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배은영 한국보건경제학회 2000 보건경제와 정책연구 Vol.6 No.2
The purpose of this paper is to investigate the determinants of market share in the pharmaceutical industry of Korea. Data sources are originators and their multiple-source drugs selected from the 37 entities. Data were obtained from various primary and secondary sources for the license dates, sales volume and units sold, and characteristics of drugs in the sample markets. A multiple regression equation was established to find the relations between market share and its dominating factors. According to the results, the market share was mainly determined by the three factors: whether the product is a originator, how many products are competing in the market, and whether the product is being advertised. However, in analgesic market, the margin rate was the most significant factor. Among the originators, the duration of monopoly significantly affected its market power. In conclusion, this study shows that the brand image of a product had a great impact on the pharmaceutical market, and the requirement of a first-mover was of great advantage in Korea.
배은영 한국보건사회연구원 2014 보건복지포럼 Vol.212 No.-
본고에서는 주로 의약품과 구별되는 치료재료의 시장특성을 살펴보고, 현재 우리나라 치료재료 급여 및 가격결정방식의 현황과 문제점, 치료재료의 평가 과정을 개선하고, 이를 급여결정에 연계하는 방안에 대해 살펴보고자 한다. 현재 적용되고 있는 치료재료의 급여관리 방안은 다양하겠으나, 본고에서는 이중 주로 치료재료의 평가와 관련성을 갖는 급여정책을 중심으로 살펴보고자 한다.
Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
배은영,이은진,강효경,이신엽,Gwang Jin,이원기,최진은,전효성,임정옥,이응배,박재영 대한의학회 2011 Journal of Korean medical science Vol.26 No.11
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of TP53 mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of TP53 mutations in lung cancer.
NICE의 설립과 변화를 통해 살펴본 영국 보건의료기술평가의 발전 배경과 과제
배은영 한국보건의료기술평가학회 2020 보건의료기술평가 Vol.8 No.2
NICE is the most influential health technology assessment (HTA) organization in the world. This study reviews the brief history of NICE and explores how an institution like NICE has been created and expanded its role, interacting with the institutional and socioeconomic environment. Factors that contributed to the UK’s health technology assessment system include its long-standing empirical academic tradition, effective mobilization of human resources through changes in research and development strategies, the influence of medical publications such as BMJ and Lancet and their support for HTA, and the centralized health care system. NICE, which was created to solve the “postcode lottery” issues, has faced several challenges since its launch, but its achievement are recognized both domestically and internationally and has continued to expand the scope of its activities. Political circles have been able to avoid responsibility for uncomfortable decisions by taking technocratic approaches, and NICE has gained some recognition from stakeholders by emphasizing transparency and communication with stakeholders from the beginning of its establishment. However, because rationing itself is a political decision, the controversy surrounding the NICE appraisal has continued, and NICE has several challenges at hand.
가자미식해에서 분리한 Lactobacillus spp.의 항헬리코박터 활성 평가
배은영,조기운,정성근,조영제,김병오 한국생명과학회 2023 생명과학회지 Vol.33 No.3
Helicobacter pylori infects the mucosa, induces chronic inflammation and ulcers, and is known as a biological carcinogen. Antibiotics are used as therapeutic agents for H. pylori, but there are problems such as resistance. Thus, research is being conducted on the use of lactic acid bacteria (LAB) as an alternative therapeutic agent. There have been many studies on LAB related to kimchi. However, studies related to Gajami Sikhae, a traditional fermented seafood in Korea, are insufficient. In this study, we investigated the inhibitory effect of LAB isolated from Gajami Sikhae on H. pylori and its use as a probiotic. Forty species of LAB isolated from Gajami Sikhae were identified as Lactobacillus plantarum, Lactobacillus brevis, Leuconostoc mesenteroides, and Weisella paramesenteroides, and 10 strains of 40 species were selected through liquid inhibition assay of H. pylori. The selected LAB supernatant at 1%, 5%, and 10% had a growth inhibitory effect on H. pylori 52, 51, e-53, and 309. The adjusted pH of 7.0 was used for the LAB culture supernatant, in reference to a study that the growth of H. pylori is affected by acid. All 10 strains of LAB at 5% and 10% concentration suppressed the growth of H. pylori 52, and 7 strains of LAB at 10% concentration suppressed the growth of H. pylori e-53. LAB also had the effect of suppressing the activity of urease. Finally, LAB isolated from Gajami Sikhae is expected to be useful for eradicating and preventing H. pylori.