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박혜련,최기헌,Park, Hye-Ryun,Choi, Ki-Heon 한국데이터정보과학회 2009 한국데이터정보과학회지 Vol.20 No.5
본 연구에서는 대기오염물질 중에서 주목을 받고 있는 분진 직경이 10마이크로미터 (micrometer) 이내의 것을 대상으로 실제로 증가하는지 감소하는지를 알아보기 위하여 교락 요인을 제외한 분진을 대상으로의 순수한 장기 추세를 연구하였다. 자료는 1996년에서 2000년까지 서울시의 기상 변수들 (최대기온, 평균습도, 최대풍속, 일사량)과 27지점에서 얻은 분진 직경이 10마이크로미터 이내의 것을 이용한다. 이 자료를 이용하여 분진과 비선형 관계를 보이는 기상 변수들의 회귀 스플라인을 이용하여 계절성을 통제한 일반화 부가모형을 세웠다. 그 결과 증가가 아닌 감소하는 순수 장기 추세를 얻을 수 있었다. Our study aimed to illustrate long term trend in 10 micrometer particular matters excluding confounding effect. Daily 10 micrometer particular matters data were measured in 27 places and meteorological data (maximum temperature, humidity and maximum wind speed, solar radiation) were obtained from the national institute of environmental research for the period from January, 1996 to December 2000. To estimate the increasing and decreasing long term trend in a set of observed data, set up the model. The model included regression spline smooth function on the time and meteorological factors to capture the seasonal time trend and any possible nonlinear relationship. The result was estimated to decrease slightly after adjusting for meteorological factors and seasonal time trend.
박혜련 ( Hye Ryun Park ),노석선 ( Seok Sun Roh ) 대전대학교 한의학연구소 2015 혜화의학회지 Vol.24 No.1
Objectives: This study was carried out to assess the risk of bias of clinical trials on acne treatment with herbal medicine that have been published in Korea. Methods: 7 electronic databases in Korea were searched for clinical trials on acne treatment. Two independent reviewers selected clinical trials on herbal medicine treatment for acne. Selected studies are categorized according to DAMI(Study Design Algorithm for Medical literature of Intervention). RCTs are assessed according to Cochrane RoB(Risk of Bias), non-randomized studies(Before-after studies) are assessed according to RoBANS(Risk of Bias Assessment tool for Non-randomized Study). Results: After selection process, 25 articles are left. Among 25 articles, 3 RCTs and 4 before-after studies are finally included. In RCTs, the proportion of ‘unclear’ is high in criteria of ‘random sequence generation’, ‘allocation concealment’, and ‘blinding’. In before-after studies, ‘high’ is high in criteria of ‘blinding for outcome assessment’ and ‘incomplete outcome data’. Conclusions: Considering the above results of the assessment, it is necessary to conduct more well designed clinical trials on acne treatment with herbal medicine.
황반부종 치료를 위한 유리체강내 트리암시놀론 주입의 효용성
김덕수,박혜련,윤영희,Deok-Soo Kim,Hye-Ryun Park,Young-Hee Yoon 대한안과학회 2005 대한안과학회지 Vol.46 No.10
Purpose: To investigate the effect of an intravitreal injection of triamcinolone acetonide (TA) for the treatment of macular edema due to several causes. Methods: One hundred eyes of 98 patients (DM, 58 eyes; branch retinal vein occlusion, 42 eyes) who received an intravitreal injection of 4mg (0.1cc) TA were included in this study. We performed preoperative and 1-, 3- and 6-month postoperative examinations that included stereoscopic biomicroscopy, fluorescein angiography (71 eyes) and optical coherence tomography (85 eyes). Pre- and postoperative visual acuity and IOP were measured. Results: After 1 month, visual improvement by 1 line or more was achieved in 62 eyes (62.0%). Sixty-five eyes (65.0%) and 49 eyes (57.6%) showed improved visual acuity after 3 and 6 months, respectively. Macular thickness decreased by 46.5% after 1 month, by 49.4% after 3 months, and by 50.8% after 6 months. There were no significant differences in visual improvement or thickness reduction between diabetic macular edema and edema secondary to branch retinal vein occlusion. There was no correlation between improvement of visual acuity and macular edema thickness decrease. Complications included a transient rise in intraocular pressure in 9 eyes and a secondary cataract in one eye. Conclusions: Intravitreal injection of triamcinolone acetonide 4 mg (0.1 cc) is an effective, simple and safe treatment for diabetic macular edema and macular edema secondary to branch retinal vein occlusion.
다양한 재질의 인공수정체를 삽입한 인공수정체안에서 고위수차의 변화
권혁락,박혜련,구본술,김태임,Hyuk-Lak Kwon,Hye-Ryun Park,Bon-Sool Koo,Tae-Im Kim 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To compare high-order aberrations in the pseudophakia with different types of intraocular lenses (IOLs), as well as with normal phakic eyes. Methods: This single-center prospective study comprised 80 cataract patients who underwent cataract surgery and 20 phakic eyes. Twenty eyes received an AF-1? VA-60BB; 20 eyes, a Corneal? ACR6D SE; 20 eyes, a Sensar? AR40e; and 20 eyes, a ClariFlex?. One month after cataract surgery, the eye aberration was measured using a Hartmann-Shack type aberrometer. The same test was performed for 20 normal phakic eyes. The individual Zernike polynomials, the root mean square (RMS) values of the third and fourth order aberration, and the total RMS among the groups were compared. Results: The individual Zernike coefficient (Z3-1, Z33, Z4-4, Z40, Z44) showed a significant difference in the IOL-implanted groups compared with the normal phakic eyes. There were statistically significant differences in the RMS values of the third and fourth order aberration, and total among each group. Conclusions: There was a statistically significant increase in aberration in patients with high refractive index IOL and a statistically significant decrease in patients with silicone IOL, compared to the normal phakic eyes.
악안면 영역의 Castleman's disease의 치험례
정인교,김욱규,신상훈,박혜련,이의훈,장원석,Chung, In-Kyo,Kim, Uk-Kyu,Shin, Sang-Hoon,Park, Hye-Ryun,Lee, Eui-Hoon,Jang, Won-Seok 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.5
본 교실에서는 우측 악하부와 우측 안와 하부의 종창으로 내원한 53세 여자 환자에서 Fine Needle Aspiration Biopsy로 림프절의 반응성 과증식으로 진단되어 다시 절제 생검을 시행하여 multi-centric Castleman's disease로 진단하였다. 조직 검사상 유리질 혈관형과 형질세포형이 공존하는 복합형으로 나타났으며 병소의 적출술만을 시행한 후 1년이 지난 지금까지는 별다른 소견없이 좋은 경과를 나타내고 있으며 앞으로도 계속 주의깊은 관찰이 필요로 한다. Castleman's disease or angiofollicular lymph node hyperplasia, is a rare lymphoproliferative disorder. It may be appear as a local or generalized tumor-like condition, usually in chest or abdomen and may involve both lymph nodes and non-nodal tissues. Castleman's disease is an unusal entity which may at times mimic malignancy but is entirely benign in nature. It is topical as it has been noted to occur with AIDS and Kaposi's sarcoma. Careful interpretation of radiogram may help to distinguish Castleman's disease from other tumor condition, such as lymphoma, neurogenic tumor, or even angiofibroma, etc. But exact diagnosis must be made on the basis of histologic confirmation. In addition to histologic features, clinical distinction between the localized and multicentric form is important in selecting appropriate management. Surgical excision of an localized mass is the first choice of treatment. Partial resection, radiotherapy or observation alone may avoid the need for exessively aggressive therapy. Patients with multicentric disease don't benefit by surgical management because of systemic manifestation and rapid deterioration. Thus, antineoplastic agents and steroids may offer an alternative form of therapy. We report a case of female patient with Castleman's disease in oral and maxillofacial region, treated by surgical excision with good results.
중등도, 고도 근시에서 라섹과 에피라식의 단기간 임상성적
권혁락,김권일,구본술,박혜련,Hyuk-Lak Kwon,Kwon-Il Kim,Bon-Sool Koo,Hye-Ryun Park 대한안과학회 2005 대한안과학회지 Vol.46 No.10
Purpose: To compare the results of laser epithelial keratomileusis (LASEK) and epi-laser in situ keratomileusis (Epi-LASIK) for the treatment of moderate to high myopia. Methods: In this study, 50 patients with a manifest refraction of moderate to high myopia were assigned to two groups: 50 eyes of 25 patients treated with LASEK and 50 eyes of 25 patients treated with epi-LASIK. Uncorrected visual acuity (UCVA), manifest refraction, corneal haze, and postoperative pain were reviewed in LASEK and epi-LASIK treated eyes at 3 months after the operation. Results: At one week after surgery, UCVA was recovered more rapidly after epi-LASIK than LASEK (LASEK: 0.61±0.23, Epi-LASIK: 0.79±0.11, p<0.05), but UCVA at both 1 and 3 months showed no significant difference between the LASEK and epi-LASIK groups. However, epi-LASIK-treated eyes had lower postoperative pain scores and lower corneal haze scores (1 month; p=0.01) than those of LASEK-treated eyes. Conclusions: Epi-LASIK showed a more rapid visual recovery than LASEK at 1 week after surgery for the correction of myopia. Epi-LASIK-treated eyes also had less postoperative pain and an earlier reduction of postoperative corneal haze. These results suggest epi-LASIK could be a viable alternative procedure for the correction of moderate to high myopia.