30 기니 픽 실험적 대장염에서 대장 운동 기능의 변화

박효진 ( Hyo Jin Park ),지상원 ( Sang Won Ji ),임정현 ( Jung Hyun Lim ),이상인 ( Sang In Lee ) 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-

Helicobacter pylori 에 대한 혈청 IgG 항체의 양성율 및 혈청 Pepsinogen 과의 상관관계

박효진(Hyo Jin Park),이병권(Byoung Kwon Lee),정준표(Jun Pyo Chung),조현근(Hyeon Geun Cho),이상인(Sang In Lee),박인서(In Suh Park),손영모(Young Mo Sohn),이창훈(Chang Hoon Lee),송경순(Kyung Soon Song) 대한내과학회 1995 대한내과학회지 Vol.48 No.1

N/A Objectives: This study was designed to estimate the prevalence of Helicobacter Pylori infection in a healthy population in Korea and correlate between H. Pylori infection and serum pepsinogen levels as markers of gastritis and atrophic gastritis. Methods: We collected sera obtained form 104 children and 173 adult who had no gastrointestinal symptoms and measured specific IgG antibodies against H. Pylori by Bio-Rad G. A. P test. Serum pepsinogen 1 and 2 concentrations were determined by radioimmunoassay. Results: 1) The frequency of H. Pylori infection increased with age and was more than 80% over age 40. 2) Serum pepsinogen 1 and 2 concentrations in the healthy population were increased with age, while the serum pepsinogen 1/2 ratio decreased. 3) There were no significant statistical differences between the titre of specific IgG antibodies against H. Pylori and serum pepsinogens. Conclusion: The data from this study suggested that the prevalence of Helicobacter Pylori infection increased with age and serum pepsinogen levels were related to the presence or absence of H. Pylori infection. We conclude that H. Pylori infection is one of the factors which helps develop atrophic gastritis, the precursor lesion of gastric cancer.

수열반응 조건에서 폐콘크리트 미분말을 사용한 경량기포콘크리트의 화학적 특성

박효진(Park, Hyo Jin),이경현(Lee, Kyung Hyun),강철(Kang, Cheol),정지용(Jeong, Ji Yong),이대근(Lee, Dae Geun),김진만(Kim, Jin Man) 한국콘크리트학회 2010 한국콘크리트학회 학술대회 논문집 Vol.2010 No.5

Nitric Oxide와 Vasoactive Intestinal Peptide가 기니 픽 위저부 평활근 이완에 미치는 영향

박효진(Hyo Jin Park),이영호(Hyo Jin Park),이혜영(Hye Young Lee),정준표(Jun Pyo Chung),이관식(Kwan Sik Lee),전재윤(Chae Yoon Chon),강복순(Bok Soon Kang),박인서(In Suh Park) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

N/A Background/Aims: The autonomic nervous system distributed throughout the stomach consists of adrenergic, cholinergic, and non-adrenergic, non-cholinergic (NANC) nerves. Of these, NANC nerve fibers are known to be distributed all throughout the gastrointestinal tract and they provide the main inhibitory nerve supply to the gut smooth muscle. NANC nerve is known to release neurotransrnitters such as nitric oxide (NO), adenosine 5-triphosphate (ATP) and vasoactive intestinal peptide (VIP). However, the effect produced by each of the NANC neurotransmitter depends on an animal species and parts of gastrointestinal tract. Therefore, this experiment applied electrical field stirnulation at the circular musc]e of a guinea pigs gastric fundus to observe any relation of NANC nerve in muscu]ar relaxation. Methods: The effect of ATP, VIP, and NO on muscle re)axation was determined through the electrical field stimulation, and each neurotrans- mitters ability to regulate the muscle relaxation was compared. Results: Muscle strips were relaxed in response to electrical field stimulation that was applied. The relaxation was not inhibited by atropine or guanethidine, but was completely inhibited by tetrodotoxin. The muscle relaxation caused by NANC nerve stimulation was inhibited by L-NNA, VIP antagonist, and suramin. L-NNA was the most potent inhibitor among them. The muscle relaxation caused by electrical field stimulation was not further inhibited by VIP antagonist after the pretreatment of L-NNA, however, it was further inhibited by L-NNA following the treatment of VIP antagonist. The electrically stimulaed induced muscle relaxation was almost complete]y abolished by coadministration of L-NNA with VIP antagonist and suramin, The exogenous VIP-induced muscle relaxation was not affected by presence or absence of L-NNA. Oxyhemoglobin or methylene blue treatment inhibited the muscle relaxation induced by electrical field stimulation. Conclusions: Non-adrenergic and non-cholinergic nerve has an inhibitory neurotransmission in a guinea pigs gastric fundus circular muscle and NO is the principal inhibitory neurotransmitter of NANC nerve. NO mediated muscle relaxation is thought to be associated with increase of cGMP in muscle cells. (Korean J Gastroen- terol 1997;29:2S9 - 300)

알칼리 수용액에서 현상이 가능한 네거티브 형태의 폴리이미드 공중합체의 합성과 광 형상화 연구

박효진(Hyo Jin Park),신해인(Hae In Shin),채다정(Da Jeong Chae),여지현(Ji Hyeon Yeo),권지은(Ji Eun Gwon),권준영(Jun Young Kwon),이승우(Seung Woo Lee) 한국고분자학회 2022 폴리머 Vol.46 No.6

광반응기로 메타아크릴로일 그룹인 hydroxyethyl methacrylate(HEMA)를 곁사슬로 가지며 알칼린 수용액에 현상이 가능한 네거티브 광감성 폴리(아믹 에스테르) 공중합체를 pyromellitic dianhydride(PMDA), 4,4’-oxydianiline(ODA)와 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane(Bis-APAF)를 기반으로 합성하였다. 합성된 광감성 폴리(아믹 에스테르) 공중합체는 열적 이미드화 방법에 의하여 폴리이미드로 전환되며, 높은 열안정성을 가짐을 확인하였다. 광감성 폴리(아믹 에스테르) 공중합체, 광개시제 및 가교제 등의 광감성 조성물의 광 형상화 연구에서 고분자 합성에 투입된 ODA와 Bis-APAF의 조성에 따라 자외선 노광에 따른 현상 속도 및 형상화에 차이를 보임을 확인하였다. 전자주사현미경을 이용하여 알칼리 수용액에서의 현상 및 열적 이미드화 후의 표면을 분석하였으며, 광감성 폴리(아믹 에스테르) 공중합체 합성 시 투입된 ODA와 Bis-APAF의 조성에 따른 특성을 분석하였다. Negative typed photo-sensitive poly(amic ester) copolymers having methacryloyl groups as a side chain were synthesized using pyromellitic dianhydride (PMDA), 4,4’-oxydianiline (ODA) and 2,2-bis(3-amino-4-hydroxyphenyl) hexafluoropropane (Bis-APAF). The poly(amic ester) copolymers converted polyimides by thermal imidization process, and the polyimides have good thermal stability. The photo-lithographic properties of the formulation containing poly(amic ester) copolymers, photo-initiator, and cross-linker were investigated with the point of composition of feeding ratio of ODA and Bis-APAF in the synthesized poly(amic ester) copolymers.

HBsAg 과 Anti - HBs 가 동시 양성예의 임상적 경과 관찰

박효진(Hyo Jin Park),김경희(Kyung Hee Kim),노형근(Hyung Keun Roh),박종훈(Chong Hoon Park),이관식(Kwan Sik Lee),문영명(Young Mung Moon),강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),송경순(Kyung Soon Song) 대한내과학회 1990 대한내과학회지 Vol.39 No.1

N/A To assess the clinical implication of concomitant HBsAg and anti-HBs in patients with HBV infection, we studied the longitudinal behavior of HBsAg, anti-HBs and their subtypes and the correlation of clinical events in 25 patients with concomitant HBsAg and anti-HBs. The results were as follows: 1) Concurrent markers were persistent in 12 (57.1%) out of 21 patients with chronic liver disease. In two patients, anti-HRs was detected intermittently during the follow-up period. In each, the recurrent antibody was persistently heterotypic, and the appearance, disappearance and reappearance of anti-HBs were not associated with alterations in the clinical course. 2) The mean level of anti-HBs was 16.6±17.7 SN ratrio and 61.9% of the patients were less than 10 SN ratio. 3) In the majority of patients, HBsAg subtype ad was accompanied by anti-y. In addition, in two patients with intermittent concomitance the recurrent amtibody was persistently heterotypic. 4) During the follow-up period, acute exacerbations of the disease occurred in four out of 21 patients with chronic hepatitis. All patients were initially HBsAg subtype ad and remained so during and after exacerbation. Therefore, the possibility of reinfection with HBV of a different subtype was not supported. In conclusion, concomitant HBsAg and anti-HBs are not uncommon in patients with acute and chronic hepatitis B and do not reflect changes in the clinical courses. The concomitance is of no practical or prognostic significance, and therefore, the attention devoted to it may be clinically unnecessary.

기니 픽 회장 운동 기능에 미치는 Phosphodiesterase 4 형과 5 형 억제제의 효과

박효진(Hyo Jin Park),최성우(Sung Woo Choi),이영호(Yong Ho Lee),임정현(Jung Hyun Lim),이상인(Sang In Lee),박인서(In Suh Park) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5

Background/Aims: Intracellular cAMP or cGMP is degraded by cyclic nucleotide phosphodiesterase ( PDE) . We hypothesized that PDE inhibitors modulate the peristalsis and nerve- induced responses of the smooth muscle of the guinea pig ileum. Methods: To examine the effect of rolipram ( type 4 inhibitor of PDE) and zaprinast ( type 5 inhibitor of PDE) , we measured peristaltic amplitude, area under curve ( AUC) , and frequency of contractions from ileal preparation using the peristaltic bath. The mechanical activity of the circular muscle was measured with a clip attached, via the three sites of serosal surface, to the underlying circular muscle of intact ileum in the peristaltic chamber. In another set of experiment, muscle strips from the ileum were stimulated by an electrical field. The effects of rolipram, and zaprinast, on peristalsis and nerve- induced contraction were explored. Results: The amplitude and AUC of peristaltic contractions were significantly decreased in rolipram or zaprinast-treated group and frequency of contractions was significantly delayed in rolipram or zaprinast-treated group. The nerve- induced contraction of smooth muscle was significantly decreased in rolipram-treated group. Conclusions: These observations suggest that PDEs may play a role in the modulation of peristaltic behavior of the ileum and PDE inhibitors may be used in the treatment of hyperkinetic bowel disorders. ( Korean J Gastroenterol 2002; 39: 343- 349)

일개 종합병원 복강경 위절제술 환자의 표준진료지침 적용효과

박효진(Hyo-Jin Park),박종(Jong Park),류소연(So-Yeon Ryu),최성우(Seong-Woo Choi) 한국콘텐츠학회 2016 한국콘텐츠학회논문지 Vol.16 No.9

본 연구는 새롭게 개발된 복강경 위절제술의 표준진료지침(Critical pathway, CP) 적용효과를 분석하기 위해 수행되었다. 연구대상은 전라남도에 소재한 C병원 위장관클리닉에서 위암으로 진단받고 복강경 위아 전절제술을 시행하고 퇴원한 20세 이상의 성인 환자로, 실험군은 2008년 10월부터 2009년 9월까지 CP를 적용하여 복강경 위아전절제술을 시행한 환자 102명으로 하였고, 대조군은 2007년 9월부터 2008년 9월까지 CP를 적용하지 않고 복강경 위아전절제술을 시행한 환자 63명으로 하였다. 본 연구결과 퇴원시 통증에서는 CP적용군이 비적용군보다 퇴원 당일 통증이 있는 경우가 0.07배 낮았다(Odds ratio [OR], 0.07; 95% Confidence interval [CI], 0.03-0.21). 총 재원일수는 CP적용군에서는 평균(표준오차)은 8.95(1.33)일, 비적용군에서는 평균 10.69(4.04)일로 유의한 차이를 보였고(p<0.001), 수술 후 재원일수 또한 CP적용군이 평균 7.16(0.94)일, 비적용군이 평균 8.79(3.90)일로 통계적으로 유의한 차이(p<0.001)를 보였다. 본 연구 결과 복강경 위절제술에 대한 CP의 적용은 퇴원시 통증감소, 총 재원일수 및 수술 후 재원일수를 단축시키는 효과를 보였다. This study is aim to investigate how applying a critical pathway(CP) to stomach cancer patients affects their recovery and treatment. The subjects were 165 patients over the age of 20 who were diagnosed with stomach cancer at the gastrointestinal clinic of C hospital and who underwent laparoscopic subtotal gastrectomy. The case group inclueded 102 patients who underwent laparoscopic subtotal gastrectomy with applying the CP from October 2008 to September 2009. The control group included 63 patients who underwent laparoscopic subtotal gastrectomy without applying the CP from September 2007 to September 2008. Pain at the time of discharge was significantly lower in the CP applicated group than in the non-applicated group (Odds ratio [OR], 0.07; 95% Confidence interval [CI], 0.03-0.21). The CP applied group was significantly lower than non-applied group in total hospitalization days (CP applied group: 8.95[1.33], non-applied group: 10.69[4.04], p<0.001) and in postoperative hospitalization days (CP applied group: 7.16[0.94], non-applied group: 8.79[3.90], p<0.001). In conclusion, application of a critical pathway to laparoscopic subtotal gastrectomy reduced pain at the time of discharge, total hospitalization days and postoperative hospitalization days.

영유아기 손자녀를 둔 조모의 양육 지원에 영향을 미치는 요인에 관한 연구

박효진(Park, Hyo-Jin),박소영(Park, So-Young) 한국영유아보육학회 2013 한국영유아보육학 Vol.0 No.77

본 연구는 영유아기 손자녀를 둔 조모의 양육 지원에 영향을 미치는 요인을 파악하기 위한 목적으로 이루어졌다. 이를 위해 여성가족패널자료를 활용하여 영유아 손자녀를 둔 조모 중 손자녀를 돌보는 조모의 양육 지원 특성을 살펴보았으며, 양육 지원에 영향을 미치는 요인을 분석하였다. 연구결과 영유아기 손자녀에 대한 조모의 양육 지원에 영향을 미치는 요인으로는 학력, 배우자 유무, 근로 유무, 영유아기 손자녀와의 동거유무, 성인자녀로부터 받는 경제적 도움, 생활비 부족액, 가사노동 환산액, 여성취업에 대한 인식으로 나타났다. 이러한 연구결과를 바탕으로 정책적, 실천적 제언이 이루어졌다. This study was designed to explore the factors affecting care support of grandmothers. Using women’s panel data of Korea Women’s Development Institute, the researchers explored the characteristics of care support of grandmothers who care for grandchildren and analyzed the factors affecting the grandmothers’ care support. The results were as follows. The factors affecting the grandmothers’ care support were education background, with/without spouse and labor living together with grandchildren or not, economic help from adult children, the deficiency of living, and the perception on women’s job. On the basis of this results, suggestions for policy and practice were offered.

고등학교 과학과 지국과학 교과서의 평균자오면순환의 오류와 수정을 위한 제안

박효진 ( Hyo Jin Park ),문병권 ( Byung Kwon Moon ) 전북대학교 과학교육연구소 2013 과학과 과학교육 논문지 Vol.38 No.2

2009년 개정 교육과정에 따른 고등학교 과학과 지구과학 교과서에는 평균자오면 순환이 소개되어 있다. 그런데 몇몇의 교과서는 평균자오면순환 중 페렐순환의 상층의 방향이 일치하지 않는다. 이 논문은 12종의 고등학교 과학과 지구과학 교과서에 소개되어 있는 평균자오면순환 그림을 분석하고, 관측자료 분석을 통해 평균자오면순환의 정확한 그림을 제시하는 것에 목적이 있다. 또한 OpenGrADS을 이용하여 평균자오면순환을 직접 그릴 수 있는 방법을 소개하였다. The purpose of this study is to correct a error in the mean meridional circulation (MMC) figures of the science textbooks. The Ferrel circulation from the 12 high school textbooks are shown in two different types in term of the direction of the upper branch in the circulation. The upper atmospheric flow associated with Ferrel cell from the 8 textbooks shows northerly (from the north to the south), but others southerly (from the south to the north). We calculate the MMC from the two observation data (ECMWF and NCEP). The Ferrell cell has sinking motion at 30°N and 30°S, relatively weak rising motion approximately near 60°. The mass continuity indicates that upper branch of the Ferrel cell should flow toward the equatorward. We also introduced the OpenGrADS software which enables teachers and students to create their own figures of MMC, thus, helps better understand the general circulation.