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正常 및 異常妊娠에 있어서의 尿中Estriol에 關한 硏究
李敬子 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.1
Urinary estriol estimation is very helpful for fetal program during pregnancy although it has not been widely used in Obstetrics. In this paper the fluctuations of maternal esteriol both in normal and abnornal pregnancies, hypertensive or toxemic state, intra-uterine fetal death or similar conditions. and of post-dated pregnancy were studeid. The data presented here are based on 52 pregnant patients examined in Ewha Woman's University Hospital, Seoul, Korea. Twenty-four hour urine was collected and analyzed by the Brown method. At the same time the vaginal smear was taken from mid-lateral portion of vaginal wall and stained by papanicolaou technique. The obtained results are as follows: 1. Urinary estriol in normal pregnancy gradually increases in the 20th week of gestation up to term, and the mean estriol level during the period of 36th week to term was 15.6㎎/24hours. No less than 4㎎/24hours was observed in or after 26th week of gestation in normal conditions. 2. Generally, in toxemia or hypertensive complication of pregnancy, the estriol excretion decreases significantly(P<0.05) with the mean value of 8.11 ㎎/24hours±S.E. 0.91 in the 37th week up to term. There appears tendency of chronic placental insufficiency or fetal distress in toxemia of pregnancy on the basis of the decreased fetal weight as well as poor Apgar scores. 3. In general, the higher the systolic blood pressure the greater decrease of the urinary estriol level. There was no significant difference between mild and severe toxemias in the urinary estriol level. It is interesting to note that once the systolic blood pressure is elevated up to 150㎜Hg, the estriol excretion decreases to the same level as that at a much higher level of systolic pressure, such as 160-200㎜Hg. 4. The levels of maternal urinary estriol in preeclampsia and eclampsia were not significantly different. No fetal loss was encountered even in preeclampsia with a markedly decreased estriol level. On the other hand, it was noted that a greater number of fetal loss was encountered in eclampsia with relatively higher estriol. 5. Vaginal cytologic smear test is a good method for the evaluation of the urinary estriol level and it is an adjunct of the fetoplacental function test. 6. In the last month of pregnancy, although there was no recognizable correlation in between the fetal weight and the urinary estriol level in toxemia of pregnancy as the fetal weight increases. 7. In toxemia of pregnancy, there was no correlation between the urinary estriol and the uric acid level. 8. Urinary estriol excretion in the intra-uterine fetal death without hypertensive complication of pregnancy showed significantly lower level, less than 2.0㎎/24hours. On the contrary, the estriol level in the intra-uterine fetal death in convulsive or eclamptic woman did not decrease to such a remarkable degree as in the intra-uterine fetal death in non-toxic state, suggesting a restriction in the fetoplacental evaluation. Vaginal cytology in the intra-uterine fetal death gives an information of the level of urinary estriol, and shows a placental insufficiency picture. 9. The so called "post-dated pregnancy" merely based on the menstrual age did not invariably show a true overmaturity, hormonally or cytologically.
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최종현,이응수,이홍균 인제대학교 1988 仁濟醫學 Vol.9 No.4
A case of holoprosencephaly associated with hydramnios is presented with a brief review of its literatures, This lobal type holoprosencephaly has following anomalies of fused thalamus and agenesis of corpus callosum, dorsal cyst, microphthalmia, one nostril and undetectable pituitary gland.
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생쥐의 卵子自然成熟 및 體外受精에 있어서 卵丘細胞의 役割
이희섭,홍기연,이희민,최은하,김원신 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
This study was to determine whether cumulus cell augments spontaneous maturation in vitro of oocyte and in vitro fertilization of the mouse. The maturation rate was evaluated by analyzing the metaphase Ⅱ chromosomal configurations 24 hour after incubation and the fertilization frequency was evaluated by observation of zygotic division to 2-cell 16 hour after insemination. The maturation rate of cumulus-oocyte complex was not significantly different in that of denuded oocytes(86% versus 81%). The fertilization frequency of cumulus-oocyte complex was significantly higher than that of denuded oocytes (59% versus 29%, p<0.05). It is concluded that the presence of cumulus cell does not augment the spontaneous maturation of immature oocyte but augments the fertilization frequency in mouse.
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