황지예,정인선 한국정맥경장영양학회 2011 한국정맥경장영양학회 학술대회집 Vol.2011 No.-

배경: 경장영양은 낮은 감염 합병증과 저렴한 가격, 면역 기능 증진, 위장관 기능 유지, 위장관으로의 편리한 접근성 등의 이점이 있어 선호된다. 하지만 경장 영양의 시행에 따른 통일된 관리 기준이 없어 표준화된 지침서 및 평가 도구에 대한 개발의 필요성이 제기되었다. 그러므로 경양 영양 주입에 관련된 관리 실태를 조사하여 현황을 파악하고 표준화 지침 개발의 기초 자료를 마련하고자 하였다. 방법: 2010년 7월 1일에서 2011년 6월30일까지 세브란스병원에서 외과 수술 후 경장영양을 하루 이상 시행하였던 117명 중 중환자실에서만 경장영양을 시행한 17명을 제외한 100명을 대상으로 후향적으로 의무기록을 조사 하였다. 환자의 나이, 진단명, 수술명, 경장영양 시행 시작에서 종료까지의 기간, 주입 방법, flushing, 위잔여량, 튜브의 위치, 튜브 굵기, 튜브를 통한 투약 여부 및 경장영양 관련 합병증 등을 분석하였다. 결과: 환자의 평균 연령은 60.5세로 남자가 65명, 여자가 35명이었다. 간담췌악성종양 28명, 위, 십이지장암 8명, 대장직장암 4명, 복막염, 혈복증 및 장폐색 13명, 기타 47명이었다. 경장영양을 시행한 평균기간은 11.72일이었고 튜브 거치 위치는 위 56%, 공장 39%, 십이지장 3%로 튜브 거치 위치와 굵기에 있어 미기재로 알 수 없는 경우가 각각 2%, 22%였다. 경장 영양 주입 방법은 지속적 투여가 19%, 주기적 투여가 75%, 간헐적투여가 3%, bolus 주입이 3%였다. 튜브를 통해 경구약물이 공급된 예가 60%였으나 flushing에 대한 기록은 1%, 위잔여량에 대한 기록은 16%에서 조사되었다. 합병증 여부에 있어 튜브 막힘은 5%, 설사 9%, 복통 9%, 그 밖의 증상 13%이며 경장영양 중 중단은 40%를 차지하였다. 주입 특성과 합병증, 그리고 경장 영양 중단의 관련성등에 대한 기록이 미비하여 분석할 수 없었다. 결론: 관리실태 조사에 있어 의무기록을 통한 경장영양 관련 기록의 세부적 항목이 없어 처음 연구 목적으로 분석하려고 했던 합병증과의 관련성 연구를 위한 통계를 시행할 수 없었다. 그러므로 표준화된 지침을 개발하기 위해서는 경장영양 시행 기록에 대한 표준화된 도구가 필요함을 제언한다.