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상영호,이국형,정상립,김도원 ( Young Ho Sang,Kuk Hyeong Lee,Sang Lip Chung,Do Won Kim ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5
A Case of Bullous Pemphigoid in a Patient with Chronic Renal Faiure Young Ho Sang, M.D., Kuk Hyeong Lee, M.D., Sang Lip Chung, M.D., Do Won Kim, M.D. Department of Dermatology, Kyungpook National University, School of Medicine, Toegu, Korea We report a case of bullous pemphigoid in patient with chronic renal failure. The patient was a 17 years-old female who had noted Henoch Schoenlein purpura with nephrotic syndrom(HSPN) 8 years ago. Three years prior to visit, HSPN had progressed to renal failure. Therefore she discontinued furosemide therapy for hypertension and has been treated with maintenance hemodialysis. She revealed multiple tense bullae on the face, neck, abdomen and axilla for 10 days. Histologic findings of early bullous lesion showed subepidermal bullae and direct immunofluorescent study of perilesional skin revealed linear lgG deposition at the dermoepidermal junction. We suggest that there is close relationship between bullous pemphigoid and chronic renal failure, especially uremia. (Kor J Dermatol 28(5) : 615-619, 1990)
기저 세포암 , 편평 상피 세포암 및 건선 병변에서의 Fibronectin의 분포
상영호(Young Ho Sang),정상립(Sang Lip Chung) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.6
Fibronectin(FN) is a major component of the extracellular matrix and is able to bind to cells and other components of the matrix. Although the cell producing the largest amounts of fibronectin is fibroblast, the pro duct,ion on FN also has been described in cultured keratinocyt,e and epithelial tumor cells of basal cell carcinoma(BCC). Recently, functional role nf FN in relation to biologic behavior of BCC and squamous cell carcinoma(SCC) is open to speculation. The authors investigated the localization of FN in the lesional skin of 5 cases of BCC, 4 of SCC, 5 of psoriasis and 5 normal skin using direct immunofluorescence technique with antifibronectin antibody to find out the production of FN in keratinocytes and tumor cells. 1. In the skin of BCC, FN was presented in a thick, linear depositions along the margin of tumor lobules in all cases, and as fillamentous deposits or scattered points in the nest of tumor cells in 3 cases. 2. In the skin of SCC, FN was presented in a thin, coarse depositions around the margin of tumor but not presented within the tumor nest in all cases. R. In psoriasis, FN was observed in horney layer and upper part of epidermis. It was presented more abundantly in dermo-epidermal junction, papillary and reticular dermis than in normal skin. 4. In normal skin, FN was absent in the epidermis but presented in dermo-epidermal junction and blood vessel wall of upper dermis, the amount of FN was decreased from papillary to lower dermis. (Kor J Dermatol 28(6):708 714, 1990)
상영호(Young Ho Sang),서호철(Ho Chul Suh),전재복(Jae Bok Jun),김도원(Do Won Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1
We report a case of neurofibromatosis with unusual clinical manifestations in a 10-year-old girl. The patient showed an adult palm sized, brightly brown macular patch over the left temporal and zygomatic area with underlying tender soft swelling. The entire scalp and the patch were covered with short curling hairs Histopathologic P.XBmination of a biopsy specimen from the lesion of the zygomatic area revealed increased melanin pigments in the basal layer. Thin wavy fibers, intermingled with cells with oval to spindle shaped nuclei were lying in loosely textured strands and numerous mast, cells were noted in the deep dermis, Hypoplastic changes of left. temporal muscle, zygomatic arch and facial bone were found uncler the skin lesion by brain computed tomrgraphy. (Kor J Dermatol 29(1): 95 99, 1991)