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변희진 ( Hee Jin Byun ),원종현 ( Chong Hyun Won ),허창훈 ( Chang Hun Huh ),조소연 ( So Yun Cho ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),박하나 ( Ha Na Park ),장성은 ( Sung Eun Chang ),최지호 ( Jee Ho Choi ),이양원 ( Ya 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Background: Sarcoidosis is a systemic noncaseating granulomatous disorder of unknown origin, which can involve any organs including the skin. Objective: The purpose of this study is to investigate the clinical characteristics of sarcoidosis in patients in Seoul and Gyeonggi-do. Methods: A total of 62 patients with sarcoidosis, where sarcoidosis was confirmed by histopathologic examinations at seven university hospitals in Seoul and Gyeonggi-do from 2000 to 2006, were enrolled in this study. The clinical characteristics were analyzed by a thorough review of medical records, histopathologic and radiologic examinations. Results: Man to woman ratio was 1:1.48 and 42% of the patients were in their fifth decade. The most frequent chief complaints were cutaneous symptoms (37%), followed by respiratory symptoms (31%). The most frequently involved organs were intrathoracic organs (84%), followed by the skin (37%), peripheral lymph nodes (13%), bones (11%), spleen (8%) and eyes (5%). The most common cutaneous lesion was subcutaneous nodule (74%), followed by papule (13%). Extremities (65%) were the most frequent sites of cutaneous lesions. Systemic organ involvements were observed in 70% of patients with cutaneous sarcoidosis. Among them, the most frequently involved organs were intrathoracic organs (81%), followed by bones (25%), eyes (19%), and peripheral lymph nodes (19%). Conclusion: The results were generally similar with the previous domestic reports. Compared with the foreign reports, cutaneous involvement was more frequent and ophthalmic involvement was less frequent. Subcutaneous nodule was the most frequent cutaneous lesion which seems to be a unique feature of this study. (Korean J Dermatol 2007;45(9):877∼883)
주기적 면역글로불린 정맥 투여로 호전된 청피반성 혈관염 2예
변희진 ( Hee Jin Byun ),박현선 ( Hyun Sun Park ),민성욱 ( Seong Uk Min ),신효승 ( Hyo Seung Shin ),이갑석 ( Kap Sok Li ),원종현 ( Chong Hyun Won ),조소연 ( So Yun Cho ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.10
Livedo vasculitis is a chronic dermatosis characterized by recurrent painful ulceration of the lower limbs, which heals to leave atrophie blanche. The precise pathophysiology is not known. Antiplatelet, anticoagulant, fibrinolytic therapies and anabolic steroids have been reported to be helpful in this syndrome. However, no consistent benefit has been demonstrated with any treatment modality. Recently, pulsed intravenous immunoglobulin therapy has been reported to be effective in some refractory cases. We herein report two cases of recalcitrant livedo vasculitis which were effectively treated with pulsed intravenous immunoglobulin therapy. These were the first trials carried out in Korea. (Korean J Dermatol 2006;44(10):1231~1234)
인공피부모델에서 지방조직 유래 중간엽 줄기세포가 표피와 기저막 형성에 미치는 효과
변희진 ( Hee Jin Byun ),이승호 ( Seung Ho Lee ),김지은 ( Ji Eun Kim ),김연경 ( Yon Kyung Kim ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.9
Background: There is an increasing need for making a more ideal artificial skin model. Objective: To evaluate the effects of adipose tissue-derived mesenchymal stem cells (ATMSC) on the formation of epidermis and basement membrane in artificial skin models. Methods: ATMSC were isolated from lipo-aspirated fat tissues, and their phenotypes were confirmed by cell surface markers. Three kinds of artificial skin models were made using three different dermal substitutes. The dermal substitutes in the three models contained fibroblasts only, fibroblasts together with ATMSC or ATMSC only. The formation of epidermis and basement membrane was evaluated by immunohistochemical stains and transmission electron microscopy. Results: Among the three models, the model with both fibroblasts and ATMSC in the dermal substitute showed the most excellent formation of epidermis and, especially, basement membrane. In this model, the basement membrane proteins, laminin and type IV collagen, were expressed most apparently at the dermo-epidermal junction and, lamina lucida, lamina densa and anchoring fibrils were most evidently observed under transmission electron microscopy. Whereas, the model with only ATMSC did not show keratin 1 expression, suggesting that the ``skin-type`` stratified squamous epithelium was not formed well. Conclusion: ATMSC together with fibroblasts can be used effectively in constructing artificial skin models. (Korean J Dermatol 2008;46(9):1186~1193)
치유된 대상포진 부위에 발생한 혈관육종 Wolf`s Isotopic Response
조현희 ( Hyun Hee Cho ),백승환 ( Seung Hwan Paik ),변희진 ( Hee Jin Byun ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4
Angiosarcoma is a rare malignant vascular tumor of endothelial origin. It can involve any organ, including the skin, soft tissue, liver, bone, spleen, and orbit. Skin is the most frequent site of primary angiosarcoma, however, metastatic skin involvement of angiosarcoma is exceptional. Wolf`s isotopic response implies that the new disease appeared at the site of an already healed skin disease. Several types of cutaneous lesions have been described, occurring within cleared cutaneous herpes zoster, or herpes simplex lesions. These lesions include comedones, granulomatous diseases, tinea, furunculosis, wart, psoriasis, pseudolymphoma, leukemia, lymphoma, basal cell carcinoma, squamous cell carcinoma and cutaneous metastases, from internal carcinoma. Herein, we report a case of cutaneous angiosarcoma of unknown origin that has developed at the site of a scar, after herpes zoster in a 79-year-old man as isotopic response. (Korean J Dermatol 2012;50(4):367∼370)
이갑석 ( Kap Sok Li ),변희진 ( Hee Jin Byun ),이동훈 ( Dong Hun Lee ),원종현 ( Chong Hyun Won ),조소연 ( So Yun Cho ),김범준 ( Beom Joon Kim ),김명남 ( Myueng Nam Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Pellagra is a chronic wasting disorder characterized by 3 clinical distinct symptoms; dermatitis; dementia; and diarrhea. It results from a marked cellular deficiency of water-soluble vitamin B3, also called niacin. Dermatitis begins as an erythema and shows bilateral symmetrical eruption at cutaneous sites of solar exposure. Herein we report 2 cases of pellagra in chronic alcoholics. (Korean J Dermatol 2007;45(9):956∼958)
나정임 ( Jung Im Na ),변희진 ( Hee Jin Byun ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.4
Papuloerythroderma of Ofuji (PEO) is an uncommon entity of unknown etiology, characterized by coalescing erythematous papules sparing skin folds. A number of cases have described the association of this disorder with malignant with pathology, mainly with cutaneous T cell lymphoma. Such reports give rise to the suggestion that PEO may be a precursor of lymphoma or a form of cutaneous T cell lymphoma. We report a case of PEO, which was diagnosed as cutaneous T-cell lymphoma only 2 months after the development of skin lesions, and rapidly progressed. This case suggests the presence of a variant of cutaneous T cell lymphoma with clinical feature of PEO, which is different from mycosis fungoides or Sezary syndrome. (Korean J Dermatol 2007;45(4):373~377)
최미라 ( Mi Ra Choi ),박현선 ( Hyun Sun Park ),변희진 ( Hee Jin Byun ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Background: Dermatologic problems may represent a primary cutaneous disorder or an underlying systemic disease and are common but frequently overlooked in inpatients. Objective: We described and quantified dermatologic consultations in Seoul National University Hospital over 9 years for comparison with other reports. Methods: We retrospectively studied the records of 9,529 hospitalized patients for which a dermatologist consultation was requested. Results: Consult patients numbered 9,529 among 506,927 inpatients (1.88%). The total number of male and female patients were 5,428 (56.96%) and 4,101 (43.04%), respectively (M: F=1.32:1). The most frequent age group was the 6th decade (19.05%) and the lowest age group was the 1st decade (5.14%). In 2008, most of the consultations (72.24%) were made by internal medicine, followed by neurology (6.34%), and pediatrics (4.59%). Patients with cancer were most frequently consulted for underlying disease (24.58%), followed by hematologic malignancy (22.66%), and liver disease (10.69%). The most common skin disorders were drug eruption (24.5%), followed by eczema (15.7%), and viral infection (12.6%), and with more consults for drug eruption and viral infection than previous studies. The most common reasons for consultation were: dermatologic diseases or conditions (73.8%), diseases related to treatment (16.2%), and skin lesions of systemic disease (8.8%). Conclusion: Inpatient dermatology consultations not only improve the quality of patient care but also can provide opportunities for residency education and experience with clinical dermatology. (Korean J Dermatol 2010;48(3):163~170)
건강검진 수진자들에서 성별, 나이 및 체질량지수에 따른 간효소치의 상세 분포 연구
최승호 ( Seung Ho Choi ),양종인 ( Jong In Yang ),이창현 ( Changhyun Lee ),변희진 ( Hee Jin Byun ),강정묵 ( Jung Mook Kang ),김세룡 ( Se Young Kim ),임정윤 ( Jeong Yoon Yim ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.4
Background/Aims: The aim of this study was to examine the distribution of range of liver enzymes according to age and BMI in each gender using large-scale data. Methods: Data were gathered from 65,715 subjects who underwent a routine health check-up and did not have HBsAg and anti-HCV. Boxplot analysis was used to examine the distribution of range of liver enzymes according to age and BMI in each gender. Multivariate linear regression analysis was performed for assessment of the association of liver enzymes with age and BMI, and to determine whether the range of liver enzymes was affected by risk factors for metabolic syndrome in each gender. Results: ALT, AST, and GGT levels showed significant association with BMI in both male and female after adjusting for age. The range of ALT, AST, and GGT levels varied more widely according to the increase in BMI in males than in females, and this finding was more prominent in younger subjects than in older subjects. All risk factors for metabolic syndrome were shown to affect liver enzyme levels in male subjects. However, although most risk factors for metabolic syndrome affected liver enzyme levels, there might be weak or no effect of fasting hyperglycemia on AST, and low serum HDL-cholesterol level on GGT in female subjects. Conclusions: Age, BMI, and other risk factors for metabolic syndrome had a significant effect on the distribution of range of liver enzymes in each gender, even in this study conducted from Korean health checkup subjects. (Korean J Gastroenterol 2014;64:213-223)